{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:47:31Z","timestamp":1791658051160,"version":"4.3.4"},"reference-count":58,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MC048"],"award-info":[{"award-number":["ZR2021MC048"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2022TSGC1275"],"award-info":[{"award-number":["2022TSGC1275"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["SDAIT-08-05"],"award-info":[{"award-number":["SDAIT-08-05"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong science and technology-based small and medium-sized enterprises innovation capacity improvement project","award":["ZR2021MC048"],"award-info":[{"award-number":["ZR2021MC048"]}]},{"name":"Shandong science and technology-based small and medium-sized enterprises innovation capacity improvement project","award":["2022TSGC1275"],"award-info":[{"award-number":["2022TSGC1275"]}]},{"name":"Shandong science and technology-based small and medium-sized enterprises innovation capacity improvement project","award":["SDAIT-08-05"],"award-info":[{"award-number":["SDAIT-08-05"]}]},{"name":"Shandong Province Pig Industry Technology System","award":["ZR2021MC048"],"award-info":[{"award-number":["ZR2021MC048"]}]},{"name":"Shandong Province Pig Industry Technology System","award":["2022TSGC1275"],"award-info":[{"award-number":["2022TSGC1275"]}]},{"name":"Shandong Province Pig Industry Technology System","award":["SDAIT-08-05"],"award-info":[{"award-number":["SDAIT-08-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>In this study, we aimed to assess the effect of diet ZEA on serum hormones, the location and expression of estrogen receptor ER\u03b1\/\u03b2 and progesterone receptor (PR) of the uterus in weaned piglets and to reveal the mechanism underneath. A total of 40 healthy weaned gilts were randomly allocated to basal diet supplemented with 0 (Control), 0.5 (ZEA0.5), 1.0 (ZEA1.0) and 1.5 (ZEA1.5) mg ZEA\/kg and fed individually for 35 days. Meanwhile, the porcine endometrial epithelial cells (PECs) were incubated for 24 h with ZEA at 0 (Control), 5 (ZEA5), 20 (ZEA20) and 80 (ZEA80) \u03bcmol\/L, respectively. The results showed that nutrient apparent digestibility (CP and GE), nutrient apparent availability (ME\/GE, BV and NPU), the uterine immunoreactive integrated optic density (IOD), relative mRNA and protein expression of ER-\u03b1, ER-\u03b2 and PR and the relative mRNA and protein expression of ER-\u03b1 and ER-\u03b2 in PECs all increased linearly (p &lt; 0.05) with ZEA. Collectively, ZEA can interfere with the secretion of some reproductive hormones in the serum and promote the expression of estrogen\/progesterone receptors in the uterus and PECs. All these indicate that ZEA may promote the development of the uterus in weaned gilts through estrogen receptor pathway.<\/jats:p>","DOI":"10.3390\/toxins14110732","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T11:53:51Z","timestamp":1666785231000},"page":"732","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Zearalenone Promotes Uterine Development of Weaned Gilts by Interfering with Serum Hormones and Up-Regulating Expression of Estrogen and Progesterone Receptors"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-2701","authenticated-orcid":false,"given":"Tingting","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Department of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhangjiakou Municipal Bureau of Agriculture and Rural Affairs, Zhangjiakou 075000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangming","family":"Ma","sequence":"additional","affiliation":[{"name":"Dongying Science and Technology Innovation Service Center, No. 359 Nanyi Road, Dongying District, Dongying 257091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhongcheng Feed Technology Co., Ltd., Feicheng 271600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiren","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Department of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Department of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Department of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Department of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-0322","authenticated-orcid":false,"given":"Shuzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Department of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Moretti, A., Logrieco, A.F., and Susca, A. (2017). Mycotoxins: An underhand food problem. Mycotoxigenic Fungi, Springer.","DOI":"10.1007\/978-1-4939-6707-0"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1080\/10408398.2019.1658570","article-title":"Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited \u2018FAO estimate\u2019 of 25","volume":"60","author":"Eskola","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tox.2008.07.065","article-title":"Cytotoxicity effects induced by Zearalenone metabolites, \u03b1 Zearalenol and \u03b2 Zearalenol, on cultured Vero cells","volume":"252","author":"Othmen","year":"2008","journal-title":"Toxicology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.bjm.2017.05.001","article-title":"Zearalenone adsorption capacity of lactic acid bacteria isolated from pigs","volume":"48","author":"Vega","year":"2017","journal-title":"Braz. J. Microbiol."