{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:38:08Z","timestamp":1784770688126,"version":"3.55.0"},"reference-count":43,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The review is an introduction to medical, non-cosmetic treatments with botulinum neurotoxin (BoNT) in the orofacial region. It focuses on the current most common, best-documented and safest indications of interest for dentists in terms of dystonia and sialorrhea. These conditions are recommended to start with and suitable to gain better skill and experience with BoNT. The introduction also stresses the importance of correct diagnostics based on interdisciplinary cooperation, precise targeting of the injections, measurements of treatment effect, and control of the oral health with regard to side effects.<\/jats:p>","DOI":"10.3390\/toxins14100667","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T01:23:16Z","timestamp":1664414596000},"page":"667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Botulinum Toxin, a Drug with Potential Interest for Dentists\u2014An Introduction"],"prefix":"10.3390","volume":"14","author":[{"given":"Merete","family":"Bakke","sequence":"first","affiliation":[{"name":"Clinical Oral Physiology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"ref_1","first-page":"894","article-title":"Botulinum toxin\u2014Et l\u00e6gemiddel af potentiel interesse for tandl\u00e6ger","volume":"117","author":"Bakke","year":"2013","journal-title":"Tandlaegebladet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Rosales, R., and Dressler, D. (2016). What clinical strategies are applied for botulinum toxin injection in the oromandibular region?. Botulinum Toxin Therapy Manual for Dystonia and Spasticity, InTech.","DOI":"10.5772\/61878"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1124\/pr.116.012658","article-title":"Botulinum neurotoxins: Biology, pharmacology, and toxicology","volume":"69","author":"Pirazzini","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Park, J., and Park, J.P. (2017). Botulinum toxin for the treatment of neuropathic pain. Toxins, 9.","DOI":"10.3390\/toxins9090260"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s10194-017-0744-z","article-title":"Botulinum neurotoxin type A for the treatment of pain: Not just in migraine and trigeminal neuralgia","volume":"18","author":"Sandrini","year":"2017","journal-title":"J. Headache Pain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.3390\/toxins7082791","article-title":"Temporomandibular myofacial pain treated with botulinum toxin injection","volume":"7","author":"Mor","year":"2015","journal-title":"Toxins"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tox.2013.02.006","article-title":"Botulinum toxins: Mechanisms of action, antinociception and clinical applications","volume":"306","author":"Wheeler","year":"2013","journal-title":"Toxicology"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Waskitho, A., Yamamoto, Y., Raman, S., Kano, F., Yan, H., Raju, R., Afroz, S., Morita, T., Ikutame, D., and Okura, K. (2021). Peripherally administered botulinum toxin type A localizes bilaterally in trigeminal ganglia of animal model. Toxins, 13.","DOI":"10.3390\/toxins13100704"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pneurobio.2014.06.001","article-title":"Botulinum toxin A, brain and pain","volume":"119\u2013120","author":"Matak","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/j.pain.2011.03.036","article-title":"Efficacy of botulinum toxin type A for treatment of persistent myofascial TMD pain: A randomized, controlled, double-blind multicenter study","volume":"152","author":"Ernberg","year":"2011","journal-title":"Pain"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jpain.2019.08.011","article-title":"Botulinum Toxin Type A for painful temporomandibular disorders: Systematic review and meta-analysis","volume":"21","author":"Machado","year":"2020","journal-title":"J. Pain"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"De la Torre Canales, G., Alvarez-Pinzon, N., Mu\u00f1oz-Lora, V.R.M., Peroni, L.V., Gomes, A.F., S\u00e1nchez-Ayala, A., Haiter-Neto, F., Manfredini, D., and Rizzatti-Barbosa, C.M. (2020). Efficacy and safety of botulinum toxin type A on persistent myofascial pain: A randomized clinical trial. Toxins, 12.","DOI":"10.3390\/toxins12060395"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4103\/0975-5950.183860","article-title":"Application of botulinum toxin in dentistry: A comprehensive review","volume":"6","author":"Srivastava","year":"2015","journal-title":"Natl. J. Maxillofac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/joor.12768","article-title":"Oromandibular dystonia, mental distress and oro-facial dysfunction\u2014A follow-up 8\u201310 years after start of treatment with botulinum toxin","volume":"46","author":"Bakke","year":"2019","journal-title":"J. Oral Rehabil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.tripleo.2004.11.019","article-title":"Treatment of severe temporomandibular joint clicking with botulinum toxin in the lateral pterygoid muscle in two cases of anterior disc displacement","volume":"100","author":"Bakke","year":"2005","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/mds.21304","article-title":"Oromandibular dystonia involving the lateral pterygoid muscles: Four cases with different complexity","volume":"22","author":"Bakke","year":"2007","journal-title":"Mov. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Yoshida, K. (2018). Botulinum neurotoxin injection for the treatment of recurrent temporomandibular joint dislocation with and without neurogenic muscular hyperactivity. Toxins, 10.","DOI":"10.3390\/toxins10050174"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yoshida, K. (2021). Effects of botulinum toxin type A on pain among trigeminal neuralgia, myofascial temporomandibular disorders, and oromandibular dystonia. Toxins, 13.","DOI":"10.3390\/toxins13090605"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1875-595X.2011.00085.x","article-title":"Efficacy of botulinum toxins on bruxism: An evidence-based review. Efficacy of botulinum toxins on bruxism: An evidence-based review","volume":"62","author":"Long","year":"2012","journal-title":"Int. Dent. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.oooo.2012.04.023","article-title":"Oromandibular dystonia\u2014Functional and clinical characteristics: A report on 21 cases","volume":"115","author":"Bakke","year":"2013","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s13760-020-01404-4","article-title":"Oral appliances in the treatment of oromandibular dystonia: A systematic review","volume":"120","author":"Vereecke","year":"2020","journal-title":"Acta Neurol. Belg."},{"key":"ref_22","first-page":"658","article-title":"Oromandibul\u00e6r dystoni","volume":"125","author":"Kjelde","year":"2021","journal-title":"Tandlaegebladet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1212\/WNL.53.9.2102","article-title":"Botulinum toxin A in patients with oromandibular dystonia: Long-term follow-up","volume":"53","author":"Tan","year":"1999","journal-title":"Neurology"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yoshida, K. (2022). Botulinum toxin therapy for oromandibular dystonia and other movement disorders in the stomatognathic system. Toxins, 14.","DOI":"10.3390\/toxins14040282"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00702-018-1960-7","article-title":"Botulinum neurotoxin a therapy efficacy and safety for oromandibular dystonia: A meta-analysis","volume":"126","author":"Dadgardoust","year":"2019","journal-title":"J. Neural Transm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.toxicon.2018.02.006","article-title":"Systematic review of botulinum toxin treatment for oromandibular dystonia","volume":"147","author":"Comella","year":"2018","journal-title":"Toxicon"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Choudhury, S., Baker, M.R., Chatterjee, S., and Hrishikesh, K. (2021). Botulinum toxin: An update on pharmacology and newer products in development. Toxins, 13.","DOI":"10.3390\/toxins13010058"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Balanta-Melo, J., Toto-Ibacache, V., Kupczik, K., and Buvinic, S. (2019). Mandibular bone loss after masticatory muscles intervention with botulinum toxin: An approach from basic research to clinical findings. Toxins, 11.","DOI":"10.3390\/toxins11020084"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.oooo.2019.03.007","article-title":"Mandibular bone effects of botulinum toxin injections in masticatory muscles in adult","volume":"129","author":"Kahn","year":"2020","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.tripleo.2003.08.011","article-title":"Treatment of perioral dystonia with botulinum toxin in 4 cases of Meige\u2019s syndrome","volume":"96","author":"Werdelin","year":"2003","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1002\/lary.23265","article-title":"Oromandibular dystonia: Long-term management with botulinum toxin","volume":"123","author":"Sinclair","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s40120-019-00155-6","article-title":"Therapy of sialorrhea with botulinum neurotoxin","volume":"8","author":"Jost","year":"2019","journal-title":"Neurol. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/00016357.2010.545035","article-title":"Treatment of severe drooling with botulinum toxin in amyotrophic lateral sclerosis and Parkinson\u2019s disease: Efficacy and possible mechanisms","volume":"69","author":"Karlsborg","year":"2011","journal-title":"Acta Odont. Scand."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1044\/sasd21.1.15","article-title":"Severe drooling and treatment with botulinum toxin","volume":"21","author":"Bakke","year":"2012","journal-title":"Perspect. Swallowing Swallowing Disord. (Dysphagia)"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00702-015-1416-2","article-title":"The option of sonographic guidance in botulinum toxin injection for drooling in Parkinson\u2019s disease","volume":"123","author":"Jost","year":"2016","journal-title":"J. Neural. Transm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF02412423","article-title":"Three treatment approaches and clinical factors in the reduction of drooling","volume":"3","author":"Greenberg","year":"1988","journal-title":"Dysphagia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e1982","DOI":"10.1212\/WNL.0000000000007368","article-title":"Placebo-controlled, randomized, double-blind study of incobotulinumtoxin A for sialorrhea","volume":"92","author":"Jost","year":"2019","journal-title":"Neurology"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ruiz-Roca, J.A., Pons-Fuster, E., and Lopez-Jorne, P. (2019). Effectiveness of the botulinum toxin for treating sialorrhea in patients with Parkinson\u2019s disease: A systematic review. J. Clin. Med., 8.","DOI":"10.3390\/jcm8030317"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hung, S.A., Liao, C.L., Lin, W.P., Hsu, J.C., Guo, Y.H., and Lin, Y.C. (2021). Botulinum toxin injections for treatment of drooling in children with cerebral palsy: A systematic review and meta-analysis. Children, 8.","DOI":"10.3390\/children8121089"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00784-016-1826-z","article-title":"Does the botulinum neuro-toxin type A treatment for sialorrhea change oral health?","volume":"21","author":"Taba","year":"2017","journal-title":"Clin. Oral Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jdent.2018.08.010","article-title":"The role of natural salivary defences in maintaining a healthy oral microbiota","volume":"80","year":"2019","journal-title":"J. Dent."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.4317\/medoral.24101","article-title":"Oral health effects of botulinum toxin treatment for drooling: A systematic review","volume":"26","author":"Correa","year":"2021","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s10072-018-3279-4","article-title":"Saliva changes in Parkinson\u2019s disease patients after injection of botulinum neurotoxin type A","volume":"39","author":"Tamme","year":"2018","journal-title":"Neurol. 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