{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:32:26Z","timestamp":1773401546788,"version":"3.50.1"},"reference-count":73,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>In the soft treatment of cancer tumours, consequent downregulation of the malignant tissue angiogenesis constitutes an efficient way to stifle tumour development and metastasis spreading. As angiogenesis requires integrin\u2013promoting endothelial cell adhesion, migration, and vessel tube formation, integrins represent potential targets of new therapeutic anti\u2013angiogenic agents. Our work is a contribution to the research of such therapeutic disintegrins in animal venoms. We report isolation of one peptide, named Dabmaurin\u20131, from the hemotoxic venom of snake Daboia mauritanica, and we evaluate its potential anti\u2013tumour activity through in vitro inhibition of the human vascular endothelial cell HMECs functions involved in tumour angiogenesis. Dabmaurin\u20131 altered, in a dose\u2013dependent manner, without any significant cytotoxicity, HMEC proliferation, adhesion, and their mesenchymal migration onto various extracellular matrix proteins, as well as formation of capillary\u2013tube mimics on MatrigelTM. Via experiments involving HMEC or specific cancers cells integrins, we demonstrated that the above Dabmaurin\u20131 effects are possibly due to some anti\u2013integrin properties. Dabmaurin\u20131 was demonstrated to recognize a broad panel of prooncogenic integrins (\u03b1v\u03b26, \u03b1v\u03b23 or \u03b1v\u03b25) and\/or particularly involved in control of angiogenesis (\u03b15\u03b21, \u03b16\u03b24, \u03b1v\u03b23 or \u03b1v\u03b25). Furthermore, mass spectrometry and partial N\u2013terminal sequencing of this peptide revealed, it is close to Lebein\u20131, a known anti\u2013\u03b21 disintegrin from Macrovipera lebetina venom. Therefore, our results show that if Dabmaurin\u20131 exhibits in vitro apparent anti\u2013angiogenic effects at concentrations lower than 30 nM, it is likely because it acts as an anti\u2013tumour disintegrin.<\/jats:p>","DOI":"10.3390\/toxins12020102","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T03:13:27Z","timestamp":1581045207000},"page":"102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Isolation of an Anti\u2013tumour Disintegrin: Dabmaurin\u20131, a Peptide Lebein\u20131\u2013like, from Daboia mauritanica Venom"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8083-2194","authenticated-orcid":false,"given":"Florence","family":"Chalier","sequence":"first","affiliation":[{"name":"INP, Institut de Neurophysiopathologie, UMR 7051\u2013CNRS &amp; Aix\u2013Marseille Universit\u00e9, Facult\u00e9 de Pharmacie, 27 bd Jean Moulin, 13285 Marseille cedex 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mugnier","sequence":"additional","affiliation":[{"name":"ICR, Institut de Chimie Radicalaire, UMR 7273\u2013CNRS &amp; Aix\u2013Marseille Universit\u00e9\u2014Facult\u00e9 des Sciences de Saint J\u00e9r\u00f4me, Avenue Escadrille Normandie Ni\u00e9men, 13397 Marseille Cedex 20, France"},{"name":"Latoxan Laboratory, Z.A Aur\u00e9ats, 845 Avenue Pierre Brossolette, 26800 PORTES l\u00e8s VALENCE, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Tarbe","sequence":"additional","affiliation":[{"name":"ICR, Institut de Chimie Radicalaire, UMR 7273\u2013CNRS &amp; Aix\u2013Marseille Universit\u00e9\u2014Facult\u00e9 des Sciences de Saint J\u00e9r\u00f4me, Avenue Escadrille Normandie Ni\u00e9men, 13397 Marseille Cedex 20, France"},{"name":"Latoxan Laboratory, Z.A Aur\u00e9ats, 845 Avenue Pierre Brossolette, 26800 PORTES l\u00e8s VALENCE, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soioulata","family":"Aboudou","sequence":"additional","affiliation":[{"name":"ICR, Institut de Chimie Radicalaire, UMR 7273\u2013CNRS &amp; Aix\u2013Marseille Universit\u00e9\u2014Facult\u00e9 des Sciences de Saint J\u00e9r\u00f4me, Avenue Escadrille Normandie Ni\u00e9men, 13397 Marseille Cedex 20, France"},{"name":"Latoxan Laboratory, Z.A Aur\u00e9ats, 845 Avenue Pierre Brossolette, 26800 PORTES l\u00e8s VALENCE, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Villard","sequence":"additional","affiliation":[{"name":"INP, Institut de Neurophysiopathologie, UMR 7051\u2013CNRS &amp; Aix\u2013Marseille Universit\u00e9, Facult\u00e9 de Pharmacie, 27 bd Jean Moulin, 13285 Marseille cedex 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6509-4210","authenticated-orcid":false,"given":"Herv\u00e9","family":"Kovacic","sequence":"additional","affiliation":[{"name":"INP, Institut de Neurophysiopathologie, UMR 7051\u2013CNRS &amp; Aix\u2013Marseille Universit\u00e9, Facult\u00e9 de Pharmacie, 27 bd Jean Moulin, 13285 Marseille cedex 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Gigmes","sequence":"additional","affiliation":[{"name":"ICR, Institut de Chimie Radicalaire, UMR 7273\u2013CNRS &amp; Aix\u2013Marseille Universit\u00e9\u2014Facult\u00e9 des Sciences de Saint J\u00e9r\u00f4me, Avenue Escadrille Normandie Ni\u00e9men, 13397 Marseille Cedex 20, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Mansuelle","sequence":"additional","affiliation":[{"name":"IMM (MaP), Institut de Microbiologie de la M\u00e9diterran\u00e9e (Marseille Prot\u00e9omique), FR 3479\u2014CNRS &amp; Aix\u2013Marseille Universit\u00e9, 31 Chemin Joseph Aiguier, 13009 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"de Pomyers","sequence":"additional","affiliation":[{"name":"Latoxan Laboratory, Z.A Aur\u00e9ats, 845 Avenue Pierre Brossolette, 26800 PORTES l\u00e8s VALENCE, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Luis","sequence":"additional","affiliation":[{"name":"INP, Institut de Neurophysiopathologie, UMR 7051\u2013CNRS &amp; Aix\u2013Marseille Universit\u00e9, Facult\u00e9 de Pharmacie, 27 bd Jean Moulin, 13285 Marseille cedex 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel","family":"Mabrouk","sequence":"additional","affiliation":[{"name":"ICR, Institut de Chimie Radicalaire, UMR 7273\u2013CNRS &amp; Aix\u2013Marseille Universit\u00e9\u2014Facult\u00e9 des Sciences de Saint J\u00e9r\u00f4me, Avenue Escadrille Normandie Ni\u00e9men, 13397 Marseille Cedex 20, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.17352\/atte.000004","article-title":"Snake bites in morocco: Progress and challenges","volume":"3","author":"Oukkache","year":"2019","journal-title":"Adv. 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