{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:27:12Z","timestamp":1792121232558,"version":"4.4.0"},"reference-count":54,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Thailand Science Research and Innovation Fundamental Fund","award":["2461863"],"award-info":[{"award-number":["2461863"]}]},{"name":"Thailand Science Research and Innovation Fundamental Fund","award":["B16F640114"],"award-info":[{"award-number":["B16F640114"]}]},{"name":"National Science, Research and Innovation Fund (NSRF)","award":["2461863"],"award-info":[{"award-number":["2461863"]}]},{"name":"National Science, Research and Innovation Fund (NSRF)","award":["B16F640114"],"award-info":[{"award-number":["B16F640114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The contamination of animal feed with aflatoxins is an ongoing and growing serious issue, particularly for livestock farmers in tropical and subtropical regions. Exposure of animals to an aflatoxin-contaminated diet impairs feed efficiency and increases susceptibility to diseases, resulting in mortality, feed waste, and increased production costs. They can also be excreted in milk and thus pose a significant human health risk. This systematic review and network meta-analysis aim to compare and identify the most effective intervention to alleviate the negative impact of aflatoxins on the important livestock sector, poultry production. Eligible studies on the efficacy of feed additives to mitigate the toxic effect of aflatoxins in poultry were retrieved from different databases. Additives were classified into three categories based on their mode of action and composition: organic binder, inorganic binder, and antioxidant. Moreover, alanine transaminase (ALT), a liver enzyme, was the primary indicator. Supplementing aflatoxin-contaminated feeds with different categories of additives significantly reduces serum ALT levels (p &lt; 0.001) compared with birds fed only a contaminated diet. Inorganic binder (P-score 0.8615) was ranked to be the most efficient in terms of counteracting the toxic effect of aflatoxins, followed by antioxidant (P-score 0.6159) and organic binder (P-score 0.5018). These findings will have significant importance for farmers, veterinarians, and animal nutrition companies when deciding which type of additives to use for mitigating exposure to aflatoxins, thus improving food security and the livelihoods of smallholder farmers in developing countries.<\/jats:p>","DOI":"10.3390\/toxins14100707","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:08:02Z","timestamp":1665983282000},"page":"707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Efficacy of Additives for the Mitigation of Aflatoxins in Animal Feed: A Systematic Review and Network Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"given":"Oluwatobi","family":"Kolawole","sequence":"first","affiliation":[{"name":"Institute for Global Food Security, National Measurement Laboratory: Centre of Excellence in Agriculture and Food Integrity, Queen\u2019s University Belfast, 19 Chlorine Gardens, Belfast BT9 5DL, UK"},{"name":"The International Joint Research Center on Food Security (IJC-FOODSEC), 113 Thailand Science Park, Pahonyothin Road, Khong Luang, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4061-7454","authenticated-orcid":false,"given":"Wipada","family":"Siri-Anusornsak","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok 10900, Thailand"},{"name":"Scientific Equipment and Research Division, Kasetsart University Research and Development Institute (KURDI), Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-2191","authenticated-orcid":false,"given":"Awanwee","family":"Petchkongkaw","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security, National Measurement Laboratory: Centre of Excellence in Agriculture and Food Integrity, Queen\u2019s University Belfast, 19 Chlorine Gardens, Belfast BT9 5DL, UK"},{"name":"The International Joint Research Center on Food Security (IJC-FOODSEC), 113 Thailand Science Park, Pahonyothin Road, Khong Luang, Pathum Thani 12120, Thailand"},{"name":"School of Food Science and Technology, Faculty of Science and Technology, Thammasat University, 99 Mhu 18, Pahonyothin Road, Khong Luang, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Meneely","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security, National Measurement Laboratory: Centre of Excellence in Agriculture and Food Integrity, Queen\u2019s University Belfast, 19 Chlorine Gardens, Belfast BT9 5DL, UK"},{"name":"The International Joint Research Center on Food Security (IJC-FOODSEC), 113 Thailand Science Park, Pahonyothin Road, Khong Luang, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-2909","authenticated-orcid":false,"given":"Christopher","family":"Elliott","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security, National Measurement Laboratory: Centre of Excellence in Agriculture and Food Integrity, Queen\u2019s University Belfast, 19 Chlorine Gardens, Belfast BT9 5DL, UK"},{"name":"The International Joint Research Center on Food Security (IJC-FOODSEC), 113 Thailand Science Park, Pahonyothin Road, Khong Luang, Pathum Thani 12120, Thailand"},{"name":"School of Food Science and Technology, Faculty of Science and Technology, Thammasat University, 99 Mhu 18, Pahonyothin Road, Khong Luang, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1574-6968.2009.01890.x","article-title":"Molecular strategy for identification in Aspergillus section Flavi","volume":"304","author":"Godet","year":"2010","journal-title":"FEMS Microbiol. 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