{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:15:32Z","timestamp":1793427332100,"version":"4.5.0"},"reference-count":72,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406334\/2013-7"],"award-info":[{"award-number":["406334\/2013-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.169585\/2018-00"],"award-info":[{"award-number":["88887.169585\/2018-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Intravascular stent infection is a rare complication with a high morbidity and high mortality; bacteria from the hospital environment form biofilms and are often multidrug-resistant (MDR). Antimicrobial peptides (AMPs) have been considered as alternatives to bacterial infection treatment. We analyzed the formation of the bacterial biofilm on the vascular stents and also tested the inhibition of this biofilm by AMPs to be used as treatment or coating. Antimicrobial activity and antibiofilm were tested with wasp (Agelaia-MPI, Polybia-MPII, Polydim-I) and scorpion (Con10 and NDBP5.8) AMPs against Acinetobacter baumannii clinical strains. A. baumannii formed a biofilm on the vascular stent. Agelaia-MPI and Polybia-MPII inhibited biofilm formation with bacterial cell wall degradation. Coating biofilms with polyethylene glycol (PEG 400) and Agelaia-MPI reduced 90% of A. baumannii adhesion on stents. The wasp AMPs Agelaia-MPI and Polybia-MPII had better action against MDR A. baumannii adherence and biofilm formation on vascular stents, preventing its formation and treating mature biofilm when compared to the other tested peptides.<\/jats:p>","DOI":"10.3390\/toxins11040216","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T11:25:08Z","timestamp":1554895508000},"page":"216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii"],"prefix":"10.3390","volume":"11","author":[{"given":"Rog\u00e9rio Coutinho","family":"das Neves","sequence":"first","affiliation":[{"name":"Laboratory of Immunopathology of infectious diseases, Department of Immunology, Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, Rua 235, Goiania, 74605-050 Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Renata","family":"Mortari","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropharmacology, Department of Physiological Sciences, Institute of Biological Sciences, University of Bras\u00edlia, 70910-900 Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8239-4055","authenticated-orcid":false,"given":"Elisabeth Ferroni","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropharmacology, Department of Physiological Sciences, Institute of Biological Sciences, University of Bras\u00edlia, 70910-900 Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-106X","authenticated-orcid":false,"given":"Andr\u00e9","family":"Kipnis","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology of infectious diseases, Department of Immunology, Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, Rua 235, Goiania, 74605-050 Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4200-6617","authenticated-orcid":false,"given":"Ana Paula","family":"Junqueira-Kipnis","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology of infectious diseases, Department of Immunology, Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, Rua 235, Goiania, 74605-050 Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.peptides.2007.10.001","article-title":"The antimicrobial peptide Tachyplesin III coated alone and in combination with intraperitoneal piperacillin-tazobactam prevents ureteral stent Pseudomonas infection in a rat subcutaneous pouch model","volume":"28","author":"Minardi","year":"2007","journal-title":"Peptides"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.12.003","article-title":"Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145","volume":"222","author":"Riool","year":"2016","journal-title":"J. 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