{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:35:35Z","timestamp":1789079735306,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China, Project","award":["2018YFD0500601 and 2016YFD0501207"],"award-info":[{"award-number":["2018YFD0500601 and 2016YFD0501207"]}]},{"name":"Open Project of Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province","award":["KLAMEMB-2017-05"],"award-info":[{"award-number":["KLAMEMB-2017-05"]}]},{"name":"Innovation Group of Hubei Natural Science Foundation","award":["2018CFA020"],"award-info":[{"award-number":["2018CFA020"]}]},{"name":"Jiangsu Aomai Bio-technology Co., Ltd","award":["No"],"award-info":[{"award-number":["No"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The objective of this study was to evaluate the ability of a modified hydrated sodium calcium aluminosilicate (HSCAS) adsorbent to reduce the toxicity of T-2 toxin in broilers. Ninety-six one-day-old male broilers were randomly allocated into four experimental groups with four replicates of six birds each. The four groups, 1\u20134, received a basal diet (BD), a BD plus 6.0 mg\/kg T-2 toxin, a BD plus 6.0 mg\/kg T-2 toxin with 0.05% modified HSCAS adsorbent, and a BD plus 0.05% modified HSCAS adsorbent, respectively, for two weeks. Growth performance, nutrient digestibility, serum biochemistry, and small intestinal histopathology were analyzed. Compared to the control group, dietary supplementation of T-2 toxin decreased (p &lt; 0.05) body weight gain, feed intake, and the feed conversion ratio by 11.4\u201331.8% during the whole experiment. It also decreased (p &lt; 0.05) the apparent metabolic rates of crude protein, calcium, and total phosphorus by 14.9\u201316.1%. The alterations induced by T-2 toxin were mitigated (p &lt; 0.05) by the supplementation of the modified HSCAS adsorbent. Meanwhile, dietary modified HSCAS adsorbent supplementation prevented (p &lt; 0.05) increased serum aspartate aminotransferase by T-2 toxin at d 14. It also prevented (p &lt; 0.05) T-2 toxin-induced morphological changes and damage in the duodenum, jejunum, and ileum of broilers. However, dietary supplementation of the modified HSCAS adsorbent alone did not affect (p &gt; 0.05) any of these variables. In conclusion, these findings indicate that the modified HSCAS adsorbent could be used against T-2 toxin-induced toxicity in growth performance, nutrient digestibility, and hepatic and small intestinal injuries in chicks.<\/jats:p>","DOI":"10.3390\/toxins11040199","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T03:39:28Z","timestamp":1554262768000},"page":"199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["A Novel Modified Hydrated Sodium Calcium Aluminosilicate (HSCAS) Adsorbent Can Effectively Reduce T-2 Toxin-Induced Toxicity in Growth Performance, Nutrient Digestibility, Serum Biochemistry, and Small Intestinal Morphology in Chicks"],"prefix":"10.3390","volume":"11","author":[{"given":"Jin-Tao","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province, Institute of Animal Husbandry and Veterinary Sciences, Hubei Academy of Agricultural Sciences, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-6080","authenticated-orcid":false,"given":"Kun-Tan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province, Institute of Animal Husbandry and Veterinary Sciences, Hubei Academy of Agricultural Sciences, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-6669","authenticated-orcid":false,"given":"Mahmoud Mohamed","family":"Khalil","sequence":"additional","affiliation":[{"name":"Animal Production Department, Faculty of Agriculture, Benha University, Benha 13736, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Fan","family":"Dai","sequence":"additional","affiliation":[{"name":"Sichuan Green Food Development Center, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Animal Disease Prevention and Control Center, Tianjin 300402, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Aomai Bio-Technology Co., Ltd., Nanjing 211226, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni-Ya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Sheng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv-Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province, Institute of Animal Husbandry and Veterinary Sciences, Hubei Academy of Agricultural Sciences, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1007\/s00204-017-2118-3","article-title":"Trichothecenes: Immunomodulatory effects, mechanisms, and anti-cancer potential","volume":"91","author":"Wu","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_2","unstructured":"Gareis, M., Zimmermann, C., and Schothorst, R.C. (2019, April 02). Collection of Occurrence Data of Fusarium Toxin in Food and Assessment of Dietary Intake by the Population of EU Member States. Available online: https:\/\/ci.nii.ac.jp\/naid\/20001046845\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/0265203031000082495","article-title":"Deoxynivalenol and other Fusarium toxins in wheat and rye flours on the Danish market","volume":"20","author":"Rasmussen","year":"2003","journal-title":"Food Addit. Contam."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Makowska, K., Obremski, K., and Gonkowski, S. (2018). The impact of T-2 toxin on vasoactive intestinal polypeptide-like immunoreactive (VIP-LI) nerve structures in the wall of the porcine stomach and duodenum. Toxins, 10.","DOI":"10.3390\/toxins10040138"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Makowska, K., Obremski, K., Zielonka, L., and Gonkowski, S. (2017). The influence of low doses of zearalenone and t-2 toxin on calcitonin gene related peptide-like immunoreactive (CGRP-LI) neurons in the ens of the porcine descending colon. Toxins, 9.","DOI":"10.3390\/toxins9030098"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhang, J., Zhang, H., Liu, S., Wu, W., and Zhang, H. (2018). Comparison of anorectic potencies of type A trichothecenes T-2 toxin, HT-2 toxin, Diacetoxyscirpenol, and Neosolaniol. Toxins, 10.","DOI":"10.3390\/toxins10050179"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3382\/ps.0560306","article-title":"Subacute toxicity of T-2 toxin in broiler chicks","volume":"56","author":"Chi","year":"1977","journal-title":"Poult. