{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:41:23Z","timestamp":1792003283287,"version":"4.4.0"},"reference-count":20,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Medical Device Development Fund","award":["1711138194"],"award-info":[{"award-number":["1711138194"]}]},{"name":"Korea Medical Device Development Fund","award":["KMDF_PR_20200901_0109-01"],"award-info":[{"award-number":["KMDF_PR_20200901_0109-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Botulinum neurotoxin injections near the lateral canthal rhytids are commonly used in cosmetic settings; however, there is a lack of thorough anatomical knowledge, and an effective way to treat them with accumulating knowledge is needed. The anatomical characteristics concerning the injection of botulinum neurotoxin into the orbicularis oculi muscle were evaluated in this review. Current knowledge on the identification of botulinum neurotoxin injection points from recent anatomical research was assessed. The lateral canthal lines are involved with the orbicularis oculi muscle and nearby anatomical structures, and the injection points can be more precisely defined. The best possible injection sites were provided, and the injection procedure was described. This review proposes evidence for injection sites associated with the surface anatomy of the orbicularis oculi muscles to enhance the effectiveness of easing lateral canthal rhytids.<\/jats:p>","DOI":"10.3390\/toxins14070462","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T21:15:52Z","timestamp":1657142152000},"page":"462","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Novel Anatomical Proposal for Botulinum Neurotoxin Injection Targeting Lateral Canthal Rhytids"],"prefix":"10.3390","volume":"14","author":[{"given":"Kyu-Ho","family":"Yi","sequence":"first","affiliation":[{"name":"Wonju Public Health Center, Wonjusi 26417, Korea"},{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 PLUS Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 PLUS Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Communications, Incheon Catholic University, Incheon 23058, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Wook","family":"Yoon","sequence":"additional","affiliation":[{"name":"BongHwa Public Health Center, Bonghwa-gun 36238, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook","family":"Oh","sequence":"additional","affiliation":[{"name":"Maylin Clinic (Yeouido), Seoul 07335, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1139-6261","authenticated-orcid":false,"given":"Hee-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 PLUS Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/01.sap.0000244968.16977.1f","article-title":"An objective assessment of botulinum toxin A effect on superficial skin texture","volume":"58","author":"Dessy","year":"2007","journal-title":"Ann. 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