{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:46:07Z","timestamp":1793393167474,"version":"4.5.0"},"reference-count":147,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea government (MSIT)","award":["2020R1A2C2013373"],"award-info":[{"award-number":["2020R1A2C2013373"]}]},{"name":"Korea government (MSIT)","award":["20210651"],"award-info":[{"award-number":["20210651"]}]},{"name":"Ministry of Oceans and Fisheries, Korea","award":["2020R1A2C2013373"],"award-info":[{"award-number":["2020R1A2C2013373"]}]},{"name":"Ministry of Oceans and Fisheries, Korea","award":["20210651"],"award-info":[{"award-number":["20210651"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Phytoplankton are photosynthetic microorganisms in aquatic environments that produce many bioactive substances. However, some of them are toxic to aquatic organisms via filter-feeding and are even poisonous to humans through the food chain. Human poisoning from these substances and their serious long-term consequences have resulted in several health threats, including cancer, skin disorders, and other diseases, which have been frequently documented. Seafood poisoning disorders triggered by phytoplankton toxins include paralytic shellfish poisoning (PSP), neurotoxic shellfish poisoning (NSP), amnesic shellfish poisoning (ASP), diarrheic shellfish poisoning (DSP), ciguatera fish poisoning (CFP), and azaspiracid shellfish poisoning (AZP). Accordingly, identifying harmful shellfish poisoning and toxin-producing species and their detrimental effects is urgently required. Although the harmful effects of these toxins are well documented, their possible modes of action are insufficiently understood in terms of clinical symptoms. In this review, we summarize the current state of knowledge regarding phytoplankton toxins and their detrimental consequences, including tumor-promoting activity. The structure, source, and clinical symptoms caused by these toxins, as well as their molecular mechanisms of action on voltage-gated ion channels, are briefly discussed. Moreover, the possible stress-associated reactive oxygen species (ROS)-related modes of action are summarized. Finally, we describe the toxic effects of phytoplankton toxins and discuss future research in the field of stress-associated ROS-related toxicity. Moreover, these toxins can also be used in different pharmacological prospects and can be established as a potent pharmacophore in the near future.<\/jats:p>","DOI":"10.3390\/toxins14060397","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T06:31:59Z","timestamp":1655101919000},"page":"397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5410-7511","authenticated-orcid":false,"given":"Biswajita","family":"Pradhan","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Sangmyung University, Seoul 03016, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Sangmyung University, Seoul 03016, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Abassi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Sangmyung University, Seoul 03016, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-9262","authenticated-orcid":false,"given":"Jang-Seu","family":"Ki","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Sangmyung University, Seoul 03016, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pradhan, B., Maharana, S., Bhakta, S., and Jena, M. 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