{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:51:00Z","timestamp":1790650260321,"version":"4.1.0"},"reference-count":140,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>During infection, the foodborne bacterial pathogen Listeria monocytogenes dynamically influences the gene expression profile of host cells. Infection-induced transcriptional changes are a typical feature of the host-response to bacteria and contribute to the activation of protective genes such as inflammatory cytokines. However, by using specialized virulence factors, bacterial pathogens can target signaling pathways, transcription factors, and epigenetic mechanisms to alter host gene expression, thereby reprogramming the response to infection. Therefore, the transcriptional profile that is established in the host is delicately balanced between antibacterial responses and pathogenesis, where any change in host gene expression might significantly influence the outcome of infection. In this review, we discuss the known transcriptional and epigenetic processes that are engaged during Listeria monocytogenes infection, the virulence factors that can remodel them, and the impact these processes have on the outcome of infection.<\/jats:p>","DOI":"10.3390\/toxins12050294","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T04:46:07Z","timestamp":1588826767000},"page":"294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pathogenic Biohacking: Induction, Modulation and Subversion of Host Transcriptional Responses by Listeria monocytogenes"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6538-4012","authenticated-orcid":false,"given":"Matthew J. G.","family":"Eldridge","sequence":"first","affiliation":[{"name":"Chromatine et Infection G5, Institut Pasteur, 75015 Paris, France"},{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cossart","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie A.","family":"Hamon","sequence":"additional","affiliation":[{"name":"Chromatine et Infection G5, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrg.2016.59","article-title":"The molecular hallmarks of epigenetic control","volume":"17","author":"Allis","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin Modifications and Their Function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev-biochem-061809-175347","article-title":"Signals and Combinatorial Functions of Histone Modifications","volume":"80","author":"Suganuma","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nsmb.2581","article-title":"Scratching the (lateral) surface of chromatin regulation by histone modifications","volume":"20","author":"Tropberger","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1124000","article-title":"Histone H4-K16 acetylation controls chromatin structure and protein interactions","volume":"311","author":"Ishii","year":"2006","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/35065132","article-title":"Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins","volume":"410","author":"Lachner","year":"2001","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.cell.2008.12.043","article-title":"Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells","volume":"136","author":"Ezhkova","year":"2009","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cell.2007.08.016","article-title":"Selective Anchoring of TFIID to Nucleosomes by Trimethylation of Histone H3 Lysine 4","volume":"131","author":"Vermeulen","year":"2007","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0092-8674(02)01077-2","article-title":"Deciphering the transcriptional histone acetylation code for a human gene","volume":"111","author":"Agalioti","year":"2002","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/genes3020320","article-title":"The Role of Bromodomain Proteins in Regulating Gene Expression","volume":"3","author":"Josling","year":"2012","journal-title":"Genes"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.str.2008.01.010","article-title":"Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP\/p300","volume":"16","author":"Zeng","year":"2008","journal-title":"Structure"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7610","DOI":"10.1074\/jbc.M109.062422","article-title":"Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain","volume":"285","author":"Umehara","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35065138","article-title":"Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain","volume":"410","author":"Bannister","year":"2001","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.molcel.2017.12.011","article-title":"Structural Basis of Heterochromatin Formation by Human HP1","volume":"69","author":"Machida","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"R2","DOI":"10.1186\/gb-2002-4-1-r2","article-title":"A gene-expression program reflecting the innate immune response of cultured intestinal epithelial cells to infection by Listeria monocytogenes","volume":"4","author":"Baldwin","year":"2003","journal-title":"Genome Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1073\/pnas.022649799","article-title":"Human macrophage activation programs induced by bacterial pathogens","volume":"99","author":"Nau","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11386","DOI":"10.1073\/pnas.0403215101","article-title":"A specific gene expression program triggered by Gram-positive bacteria in the cytosol","volume":"101","author":"McCaffrey","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Leber, J.H., Crimmins, G.T., Raghavan, S., Meyer-Morse, N.P., Cox, J.S., and Portnoy, D.A. (2008). Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.0040006"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15065","DOI":"10.1074\/jbc.M610926200","article-title":"Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model","volume":"282","author":"Lecuit","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Pitt, J.M., Blankley, S., Potempa, K., Graham, C.M., Moreira-Teixeira, L., McNab, F.W., Howes, A., Stavropoulos, E., Pascual, V., and Banchereau, J. (2016). Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150251"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrmicro.2017.126","article-title":"Listeria monocytogenes: Towards a complete picture of its physiology and pathogenesis","volume":"16","author":"Radoshevich","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Pizarro-Cerd\u00e1, J., K\u00fchbacher, A., and Cossart, P. (2012). Entry of listeria monocytogenes in mammalian epithelial cells: An updated view. Cold Spring Harb. Perspect. Med., 2.","DOI":"10.1101\/cshperspect.a010009"},{"key":"ref_26","first-page":"1","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal. Transduct. Target. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mib.2014.10.008","article-title":"Antimicrobial inflammasomes: Unified signalling against diverse bacterial pathogens","volume":"23","author":"Eldridge","year":"2015","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-biophys-083012-130338","article-title":"Molecular Basis of NF-\u03baB Signaling","volume":"42","author":"Napetschnig","year":"2013","journal-title":"Annu. Rev. Biophys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1101\/cshperspect.a006049","article-title":"Signaling in innate immunity and inflammation","volume":"4","author":"Newton","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"17333","DOI":"10.1073\/pnas.1007765107","article-title":"The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I\u03baB kinase subunit IKK\u03b1","volume":"107","author":"Gouin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1074\/mcp.M116.061333","article-title":"Human Sirtuin 2 Localization, Transient Interactions, and Impact on the Proteome Point to Its Role in Intracellular Trafficking","volume":"15","author":"Budayeva","year":"2016","journal-title":"Mol. Cell. Proteom."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/IAI.01243-10","article-title":"K+ Efflux Is Required for Histone H3 Dephosphorylation by Listeria monocytogenes Listeriolysin O and Other Pore-Forming Toxins","volume":"79","author":"Hamon","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41564-019-0367-z","article-title":"Intracellular bacteria engage a STING\u2013TBK1\u2013MVB12b pathway to enable paracrine cGAS\u2013STING signalling","volume":"4","author":"Nandakumar","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4161\/viru.1.5.12787","article-title":"Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infections","volume":"1","author":"Rayamajhi","year":"2010","journal-title":"Virulence"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.tcb.2015.01.003","article-title":"Organelle targeting during bacterial infection: Insights from Listeria","volume":"25","author":"Lebreton","year":"2015","journal-title":"Trends Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/sj.embor.7400248","article-title":"Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition","volume":"5","author":"Travassos","year":"2004","journal-title":"EMBO Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.4049\/jimmunol.1203245","article-title":"Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages","volume":"191","author":"Regan","year":"2013","journal-title":"J. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.micpath.2018.04.059","article-title":"Evaluation of Caco-2 cells response to Listeria monocytogenes virulence factors by RT-PCR","volume":"120","author":"Xie","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.4049\/jimmunol.178.4.2380","article-title":"RICK\/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs","volume":"178","author":"Park","year":"2007","journal-title":"J. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-065X.2010.00993.x","article-title":"Cell biology and immunology of Listeria monocytogenes infections: Novel insights","volume":"240","author":"Stavru","year":"2011","journal-title":"Immunol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.immuni.2007.12.012","article-title":"The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands","volume":"28","author":"Kim","year":"2008","journal-title":"Immunity"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1128\/IAI.72.4.2131-2139.2004","article-title":"Toll-Like Receptor 2 Is Required for Optimal Control of Listeria monocytogenes Infection","volume":"72","author":"Torres","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.4049\/jimmunol.181.3.2028","article-title":"Lipoproteins of Listeria monocytogenes Are Critical for Virulence and TLR2-Mediated Immune Activation","volume":"181","author":"Machata","year":"2008","journal-title":"J. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.4049\/jimmunol.169.7.3869","article-title":"MyD88-Dependent but Toll-Like Receptor 2-Independent Innate Immunity to Listeria: No Role for Either in Macrophage Listericidal Activity","volume":"169","author":"Edelson","year":"2002","journal-title":"J. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.4049\/jimmunol.169.7.3863","article-title":"Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of Listeria monocytogenes in Mice","volume":"169","author":"Seki","year":"2002","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.1104911","article-title":"Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract","volume":"307","author":"Kobayashi","year":"2005","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1128\/IAI.01068-08","article-title":"Nonhematopoietic cells control the outcome of infection with Listeria monocytogenes in a nucleotide oligomerization domain 1-dependent manner","volume":"77","author":"Mosa","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.immuni.2018.07.016","article-title":"A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns","volume":"49","author":"Price","year":"2018","journal-title":"Immunity"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.20070563","article-title":"MyD88-mediated signals induce the bactericidal lectin RegIII\u03b3 and protect mice against intestinal Listeria monocytogenes infection","volume":"204","author":"Brandl","year":"2007","journal-title":"J. Exp. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tig.2015.10.007","article-title":"Lateral Thinking: How Histone Modifications Regulate Gene Expression","volume":"32","author":"Lawrence","year":"2016","journal-title":"Trends Genet."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Bierne, H., Hamon, M., and Cossart, P. (2012). Epigenetics and bacterial infections. Cold Spring Harb. Perspect. Med., 2.","DOI":"10.1101\/cshperspect.a010272"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.4049\/jimmunol.175.5.2843","article-title":"Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification","volume":"175","author":"Schmeck","year":"2005","journal-title":"J. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"484","DOI":"10.4049\/jimmunol.176.1.484","article-title":"Listeria monocytogenes Activated p38 MAPK and Induced IL-8 Secretion in a Nucleotide-Binding Oligomerization Domain 1-Dependent Manner in Endothelial Cells","volume":"176","author":"Opitz","year":"2006","journal-title":"J. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.4049\/jimmunol.1600599","article-title":"The Essential Role of Neutrophils during Infection with the Intracellular Bacterial Pathogen Listeria monocytogenes","volume":"197","author":"Witter","year":"2016","journal-title":"J. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Dussurget, O., Bierne, H., and Cossart, P. (2014). The bacterial pathogen Listeria monocytogenes and the interferon family: Type I, type II and type III interferons. Front. Cell. Infect. Microbiol., 4.","DOI":"10.3389\/fcimb.2014.00050"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Radoshevich, L., Impens, F., Ribet, D., Quereda, J.J., Tham, T.N., Nahori, M.A., Bierne, H., Dussurget, O., Pizarro-Cerd\u00e1, J., and Knobeloch, K.P. (2015). ISG15 counteracts Listeria monocytogenes infection. Elife, 4.","DOI":"10.7554\/eLife.06848"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kernbauer, E., Maier, V., Rauch, I., M\u00fcller, M., and Decker, T. (2013). Route of Infection Determines the Impact of Type I Interferons on Innate Immunity to Listeria monocytogenes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065007"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.4049\/jimmunol.1502192","article-title":"Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes","volume":"196","author":"Pitts","year":"2016","journal-title":"J. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Pontiroli, F., Dussurget, O., Zanoni, I., Urbano, M., Beretta, O., Granucci, F., Ricciardi-Castagnoli, P., Cossart, P., and Foti, M. (2012). The Timing of IFN\u03b2 Production Affects Early Innate Responses to Listeria monocytogenes and Determines the Overall Outcome of Lethal Infection. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043455"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Aubry, C., Corr, S.C., Wienerroither, S., Goulard, C., Jones, R., Jamieson, A.M., Decker, T., O\u2019Neill, L.A.J., Dussurget, O., and Cossart, P. (2012). Both TLR2 and TRIF Contribute to Interferon-\u03b2 Production during Listeria Infection. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033299"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"ra20","DOI":"10.1126\/scisignal.2002521","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci. Signal."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1126\/science.1189801","article-title":"C-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response","volume":"328","author":"Woodward","year":"2010","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1128\/IAI.06286-11","article-title":"Hyperinduction of host beta interferon by a Listeria monocytogenes strain naturally overexpressing the multidrug efflux pump MdrT","volume":"80","author":"Schwartz","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.15252\/embj.201488029","article-title":"Listeria monocytogenes induces IFN\u03b2 expression through an IFI16-, cGAS- and STING-dependent pathway","volume":"33","author":"Hansen","year":"2014","journal-title":"EMBO J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1038\/emboj.2012.274","article-title":"RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids","volume":"31","author":"Abdullah","year":"2012","journal-title":"EMBO J."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Hagmann, C.A., Herzner, A.M., Abdullah, Z., Zillinger, T., Jakobs, C., Schuberth, C., Coch, C., Higgins, P.G., Wisplinghoff, H., and Barchet, W. (2013). RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062872"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.it.2016.12.004","article-title":"Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways","volume":"38","author":"Zevini","year":"2017","journal-title":"Trends Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20040712","article-title":"Type I interferon production enhances susceptibility to Listeria monocytogenes infection","volume":"200","author":"Saha","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.20091746","article-title":"Induction of IFN-\u03b1\u03b2 enables Listeria monocytogenes to suppress macrophage activation by IFN-\u03b3","volume":"207","author":"Rayamajhi","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1126\/science.8456301","article-title":"Immune response in mice that lack the interferon-\u03b3 receptor","volume":"259","author":"Huang","year":"1993","journal-title":"Science"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/1074-7613(95)90163-9","article-title":"Specific immunity to listeria monocytogenes in the absence of IFN\u03b3","volume":"3","author":"Harty","year":"1995","journal-title":"Immunity"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.175.1.49","article-title":"A protective role of \u03b3\/\u03b4 T cells in primary inaction with Listeria monocytogenes in mice","volume":"175","author":"Hiromatsu","year":"1992","journal-title":"J. Exp. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1073\/pnas.90.8.3725","article-title":"Interleukin 12 and tumor necrosis factor \u03b1 are costimulators of interferon \u03b3 production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist","volume":"90","author":"Tripp","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.4049\/jimmunol.161.10.5600","article-title":"Early IFN-gamma production and innate immunity during Listeria monocytogenes infection in the absence of NK cells","volume":"161","author":"Andersson","year":"1998","journal-title":"J. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1126\/science.1201711","article-title":"A family of IFN-\u03b3-inducible 65-kD GTPases protects against bacterial infection","volume":"332","author":"Kim","year":"2011","journal-title":"Science"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1217141","article-title":"GBP5 Promotes NLRP3 inflammasome assembly and immunity in mammals","volume":"336","author":"Shenoy","year":"2012","journal-title":"Science"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Kernbauer, E., Maier, V., Stoiber, D., Strobl, B., Schneckenleithner, C., Sexl, V., Reichart, U., Reizis, B., Kalinke, U., and Jamieson, A. (2012). Conditional Stat1 Ablation Reveals the Importance of Interferon Signaling for Immunity to Listeria monocytogenes Infection. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002763"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Bierne, H., Travier, L., Mahlak\u00f5iv, T., Tailleux, L., Subtil, A., Lebreton, A., Paliwal, A., Gicquel, B., Staeheli, P., and Lecuit, M. (2012). Activation of Type III Interferon Genes by Pathogenic Bacteria in Infected Epithelial Cells and Mouse Placenta. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039080"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.chom.2019.10.004","article-title":"An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling","volume":"26","author":"Pagliuso","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Frantz, R., Teubner, L., Schultze, T., La Pietra, L., M\u00fcller, C., Gwozdzinski, K., Pillich, H., Hain, T., Weber-Gerlach, M., and Panagiotidis, G.D. (2019). The secRNome of Listeria monocytogenes harbors small noncoding rnas that are potent inducers of beta interferon. MBio, 10.","DOI":"10.1128\/mBio.01223-19"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.it.2006.09.005","article-title":"Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens","volume":"27","author":"Carrero","year":"2006","journal-title":"Trends Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cellimm.2011.11.008","article-title":"Type I interferon signaling regulates the composition of inflammatory infiltrates upon infection with Listeria monocytogenes","volume":"273","author":"Hiltbold","year":"2012","journal-title":"Cell. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Archer, K.A., Durack, J., and Portnoy, D.A. (2014). STING-Dependent Type I IFN Production Inhibits Cell-Mediated Immunity to Listeria monocytogenes. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1003861"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.4049\/jimmunol.1203510","article-title":"Type I IFNs Downregulate Myeloid Cell IFN-\u03b3 Receptor by Inducing Recruitment of an Early Growth Response 3\/NGFI-A Binding Protein 1 Complex That Silences ifngr1 Transcription","volume":"191","author":"Kearney","year":"2013","journal-title":"J. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1126\/science.1233665","article-title":"Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses","volume":"339","author":"Teles","year":"2013","journal-title":"Science"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.coi.2018.05.014","article-title":"Crosstalk between type I and II interferons in regulation of myeloid cell responses during bacterial infection","volume":"54","author":"Crisler","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/cyto.a.20952","article-title":"Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1\u03b2, TNF-\u03b1, and LPS","volume":"77A","author":"Herczenik","year":"2010","journal-title":"Cytom. Part A"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1046\/j.1365-2958.1999.01305.x","article-title":"Listeriolysin O-dependent activation of endothelial cells during infection with Listeria monocytogenes: Activation of NF-kappaB and upregulation of adhesion molecules and chemokines","volume":"31","author":"Kayal","year":"1999","journal-title":"Mol. Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1046\/j.1365-2958.2002.02973.x","article-title":"Listeriolysin O secreted by Listeria monocytogenes induces NF-\u03baB signalling by activating the I\u03baB kinase complex","volume":"44","author":"Kayal","year":"2002","journal-title":"Mol. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1128\/IAI.73.7.3869-3877.2005","article-title":"Listeriolysin O-induced membrane permeation mediates persistent interleukin-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro","volume":"73","author":"Tsuchiya","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.chom.2018.03.004","article-title":"Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation","volume":"23","author":"Drolia","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0092-8674(00)00141-0","article-title":"InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase","volume":"103","author":"Shen","year":"2000","journal-title":"Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"17025","DOI":"10.1074\/jbc.274.24.17025","article-title":"The Listeria monocytogenes protein InlB is an agonist of mammalian phosphoinositide 3-kinase","volume":"274","author":"Ireton","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1600-0854.2005.00290.x","article-title":"The Listeria protein internalin B mimics hepatocyte growth factor-induced receptor trafficking","volume":"6","author":"Li","year":"2005","journal-title":"Traffic"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"43597","DOI":"10.1074\/jbc.M105202200","article-title":"Internalin B Activates Nuclear Factor-\u03baB via Ras, Phosphoinositide 3-Kinase, and Akt","volume":"276","author":"Mansell","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2007.05.037","article-title":"Structure of the Human Receptor Tyrosine Kinase Met in Complex with the Listeria Invasion Protein InlB","volume":"130","author":"Niemann","year":"2007","journal-title":"Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7783","DOI":"10.1074\/jbc.M211666200","article-title":"Multiple regions of internalin B contribute to its ability to turn on the Ras-mitogen-activated protein kinase pathway","volume":"278","author":"Copp","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1462-5822.2000.00038.x","article-title":"A novel function of InlB from Listeria monocytogenes: Activation of NF-kappaB in J774 macrophages","volume":"2","author":"Mansell","year":"2000","journal-title":"Cell. Microbiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/43466","article-title":"NF-\u03baB activation by tumour necrosis factor requires tie Akt serine- threonine kinase","volume":"401","author":"Ozes","year":"1999","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrmicro1413","article-title":"Listeria monocytogenes: A multifaceted model","volume":"4","author":"Hamon","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1099\/mic.0.069369-0","article-title":"Bacterial interference with canonical NF\u03baB signalling","volume":"159","author":"Johannessen","year":"2013","journal-title":"Microbiology (U. K.)"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1462-5822.2011.01719.x","article-title":"Subversion of innate immune responses by bacterial hindrance of NF-\u03baB pathway","volume":"14","year":"2012","journal-title":"Cell. Microbiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrmicro2539","article-title":"Modulation of NF-\u03baB signalling by microbial pathogens","volume":"9","author":"Rahman","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nature01576","article-title":"Histone H3 phosphorylation by IKK-\u03b1 is critical for cytokine-induced gene expression","volume":"423","author":"Yamamoto","year":"2003","journal-title":"Nature"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nature01648","article-title":"A nucleosomal function for i\u03bab kinase-\u03b1 in nf-\u03bab-dependent gene expression","volume":"423","author":"Anest","year":"2003","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e02778-19","DOI":"10.1128\/mBio.02778-19","article-title":"Ubiquitination of listeria virulence factor inlc contributes to the host response to infection","volume":"10","author":"Gouin","year":"2019","journal-title":"MBio"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.febslet.2010.05.012","article-title":"Post-translational modifications in host cells during bacterial infection","volume":"584","author":"Ribet","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.3389\/fmicb.2015.01145","article-title":"Inactivation of the MAPK signaling pathway by Listeria monocytogenes infection promotes trophoblast giant cell death","volume":"6","author":"Hashino","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"12432","DOI":"10.1073\/pnas.1413825111","article-title":"Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli","volume":"111","author":"Impens","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nature08963","article-title":"Listeria monocytogenes impairs SUMOylation for efficient infection","volume":"464","author":"Ribet","year":"2010","journal-title":"Nature"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1074\/mcp.RA118.000767","article-title":"Rapid remodeling of the host epithelial cell proteome by the listeriolysin O (LLO) pore-forming toxin","volume":"17","author":"Malet","year":"2018","journal-title":"Mol. Cell. Proteomics"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.celrep.2017.01.015","article-title":"The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1\u03b2 Secretion by Inflammasomes","volume":"18","author":"Eldridge","year":"2017","journal-title":"Cell Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrm.2016.81","article-title":"A comprehensive compilation of SUMO proteomics","volume":"17","author":"Hendriks","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/BJ20100158","article-title":"Mechanisms, regulation and consequences of protein SUMOylation","volume":"428","author":"Wilkinson","year":"2010","journal-title":"Biochem. J."