{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:44:38Z","timestamp":1785329078330,"version":"3.55.0"},"reference-count":84,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n de Colombia - MINCIENCIAS (100007637)","award":["869\/2017"],"award-info":[{"award-number":["869\/2017"]}]},{"name":"Universidad del Cauca (501100005682)","award":["ID4680"],"award-info":[{"award-number":["ID4680"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Among other scorpion species, Colombia has two genera of the Buthidae family Centruroides and Tityus, considered to be dangerous to humans. This research shares scientific knowledge aiming to a better understanding about the pathophysiological effects of such venoms. The venom of the three species: Centruroides margaritarus, Tityus pachyurus, and T. n. sp. aff. metuendus with biomedical interest were studied. An initial pre-glycemic sample was taken from ICR mice. They were later intraperitoneally inoculated with doses of 35% and 70% of LD50 of total venom. Poisoning signs were observed during a 6-h period to determine the level of scorpionism. After observation, a second glycemic sample was taken, and a histopathological evaluation of different organs was performed. This work revealed that all three venoms showed considerably notorious histopathological alterations in main organs such as heart and lungs; and inducing multiple organ failure, in relation to the glycemia values, only C. margaritatus and T. n. sp. aff. metuendus showed significant changes through manifestation of hyperglycemia. According to the Colombian scorpionism level; signs were mild to severe affecting the autonomous nervous system.<\/jats:p>","DOI":"10.3390\/toxins13110757","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T21:42:05Z","timestamp":1635198125000},"page":"757","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of the Scorpionism Caused by Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. metuendus Scorpion Venoms in Colombia"],"prefix":"10.3390","volume":"13","author":[{"given":"Leydy Lorena","family":"Mendoza-Tobar","sequence":"first","affiliation":[{"name":"Programa de Doctorado en Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Tecnol\u00f3gica de Pereira, Pereira 660003, Colombia"},{"name":"Grupo de Investigaciones Herpetol\u00f3gicas y Toxinol\u00f3gicas, Centro de Investigaciones Biom\u00e9dicas-Bioterio, Departamento de Biolog\u00eda, Facultad de Ciencias Naturales, Exactas y de la Educaci\u00f3n, Universidad del Cauca, Popay\u00e1n 190002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne Alejandra","family":"Meza-Cabrera","sequence":"additional","affiliation":[{"name":"Compa\u00f1\u00eda de Pat\u00f3logos del Cauca, Facultad de Ciencias de la Salud, Universidad del Cauca, Popay\u00e1n 190002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5410-5997","authenticated-orcid":false,"given":"Juan C.","family":"Sep\u00falveda-Arias","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Tecnol\u00f3gica de Pereira, Pereira 660003, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-5508","authenticated-orcid":false,"given":"Jimmy Alexander","family":"Guerrero-Vargas","sequence":"additional","affiliation":[{"name":"Grupo de Investigaciones Herpetol\u00f3gicas y Toxinol\u00f3gicas, Centro de Investigaciones Biom\u00e9dicas-Bioterio, Departamento de Biolog\u00eda, Facultad de Ciencias Naturales, Exactas y de la Educaci\u00f3n, Universidad del Cauca, Popay\u00e1n 190002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actatropica.2008.05.021","article-title":"Epidemiology of scorpionism: A global appraisal","volume":"107","author":"Chippaux","year":"2008","journal-title":"Acta Trop."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.trstmh.2011.03.007","article-title":"Classification of clinical consequences of scorpion stings: Consensus development","volume":"105","author":"Khattabi","year":"2011","journal-title":"Trans. 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