{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:37:03Z","timestamp":1788446223636,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Alteration of sphingolipid synthesis is a key event in fumonisins toxicity, but only limited data have been reported regarding the effects of fumonisins on the sphingolipidome. Recent studies in chickens found that the changes in sphingolipids in liver, kidney, lung, and brain differed greatly. This study aimed to determine the effects of fumonisins on sphingolipids in heart, gizzard, and breast muscle in chickens fed 20.8 mg FB1 + FB2\/kg for 9 days. A significant increase in the sphinganine:sphingosine ratio due to an increase in sphinganine was observed in heart and gizzard. Dihydroceramides and ceramides increased in the hearts of chickens fed fumonisins, but decreased in the gizzard. The dihydrosphingomyelin, sphingomyelin, and glycosylceramide concentrations paralleled those of ceramides, although the effects were less pronounced. In the heart, sphingolipids with fatty acid chain lengths of 20 to 26 carbons were more affected than those with 14\u201316 carbons; this difference was not observed in the gizzard. Partial least squares-discriminant analysis on sphingolipids in the heart allowed chickens to be divided into two distinct groups according to their diet. The same was the case for the gizzard. Pearson coefficients of correlation among all the sphingolipids assayed revealed strong positive correlations in the hearts of chickens fed fumonisins compared to chickens fed a control diet, as well as compared to gizzard, irrespective of the diet fed. By contrast, no effect of fumonisins was observed on sphingolipids in breast muscle.<\/jats:p>","DOI":"10.3390\/toxins14120828","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T05:09:08Z","timestamp":1669266548000},"page":"828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Targeted Sphingolipid Analysis in Heart, Gizzard, and Breast Muscle in Chickens Reveals Possible New Target Organs of Fumonisins"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9777-3784","authenticated-orcid":false,"given":"Philippe","family":"Guerre","sequence":"first","affiliation":[{"name":"National Veterinary School of Toulouse, ENVT, Universit\u00e9 de Toulouse, F-31076 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Gilleron","sequence":"additional","affiliation":[{"name":"Olmix S.A., ZA du Haut du Bois, F-56580 Br\u00e9han, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Matard-Mann","sequence":"additional","affiliation":[{"name":"Olmix S.A., ZA du Haut du Bois, F-56580 Br\u00e9han, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi","family":"Nyvall Coll\u00e9n","sequence":"additional","affiliation":[{"name":"Olmix S.A., ZA du Haut du Bois, F-56580 Br\u00e9han, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"EFSA, Knutsen, H., Alexander, J., Barreg\u00e5rd, L., Bignami, M., Br\u00fcschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., and Edler, L. 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