{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:56:25Z","timestamp":1791644185338,"version":"4.3.4"},"reference-count":70,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172791"],"award-info":[{"award-number":["32172791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Research Council Vetenskapsr\u00e5det","award":["VR Grant 2016\u201305885"],"award-info":[{"award-number":["VR Grant 2016\u201305885"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Bee venom (BV) is a typical toxin secreted by stingers of honeybee workers. BV and BV therapy have long been attractive to different cultures, with extensive studies during recent decades. Nowadays, BV is applied to combat several skin diseases, such as atopic dermatitis, acne vulgaris, alopecia, vitiligo, and psoriasis. BV is used extensively in topical preparations as cosmetics and used as dressing for wound healing, as well as in facemasks. Nevertheless, the safety of BV as a therapeutic choice has always been a concern due to the immune system reaction in some people due to BV use. The documented unfavorable impact is explained by the fact that the skin reactions to BV might expand to excessive immunological responses, including anaphylaxis, that typically resolve over numerous days. This review aims to address bee venom therapeutic uses in skin cosmetics.<\/jats:p>","DOI":"10.3390\/toxins13110810","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T02:43:31Z","timestamp":1637289811000},"page":"810","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cosmetic Applications of Bee Venom"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-3507","authenticated-orcid":false,"given":"Aida A. Abd","family":"El-Wahed","sequence":"first","affiliation":[{"name":"Department of Bee Research, Plant Protection Research Institute, Agricultural Research Centre, Giza 12627, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaden A. M.","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-106 91 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6772-3279","authenticated-orcid":false,"given":"Mohamed H.","family":"Elashal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed G.","family":"Musharraf","sequence":"additional","affiliation":[{"name":"H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamer","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-0789","authenticated-orcid":false,"given":"Alfi","family":"Khatib","sequence":"additional","affiliation":[{"name":"Pharmacognosy Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang Darul Makmur, Malaysia"},{"name":"Faculty of Pharmacy, Airlangga University, Surabaya 60155, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon Elrasheid","family":"Tahir","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8111-918X","authenticated-orcid":false,"given":"Yahya Al","family":"Naggar","sequence":"additional","affiliation":[{"name":"General Zoology, Institute for Biology, Martin Luther University Halle-Wittenberg, Hoher Weg 8, 06120 Halle, Germany"},{"name":"Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-375X","authenticated-orcid":false,"given":"Arshad","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-5293","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham R.","family":"El-Seedi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt"},{"name":"Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, Box 591, SE-751 24 Uppsala, Sweden"},{"name":"International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Aufschnaiter, A., Kohler, V., Khalifa, S., El-Wahed, A., Du, M., El-Seedi, H., and B\u00fcttner, S. 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