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tox.2008.02.003","article-title":"Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs","volume":"247","author":"Meissonnier","year":"2008","journal-title":"Toxicology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/ps\/76.9.1239","article-title":"Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and T-2 toxin or deoxynivalenol in broiler chicks","volume":"76","author":"Kubena","year":"1997","journal-title":"Poult. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3920\/WMJ2010.1234","article-title":"Effect of ochratoxin A on coccidiosis-challenged broiler chicks","volume":"4","author":"Manafi","year":"2011","journal-title":"World Mycotoxin J."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wu, J., Zhou, Y., Yuan, Z., Yi, J., Chen, J., Wang, N., and Tian, Y. (2019). Autophagy and apoptosis interact to modulate T-2 toxin-induced toxicity in liver cells. Toxins, 11.","DOI":"10.3390\/toxins11010045"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF01088331","article-title":"Effects of gamma irradiation on mycotoxin disappearance and amino acid contents of corn, wheat, and soybeans with different moisture contents","volume":"47","author":"Hooshmand","year":"1995","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/BF00197364","article-title":"Adjustment of the conditions required for complete decontamination of T-2 toxin residues with alkaline sodium hypochlorite","volume":"52","author":"Faifer","year":"1994","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/japr\/14.2.226","article-title":"Evaluation of the efficacy of four feed additives against the adverse effects of T-2 toxin in growing broiler chickens","volume":"14","author":"Diaz","year":"2005","journal-title":"J. Appl. Poult. Res."},{"key":"ref_15","unstructured":"Piva, A., and Galvano, F. (1999). Nutritional approaches to reduce the impact of mycotoxins. Biotechnology in the Feed Industry, Nottingham University Press."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0378-4274(01)00360-5","article-title":"Mycotoxin detoxication of animal feed by different adsorbents","volume":"122","author":"Huwig","year":"2001","journal-title":"Toxicol. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Gerez, J., Buck, L., Marutani, V., Calliari, C., and Bracarense, A. (2018). Low levels of chito-oligosaccharides are not effective in reducing deoxynivalenol toxicity in swine jejunal explants. Toxins, 10.","DOI":"10.3390\/toxins10070276"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/00071669987935","article-title":"Effect of sodium bentonite on the performance and blood variables of broiler chickens intoxicated with aflatoxins","volume":"40","author":"Santurio","year":"1999","journal-title":"Br. Poult. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/ps\/84.6.959","article-title":"Adsorption of aflatoxin B1 on montmorillonite","volume":"84","author":"Desheng","year":"2005","journal-title":"Poult. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ps\/79.1.1","article-title":"Efficacy of synthetic zeolite to reduce the toxicity of aflatoxin in broiler chicks","volume":"79","author":"Miazzo","year":"2000","journal-title":"Poult. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.intimp.2006.03.012","article-title":"Preventive role of phyllosilicate clay on the immunological and biochemical toxicity of zearalenone in Balb\/c mice","volume":"6","author":"Abbes","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/jat.2942","article-title":"Calcium montmorillonite clay reduces AFB1 and FB1 biomarkers in rats exposed to single and co-exposures of aflatoxin and fumonisin","volume":"34","author":"Mitchell","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.5713\/ajas.2006.877","article-title":"Efficacy of Glucomannan-containing Yeast Product (Mycosorb \uc9f0) and Hydrated Sodium Calcium Aluminosilicate in Preventing the Individual and Combined Toxicity of Aflatoxin and T-2 Toxin in Commercial Broilers","volume":"19","author":"Girish","year":"2006","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/0007166031000085300","article-title":"Effects of graded levels of Fusarium toxin-contaminated wheat and of a detoxifying agent in broiler diets on performance, nutrient digestibility and blood chemical parameters","volume":"44","author":"Danicke","year":"2003","journal-title":"Br. Poult. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.3382\/ps.0611646","article-title":"Comparison of ochratoxin, aflatoxin, and T-2 toxin for their effects on selected parameters related to digestion and evidence for specific metabolism of carotenoids in chickens","volume":"61","author":"Osborne","year":"1982","journal-title":"Poult. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0169-409X(02)00069-8","article-title":"Drug administration to poultry","volume":"54","author":"Vermeulen","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_27","first-page":"1584","article-title":"Influence of T-2 toxin on nutrient apparent digestibility and small intestinal morphology in BALB\/c Mice","volume":"46","author":"Yang","year":"2015","journal-title":"Chin. J. Anim. Vet. