{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:17:38Z","timestamp":1789024658506,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jing Wu","award":["2021JJ30343; 2020JJ4368; 2020NK2032"],"award-info":[{"award-number":["2021JJ30343; 2020JJ4368; 2020NK2032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Citrinin (CTN) is a mycotoxin found in crops and agricultural products and poses a serious threat to human and animal health. The aim of this study is to investigate the hepatotoxicity of CTN in mice and analyze its mechanisms from Ca2+-dependent endoplasmic reticulum (ER) stress perspective. We showed that CTN induced histopathological damage, caused ultrastructural changes in liver cells, and induced abnormal values of biochemical laboratory tests of some liver functions in mice. Treatment with CTN could induce nitric oxide (NO), malondialdehyde (MDA), and reactive oxygen species (ROS) accumulation in mice, accompanied with losses of activities of superoxide dismutase (SOD) and catalase (CAT), levels of glutathione (GSH), and capacities of total antioxidant (T-AOC), resulting in oxidative stress in mice. Furthermore, CTN treatment significantly increased Ca2+ accumulation, upregulated protein expressions of ER stress-mediated apoptosis signal protein (glucose regulated protein 78 (GRP78\/BIP), C\/EBP-homologous protein (CHOP), Caspase-12, and Caspase-3), and induced hepatocyte apoptosis. These adverse effects were counteracted by 4-phenylbutyric acid (4-PBA), an ER stress inhibitor. In summary, our results showed a possible underlying molecular mechanism for CTN that induced hepatocyte apoptosis in mice by the regulation of the Ca2+\/ER stress signaling pathway.<\/jats:p>","DOI":"10.3390\/toxins14040259","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T22:23:23Z","timestamp":1649370203000},"page":"259","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Citrinin-Induced Hepatotoxicity in Mice Is Regulated by the Ca2+\/Endoplasmic Reticulum Stress Signaling Pathway"],"prefix":"10.3390","volume":"14","author":[{"given":"Dongyi","family":"Wu","sequence":"first","affiliation":[{"name":"Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"},{"name":"Hunan Engineering Research Center of Livestock and Poultry Health Care, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Yang","sequence":"additional","affiliation":[{"name":"Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"},{"name":"Hunan Engineering Research Center of Livestock and Poultry Health Care, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengran","family":"Yang","sequence":"additional","affiliation":[{"name":"Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"},{"name":"Hunan Engineering Research Center of Livestock and Poultry Health Care, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Wu","sequence":"additional","affiliation":[{"name":"Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"},{"name":"Hunan Engineering Research Center of Livestock and Poultry Health Care, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Mao","sequence":"additional","affiliation":[{"name":"Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"},{"name":"Hunan Engineering Research Center of Livestock and Poultry Health Care, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"},{"name":"Hunan Engineering Research Center of Livestock and Poultry Health Care, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-3563","authenticated-orcid":false,"given":"Ji","family":"Wang","sequence":"additional","affiliation":[{"name":"Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"},{"name":"Hunan Engineering Research Center of Livestock and Poultry Health Care, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-4719","authenticated-orcid":false,"given":"Zhihang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"},{"name":"Hunan Engineering Research Center of Livestock and Poultry Health Care, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"},{"name":"Hunan Engineering Research Center of Livestock and Poultry Health Care, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1017\/S095442241200008X","article-title":"The role of biomarkers in evaluating human health concerns from fungal contaminants in food","volume":"25","author":"Turner","year":"2012","journal-title":"Nutr. 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