},{"key":"ref_5","unstructured":"Council for Agricultural Science and Technology (CAST) (2003). Mycotoxins: Risks in Plant, Animal and Human Systems, CAST. Task Force Report No. 139."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6214538","DOI":"10.2527\/jas1982.5511","article-title":"Effects of zearalenone (F2) on estrous activity and reproduction in gilts","volume":"55","author":"Etienne","year":"1982","journal-title":"J. Anim. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.reprotox.2014.01.003","article-title":"Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice","volume":"45","author":"Zatecka","year":"2014","journal-title":"Reprod. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3390\/toxins6031080","article-title":"Zearalenone, an estrogenic mycotoxin, is an immunotoxic compound","volume":"6","author":"Hueza","year":"2014","journal-title":"Toxins"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.18632\/oncotarget.6220","article-title":"Prostate cancer stem cells: The role of androgen and estrogen receptors","volume":"7","author":"Galasso","year":"2016","journal-title":"Oncotarget"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1177\/153537020222701104","article-title":"Mechanism of action of progesterone antagonists","volume":"227","author":"Leonhardt","year":"2002","journal-title":"Exp. Biol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/cncr.10445","article-title":"Expression of estrogen receptor, progesterone receptor, and insulin-like growth factor receptor-1 and of MIB-1 in patients with recurrent pleomorphic adenoma of the parotid gland","volume":"94","author":"Glas","year":"2002","journal-title":"Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.etap.2016.10.015","article-title":"Zearalenone as an endocrine disruptor in humans","volume":"48","author":"Kowalska","year":"2016","journal-title":"Environ. Toxicol. Phar."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.toxicon.2016.08.009","article-title":"Zearalenone and 17 \u03b2-estradiol induced damages in male rats reproduction potential; evidence for ER\u03b1 and ER\u03b2 receptors expression and steroidogenesis","volume":"120","author":"Adibnia","year":"2016","journal-title":"Toxicon"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.aquatox.2016.11.019","article-title":"Reproduction impairment and endocrine disruption in adult zebrafish (Danio rerio) after waterborne exposure to TBOEP","volume":"182","author":"Xu","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1002\/jat.3652","article-title":"Mycotoxin zearalenone induced gonadal impairment and altered gene expression in the hypothalamic\u2013pituitary\u2013gonadal axis of adult female zebrafish (Danio rerio)","volume":"38","author":"Muthulakshmi","year":"2018","journal-title":"J. Appl. Toxicol."},{"key":"ref_16","first-page":"4510","article-title":"Effects of zearalenone on ovary index, distribution and expression of progesterone receptors in ovaries of weaned gilts","volume":"29","author":"Yang","year":"2017","journal-title":"Chinese J. Anim. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ropejko, K., and Twaru\u017cek, M. (2021). Zearalenone and its metabolites\u2014General overview, occurrence, and toxicity. Toxins, 13.","DOI":"10.3390\/toxins13010035"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.anifeedsci.2016.06.006","article-title":"Effects of dietary deoxynivalenol and zearalenone on apparent ileal digestibility of amino acids in growing pigs","volume":"219","author":"Jo","year":"2016","journal-title":"Anim. Feed Sci. Tech."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.livsci.2011.11.004","article-title":"Effect of purified zearalenone with or without modified montmorillonite on nutrient availability, genital organs and serum hormones in post-weaning piglets","volume":"144","author":"Jiang","year":"2012","journal-title":"Livest. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.anifeedsci.2012.09.004","article-title":"Effects of montmorillonite clay on growth performance, nutrient digestibility, vulva size, faecal microflora, and oxidative stress in weaning gilts challenged with zearalenone","volume":"178","author":"Wang","year":"2012","journal-title":"Anim. Feed Sci. Tech."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1590\/S0100-204X2007000200010","article-title":"Digestibility and metabolism of piglet diets containing zearalenone with addition of organoaluminosilicate","volume":"42","author":"Hauschild","year":"2007","journal-title":"Pesqui. Agropecu. Bras."