{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:32:33Z","timestamp":1783704753873,"version":"3.55.0"},"reference-count":32,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Daejeon University and Ministry of Science, ICT &amp; Future Planning","award":["NRF \u2013 2021R1A2C2013483"],"award-info":[{"award-number":["NRF \u2013 2021R1A2C2013483"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Background: Bee venom acupuncture (BVA) is an effective treatment method for various diseases. Bee venom, however, can cause adverse effects, even rarely including life-threatening anaphylaxis, so safety-related evidence is required. In this study, we systematically estimated the incidence rate of anaphylaxis in response to BVA. Methods: We searched eight databases (MEDLINE (Pubmed), EMBASE, Cochrane Central Register of Controlled, KISS, KMBASE, Koreamed, OASIS, and NDSL) and systematically reviewed the articles that met the inclusion\/exclusion criteria. Results: Among 225 potentially relevant articles, 49 were selected for this study. The overall incidence rate of anaphylaxis in response to BVA was 0.045% (95% CI 0.028\u20130.062). Women (0.083%, 95% CI 0.010\u20130.157) showed a higher incidence rate than men (0.019%, 95% CI \u22120.018 to 0.055), while the incidence for patients who had a skin test conducted (0.041%, 95% CI 0.011\u20130.072) was not significantly different compared to that obtained for patients for which there was no information about a skin test (0.047%, 95% CI 0.026\u20130.067). The publication year affected the incidence rate: it was highest before 1999 (1.099%, 95% CI \u22121.043 to 3.241), lower between 2000 and 2009 (0.049%, 95% CI 0.025\u20130.073), and lowest between 2010 and 2021 (0.037% 95% CI 0.014\u20130.060). Conclusions: In this study, we provide reference data about risk size and factors of BVA-related anaphylaxis, which is essentially required for BVA application in clinics.<\/jats:p>","DOI":"10.3390\/toxins14040238","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:31:25Z","timestamp":1648416685000},"page":"238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Seong-Hwan","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-8389","authenticated-orcid":false,"given":"Hyeon-Muk","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Korean Internal Medicine, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Eun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Ju","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Jin","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine, Graduate School of Integrative Medicine, CHA University, 120 Haeryong-ro, Kyeong-gi, Pocheon 11160, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Seok","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Gue","family":"Son","sequence":"additional","affiliation":[{"name":"Liver and Immunology Research Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon 35235, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-9694","authenticated-orcid":false,"given":"Eun-Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"ref_1","first-page":"470","article-title":"A phase I study of the safety of honeybee venom extract as a possible treatment for patients with progressive forms of multiple sclerosis","volume":"26","author":"Castro","year":"2005","journal-title":"Allergy Asthma Proc."},{"key":"ref_2","first-page":"69","article-title":"Studies on bee venom and its medical uses","volume":"1","author":"Ali","year":"2012","journal-title":"Int. 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