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fct.2014.10.020","article-title":"Hepatotoxic effects of mycotoxin combinations in mice","volume":"74","author":"Sun","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.33899\/ijvs.2007.5618","article-title":"Ineffectiveness of different adsorbents in alleviation of oral lesions induced by feeding T-2 toxin in broiler chickens","volume":"21","author":"Shareef","year":"2007","journal-title":"Iraqi J. Vet. Sci."},{"key":"ref_30","first-page":"4983","article-title":"Effect of diatomaceous earth on performance, internalorgans and biochemical alterations in T-2 toxicosis of broiler chickens","volume":"15","author":"Shivashankar","year":"2015","journal-title":"J. Cell Tissue Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3382\/japr.2010-00271","article-title":"Deactivation of T-2 toxin in broiler ducks by biotransformation","volume":"21","author":"Kutasi","year":"2012","journal-title":"J. Appl. Poult. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.anifeedsci.2007.06.012","article-title":"The effect of vitamin E supplementation on reduction of lymphocyte DNA damage induced by T-2 toxin and deoxynivalenol in weaned pigs","volume":"141","author":"Salobir","year":"2008","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.17221\/7893-VETMED","article-title":"Combined effects of repeated low doses of aflatoxin B1 and T-2 toxin on the Chinese hamster","volume":"46","author":"Rajmon","year":"2001","journal-title":"Vet. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Chen, S.S., Li, Y.H., and Lin, M.F. (2017). Chronic exposure to the Fusarium mycotoxin deoxynivalenol: Impact on performance, immune organ, and intestinal integrity of slow-growing chickens. Toxins, 9.","DOI":"10.3390\/toxins9100334"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1021\/jf970604v","article-title":"Isothermal adsorption of aflatoxin B1 on HSCAS clay","volume":"46","author":"Grant","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1093\/ps\/77.11.1623","article-title":"Efficacy of various inorganic sorbents to reduce the toxicity of aflatoxin and T-2 toxin in broiler chickens","volume":"77","author":"Bailey","year":"1998","journal-title":"Poult. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"615","DOI":"10.4141\/cjas93-065","article-title":"Efficacy of hydrated sodium calcium aluminosilicate, screening and dilution in reducing the effects of mold contaminated corn in pigs","volume":"73","author":"Patterson","year":"1993","journal-title":"Can. J. Anim. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1387-1811(03)00365-2","article-title":"Surfactant modified zeolites\u2013new efficient adsorbents for mycotoxins","volume":"61","author":"Rottinghaus","year":"2003","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.5713\/ajas.2004.259","article-title":"Ability of modified glucomannan to sequestrate T-2 toxin in the gastrointestinal tract of chicken","volume":"17","author":"Reddy","year":"2004","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/009841001459405","article-title":"Investigation of organophilic montmorillonite clay inclusion in zearalenone-contaminated diets using the mouse uterine weight bioassay","volume":"62","author":"Lemke","year":"2001","journal-title":"J. Toxicol. Environ. Health"},{"key":"ref_41","first-page":"412","article-title":"Effect of Myco-ad on experimental T-2 toxicosis in broiler chickens","volume":"122","author":"Fazekas","year":"2000","journal-title":"Magyar \u00c1llatorvosok Lapja"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3920\/WMJ2008.1127","article-title":"Dietary glucomannan improves the vaccinal response in pigs exposed to aflatoxin B1 or T-2 toxin","volume":"2","author":"Meissonnier","year":"2009","journal-title":"World Mycotoxin J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.toxicon.2006.01.016","article-title":"The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice","volume":"47","author":"Abbes","year":"2006","journal-title":"Toxicon"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1093\/jn\/nxy114","article-title":"Dietary Silymarin Supplementation Alleviates Zearalenone-Induced Hepatotoxicity and Reproductive Toxicity in Rats","volume":"148","author":"Gao","year":"2018","journal-title":"J. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3945\/jn.115.224626","article-title":"Prevention of aflatoxin B1 hepatoxicity by dietary selenium is associated with inhibition of cytochrome P450 isozymes and up-regulation of 6 selenoprotein genes in chick liver","volume":"146","author":"Sun","year":"2016","journal-title":"J. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.3382\/ps.2008-00341","article-title":"Effects of dietary AflaDetox on performance, serum biochemistry, histopathological changes, and aflatoxin residues in broilers exposed to aflatoxin B1","volume":"88","author":"Denli","year":"2009","journal-title":"Poult. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/ps\/78.9.1317","article-title":"Effect of phytase enzyme on dietary nitrogen-corrected apparent metabolizable energy and the ileal digestibility of nitrogen and amino acids in broiler chicks","volume":"78","author":"Namkung","year":"1999","journal-title":"Poult. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.3382\/ps\/pey196","article-title":"Efficacy of 2-hydroxy-4-methylthiobutanoic acid compared to DL-Methionine on growth performance, carcass traits, feather growth, and redox status of Cherry Valley ducks","volume":"97","author":"Zhao","year":"2018","journal-title":"Poult. Sci."}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/11\/4\/199\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:42:29Z","timestamp":1760186549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/11\/4\/199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,2]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4]]}},"alternative-id":["toxins11040199"],"URL":"https:\/\/doi.org\/10.3390\/toxins11040199","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,2]]}}}