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.prevetmed.2011.04.008","article-title":"The Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) in animal feeding","volume":"102","year":"2011","journal-title":"Prev. Vet. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jsbmb.2006.08.008","article-title":"Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro","volume":"103","author":"Takemura","year":"2007","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wan, B., Yuan, X., Yang, W., Jiao, N., Li, Y., Liu, F., Liu, M., Yang, Z., Huang, L., and Jiang, S. (2021). The effects of zearalenone on the localization and expression of reproductive hormones in the ovaries of weaned gilts. Toxins, 13.","DOI":"10.3390\/toxins13090626"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40104-022-00686-3","article-title":"Zearalenone toxicosis on reproduction as estrogen receptor selective modulator and alleviation of zearalenone biodegradative agent in pregnant sows","volume":"13","author":"Zhou","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Fu, G., Ma, J., Wang, L., Yang, X., Liu, J., and Zhao, X. (2016). Effect of degradation of zearalenone-contaminated feed by Bacillus licheniformis CK1 on postweaning female piglets. Toxins, 8.","DOI":"10.3390\/toxins8100300"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.toxicon.2020.11.005","article-title":"Effects of zearalenone on genital organ development, serum immunoglobulin, antioxidant capacity, sex hormones and liver function of prepubertal gilts","volume":"189","author":"Wu","year":"2021","journal-title":"Toxicon"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1093\/jas\/sky301","article-title":"Bacillus licheniformis CK1 alleviates the toxic effects of zearalenone in feed on weaned female Tibetan piglets","volume":"96","author":"Fu","year":"2018","journal-title":"J. Anim. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2017.08.010","article-title":"Zearalenone and alpha-zearalenol inhibit the synthesis and secretion of pig follicle stimulating hormone via the non-classical estrogen membrane receptor GPR30","volume":"461","author":"He","year":"2018","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.fct.2019.02.031","article-title":"Effects of zearalenone and its derivatives on the synthesis and secretion of mammalian sex steroid hormones: A review","volume":"126","author":"Zheng","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.3390\/toxins7083210","article-title":"Zearalenone in the intestinal tissues of immature gilts exposed per os to mycotoxins","volume":"7","author":"Zielonka","year":"2015","journal-title":"Toxins"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.beem.2015.04.008","article-title":"Estrogen receptor alpha and beta in health and disease","volume":"29","author":"Jia","year":"2015","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/13453","article-title":"Estrogen hits the surface","volume":"5","author":"Collins","year":"1999","journal-title":"Nat. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1210\/en.2005-1314","article-title":"Classical Genotropic versus Kinase-Initiated Regulation of Gene Transcription by the Estrogen Receptor \u03b1","volume":"147","author":"Almeida","year":"2006","journal-title":"Endocrinology"},{"key":"ref_35","first-page":"719","article-title":"Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity","volume":"104","author":"Kousteni","year":"2001","journal-title":"Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"812540","DOI":"10.4061\/2011\/812540","article-title":"The dynamic structure of the estrogen receptor","volume":"2011","author":"Kumar","year":"2011","journal-title":"J. Amino Acids"},{"key":"ref_37","first-page":"45","article-title":"Transcriptional activation by oestrogen receptors","volume":"63","author":"Parker","year":"1998","journal-title":"Biochem. Soc. Symp."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.anifeedsci.2007.06.008","article-title":"Clinical effects and biochemical mechanisms associated with exposure to the mycoestrogen zearalenone","volume":"137","author":"Malekinejad","year":"2007","journal-title":"Anim. Feed Sci. Tech."