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However, treating the different diseases generated by microorganisms requires a gradual increase in acquired resistance when applying or using them against various antibiotic therapies. Resistance is caused by various molecular mechanisms of microorganisms, thus reducing their effectiveness. Consequently, there is a need to search for new opportunities through natural sources with antimicrobial activity. One alternative is using peptides present in different scorpion venoms, specifically from the Buthidae family. Different peptides with biological activity in microorganisms have been characterized as preventing their growth or inhibiting their replication. Therefore, they represent an alternative to be used in the design and development of new-generation antimicrobial drugs in different types of microorganisms, such as bacteria, fungi, viruses, and parasites. Essential aspects for its disclosure, as shown in this review, are the studies carried out on different types of peptides in scorpion venoms with activity against pathogenic microorganisms, highlighting their high therapeutic potential.<\/jats:p>","DOI":"10.3390\/toxins14110740","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T10:47:57Z","timestamp":1667126877000},"page":"740","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component"],"prefix":"10.3390","volume":"14","author":[{"given":"Clara Andrea","family":"Rinc\u00f3n-Cort\u00e9s","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Productor Naturales, Facultad de Ciencias, Universidad De Ciencias Aplicadas y Ambientales U.D.C.A, Calle 222 No 55-37, Bogot\u00e1 111166, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn Alonso","family":"Bayona-Rojas","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n GIBGA, Facultad de Ciencias de la Salud, Universidad De Ciencias Aplicadas y Ambientales U.D.C.A, Calle 222 No 55-37, Bogot\u00e1 111166, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-2125","authenticated-orcid":false,"given":"Edgar Antonio","family":"Reyes-Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Prote\u00ednas, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogot\u00e1, Av Cr 30 No 45-30, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5938-676X","authenticated-orcid":false,"given":"Nohora Ang\u00e9lica","family":"Vega-Castro","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Prote\u00ednas, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogot\u00e1, Av Cr 30 No 45-30, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41545-020-0051-0","article-title":"Antibiotic resistance genes from livestock waste: Occurrence, dissemination, and treatment","volume":"3","author":"He","year":"2020","journal-title":"NPJ Clean Water"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.7705\/biomedica.4131","article-title":"Resistencia a la meticilina y producci\u00f3n de biopel\u00edcula en aislamientos cl\u00ednicos de staphylococcus aureus y staphylococcus coagulasa negativa en m\u00e9xico","volume":"39","author":"Paredes","year":"2019","journal-title":"Biom\u00e9dica"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1473-3099(16)30127-X","article-title":"Reflecting on the final report of the o\u2019neill review on antimicrobial resistance","volume":"16","author":"Piddock","year":"2016","journal-title":"Lancet Infect. 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