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Ribet, D., Lallemand-Breitenbach, V., Ferhi, O., Nahori, M.A., Varet, H., De Th\u00e9, H., and Cossart, P. (2017). Promyelocytic leukemia protein (PML) controls listeria monocytogenes infection. MBio, 8.","DOI":"10.1128\/mBio.02179-16"},{"key":"ref_118","first-page":"1","article-title":"miRNAs reshape immunity and inflammatory responses in bacterial infection","volume":"3","author":"Zhou","year":"2018","journal-title":"Signal. Transduct. Target. Ther."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Schnitger, A.K.D., Machova, A., Mueller, R.U., Androulidaki, A., Schermer, B., Pasparakis, M., Kr\u00f6nke, M., and Papadopoulou, N. (2011). Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027435"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3390\/ijms13011173","article-title":"MicroRNA response to listeria monocytogenes infection in epithelial cells","volume":"13","author":"Izar","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"28226","DOI":"10.18632\/oncotarget.15999","article-title":"MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in cervical cancer","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.tim.2012.04.006","article-title":"Listeriolysin O: The Swiss army knife of Listeria","volume":"20","author":"Hamon","year":"2012","journal-title":"Trends Microbiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"13467","DOI":"10.1073\/pnas.0702729104","article-title":"Histone modifications induced by a family of bacterial toxins","volume":"104","author":"Hamon","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1016\/j.celrep.2020.02.116","article-title":"Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase","volume":"30","author":"Dong","year":"2020","journal-title":"Cell Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1238858","DOI":"10.1126\/science.1238858","article-title":"A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection","volume":"341","author":"Eskandarian","year":"2013","journal-title":"Science"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-58397-6","article-title":"Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins","volume":"10","author":"Eldridge","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.celrep.2018.03.116","article-title":"Infection Reveals a Modification of SIRT2 Critical for Chromatin Association","volume":"23","author":"Pereira","year":"2018","journal-title":"Cell Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"13826","DOI":"10.1073\/pnas.0901259106","article-title":"Human BAHD1 promotes heterochromatic gene silencing","volume":"106","author":"Bierne","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1126\/science.1200120","article-title":"A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response","volume":"331","author":"Lebreton","year":"2011","journal-title":"Science"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Lebreton, A., Job, V., Ragon, M., Le Monnier, A., Dessen, A., Cossart, P., and Bierne, H. (2014). Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA. MBio, 5.","DOI":"10.1128\/mBio.00775-13"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4161\/viru.2.5.17703","article-title":"The arsenal of virulence factors deployed by Listeria monocytogenes to promote its cell infection cycle","volume":"2","author":"Camejo","year":"2011","journal-title":"Virulence"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"L905","DOI":"10.1152\/ajplung.00094.2010","article-title":"A tandem repeat of a fragment of Listeria monocytogenes internalin B protein induces cell survival and proliferation","volume":"299","author":"Mungunsukh","year":"2010","journal-title":"Am. J. Physiol. - Lung Cell. Mol. Physiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-15126-x","article-title":"Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver","volume":"11","author":"Jabs","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41564-019-0659-3","article-title":"The microbiota programs DNA methylation to control intestinal homeostasis and inflammation","volume":"5","author":"Ansari","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature18847","article-title":"The microbiome and innate immunity","volume":"535","author":"Thaiss","year":"2016","journal-title":"Nature"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3389\/fgene.2019.00638","article-title":"Epigenetic regulation at the interplay between gut microbiota and host metabolism","volume":"10","author":"Yanes","year":"2019","journal-title":"Front. Genet."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1073\/pnas.1523899113","article-title":"Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection","volume":"113","author":"Quereda","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.chom.2019.10.016","article-title":"A Listeria monocytogenes Bacteriocin Can Target the Commensal Prevotella copri and Modulate Intestinal Infection","volume":"26","author":"Rolhion","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nri2432","article-title":"Two ways to survive infection: What resistance and tolerance can teach us about treating infectious diseases","volume":"8","author":"Schneider","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1586\/eri.12.16","article-title":"Immunomodulation and infection: Back to the future","volume":"10","author":"Labro","year":"2012","journal-title":"Expert Rev. Anti. Infect. Ther."}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/12\/5\/294\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:25:20Z","timestamp":1760361920000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/12\/5\/294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":140,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5]]}},"alternative-id":["toxins12050294"],"URL":"https:\/\/doi.org\/10.3390\/toxins12050294","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,5]]}}}