{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:00:29Z","timestamp":1793239229902,"version":"4.5.0"},"reference-count":216,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["5P01ES028942-04"],"award-info":[{"award-number":["5P01ES028942-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The effects of global warming are not limited to rising global temperatures and have set in motion a complex chain of events contributing to climate change. A consequence of global warming and the resultant climate change is the rise in cyanobacterial harmful algal blooms (cyano-HABs) across the world, which pose a threat to public health, aquatic biodiversity, and the livelihood of communities that depend on these water systems, such as farmers and fishers. An increase in cyano-HABs and their intensity is associated with an increase in the leakage of cyanotoxins. Microcystins (MCs) are hepatotoxins produced by some cyanobacterial species, and their organ toxicology has been extensively studied. Recent mouse studies suggest that MCs can induce gut resistome changes. Opportunistic pathogens such as Vibrios are abundantly found in the same habitat as phytoplankton, such as cyanobacteria. Further, MCs can complicate human disorders such as heat stress, cardiovascular diseases, type II diabetes, and non-alcoholic fatty liver disease. Firstly, this review describes how climate change mediates the rise in cyanobacterial harmful algal blooms in freshwater, causing increased levels of MCs. In the later sections, we aim to untangle the ways in which MCs can impact various public health concerns, either solely or in combination with other factors resulting from climate change. In conclusion, this review helps researchers understand the multiple challenges brought forth by a changing climate and the complex relationships between microcystin, Vibrios, and various environmental factors and their effect on human health and disease.<\/jats:p>","DOI":"10.3390\/toxins15040289","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T05:51:41Z","timestamp":1681710701000},"page":"289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Cyanobacterial Harmful Algal Bloom Toxin Microcystin and Increased Vibrio Occurrence as Climate-Change-Induced Biological Co-Stressors: Exposure and Disease Outcomes via Their Interaction with Gut\u2013Liver\u2013Brain Axis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1649-7149","authenticated-orcid":false,"given":"Saurabh","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Environmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, University of California\u2013Irvine, Irvine, CA 92697, USA"},{"name":"Toxicology Core, NIEHS Center for Oceans and Human Health on Climate Change Interactions, Department of Environmental and Occupational Health, Program in Public Health, University of California\u2013Irvine, Irvine, CA 92697, USA"},{"name":"Division of Infectious Disease, Department of Medicine, UCI School of Medicine, University of California\u2013Irvine, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhura","family":"More","sequence":"additional","affiliation":[{"name":"Environmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, University of California\u2013Irvine, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Reynolds, C.S. (2006). The Ecology of Phytoplankton, Cambridge University Press.","DOI":"10.1017\/CBO9780511542145"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2019.05.007","article-title":"Cyanobacteria evolution: Insight from the fossil record","volume":"140","author":"Demoulin","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41579-018-0040-1","article-title":"Cyanobacterial blooms","volume":"16","author":"Huisman","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e2107387118","DOI":"10.1073\/pnas.2107387118","article-title":"Evidence for massive and recurrent toxic blooms of Alexandrium catenella in the Alaskan Arctic","volume":"118","author":"Anderson","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101989","DOI":"10.1016\/j.hal.2021.101989","article-title":"Harmful algal blooms and their effects in coastal seas of Northern Europe","volume":"102","author":"Karlson","year":"2021","journal-title":"Harmful Algae"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101852","DOI":"10.1016\/j.hal.2020.101852","article-title":"Three decades of Canadian marine harmful algal events: Phytoplankton and phycotoxins of concern to human and ecosystem health","volume":"102","author":"McKenzie","year":"2021","journal-title":"Harmful Algae"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11217","DOI":"10.1073\/pnas.0910818107","article-title":"Predicting global atmospheric ice nuclei distributions and their impacts on climate","volume":"107","author":"DeMott","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_8","unstructured":"Hoagland, P., and Scatasta, S. (2006). The Economic Effects of Harmful Algal Blooms, Springer."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1890\/0012-9658(1997)078[0272:OTDOFC]2.0.CO;2","article-title":"On the Dominance of Filamentous Cyanobacteria Inshallow, Turbid Lakes","volume":"78","author":"Scheffer","year":"1997","journal-title":"Ecology"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lad, A., Breidenbach, J.D., Su, R.C., Murray, J., Kuang, R., Mascarenhas, A., Najjar, J., Patel, S., Hegde, P., and Youssef, M. (2022). As We Drink and Breathe: Adverse Health Effects of Microcystins and Other Harmful Algal Bloom Toxins in the Liver, Gut, Lungs and Beyond. Life, 12.","DOI":"10.3390\/life12030418"},{"key":"ref_11","unstructured":"Schaechter, M. (2009). Encyclopedia of Microbiology, Academic Press. [3rd ed.]