{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:11:48Z","timestamp":1781133108524,"version":"3.54.1"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Auriculotemporal neuralgia is a rare pain disorder in which anesthetic nerve blockade is usually effective but not always resolutive. Botulinum toxin type A has proven to be effective in treating neuropathic pain, and patients with auriculotemporal neuralgia could also benefit from this treatment. We described nine patients with auriculotemporal neuralgia treated with botulinum toxin type A in the territory of auriculotemporal nerve innervation. We compared the basal NRS and Penn facial pain scale scores with those obtained 1 month after BoNT\/A injections. Both Penn facial pain scale (96.67 \u00b1 24.61 vs. 45.11 \u00b1 36.70, p 0.004; mean reduction 52.57 \u00b1 36.50) and NRS scores (8.11 \u00b1 1.27 vs. 4.22 \u00b1 2.95, p 0.009; mean reduction 3.89 \u00b1 2.52) improved significantly at one month after treatment. The mean duration of the effect of BoNT\/A on pain was 95.00 \u00b1 53.03 days and no adverse effects were reported.<\/jats:p>","DOI":"10.3390\/toxins15040274","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T05:21:23Z","timestamp":1680758483000},"page":"274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Botulinum Toxin Type A for the Treatment of Auriculotemporal Neuralgia\u2014A Case Series"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4200-761X","authenticated-orcid":false,"given":"Yan","family":"Tereshko","sequence":"first","affiliation":[{"name":"Clinical Neurology Unit, Udine University Hospital, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Belgrado","sequence":"additional","affiliation":[{"name":"Neurology Unit, Udine University Hospital, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lettieri","sequence":"additional","affiliation":[{"name":"Neurology Unit, Udine University Hospital, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian","family":"Gigli","sequence":"additional","affiliation":[{"name":"Clinical Neurology Unit, Udine University Hospital, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Valente","sequence":"additional","affiliation":[{"name":"Clinical Neurology Unit, Udine University Hospital, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.joms.2008.09.012","article-title":"Unusual Organization of Auriculotemporal Nerve and Its Clinical Implications","volume":"67","author":"Soni","year":"2009","journal-title":"J. Oral Maxillofac. Surg. Off. J. Am. Assoc. Oral Maxillofac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0030-4220(90)90290-9","article-title":"Nerve Entrapment in the Lateral Pterygoid Muscle","volume":"69","author":"Loughner","year":"1990","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Trescot, A.M. (2016). Auriculotemporal Nerve Entrapment BT\u2014Peripheral Nerve Entrapments: Clinical Diagnosis and Management, Springer International Publishing.","DOI":"10.1007\/978-3-319-27482-9"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ca.20068","article-title":"Variations in the Anatomy of the Auriculotemporal Nerve","volume":"18","author":"Anil","year":"2005","journal-title":"Clin. Anat."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1097\/PRS.0b013e3181d4fb05","article-title":"Anatomy of the Auriculotemporal Nerve: Variations in Its Relationship to the Superficial Temporal Artery and Implications for the Treatment of Migraine Headaches","volume":"125","author":"Janis","year":"2010","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1079-2104(98)90119-6","article-title":"The Distribution of the Auriculotemporal Nerve around the Temporomandibular Joint","volume":"86","author":"Schmidt","year":"1998","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00276-001-0097-8","article-title":"The Frontotemporal Peripheral Nerves. Topographic Variations of the Supraorbital, Supratrochlear and Auriculotemporal Nerves and Their Possible Clinical Significance","volume":"23","author":"Andersen","year":"2001","journal-title":"Surg. Radiol. Anat."},{"key":"ref_8","first-page":"e25643","article-title":"Nervous Interconnection Between the Lesser Occipital and Auriculotemporal Nerves","volume":"14","author":"Gebara","year":"2022","journal-title":"Cureus"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11916-005-0037-0","article-title":"Auriculotemporal Neuralgia","volume":"9","author":"Speciali","year":"2005","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_10","first-page":"100","article-title":"Auriculo-Temporal Neuralgia\u2014An Original Diagnostic and Therapeutic Approach","volume":"53","author":"Damarjian","year":"1970","journal-title":"Rhode Isl. Med J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1093\/pm\/pnw016","article-title":"Auriculotemporal Neuralgia: Eight New Cases Report","volume":"17","author":"Ruiz","year":"2016","journal-title":"Pain Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.5935\/1806-0013.20150064","article-title":"Primary Auriculotemporal Neuralgia. Case Report","volume":"16","author":"Kosminsky","year":"2015","journal-title":"Rev. Dor."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/PRS.0b013e3181e094d7","article-title":"The Zygomaticotemporal Branch of the Trigeminal Nerve: Part II. Anatomical Variations","volume":"126","author":"Janis","year":"2010","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/PRS.0b013e3182589dd5","article-title":"The Auriculotemporal Nerve in Etiology of Migraine Headaches: Compression Points and Anatomical Variations","volume":"130","author":"Chim","year":"2012","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0266-4356(03)00113-X","article-title":"Variations in the Anatomy of the Inferior Alveolar Nerve","volume":"41","author":"Anil","year":"2003","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/08869634.2003.11746246","article-title":"The Anatomical Relationship between the Position of the Auriculotemporal Nerve and Mandibular Condyle","volume":"21","author":"Fernandes","year":"2003","journal-title":"Cranio"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd Edition","volume":"38","author":"Olesen","year":"2018","journal-title":"Cephalalgia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/head.14043","article-title":"Botulinum Toxin as a Novel Therapeutic Approach for Auriculotemporal Neuralgia","volume":"61","author":"Pinto","year":"2021","journal-title":"Headache"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3390\/toxins4100913","article-title":"Clinical Uses of Botulinum Neurotoxins: Current Indications, Limitations and Future Developments","volume":"4","author":"Chen","year":"2012","journal-title":"Toxins"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.toxicon.2018.01.017","article-title":"Botulinum Toxin Treatment of Pain Syndromes\u2014An Evidence Based Review","volume":"147","author":"Safarpour","year":"2018","journal-title":"Toxicon"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11916-019-0810-0","article-title":"A Comprehensive Review of Trigeminal Neuralgia","volume":"23","author":"Jones","year":"2019","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Datta Gupta, A., Edwards, S., Smith, J., Snow, J., Visvanathan, R., Tucker, G., and Wilson, D. (2022). A Systematic Review and Meta-Analysis of Efficacy of Botulinum Toxin A for Neuropathic Pain. Toxins, 14.","DOI":"10.3390\/toxins14010036"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.3390\/toxins7083127","article-title":"Botulinum Toxin for Neuropathic Pain: A Review of the Literature","volume":"7","author":"Oh","year":"2015","journal-title":"Toxins"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"21338","DOI":"10.1016\/S0021-9258(19)36614-1","article-title":"Tetanus Toxin and Botulinum Toxins Type A and B Inhibit Glutamate, Gamma-Aminobutyric Acid, Aspartate, and Met-Enkephalin Release from Synaptosomes. Clues to the Locus of Action","volume":"267","author":"McMahon","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0014-2999(89)90229-X","article-title":"Effects of Botulinum A Toxin on Presynaptic Modulation of Evoked Transmitter Release","volume":"164","author":"Nakov","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1526-4610.2004.04007.x","article-title":"Regulation of Calcitonin Gene-Related Peptide Secretion from Trigeminal Nerve Cells by Botulinum Toxin Type A: Implications for Migraine Therapy","volume":"44","author":"Durham","year":"2004","journal-title":"Headache"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0006-2952(00)00260-4","article-title":"Capsaicin-Stimulated Release of Substance P from Cultured Dorsal Root Ganglion Neurons: Involvement of Two Distinct Mechanisms","volume":"59","author":"Purkiss","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.pain.2014.04.027","article-title":"Botulinum Toxin Type A Selectivity for Certain Types of Pain Is Associated with Capsaicin-Sensitive Neurons","volume":"155","author":"Matak","year":"2014","journal-title":"Pain"},{"key":"ref_29","first-page":"347","article-title":"Increased Levels of SV2A Botulinum Neurotoxin Receptor in Clinical Sensory Disorders and Functional Effects of Botulinum Toxins A and E in Cultured Human Sensory Neurons","volume":"4","author":"Yiangou","year":"2011","journal-title":"J. Pain Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nbd.2012.07.010","article-title":"Reduction of TRPV1 Expression in the Trigeminal System by Botulinum Neurotoxin Type-A","volume":"48","author":"Shimizu","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/bph.13366","article-title":"Activity of Botulinum Toxin Type A in Cranial Dura: Implications for Treatment of Migraine and Other Headaches","volume":"173","author":"Matak","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Marinelli, S., Vacca, V., Ricordy, R., Uggenti, C., Tata, A.M., Luvisetto, S., and Pavone, F. (2012). The Analgesic Effect on Neuropathic Pain of Retrogradely Transported Botulinum Neurotoxin A Involves Schwann Cells and Astrocytes. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047977"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.nbd.2015.04.011","article-title":"Botulinum Toxin in Migraine: Role of Transport in Trigemino-Somatic and Trigemino-Vascular Afferents","volume":"79","author":"Ramachandran","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.neuropharm.2013.02.011","article-title":"Involvement of \u03bc-Opioid Receptors in Antinociceptive Action of Botulinum Toxin Type A","volume":"70","author":"Drinovac","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00702-013-1150-6","article-title":"Association of Antinociceptive Action of Botulinum Toxin Type A with GABA-A Receptor","volume":"121","author":"Drinovac","year":"2014","journal-title":"J. Neural Transm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuroscience.2010.11.040","article-title":"The Effect of Botulinum Neurotoxin A on Sciatic Nerve Injury-Induced Neuroimmunological Changes in Rat Dorsal Root Ganglia and Spinal Cord","volume":"175","author":"Mika","year":"2011","journal-title":"Neuroscience"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fcimb.2017.00141","article-title":"Comparison of the Expression Changes after Botulinum Toxin Type A and Minocycline Administration in Lipopolysaccharide-Stimulated Rat Microglial and Astroglial Cultures","volume":"7","author":"Piotrowska","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Park, J., and Park, H.J. (2017). Botulinum Toxin for the Treatment of Neuropathic Pain. Toxins, 9.","DOI":"10.3390\/toxins9090260"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.nec.2016.02.003","article-title":"Measurement of Trigeminal Neuralgia Pain: Penn Facial Pain Scale","volume":"27","author":"Sandhu","year":"2016","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1515\/sjpain-2018-0012","article-title":"The Validity of Pain Intensity Measures: What Do the NRS, VAS, VRS, and FPS-R Measure?","volume":"18","author":"Thong","year":"2018","journal-title":"Scand. J. Pain"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jpain.2015.02.007","article-title":"Patients\u2019 Impression of Change Following Treatment for Chronic Pain: Global, Specific, a Single Dimension, or Many?","volume":"16","author":"Scott","year":"2015","journal-title":"J. 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