{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:38:43Z","timestamp":1760233123419,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T00:00:00Z","timestamp":1671321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Provincial College and University Foundation for Natural Sciences","award":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"],"award-info":[{"award-number":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"]}]},{"name":"Innovation training program of Jiangsu Agriculture and Forestry Vocational and Technical College","award":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"],"award-info":[{"award-number":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"]}]},{"name":"Science and Technology Project of Jiangsu Agriculture and Forestry Vocational and Technical College","award":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"],"award-info":[{"award-number":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"]}]},{"name":"China-CEEC Joint University Education Project","award":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"],"award-info":[{"award-number":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"]}]},{"name":"National Natural Science Foundation of China","award":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"],"award-info":[{"award-number":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"]}]},{"name":"Natural Science Foundation of Jiangsu Province of China","award":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"],"award-info":[{"award-number":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"]}]},{"name":"China Postdoctoral Science Foundation","award":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"],"award-info":[{"award-number":["20KJB230010","202013103031Y","2019kj006","202010","32172922","31972741","BK20211216","2016T90477"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Type B trichothecenes commonly contaminate cereal grains and include five structurally related congeners: deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), fusarenon X (FX), and nivalenol (NIV). These toxins are known to have negative effects on human and animal health, particularly affecting food intake. However, the pathophysiological basis for anorexic effect is not fully clarified. The purpose of this study is to explore the potential roles of the brain-gut peptides substance P (SP) and glucagon-like peptide-17-36 amide (GLP-1) in anorexic responses induced by type B trichothecenes following both intraperitoneal (IP) and oral administration. SP and GLP-1 were elevated at 1 or 2 h and returned to basal levels at 6 h following exposure to DON and both ADONs. FX induced the production of both brain gut peptides with initial time at 1 or 2 h and duration &gt; 6 h. Similar to FX, exposing IP to NIV caused elevations of SP and GLP-1 at 1 h and lasted more than 6 h, whereas oral exposure to NIV only increased both brain gut peptides at 2 h. The neurokinin-1 receptor (NK-1R) antagonist Emend\u00ae dose-dependently attenuated both SP- and DON-induced anorexic responses. Pretreatment with the GLP-1 receptor (GLP-1R) antagonist Exending9-39 induced a dose-dependent attenuation of both GLP-1- and DON-induced anorexic responses. To summarize, the results suggest that both SP and GLP-1 play important roles in anorexia induction by type B trichothecenes.<\/jats:p>","DOI":"10.3390\/toxins14120885","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T09:05:09Z","timestamp":1671440709000},"page":"885","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Substance P and Glucagon-like Peptide-17-36 Amide Mediate Anorexic Responses to Trichothecene Deoxynivalenol and Its Congeners"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-2964","authenticated-orcid":false,"given":"Hui","family":"Jia","sequence":"first","affiliation":[{"name":"School of Animal Husbandry and Veterinary Medicine, Jiangsu Vocational College of Agriculture and Forestry, Jurong 212400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihui","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China"},{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Wei","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Guo","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiping","family":"Xiao","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayue","family":"Zhang","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zelin","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic"},{"name":"College of Life Science, Yangtze University, Jingzhou 434025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruibo","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Animal Husbandry and Veterinary Medicine, Jiangsu Vocational College of Agriculture and Forestry, Jurong 212400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2528-4655","authenticated-orcid":false,"given":"Wenda","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China"},{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.toxicon.2022.01.011","article-title":"Trichothecenes in food and feed: Occurrence, impact on human health and their detection and management strategies","volume":"208","author":"Mahato","year":"2022","journal-title":"Toxicon"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kumar, P., Mahato, D.K., Gupta, A., Pandey, S., Paul, V., Saurabh, V., Pandey, A.K., Selvakumar, R., Barua, S., and Kapri, M. (2022). Nivalenol Mycotoxin Concerns in Foods: An Overview on Occurrence, Impact on Human and Animal Health and Its Detection and Management Strategies. Toxins, 14.","DOI":"10.3390\/toxins14080527"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ekwomadu, T.I., Akinola, S.A., and Mwanza, M. (2021). Fusarium Mycotoxins, Their Metabolites (Free, Emerging, and Masked), Food Safety Concerns, and Health Impacts. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182211741"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00204-010-0579-8","article-title":"Deoxynivalenol: Mechanisms of action, human exposure, and toxicological relevance","volume":"84","author":"Pestka","year":"2010","journal-title":"Arch. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.3390\/toxins3121484","article-title":"Trichothecene Mycotoxins Inhibit Mitochondrial Translation\u2014Implication for the Mechanism of Toxicity","volume":"3","author":"McLaughlin","year":"2011","journal-title":"Toxins"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.fct.2012.03.055","article-title":"Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol","volume":"50","author":"Wu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/00071668.2019.1596224","article-title":"Feed preference and feeding behaviours in grower broilers fed diets containing wheat naturally contaminated with fusarium mycotoxins","volume":"60","author":"Wang","year":"2019","journal-title":"Br. Poult. Sci."},{"key":"ref_8","first-page":"21","article-title":"Effects of feeding grains naturally contaminated with Fusarium toxins on selected haematological pa-rameters and lymphocyte subsets in primiparous sows","volume":"56","author":"Kopitar","year":"2019","journal-title":"Slov. Vet. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/009841096161447","article-title":"Toxicology of deoxynivalenol (vomitoxin)","volume":"48","author":"Rotter","year":"1996","journal-title":"J. Toxicol. Env. Ment. Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuro.2015.04.009","article-title":"Dysregulation of energy balance by trichothecene mycotoxins: Mechanisms and prospects","volume":"49","author":"Lebrun","year":"2015","journal-title":"Neurotoxicology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuro.2012.10.020","article-title":"c-Fos immunoreactivity in the pig brain following deoxynivalenol intoxication: Focus on NUCB2\/nesfatin-1 ex-pressing neurons","volume":"34","author":"Gaige","year":"2013","journal-title":"Neurotoxicology"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Girardet, C., Bonnet, M.S., Jdir, R., Sadoud, M., Thirion, S., Tardivel, C., Roux, J., Lebrun, B., Wanaverbecq, N., and Mounien, L. (2011). The Food-Contaminant Deoxynivalenol Modifies Eating by Targeting Anorexigenic Neurocircuitry. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0026134"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/toxsci\/kfs255","article-title":"Anorexia Induction by the Trichothecene Deoxynivalenol (Vomitoxin) Is Mediated by the Release of the Gut Satiety Hormone Peptide YY","volume":"130","author":"Flannery","year":"2012","journal-title":"Toxicol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuropharm.2012.02.004","article-title":"Hypothalamic neuropeptides and the regulation of appetite","volume":"63","author":"Parker","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/toxsci\/kfx112","article-title":"Role of Glucagon-Like Peptide-1 and Gastric Inhibitory Peptide in Anorexia Induction Following Oral Exposure to the Trichothecene Mycotoxin Deoxynivalenol (Vomitoxin)","volume":"159","author":"Jia","year":"2017","journal-title":"Toxicol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1159\/000512806","article-title":"Glucagon-like peptide-1 regulates the proopiomelanocortin neurons of the arcuate nucleus both directly and indi-rectly via presynaptic action","volume":"111","author":"Peterfi","year":"2021","journal-title":"Neuroendocrinology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1592\/phco.21.13.1061.34612","article-title":"Substance P: A New Era, a New Role","volume":"21","author":"DeVane","year":"2001","journal-title":"Pharmacotherapy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.0954-6820.2000.00773.x","article-title":"Substance P: A pioneer amongst neuropeptides","volume":"249","author":"Pernow","year":"2001","journal-title":"J. Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102658","DOI":"10.1016\/j.autneu.2020.102658","article-title":"Serotonin and substance P: Synergy or competition in the control of breathing","volume":"225","year":"2020","journal-title":"Auton. Neurosci. Basic Clin."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/10253890009001125","article-title":"Substance P Is Involved in Terminating the Hypothalamo-Pituitary-Adrenal Axis Response to Acute Stress Through Centrally Located Neurokinin-1 Receptors","volume":"3","author":"Jessop","year":"2000","journal-title":"Stress"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0006-8993(99)01379-7","article-title":"Food and water intake suppression by intracerebroventricular administration of substance P in food- and water-deprived rats","volume":"830","author":"Dib","year":"1999","journal-title":"Brain Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbr.2010.04.044","article-title":"Modulation of the CRH system by substance P\/NKA in an animal model of depression","volume":"213","author":"Frisch","year":"2010","journal-title":"Behav. Brain Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.regpep.2004.08.026","article-title":"Glucagon-related peptide 1 (GLP-1): Hormone and neurotransmitter","volume":"128","author":"Larsen","year":"2005","journal-title":"Regul. Pept."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40104-021-00661-4","article-title":"Invited review: Remediation strategies for mycotoxin control in feed","volume":"13","author":"Liu","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1080\/10408398.2019.1658570","article-title":"Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited \u2018FAO estimate\u2019 of 25%","volume":"60","author":"Eskola","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s40104-021-00603-0","article-title":"Occurrence of Aflatoxin B1, deoxynivalenol and zearalenone in feeds in China during 2018\u20132020","volume":"12","author":"Zhao","year":"2021","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/toxsci\/kfu166","article-title":"Comparison of Anorectic and Emetic Potencies of Deoxynivalenol (Vomitoxin) to the Plant Metabolite Deoxynivalenol-3-Glucoside and Synthetic Deoxynivalenol Derivatives EN139528 and EN139544","volume":"142","author":"Wu","year":"2014","journal-title":"Toxicol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1113\/jphysiol.2014.270850","article-title":"Gastrointestinal hormones and the dialogue between gut and brain","volume":"592","author":"Dockray","year":"2014","journal-title":"J. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1523\/JNEUROSCI.16-02-00425.1996","article-title":"Presynaptic facilitation revisited: State and time dependence","volume":"16","author":"Byrne","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00441-018-2922-y","article-title":"Substance P and pain chronicity","volume":"375","year":"2019","journal-title":"Cell Tissue Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2018.10.041","article-title":"Role of neurotransmitters 5-hydroxytryptamine and substance P in anorexia induction following oral exposure to the trichothecene T-2 toxin","volume":"123","author":"Sheng","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1113\/jphysiol.1931.sp002763","article-title":"An unidentified depressor substance in certain tissue extracts","volume":"72","author":"Euler","year":"1931","journal-title":"J. Physiol."},{"key":"ref_33","first-page":"41","article-title":"Spotlight on the perioperative use of maropitant citrate","volume":"8","year":"2017","journal-title":"Veter. Med. Res. Rep."},{"key":"ref_34","first-page":"214","article-title":"Substance P in the dorsal motor nucleus of the vagus evokes gastric motor inhibition via neurokinin 1 receptor in rat","volume":"293","author":"Krowicki","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_35","first-page":"109","article-title":"The effects of interaction between ghrelin and substance-P on mean plasma thyroid hormones concentration and body weight","volume":"17","author":"Khazali","year":"2009","journal-title":"Daru J. Pharm. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrn3105","article-title":"Common cellular and molecular mechanisms in obesity and drug addiction","volume":"12","author":"Kenny","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"614884","DOI":"10.3389\/fnbeh.2020.614884","article-title":"Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Sys-tematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol","volume":"14","author":"Yigit","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ijo.2015.172","article-title":"Intestinal GLP-1 and satiation: From man to rodents and back","volume":"40","author":"Steinert","year":"2016","journal-title":"Int. J. Obes."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuropharm.2016.07.039","article-title":"GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight","volume":"110","author":"Vogel","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1038\/npp.2017.150","article-title":"Paraventricular Thalamic Control of Food Intake and Reward: Role of Glucagon-Like Peptide-1 Receptor Signaling","volume":"42","author":"Ong","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"112771","DOI":"10.1016\/j.physbeh.2019.112771","article-title":"Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4","volume":"215","author":"Konanur","year":"2020","journal-title":"Physiol. Behav."},{"key":"ref_42","first-page":"T1","article-title":"Effects of glucagon-like peptide 1 on appetite and body weight: Focus on the CNS","volume":"221","author":"Kulve","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Rezaie, P., Bitarafan, V., Horowitz, M., and Feinle-Bisset, C. (2021). Effects of Bitter Substances on GI Function, Energy Intake and Glycaemia-Do Preclinical Findings Translate to Outcomes in Humans?. Nutrients, 13.","DOI":"10.3390\/nu13041317"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bcp.2015.07.012","article-title":"Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways","volume":"97","author":"Yu","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jep.2015.06.042","article-title":"A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db\/db mouse","volume":"172","author":"Suh","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0306-3623(94)00292-U","article-title":"The mammalian tachykinin receptors","volume":"26","author":"Maggi","year":"1995","journal-title":"Gen. Pharmacol. Vasc. Syst."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/1568026043451636","article-title":"Substance P: Structure, function, and therapeutics","volume":"4","author":"Datar","year":"2004","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","article-title":"Biology of Incretins: GLP-1 and GIP","volume":"132","author":"Baggio","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.2337\/diab.42.11.1678","article-title":"Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor","volume":"42","author":"Thorens","year":"1993","journal-title":"Diabetes"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Legi, A., Rodriguez, E., Eckols, T., Mistry, C., and Robinson, P. (2021). Substance P Antagonism Prevents Chemotherapy-Induced Cardiotoxicity. Cancers, 13.","DOI":"10.3390\/cancers13071732"}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/14\/12\/885\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:43:32Z","timestamp":1760147012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/14\/12\/885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,18]]},"references-count":50,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["toxins14120885"],"URL":"https:\/\/doi.org\/10.3390\/toxins14120885","relation":{},"ISSN":["2072-6651"],"issn-type":[{"type":"electronic","value":"2072-6651"}],"subject":[],"published":{"date-parts":[[2022,12,18]]}}}