{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:23:06Z","timestamp":1792012986114,"version":"4.4.0"},"reference-count":54,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["NIA U54AG062334"],"award-info":[{"award-number":["NIA U54AG062334"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["NIEHS P30ES019776"],"award-info":[{"award-number":["NIEHS P30ES019776"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Ciguatera poisoning is a globally occurring seafood disease caused by the ingestion of marine products contaminated with dinoflagellate produced neurotoxins. Persistent forms of ciguatera, which prove to be highly debilitating, are poorly studied and represent a significant medical issue. The present study aims to better understand chronic ciguatera manifestations and identify potential predictive factors for their duration. Medical files of 49 patients were analyzed, and the post-hospitalization evolution of the disease assessed through a follow-up questionnaire. A rigorous logistic lasso regression model was applied to select significant predictors from a list of 37 patient characteristics potentially predictive of having chronic symptoms. Missing data were handled by complete case analysis, and a survival analysis was implemented. All models used standardized variables, and multiple comparisons in the survival analyses were handled by Bonferroni correction. Among all studied variables, five significant predictors of having symptoms lasting \u22653 months were identified: age, tobacco consumption, acute bradycardia, laboratory measures of urea, and neutrophils. This exploratory, hypothesis-generating study contributes to the development of ciguatera epidemiology by narrowing the list from 37 possible predictors to a list of five predictors that seem worth further investigation as candidate risk factors in more targeted studies of ciguatera symptom duration.<\/jats:p>","DOI":"10.3390\/toxins13090646","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T21:48:01Z","timestamp":1631483281000},"page":"646","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Screening for Predictors of Chronic Ciguatera Poisoning: An Exploratory Analysis among Hospitalized Cases from French Polynesia"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-1731","authenticated-orcid":false,"given":"Cl\u00e9mence Mahana iti","family":"Gatti","sequence":"first","affiliation":[{"name":"Laboratory of Marine Biotoxins, Institut Louis Malard\u00e9 (ILM), UMR 241-EIO (IFREMER, ILM, IRD, Univ. Polyn\u00e9sie Fran\u00e7aise), Papeete, Tahiti 98713, French Polynesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3181-8326","authenticated-orcid":false,"given":"Kiyojiken","family":"Chung","sequence":"additional","affiliation":[{"name":"Laboratory of Marine Biotoxins, Institut Louis Malard\u00e9 (ILM), UMR 241-EIO (IFREMER, ILM, IRD, Univ. Polyn\u00e9sie Fran\u00e7aise), Papeete, Tahiti 98713, French Polynesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Oehler","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Polyn\u00e9sie fran\u00e7aise, Papeete, Tahiti 98713, French Polynesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-3327","authenticated-orcid":false,"given":"T. J.","family":"Pierce","sequence":"additional","affiliation":[{"name":"Gangarosa Department of Environmental Health, Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1614-2981","authenticated-orcid":false,"given":"Matthew O.","family":"Gribble","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-1278","authenticated-orcid":false,"given":"Mireille","family":"Chinain","sequence":"additional","affiliation":[{"name":"Laboratory of Marine Biotoxins, Institut Louis Malard\u00e9 (ILM), UMR 241-EIO (IFREMER, ILM, IRD, Univ. Polyn\u00e9sie Fran\u00e7aise), Papeete, Tahiti 98713, French Polynesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,12]]},"reference":[{"key":"ref_1","first-page":"615","article-title":"Origin and transfer of toxins involved in ciguatera","volume":"106","author":"Lewis","year":"1993","journal-title":"Comp. Biochem. Physiol. Part C Pharmacol. Toxicol. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Litaker, R.W., Holland, W.C., Hardison, D.R., Pisapia, F., Hess, P., Kibler, S.R., and Tester, P.A. (2017). Ciguatoxicity of Gambierdiscus and Fukuyoa species from the Caribbean and Gulf of Mexico. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0185776"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/md6030456","article-title":"Ciguatera Fish Poisoning: Treatment, Prevention and Management","volume":"6","author":"Friedman","year":"2008","journal-title":"Mar. 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