{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:37:26Z","timestamp":1776904646609,"version":"3.51.2"},"reference-count":78,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"the Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MC048"],"award-info":[{"award-number":["ZR2021MC048"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"the Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2022TSGC1275"],"award-info":[{"award-number":["2022TSGC1275"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"the Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["SDAIT-08-05"],"award-info":[{"award-number":["SDAIT-08-05"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong science and technology-based small and medium-sized enterprises innovation capacity improvement project","award":["ZR2021MC048"],"award-info":[{"award-number":["ZR2021MC048"]}]},{"name":"Shandong science and technology-based small and medium-sized enterprises innovation capacity improvement project","award":["2022TSGC1275"],"award-info":[{"award-number":["2022TSGC1275"]}]},{"name":"Shandong science and technology-based small and medium-sized enterprises innovation capacity improvement project","award":["SDAIT-08-05"],"award-info":[{"award-number":["SDAIT-08-05"]}]},{"name":"the Shandong province pig industry technology system","award":["ZR2021MC048"],"award-info":[{"award-number":["ZR2021MC048"]}]},{"name":"the Shandong province pig industry technology system","award":["2022TSGC1275"],"award-info":[{"award-number":["2022TSGC1275"]}]},{"name":"the Shandong province pig industry technology system","award":["SDAIT-08-05"],"award-info":[{"award-number":["SDAIT-08-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The aim of this study was to explore the effect of zearalenone (ZEA) exposure on uterine development in weaned gilts by quantitative proteome analysis with tandem mass spectrometry tags (TMT). A total of 16 healthy weaned gilts were randomly divided into control (basal diet) and ZEA3.0 treatments groups (basal diet supplemented with 3.0 mg\/kg ZEA). Results showed that vulva size and uterine development index were increased (p &lt; 0.05), whereas serum follicle stimulation hormone, luteinizing hormone and gonadotropin-releasing hormone were decreased in gilts fed the ZEA diet (p &lt; 0.05). ZEA, \u03b1-zearalenol (\u03b1-ZOL) and \u03b2-zearalenol (\u03b2-ZOL) were detected in the uteri of gilts fed a 3.0 mg\/kg ZEA diet (p &lt; 0.05). The relative protein expression levels of creatine kinase M-type (CKM), atriopeptidase (MME) and myeloperoxidase (MPO) were up-regulated (p &lt; 0.05), whereas aldehyde dehydrogenase 1 family member (ALDH1A2), secretogranin-1 (CHGB) and SURP and G-patch domain containing 1 (SUGP1) were down-regulated (p &lt; 0.05) in the ZEA3.0 group by western blot, which indicated that the proteomics data were dependable. In addition, the functions of differentially expressed proteins (DEPs) mainly involved the cellular process, biological regulation and metabolic process in the biological process category. Some important signaling pathways were changed in the ZEA3.0 group, such as extracellular matrix (ECM)-receptor interaction, focal adhesion and the phosphoinositide 3-kinase\u2013protein kinase B (PI3K-AKT) signaling pathway (p &lt; 0.01). This study sheds new light on the molecular mechanism of ZEA in the uterine development of gilts.<\/jats:p>","DOI":"10.3390\/toxins14100692","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T06:13:27Z","timestamp":1665468807000},"page":"692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quantitative Proteomic Analysis of Zearalenone Exposure on Uterine Development in Weaned Gilts"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-2640","authenticated-orcid":false,"given":"Xinglin","family":"Liu","sequence":"first","affiliation":[{"name":"Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Muge Animal Husbandry Equipment Co., Ltd., Yucheng 251200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhongcheng Feed Technology Co., Ltd., Feicheng 271600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libo","family":"Huang","sequence":"additional","affiliation":[{"name":"Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-6732","authenticated-orcid":false,"given":"Xuejun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Shandong Agricultural University, No. 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-1259","authenticated-orcid":false,"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Jiao","sequence":"additional","affiliation":[{"name":"Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiren","family":"Yang","sequence":"additional","affiliation":[{"name":"Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1080\/10408398.2019.1655388","article-title":"Occurrence and toxicity of a fusarium mycotoxin, zearalenone","volume":"60","author":"Rai","year":"2020","journal-title":"Crit. 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