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The persistent resistance of spastic muscles to stretching is often followed by structural and mechanical changes in musculature. This leads to functional limitations at the respective joint. Focal injection of botulinum toxin type-A (BTX-A) is effectively used to manage spasticity and improve the quality of life of the patients. By blocking acetylcholine release at the neuromuscular junction and causing temporary muscle paralysis, BTX-A aims to reduce spasticity and hereby improve joint function. However, recent studies have indicated some contradictory effects such as increased muscle stiffness or a narrower range of active force production. The potential of these toxin- and atrophy-related alterations in worsening the condition of spastic muscles that are already subjected to changes should be further investigated and quantified. By focusing on the effects of BTX-A on muscle biomechanics and overall function in children with CP, this review deals with which of these goals have been achieved and to what extent, and what can await us in the future.<\/jats:p>","DOI":"10.3390\/toxins14110772","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T10:54:40Z","timestamp":1667904880000},"page":"772","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Botulinum Toxin Intervention in Cerebral Palsy-Induced Spasticity Management: Projected and Contradictory Effects on Skeletal Muscles"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-0772","authenticated-orcid":false,"given":"Cemre Su","family":"Kaya Keles","sequence":"first","affiliation":[{"name":"Experimental Biomechanics Group, Institute of Structural Mechanics and Dynamics in Aerospace Engineering, University of Stuttgart, Pfaffenwaldring 27, 70569 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-3913","authenticated-orcid":false,"given":"Filiz","family":"Ates","sequence":"additional","affiliation":[{"name":"Experimental Biomechanics Group, Institute of Structural Mechanics and Dynamics in Aerospace Engineering, University of Stuttgart, Pfaffenwaldring 27, 70569 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.2106\/JBJS.RVW.18.00153","article-title":"Sarcopenia, Cerebral Palsy, and Botulinum Toxin Type A","volume":"7","author":"Multani","year":"2019","journal-title":"JBJS Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1080\/09638280701568437","article-title":"The Role of Botulinum Toxin Injections in the Management of Muscle Overactivity of the Lower Limb","volume":"29","author":"Gracies","year":"2007","journal-title":"Disabil. 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