{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:37:25Z","timestamp":1793777845392,"version":"4.6.1"},"reference-count":223,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["TI2018-095204-B-C22"],"award-info":[{"award-number":["TI2018-095204-B-C22"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Foundation I\/UCRC, the Center for Arthropod 509 Management Technologies","award":["No. IIP-1821914 and by industry partners (for CB)."],"award-info":[{"award-number":["No. IIP-1821914 and by industry partners (for CB)."]}]},{"name":"Universidad P\u00fablica de Navarra, Pamplona, Spain","award":["D.V.-dL. received a doctoral grant"],"award-info":[{"award-number":["D.V.-dL. received a doctoral grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The control of dipteran pests is highly relevant to humans due to their involvement in the transmission of serious diseases including malaria, dengue fever, Chikungunya, yellow fever, zika, and filariasis; as well as their agronomic impact on numerous crops. Many bacteria are able to produce proteins that are active against insect species. These bacteria include Bacillus thuringiensis, the most widely-studied pesticidal bacterium, which synthesizes proteins that accumulate in crystals with insecticidal properties and which has been widely used in the biological control of insects from different orders, including Lepidoptera, Coleoptera, and Diptera. In this review, we summarize all the bacterial proteins, from B. thuringiensis and other entomopathogenic bacteria, which have described insecticidal activity against dipteran pests, including species of medical and agronomic importance.<\/jats:p>","DOI":"10.3390\/toxins12120773","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T22:15:36Z","timestamp":1607638536000},"page":"773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Potential for Bacillus thuringiensis and Other Bacterial Toxins as Biological Control Agents to Combat Dipteran Pests of Medical and Agronomic Importance"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3965-7424","authenticated-orcid":false,"given":"Daniel","family":"Valtierra-de-Luis","sequence":"first","affiliation":[{"name":"Departamento de Agronom\u00eda, Biotecnolog\u00eda y Alimentaci\u00f3n, Universidad P\u00fablica de Navarra, 31006 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-0060","authenticated-orcid":false,"given":"Maite","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Departamento de Agronom\u00eda, Biotecnolog\u00eda y Alimentaci\u00f3n, Universidad P\u00fablica de Navarra, 31006 Pamplona, Spain"},{"name":"Bioinsectis SL, Avda Pamplona 123, Mutilva, 31192 Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Berry","sequence":"additional","affiliation":[{"name":"Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primitivo","family":"Caballero","sequence":"additional","affiliation":[{"name":"Departamento de Agronom\u00eda, Biotecnolog\u00eda y Alimentaci\u00f3n, Universidad P\u00fablica de Navarra, 31006 Pamplona, Spain"},{"name":"Bioinsectis SL, Avda Pamplona 123, Mutilva, 31192 Navarra, Spain"},{"name":"Institute for Multidisciplinary Research in Applied Biology-IMAB, Universidad P\u00fablica de Navarra, Mutilva, 31192 Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1128\/aem.55.10.2437-2442.1989","article-title":"Worldwide abundance and distribution of Bacillus thuringiensis isolates","volume":"55","author":"Martin","year":"1989","journal-title":"Appl. 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