{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:12:01Z","timestamp":1776651121370,"version":"3.51.2"},"reference-count":71,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014-23888-0"],"award-info":[{"award-number":["2014-23888-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["CNPq"],"award-info":[{"award-number":["CNPq"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conselho Nacional de Desenvolvimento cient\u00edfico e Tecnol\u00f3gico","award":["2014-23888-0"],"award-info":[{"award-number":["2014-23888-0"]}]},{"name":"Conselho Nacional de Desenvolvimento cient\u00edfico e Tecnol\u00f3gico","award":["CNPq"],"award-info":[{"award-number":["CNPq"]}]},{"name":"Conselho Nacional de Desenvolvimento cient\u00edfico e Tecnol\u00f3gico","award":["001"],"award-info":[{"award-number":["001"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7onamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2014-23888-0"],"award-info":[{"award-number":["2014-23888-0"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7onamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CNPq"],"award-info":[{"award-number":["CNPq"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7onamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"P\u00f3s-Gradua\u00e7\u00e3o (PROPESP) from Federal University of Par\u00e1 (UFPA)","award":["2014-23888-0"],"award-info":[{"award-number":["2014-23888-0"]}]},{"name":"P\u00f3s-Gradua\u00e7\u00e3o (PROPESP) from Federal University of Par\u00e1 (UFPA)","award":["CNPq"],"award-info":[{"award-number":["CNPq"]}]},{"name":"P\u00f3s-Gradua\u00e7\u00e3o (PROPESP) from Federal University of Par\u00e1 (UFPA)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>BmooMP\u03b1-I has kininogenase activity, cleaving kininogen releasing bradykinin and can hydrolyze angiotensin I at post-proline and aspartic acid positions, generating an inactive peptide. We evaluated the antihypertensive activity of BmooMP\u03b1-I in a model of two-kidney, one-clip (2K1C). Wistar rats were divided into groups: Sham, who underwent sham surgery, and 2K1C, who suffered stenosis of the right renal artery. In the second week of hypertension, we started treatment (Vehicle, BmooMP\u03b1-I and Losartan) for two weeks. We performed an electrocardiogram and blood and heart collection in the fourth week of hypertension. The 2K1C BmooMP\u03b1-I showed a reduction in blood pressure (systolic pressure: 131 \u00b1 2 mmHg; diastolic pressure: 84 \u00b1 2 mmHg versus 174 \u00b1 3 mmHg; 97 \u00b1 4 mmHg, 2K1C Vehicle, p &lt; 0.05), improvement in electrocardiographic parameters (Heart Rate: 297 \u00b1 4 bpm; QRS: 42 \u00b1 0.1 ms; QT: 92 \u00b1 1 ms versus 332 \u00b1 6 bpm; 48 \u00b1 0.2 ms; 122 \u00b1 1 ms, 2K1C Vehicle, p &lt; 0.05), without changing the hematological profile (platelets: 758 \u00b1 67; leukocytes: 3980 \u00b1 326 versus 758 \u00b1 75; 4400 \u00b1 800, 2K1C Vehicle, p &gt; 0.05), with reversal of hypertrophy (left ventricular area: 12.1 \u00b1 0.3; left ventricle wall thickness: 2.5 \u00b1 0.2; septum wall thickness: 2.3 \u00b1 0.06 versus 10.5 \u00b1 0.3; 2.7 \u00b1 0.2; 2.5 \u00b1 0.04, 2K1C Vehicle, p &lt; 0.05) and fibrosis (3.9 \u00b1 0.2 versus 7.4 \u00b1 0.7, 2K1C Vehicle, p &lt; 0.05). We concluded that BmooMP\u03b1-I improved blood pressure levels and cardiac remodeling, having a cardioprotective effect.<\/jats:p>","DOI":"10.3390\/toxins14110766","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T03:10:46Z","timestamp":1667790646000},"page":"766","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["BmooMP\u03b1-I, a Metalloproteinase Isolated from Bothrops moojeni Venom, Reduces Blood Pressure, Reverses Left Ventricular Remodeling and Improves Cardiac Electrical Conduction in Rats with Renovascular Hypertension"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-6896","authenticated-orcid":false,"given":"Jorge Eduardo Chang","family":"Estrada","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Cardiovascular System, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"},{"name":"Laboratory of Hemostasis and Venoms, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keuri Eleut\u00e9rio","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Cardiovascular System, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson","family":"Maciel","sequence":"additional","affiliation":[{"name":"Center of Study of Biomolecules Applied in Medicine (CEBio), Oswaldo Cruz Foundation (Fiocruz Rond\u00f4nia), Federal University of Rond\u00f4nia, Porto Velho 76812-245, RO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cahy Manoel","family":"Bannwart","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Cardiovascular System, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wict\u00f3ria Farias","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Cardiovascular System, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2931-4324","authenticated-orcid":false,"given":"Mois\u00e9s","family":"Hamoy","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-6923","authenticated-orcid":false,"given":"Russolina Benedeta","family":"Zingali","sequence":"additional","affiliation":[{"name":"Laboratory of Hemostasis and Venoms, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreimar Martins","family":"Soares","sequence":"additional","affiliation":[{"name":"Center of Study of Biomolecules Applied in Medicine (CEBio), Oswaldo Cruz Foundation (Fiocruz Rond\u00f4nia), Federal University of Rond\u00f4nia, Porto Velho 76812-245, RO, Brazil"},{"name":"S\u00e3o Lucas University Center, Porto Velho 76805-846, RO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Heitmann Mares Azevedo","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, Faculty of Pharmacy, Institute of Health Science, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Fernanda","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Department of Basic and Oral Biology, Faculty of Dentistry of Ribeirao Preto, University of S\u00e3o Paulo (FORP\/USP), Ribeirao Preto 14040-904, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Chagas","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Oxidative Stress, Pharmacy Faculty, Institute of Health Science, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-9837","authenticated-orcid":false,"given":"Alejandro Ferraz","family":"Prado","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Cardiovascular System, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat. 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