."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4236\/jep.2017.84032","article-title":"Sustainable Management of Eutrophic Lakes and Reservoirs","volume":"8","author":"Wagner","year":"2017","journal-title":"J. Environ. Prot."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3390\/toxins5101896","article-title":"Cyanobacteria and cyanotoxins: From impacts on aquatic ecosystems and human health to anticarcinogenic effects","volume":"5","author":"Zanchett","year":"2013","journal-title":"Toxins"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"A120","DOI":"10.1289\/ehp.108-a120","article-title":"The dead zones: Oxygen-starved coastal waters","volume":"108","author":"Joyce","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Paerl, H.W. (2018). Mitigating Toxic Planktonic Cyanobacterial Blooms in Aquatic Ecosystems Facing Increasing Anthropogenic and Climatic Pressures. Toxins, 10.","DOI":"10.3390\/toxins10020076"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.1021\/es801465w","article-title":"Isolation and characterization of the gene associated with geosmin production in cyanobacteria","volume":"42","author":"Giglio","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1758-2229.2008.00004.x","article-title":"Climate change: A catalyst for global expansion of harmful cyanobacterial blooms","volume":"1","author":"Paerl","year":"2009","journal-title":"Environ. Microbiol. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.watres.2011.08.002","article-title":"Climate change: Links to global expansion of harmful cyanobacteria","volume":"46","author":"Paerl","year":"2012","journal-title":"Water Res."},{"key":"ref_19","first-page":"10773","article-title":"Rapid and highly variable warming of lake surface waters around the globe","volume":"42","author":"Sharma","year":"2015","journal-title":"Geophys. Res. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.gloenvcha.2012.11.002","article-title":"Global river discharge and water temperature under climate change","volume":"23","author":"Franssen","year":"2013","journal-title":"Glob. Environ. Chang."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1046\/j.1529-8817.2000.98219.x","article-title":"Effect of temperature on photosynthesis-light response and growth of four phytoplankton species isolated from a tidal freshwater river","volume":"36","author":"Coles","year":"2000","journal-title":"J. Phycol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.4319\/lo.1996.41.5.1136","article-title":"Potential effects of global climate change on small north-temperate lakes: Physics, fish, and plankton","volume":"41","author":"Hill","year":"1996","journal-title":"Limnol. Oceanogr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1111\/j.1365-2486.2007.01412.x","article-title":"Earlier onset of the spring phytoplankton bloom in lakes of the temperate zone in a warmer climate","volume":"13","author":"Peeters","year":"2007","journal-title":"Glob. Chang. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1046\/j.1469-8137.1997.00754.x","article-title":"The selective advantage of buoyancy provided by gas vesicles for planktonic cyanobacteria in the Baltic Sea","volume":"136","author":"Walsby","year":"1997","journal-title":"New Phytol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1469-8137.2005.01567.x","article-title":"The Burgundy-blood phenomenon: A model of buoyancy change explains autumnal waterblooms by Planktothrix rubescens in Lake Zurich","volume":"169","author":"Walsby","year":"2006","journal-title":"New Phytol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6291","DOI":"10.3390\/md13106291","article-title":"Analysis of Mycosporine-Like Amino Acids in Selected Algae and Cyanobacteria by Hydrophilic Interaction Liquid Chromatography and a Novel MAA from the Red Alga Catenella repens","volume":"13","author":"Hartmann","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1128\/AEM.00201-07","article-title":"Responses of a thermophilic Synechococcus isolate from the microbial mat of Octopus Spring to light","volume":"73","author":"Kilian","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10265-011-0454-6","article-title":"Acclimation to high-light conditions in cyanobacteria: From gene expression to physiological responses","volume":"125","author":"Muramatsu","year":"2012","journal-title":"J. Plant. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ohad, I., Raanan, H., Keren, N., Tchernov, D., and Kaplan, A. (2010). Light-induced changes within photosystem II protects Microcoleus sp. in biological desert sand crusts against excess light. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011000"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"143605","DOI":"10.1016\/j.scitotenv.2020.143605","article-title":"Ecological impacts of freshwater algal blooms on water quality, plankton biodiversity, structure, and ecosystem functioning","volume":"758","author":"Amorim","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"102354","DOI":"10.1016\/j.hal.2022.102354","article-title":"Elevated CO(2) significantly increases N(2) fixation, growth rates, and alters microcystin, anatoxin, and saxitoxin cell quotas in strains of the bloom-forming cyanobacteria, Dolichospermum","volume":"120","author":"Kramer","year":"2022","journal-title":"Harmful Algae"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"939347","DOI":"10.3389\/fmicb.2022.939347","article-title":"Cyanobacteria as a Promising Alternative for Sustainable Environment: Synthesis of Biofuel and Biodegradable Plastics","volume":"13","author":"Agarwal","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e01614-19","DOI":"10.1128\/AEM.01614-19","article-title":"Physiological and Metabolic Responses of Freshwater and Brackish-Water Strains of Microcystis aeruginosa Acclimated to a Salinity Gradient: Insight into Salt Tolerance","volume":"85","author":"Roux","year":"2019","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s00248-001-1044-2","article-title":"Salinity effects on growth, photosynthetic parameters, and nitrogenase activity in estuarine planktonic cyanobacteria","volume":"43","author":"Moisander","year":"2002","journal-title":"Microb. Ecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1568-9883(02)00085-9","article-title":"The influence of weather conditions (temperature and wind) on cyanobacterial bloom development in the Gulf of Finland (Baltic Sea)","volume":"2","author":"Kanoshina","year":"2003","journal-title":"Harmful Algae"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/plankt\/25.4.445","article-title":"Long-term dynamics of phytoplankton assemblages: Microcystis-domination in Lake Taihu, a large shallow lake in China","volume":"25","author":"Chen","year":"2003","journal-title":"J. Plankton Res."},{"key":"ref_37","unstructured":"(2023, February 16). National Lakes Assessment 2017 Key Findings, Available online: https:\/\/www.epa.gov\/national-aquatic-resource-surveys\/national-lakes-assessment-2017-key-findings."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"102080","DOI":"10.1016\/j.hal.2021.102080","article-title":"The Lake Erie HABs Grab: A binational collaboration to characterize the western basin cyanobacterial harmful algal blooms at an unprecedented high-resolution spatial scale","volume":"108","author":"Chaffin","year":"2021","journal-title":"Harmful Algae"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"115902","DOI":"10.1016\/j.watres.2020.115902","article-title":"The magnitude and drivers of harmful algal blooms in China\u2019s lakes and reservoirs: A national-scale characterization","volume":"181","author":"Huang","year":"2020","journal-title":"Water Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nclimate1418","article-title":"Temperature-related changes in polar cyanobacterial mat diversity and toxin production","volume":"2","author":"Kleinteich","year":"2012","journal-title":"Nat. Clim. Chang."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Dziallas, C., and Grossart, H.P. (2011). Increasing oxygen radicals and water temperature select for toxic Microcystis sp.. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025569"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1128\/aem.58.4.1321-1325.1992","article-title":"Toxin Production by Microcystis aeruginosa as a Function of Light in Continuous Cultures and Its Ecological Significance","volume":"58","author":"Utkilen","year":"1992","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1128\/AEM.66.8.3387-3392.2000","article-title":"Light and the transcriptional response of the microcystin biosynthesis gene cluster","volume":"66","author":"Kaebernick","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1128\/AEM.69.3.1475-1481.2003","article-title":"Effects of light on the microcystin content of Microcystis strain PCC 7806","volume":"69","author":"Wiedner","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1128\/AEM.71.9.5177-5181.2005","article-title":"The microcystin composition of the cyanobacterium Planktothrix agardhii changes toward a more toxic variant with increasing light intensity","volume":"71","author":"Tonk","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.4319\/lo.1998.43.7.1604","article-title":"Relationship between microcystin production and cell division rates in nitrogen-limited Microcystis aeruginosa cultures","volume":"43","author":"Orr","year":"1998","journal-title":"Limnol. Oceanogr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1128\/AEM.67.1.278-283.2001","article-title":"Cellular microcystin content in N-limited Microcystis aeruginosa can be predicted from growth rate","volume":"67","author":"Long","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1128\/aem.61.2.797-800.1995","article-title":"Iron-stimulated toxin production in Microcystis aeruginosa","volume":"61","author":"Utkilen","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00248-001-0041-9","article-title":"Effect of nitrogen and phosphorus on growth of toxic and nontoxic Microcystis strains and on intracellular microcystin concentrations","volume":"43","author":"Vezie","year":"2002","journal-title":"Microb. Ecol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/tox.20106","article-title":"Microcystin content of Microcystis aeruginosa is modulated by nitrogen uptake rate relative to specific growth rate or carbon fixation rate","volume":"20","author":"Downing","year":"2005","journal-title":"Environ. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00248-004-0054-2","article-title":"Medium N:P ratios and specific growth rate comodulate microcystin and protein content in Microcystis aeruginosa PCC7806 and M. aeruginosa UV027","volume":"49","author":"Downing","year":"2005","journal-title":"Microb. Ecol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.1461-0248.2009.01383.x","article-title":"The ecological stoichiometry of toxins produced by harmful cyanobacteria: An experimental test of the carbon-nutrient balance hypothesis","volume":"12","author":"Verspagen","year":"2009","journal-title":"Ecol. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/ismej.2011.28","article-title":"Reversal in competitive dominance of a toxic versus non-toxic cyanobacterium in response to rising CO2","volume":"5","author":"Verspagen","year":"2011","journal-title":"ISME J."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Roy-Lachapelle, A., Solliec, M., Sauve, S., and Gagnon, C. (2019). A Data-Independent Methodology for the Structural Characterization of Microcystins and Anabaenopeptins Leading to the Identification of Four New Congeners. Toxins, 11.","DOI":"10.3390\/toxins11110619"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10661-022-09875-z","article-title":"Exposure to microcystin-LR in tropical reservoirs for water supply poses high risks for children and adults","volume":"194","author":"Malta","year":"2022","journal-title":"Environ. Monit. Assess."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1753-4887.2010.00304.x","article-title":"Water, hydration, and health","volume":"68","author":"Popkin","year":"2010","journal-title":"Nutr. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Tito, J.C.R., Luna, L.M.G., Noppe, W.N., and Hubert, I.A. (2022). First Report on Microcystin-LR Occurrence in Water Reservoirs of Eastern Cuba, and Environmental Trigger Factors. Toxins, 14.","DOI":"10.3390\/toxins14030209"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"121","DOI":"10.5897\/IJWREE2016.0669","article-title":"Risk assessment of cyanobacteria-toxins for small drinking water treatment plants with lake water intakes","volume":"9","author":"Uche","year":"2017","journal-title":"Int. J. Water Resour. Environ. Eng."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Oliveira, E.D.C., Castelo-Branco, R., Silva, L., Silva, N., Azevedo, J., Vasconcelos, V., Faustino, S., and Cunha, A. (2019). First Detection of Microcystin-LR in the Amazon River at the Drinking Water Treatment Plant of the Municipality of Macapa, Brazil. Toxins, 11.","DOI":"10.3390\/toxins11110669"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.toxicon.2016.02.016","article-title":"Cyanobacteria and cyanotoxins are present in drinking water impoundments and groundwater wells in desert environments","volume":"114","author":"Chatziefthimiou","year":"2016","journal-title":"Toxicon"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10661-008-0708-5","article-title":"Identification and quantification of cyanobacterial toxins (microcystins) in two Moroccan drinking-water reservoirs (Mansour Eddahbi, Almassira)","volume":"160","author":"Douma","year":"2010","journal-title":"Environ. Monit. Assess."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.scitotenv.2017.08.149","article-title":"Hot and toxic: Temperature regulates microcystin release from cyanobacteria","volume":"610\u2013611","author":"Walls","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.watres.2011.11.012","article-title":"Toxic cyanobacterial breakthrough and accumulation in a drinking water plant: A monitoring and treatment challenge","volume":"46","author":"Zamyadi","year":"2012","journal-title":"Water Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s10661-015-4829-3","article-title":"Microcystins contamination of surface water supply sources in Zaria-Nigeria","volume":"187","author":"Chia","year":"2015","journal-title":"Environ. Monit. Assess."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s00204-019-02524-4","article-title":"Global geographical and historical overview of cyanotoxin distribution and cyanobacterial poisonings","volume":"93","author":"Svircev","year":"2019","journal-title":"Arch. Toxicol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00204-016-1921-6","article-title":"Toxicology of microcystins with reference to cases of human intoxications and epidemiological investigations of exposures to cyanobacteria and cyanotoxins","volume":"91","author":"Svircev","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/carcin\/17.6.1317","article-title":"Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay","volume":"17","author":"Ueno","year":"1996","journal-title":"Carcinogenesis"},{"key":"ref_68","first-page":"96","article-title":"The relationship between cyanotoxin (microcystin, MC) in pond-ditch water and primary liver cancer in China","volume":"23","author":"Yu","year":"2001","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"ref_69","first-page":"166","article-title":"Relationship between microcystin in drinking water and colorectal cancer","volume":"15","author":"Zhou","year":"2002","journal-title":"Biomed. Environ. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1038\/s41598-019-45009-1","article-title":"Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease","volume":"9","author":"Sarkar","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2478\/10004-1254-64-2013-2320","article-title":"Human exposure to cyanotoxins and their effects on health","volume":"64","author":"Drobac","year":"2013","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/10590501.2014.967053","article-title":"Epidemiology of cancers in Serbia and possible connection with cyanobacterial blooms","volume":"32","author":"Svircev","year":"2014","journal-title":"J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10238-019-00550-1","article-title":"Microcystin-LR in peripheral circulation worsens the prognosis partly through oxidative stress in patients with hepatocellular carcinoma","volume":"19","author":"Lei","year":"2019","journal-title":"Clin. Exp. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"15818","DOI":"10.1021\/acs.est.2c02287","article-title":"Microcystin-LR Combined with Cadmium Exposures and the Risk of Chronic Kidney Disease: A Case-Control Study in Central China","volume":"56","author":"Feng","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1021\/acs.est.6b01062","article-title":"Determination of Environmental Exposure to Microcystin and Aflatoxin as a Risk for Renal Function Based on 5493 Rural People in Southwest China","volume":"50","author":"Lin","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ecoenv.2015.02.001","article-title":"Microcystin-producing and non-producing cyanobacterial blooms collected from the Central India harbor potentially pathogenic Vibrio cholerae","volume":"115","author":"Chaturvedi","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1139\/w03-114","article-title":"Role of cyanobacteria in the persistence of Vibrio cholerae O139 in saline microcosms","volume":"50","author":"Islam","year":"2004","journal-title":"Can. J. Microbiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e00333-18","DOI":"10.1128\/AEM.00333-18","article-title":"Vibrio Ecology in the Neuse River Estuary, North Carolina, Characterized by Next-Generation Amplicon Sequencing of the Gene Encoding Heat Shock Protein 60 (hsp60)","volume":"84","author":"Jesser","year":"2018","journal-title":"Appl. Environ Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0035-9203(99)90171-2","article-title":"Association of Vibrio cholerae O1 with the cyanobacterium, Anabaena sp., elucidated by polymerase chain reaction and transmission electron microscopy","volume":"93","author":"Islam","year":"1999","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1574-6941.2007.00303.x","article-title":"Growth response of Vibrio cholerae and other Vibrio spp. to cyanobacterial dissolved organic matter and temperature in brackish water","volume":"60","author":"Eiler","year":"2007","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Thompson, F.L., Austin, B., and Swings, J. (2006). The Biology of Vibrios, ASM Press.","DOI":"10.1128\/9781555815714"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1007\/s12237-018-0424-5","article-title":"Impact of Climate Change on Vibrio vulnificus Abundance and Exposure Risk","volume":"41","author":"Deeb","year":"2018","journal-title":"Estuaries Coast."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.envres.2006.07.002","article-title":"Climate change and the emergence of Vibrio vulnificus disease in Israel","volume":"103","author":"Paz","year":"2007","journal-title":"Environ. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/2017GH000094","article-title":"Temporal and Environmental Factors Driving Vibrio Vulnificus and V. Parahaemolyticus Populations and Their Associations with Harmful Algal Blooms in South Carolina Detention Ponds and Receiving Tidal Creeks","volume":"1","author":"Greenfield","year":"2017","journal-title":"Geohealth"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2166\/wh.2020.089","article-title":"Occurrence of Cyanobacteria and microcystins in hydroelectric reservoirs used for fish farming","volume":"18","author":"Rodrigues","year":"2020","journal-title":"J. Water Health"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s12275-021-0635-5","article-title":"Different distribution patterns of microorganisms between aquaculture pond sediment and water","volume":"59","author":"Dai","year":"2021","journal-title":"J. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00248-021-01731-w","article-title":"An Integrative, Multiparametric Approach for the Comprehensive Assessment of Microbial Quality and Pollution in Aquaculture Systems","volume":"83","author":"Stabili","year":"2022","journal-title":"Microb. Ecol."