{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:52:46Z","timestamp":1785034366995,"version":"3.55.0"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Council for Scientific and Technological Development (CNPq)","award":["437089\/2018-5 (LDS)"],"award-info":[{"award-number":["437089\/2018-5 (LDS)"]}]},{"name":"the National Council for Scientific and Technological Development (CNPq)","award":["2018\/15446-8 (LAO)"],"award-info":[{"award-number":["2018\/15446-8 (LAO)"]}]},{"name":"the National Council for Scientific and Technological Development (CNPq)","award":["88882.432932\/2019-01 (JSC)"],"award-info":[{"award-number":["88882.432932\/2019-01 (JSC)"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["437089\/2018-5 (LDS)"],"award-info":[{"award-number":["437089\/2018-5 (LDS)"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["2018\/15446-8 (LAO)"],"award-info":[{"award-number":["2018\/15446-8 (LAO)"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["88882.432932\/2019-01 (JSC)"],"award-info":[{"award-number":["88882.432932\/2019-01 (JSC)"]}]},{"name":"Coordination of Superior Level Staff Improvement (CAPES)","award":["437089\/2018-5 (LDS)"],"award-info":[{"award-number":["437089\/2018-5 (LDS)"]}]},{"name":"Coordination of Superior Level Staff Improvement (CAPES)","award":["2018\/15446-8 (LAO)"],"award-info":[{"award-number":["2018\/15446-8 (LAO)"]}]},{"name":"Coordination of Superior Level Staff Improvement (CAPES)","award":["88882.432932\/2019-01 (JSC)"],"award-info":[{"award-number":["88882.432932\/2019-01 (JSC)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The clinical manifestations of Bothrops atrox envenoming involve local and systemic changes, among which edema requires substantial attention due to its ability to progress to compartmental syndromes and sometimes cause tissue loss and amputations. However, the impact of edema on the poisoned body\u2019s system has not been explored. Thus, the present study aimed to explore the systemic pathological and inflammatory events that are altered by intraplantar injection of B. atrox venom in a mouse model through hematologic, lipidic, and shotgun proteomics analysis. Plasma samples collected showed a greater abundance of proteins related to complement, coagulation, lipid system, platelet and neutrophil degranulation, and pathways related to cell death and ischemic tolerance. Interestingly, some proteins, in particular, Prdx2 (peroxiredoxin 2), Hba (hemoglobin subunit alpha), and F9 (Factor IX), increased according to the amount of venom injected. Our findings support that B. atrox venom activates multiple blood systems that are involved in thromboinflammation, an observation that may have implications for the pathophysiological progression of envenomations. Furthermore, we report for the first time a potential role of Prdx2, Hba, and F9 as potential markers of the severity of edema\/inflammation in mice caused by B. atrox.<\/jats:p>","DOI":"10.3390\/toxins14090613","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:19:01Z","timestamp":1662077941000},"page":"613","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Experimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-9137","authenticated-orcid":false,"given":"Joeliton S.","family":"Cavalcante","sequence":"first","affiliation":[{"name":"Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Mayara da Cunha","family":"Brito","sequence":"additional","affiliation":[{"name":"Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laudic\u00e9ia Alves","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Curtolo","family":"De Barros","sequence":"additional","affiliation":[{"name":"Center for the Study of Venoms and Venomous Animals (CEVAP), S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-192X","authenticated-orcid":false,"given":"Cayo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Center of Mathematics, Computing Sciences and Cognition, Federal University of ABC, S\u00e3o Paulo 09210-580, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Cesar","family":"Rossini","sequence":"additional","affiliation":[{"name":"Biotechnology Institute (IBTEC), S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"},{"name":"Department of Chemical and Biological Sciences, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duaran Lopes","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, Federal University of Cear\u00e1, Fortaleza 60430-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-1499","authenticated-orcid":false,"given":"Renata Sousa","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, Federal University of Cear\u00e1, Fortaleza 60430-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Jeane Bezerra","family":"Jorge","sequence":"additional","affiliation":[{"name":"Drug Research and Development Center, Federal University of Cear\u00e1 (UFC), Fortaleza 60430-275, Brazil"},{"name":"Department of Physiology and Pharmacology, School of Medicine, Federal University of Cear\u00e1 (UFC), Fortaleza 60430-140, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5832-1825","authenticated-orcid":false,"given":"Lucilene Delazari dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"},{"name":"Biotechnology Institute (IBTEC), S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"},{"name":"Graduate Program in Research and Development (Medical Biotechnology), Botucatu Medical School (FMB), S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1590\/1809-4392201901561","article-title":"Epidemiological and clinical aspects of snakebites in the upper Juru\u00e1 River region, western Brazilian Amazonia","volume":"50","author":"Silva","year":"2019","journal-title":"Acta Amaz."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100037","DOI":"10.1016\/j.toxcx.2020.100037","article-title":"Bothrops atrox, the most 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