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1210\/endo.138.11.5496","article-title":"Tissue distribution and quantitative analysis of estrogen receptor-\u03b1 (ER\u03b1) and estrogen receptor-\u03b2 (ER\u03b2) messenger ribonucleic acid in the wild-type and ER\u03b1-knockout mouse","volume":"138","author":"Couse","year":"1997","journal-title":"Endocrinology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/humupd\/dmu053","article-title":"Estrogen receptor \u03b2: The guardian of the endometrium","volume":"21","author":"Hapangama","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrc3093","article-title":"The different roles of ER subtypes in cancer biology and therapy","volume":"11","author":"Thomas","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Liu, C., Chang, J., Wang, P., Yin, Q., Huang, W., Dang, X., Lu, F., and Gao, T. (2019). Zearalenone biodegradation by the combination of probiotics with cell-free extracts of Aspergillus oryzae and its mycotoxin-alleviating effect on pig production performance. Toxins, 11.","DOI":"10.3390\/toxins11100552"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.reprotox.2008.04.009","article-title":"Influence of in vitro exposure to mycotoxin zearalenone and its derivatives on swine sperm quality","volume":"25","author":"Benzoni","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"629006","DOI":"10.3389\/fvets.2021.629006","article-title":"Dose-effect of zearalenone on the localization and expression of growth hormone, growth hormone receptor, and heat shock protein 70 in the ovaries of post-weaning gilts","volume":"8","author":"Song","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"113061","DOI":"10.1016\/j.fct.2022.113061","article-title":"Procyanidins inhibit zearalenone-induced apoptosis and oxidative stress of porcine testis cells through activation of Nrf2 signaling pathway","volume":"165","author":"Yan","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Lee, R., Kim, D.-W., Lee, W.-Y., and Park, H.-J. (2022). Zearalenone Induces Apoptosis and Autophagy in a Spermatogonia Cell Line. Toxins, 14.","DOI":"10.3390\/toxins14020148"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lee, H.-J., Oh, S.-Y., and Jo, I. (2021). Zearalenone Induces Endothelial Cell Apoptosis through Activation of a Cytosolic Ca2+\/ERK1\/2\/p53\/Caspase 3 Signaling Pathway. Toxins, 13.","DOI":"10.3390\/toxins13030187"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hagan, C.R., and Lange, C.A. (2014). Molecular determinants of context-dependent progesterone receptor action in breast cancer. BMC Med., 12.","DOI":"10.1186\/1741-7015-12-32"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev-physiol-021909-135840","article-title":"Genomic analyses of hormone signaling and gene regulation","volume":"72","author":"Cheung","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/jrf.0.1030069","article-title":"Control of endometrial oxytocin receptors and prostaglandin F2\u03b1 production in cows by progesterone and oestradiol","volume":"103","author":"Lamming","year":"1995","journal-title":"Reproduction"},{"key":"ref_51","first-page":"46","article-title":"Effect of soy isoflavones on implantation losses in Wistar rat: Implication of progesterone receptors, vascular endothelial growth factor and estradiol receptors alpha","volume":"21","author":"Elsayed","year":"2020","journal-title":"Iran. J. Vet. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1126\/science.289.5485.1751","article-title":"Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform","volume":"289","author":"Mullinax","year":"2000","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5713\/ajas.14.0329","article-title":"Zearalenone altered the serum hormones, morphologic and apoptotic measurements of genital organs in post-weaning gilts","volume":"28","author":"Chen","year":"2015","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"32","DOI":"10.5713\/ajas.17.0526","article-title":"Effects of zearalenone on the localization and expression of the growth hormone receptor gene in the uteri of post-weaning piglets","volume":"31","author":"Zhou","year":"2018","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.2527\/jas.2010-3658","article-title":"Effects of purified zearalenone on growth performance, organ size, serum metabolites, and oxidative stress in postweaning gilts","volume":"89","author":"Jiang","year":"2011","journal-title":"J. Anim. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Zhang, K., Li, H., Dong, S., Liu, Y., Wang, D., Liu, H., Su, F., Ge, L., and Jiang, Y. (2019). Establishment and evaluation of a PRRSV-sensitive porcine endometrial epithelial cell line by transfecting SV40 large T antigen. BMC Vet. Res., 15.","DOI":"10.1186\/s12917-019-2051-1"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.neuroscience.2005.05.051","article-title":"Uncoupling protein 2\/3 immunoreactivity and the ascending dopaminergic and noradrenergic neuronal systems: Relevance for volume transmission","volume":"137","author":"Rivera","year":"2006","journal-title":"Neuroscience"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/14\/11\/732\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:02:58Z","timestamp":1760144578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/14\/11\/732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":58,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["toxins14110732"],"URL":"https:\/\/doi.org\/10.3390\/toxins14110732","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]}}}