},{"key":"ref_88","first-page":"653","article-title":"Necrotizing dermatitis due to Vibrio Vulnificus","volume":"128","author":"Dieng","year":"2001","journal-title":"Ann. Dermatol. Venereol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S0037-86822001000500002","article-title":"Identification of Vibrio spp bacteria on skin lesions of fisherman in the county of Raposa-MA","volume":"34","author":"Rodrigues","year":"2001","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1007\/s00253-021-11369-w","article-title":"Distinct bacterial communities in the environmental water, sediment and intestine between two crayfish-plant coculture ecosystems","volume":"105","author":"Wei","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s43141-021-00237-9","article-title":"Metagenomic analysis of microbial communities in the sediments of a semi-intensive penaeid shrimp culture system","volume":"19","author":"Chithira","year":"2021","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Bouaicha, N., Miles, C.O., Beach, D.G., Labidi, Z., Djabri, A., Benayache, N.Y., and Nguyen-Quang, T. (2019). Structural Diversity, Characterization and Toxicology of Microcystins. Toxins, 11.","DOI":"10.20944\/preprints201910.0034.v1"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s10646-020-02231-2","article-title":"Seasonal variation of microcystins and their accumulation in fish in two large shallow lakes of China","volume":"29","author":"Peng","year":"2020","journal-title":"Ecotoxicology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/09670269910001736462","article-title":"Cyanobacterial toxins, exposure routes and human health","volume":"34","author":"Codd","year":"1999","journal-title":"Eur. J. Phycol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1021\/acs.est.0c06653","article-title":"Toxic Cyanobacteria: A Growing Threat to Water and Air Quality","volume":"55","author":"Plaas","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1007\/s00216-017-0352-4","article-title":"Detection of freshwater cyanotoxins and measurement of masked microcystins in tilapia from Southeast Asian aquaculture farms","volume":"409","author":"Greer","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"105142","DOI":"10.1016\/j.envint.2019.105142","article-title":"High ecological and human health risks from microcystins in vegetable fields in southern China","volume":"133 Pt A","author":"Xiang","year":"2019","journal-title":"Environ. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1021\/es200285c","article-title":"Evaluating microcystin exposure risk through fish consumption","volume":"45","author":"Poste","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0041-0101(99)00084-7","article-title":"First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method","volume":"38","author":"Ito","year":"2000","journal-title":"Toxicon"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"19273","DOI":"10.1007\/s11356-015-5531-2","article-title":"Quantitatively evaluating detoxification of the hepatotoxic microcystin-LR through the glutathione (GSH) pathway in SD rats","volume":"22","author":"Guo","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_101","unstructured":"Snyder, H. (2015). Microcystin Accumulation in Fish Muscle Tissue: Exploring the Safety of Fish Consumption in Several Michigan Water Bodies, Grand Valley State University."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.2174\/1389557516666160308141549","article-title":"An Overview of the Mechanisms of Microcystin-LR Genotoxicity and Potential Carcinogenicity","volume":"16","author":"Zegura","year":"2016","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.scitotenv.2019.02.426","article-title":"Neurotoxicity induced by microcystins and cylindrospermopsin: A review","volume":"668","author":"Hinojosa","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.toxicon.2019.02.012","article-title":"Marine toxins and nephrotoxicity: Mechanism of injury","volume":"161","author":"Sitprija","year":"2019","journal-title":"Toxicon"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"110254","DOI":"10.1016\/j.envres.2020.110254","article-title":"The latest advances in the reproductive toxicity of microcystin-LR","volume":"192","author":"Zhang","year":"2021","journal-title":"Environ. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/bbrc.1995.2605","article-title":"In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A","volume":"216","author":"Runnegar","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2015.04.010","article-title":"The role of PP2A-associated proteins and signal pathways in microcystin-LR toxicity","volume":"236","author":"Liu","year":"2015","journal-title":"Toxicol. Lett."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1097(03)00100-9","article-title":"Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity","volume":"220","author":"Ding","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1021\/es304886y","article-title":"Microcystin-LR induces endoplasmatic reticulum stress and leads to induction of NFkappaB, interferon-alpha, and tumor necrosis factor-alpha","volume":"47","author":"Christen","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1021\/es201514h","article-title":"Genomic profiling of microRNAs and proteomics reveals an early molecular alteration associated with tumorigenesis induced by MC-LR in mice","volume":"46","author":"Zhao","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"11516","DOI":"10.1038\/s41598-022-15708-3","article-title":"Prior exposure to microcystin alters host gut resistome and is associated with dysregulated immune homeostasis in translatable mouse models","volume":"12","author":"Saha","year":"2022","journal-title":"Sci Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"G408","DOI":"10.1152\/ajpgi.00061.2019","article-title":"Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21","volume":"317","author":"Albadrani","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"152901","DOI":"10.1016\/j.tox.2021.152901","article-title":"Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent","volume":"461","author":"Mondal","year":"2021","journal-title":"Toxicology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"103281","DOI":"10.1016\/j.etap.2019.103281","article-title":"Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via