{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:04:46Z","timestamp":1794027886726,"version":"4.8.0"},"reference-count":36,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014382","name":"Ipsen","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100014382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Botulinum toxin type A (BoNT-A) is an effective treatment for post-stroke spasticity; however, some patients cannot access treatment until \u22651 year post-stroke. This Brazilian post-marketing study (NCT02390206) assessed the achievement of person-centered goals in patients with chronic post-stroke spasticity after a BoNT-A injection. Patients had a last documented stroke \u22651 year before study entry and post-stroke upper limb (UL) spasticity, with or without lower limb (LL) spasticity. Patients received BoNT-A injections at baseline (visit 1) and visit 2 (3\u20136 months). Primary endpoint was responder rate (achievement of primary goal from Goal Attainment Scaling (GAS)) at visit 2. Overall, 204 patients underwent GAS evaluation at visit 2, mean (SD) age was 56.4 (13.2) years and 90.7% had LL spasticity. Median (range) time between first stroke and onset of spasticity was 3.6 (0\u2212349) months, onset of spasticity and first injection was 22.7 (0\u2212350) months and waiting time for a rehabilitation appointment was 9.0 (1\u221296) months. At visit 2, 61.3% (95% CI: 54.4, 67.7) of patients were responders, which was similar for UL and LL primary goals (57.8% [95% CI: 49.9, 65.3] vs. 64.1% [95% CI: 48.4, 77.3]). This study provides evidence to support the effectiveness of BoNT-A treatment for chronic post-stroke spasticity.<\/jats:p>","DOI":"10.3390\/toxins12120770","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T22:15:36Z","timestamp":1607638536000},"page":"770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Effectiveness of Botulinum Toxin Type A (BoNT-A) Treatment in Brazilian Patients with Chronic Post-Stroke Spasticity: Results from the Observational, Multicenter, Prospective BCause Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Patricia","family":"Khan","sequence":"first","affiliation":[{"name":"Centro Catarinense de Reabilita\u00e7\u00e3o, Florian\u00f3polis, Santa Catarina 88025-301, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-8830","authenticated-orcid":false,"given":"Marcelo","family":"Riberto","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Amaury","family":"Frances","sequence":"additional","affiliation":[{"name":"Hospital Bettina Ferro de Souza, Campus IV da Universidade Federal do Par\u00e1, Bel\u00e9m, Par\u00e1 66075-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Chueire","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, Autarquia Estadual, S\u00e3o Jos\u00e9 do Rio Preto 15090-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina Ferreira Garcia","family":"Amorim","sequence":"additional","affiliation":[{"name":"Centro de Reabilita\u00e7\u00e3o e Readapta\u00e7\u00e3o Dr. Henrique Santillo (CRER), Goi\u00e2nia, Goi\u00e1s 74653-230, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Xerez","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina F\u00edsica e Reabilita\u00e7\u00e3o, Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Mo","family":"Chung","sequence":"additional","affiliation":[{"name":"Instituto de Medicina F\u00edsica e Reabilita\u00e7\u00e3o, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 04116-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Helena Costa","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Paulo\u2014UNIFESP, S\u00e3o Paulo 04024-002, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Luiz","family":"Longo","sequence":"additional","affiliation":[{"name":"Clinica Neurol\u00f3gica e Neurocir\u00fargica de Joinville, Joinville, Santa Catarina 89202-165, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Lianza","sequence":"additional","affiliation":[{"name":"Hospital Alem\u00e3o Oswaldo Cruz, S\u00e3o Paulo 01323-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Maisonobe","sequence":"additional","affiliation":[{"name":"Ipsen, 92100 Boulogne Billancourt, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane C.","family":"Ruiz-Schutz","sequence":"additional","affiliation":[{"name":"Ipsen, S\u00e3o Paulo 04571-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/01.STR.0000105386.05173.5E","article-title":"Spasticity after stroke: Its occurrence and association with motor impairments and activity limitations","volume":"35","author":"Sommerfeld","year":"2004","journal-title":"Stroke"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1191\/0269215502cr512oa","article-title":"Prevalence of spasticity post stroke","volume":"16","author":"Watkins","year":"2002","journal-title":"Clin. 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