NOX-2-MIR21 axis","volume":"73","author":"Sarkar","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0041-0101(03)00104-1","article-title":"Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR","volume":"42","author":"Li","year":"2003","journal-title":"Toxicon"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/nt.2620030602","article-title":"Effects of microcystin-LR on actin and the actin-associated proteins alpha-actinin and talin in hepatocytes","volume":"3","author":"Ghosh","year":"1995","journal-title":"Nat. Toxins"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1015868809990","article-title":"Protection against microcystin-LR-induced hepatotoxicity by Silymarin: Biochemistry, histopathology, and lethality","volume":"8","author":"Mereish","year":"1991","journal-title":"Pharm. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0041-0101(97)00026-3","article-title":"Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR","volume":"35","author":"Ito","year":"1997","journal-title":"Toxicon"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0041-0101(03)00143-0","article-title":"Nephrotoxic effects of chronic administration of microcystins -LR and -YR","volume":"42","author":"Milutinovic","year":"2003","journal-title":"Toxicon"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.scitotenv.2019.06.387","article-title":"Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR","volume":"689","author":"Wang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxicon.2016.03.007","article-title":"The toxic effects of microcystin-LR on mouse lungs and alveolar type II epithelial cells","volume":"115","author":"Wang","year":"2016","journal-title":"Toxicon"},{"key":"ref_122","first-page":"116","article-title":"Microcystin-LR induces alterations in heart muscle","volume":"52","author":"Milutinovic","year":"2006","journal-title":"Folia Biol."},{"key":"ref_123","first-page":"2049936121991374","article-title":"Climate change and antibiotic resistance: A deadly combination","volume":"8","author":"Burnham","year":"2021","journal-title":"Ther. Adv. Infect. Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"108854","DOI":"10.1016\/j.cbpc.2020.108854","article-title":"Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease","volume":"238","author":"Sarkar","year":"2020","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"103457","DOI":"10.1016\/j.etap.2020.103457","article-title":"Early microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance","volume":"80","author":"Saha","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.2147\/IDR.S173867","article-title":"Antibiotic resistance: A rundown of a global crisis","volume":"11","author":"Aslam","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(16)31079-0","article-title":"UN High-Level Meeting on antimicrobials\u2014What do we need?","volume":"388","author":"Laxminarayan","year":"2016","journal-title":"Lancet"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrmicro1614","article-title":"The antibiotic resistome: The nexus of chemical and genetic diversity","volume":"5","author":"Wright","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mib.2014.09.002","article-title":"The antibiotic resistome: What\u2019s new?","volume":"21","author":"Perry","year":"2014","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fmicb.2013.00138","article-title":"The antibiotic resistance \u201cmobilome\u201d: Searching for the link between environment and clinic","volume":"4","author":"Perry","year":"2013","journal-title":"Front. Microbiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.1220761","article-title":"The shared antibiotic resistome of soil bacteria and human pathogens","volume":"337","author":"Forsberg","year":"2012","journal-title":"Science"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.scitotenv.2017.08.229","article-title":"Behavior of antibiotic resistance genes under extremely high-level antibiotic selection pressures in pharmaceutical wastewater treatment plants","volume":"612","author":"Guo","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4103\/ijmr.IJMR_1979_17","article-title":"The human gut resistome: Current concepts & future prospects","volume":"150","author":"Singh","year":"2019","journal-title":"Indian J. Med. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.mib.2010.08.005","article-title":"Antibiotic resistance in the environment: A link to the clinic?","volume":"13","author":"Wright","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"119219","DOI":"10.1016\/j.envpol.2022.119219","article-title":"Comparing resistome profiles from anthropogenically impacted and non-impacted areas of two South Shetland Islands\u2014Maritime Antarctica","volume":"304","author":"Centurion","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"106221","DOI":"10.1016\/j.aquatox.2022.106221","article-title":"Anthropogenic impacts on antibiotic resistance genes and their hosts from pristine to urban river using metagenomic and binning approaches","volume":"249","author":"Guan","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"795206","DOI":"10.3389\/fmicb.2022.795206","article-title":"River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics","volume":"13","author":"Matviichuk","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2166\/wh.2021.151","article-title":"Antibiotic resistance genes in an urban stream before and after a state fair","volume":"19","author":"McNamara","year":"2021","journal-title":"J. Water Health"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/s41467-022-29283-8","article-title":"Assessment of global health risk of antibiotic resistance genes","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"135428","DOI":"10.1016\/j.chemosphere.2022.135428","article-title":"Tracking the influence of antibiotics, antibiotic resistomes, and salinity gradient in modulating microbial community assemblage of surface water and the ecological consequences","volume":"305","author":"Ohore","year":"2022","journal-title":"Chemosphere"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jes.2021.06.026","article-title":"Metagenomic insights into the profile of antibiotic resistomes in sediments of aquaculture wastewater treatment system","volume":"113","author":"Chen","year":"2022","journal-title":"J. Environ. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e0031622","DOI":"10.1128\/aem.00316-22","article-title":"Responses of the Soil Bacterial Community, Resistome, and Mobilome to a Decade of Annual Exposure to Macrolide Antibiotics","volume":"88","author":"Brown","year":"2022","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"113021","DOI":"10.1016\/j.envres.2022.113021","article-title":"Antibiotic resistance in soil and tomato crop irrigated with freshwater and two types of treated wastewater","volume":"211","author":"Seyoum","year":"2022","journal-title":"Environ. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.envint.2017.12.036","article-title":"Functional metagenomics reveals a novel carbapenem-hydrolyzing mobile beta-lactamase from Indian river sediments contaminated with antibiotic production waste","volume":"112","author":"Marathe","year":"2018","journal-title":"Environ. Int."},{"key":"ref_145","first-page":"3375","article-title":"Distribution and Removal of Antibiotic-Resistant Bacteria and Antibiotic Resistance Genes in Petrochemical Wastewater Treatment Plants","volume":"42","author":"Tang","year":"2021","journal-title":"Huan Jing Ke Xue"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12038-021-00220-z","article-title":"Impact of cyanobacterial bloom on microbiomes of freshwater lakes","volume":"46","author":"Pal","year":"2021","journal-title":"J. Biosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ijheh.2017.02.003","article-title":"Toxicological impacts of antibiotics on aquatic micro-organisms: A mini-review","volume":"220","author":"Valitalo","year":"2017","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Cohen, Y., and Gurevitz, M. (2006). The Cyanobacteria\u2014Ecology, Physiology and Molecular Genetics, Springer.","DOI":"10.1007\/0-387-30744-3_39"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Tyagi, R., Kaushik, B.D., and Kumar, J. (2014). Antimicrobial Activity of Some Cyanobacteria, Springer.","DOI":"10.1007\/978-81-322-1801-2_41"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1128\/AEM.02542-10","article-title":"Glutathione facilitates antibiotic resistance and photosystem I stability during exposure to gentamicin in cyanobacteria","volume":"77","author":"Cameron","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"106034","DOI":"10.1016\/j.envint.2020.106034","article-title":"Critical roles of cyanobacteria as reservoir and source for antibiotic resistance genes","volume":"144","author":"Wang","year":"2020","journal-title":"Environ. Int."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.gene.2010.11.011","article-title":"Genome-wide comparison of cyanobacterial transposable elements, potential genetic diversity indicators","volume":"473","author":"Lin","year":"2011","journal-title":"Gene"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"8731","DOI":"10.1021\/acs.est.5b01129","article-title":"Ionic Liquid Facilitates the Conjugative Transfer of Antibiotic Resistance Genes Mediated by Plasmid RP4","volume":"49","author":"Wang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"bcr-2018","DOI":"10.1136\/bcr-2018-227851","article-title":"Fatal case of necrotising fasciitis due to Vibrio vulnificus in a patient with alcoholic liver disease and diabetes mellitus","volume":"12","author":"Bhat","year":"2019","journal-title":"BMJ Case Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1111\/1462-2920.14967","article-title":"In hot water: Effects of climate change on Vibrio-human interactions","volume":"22","author":"Froelich","year":"2020","journal-title":"Environ. Microbiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrmicro2204","article-title":"Cholera transmission: The host, pathogen and bacteriophage dynamic","volume":"7","author":"Nelson","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00248-012-0140-9","article-title":"Vibrio vulnificus: Death on the half shell. A personal journey with the pathogen and its ecology","volume":"65","author":"Oliver","year":"2013","journal-title":"Microb. Ecol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"S391","DOI":"10.1093\/cid\/cis243","article-title":"Increasing rates of vibriosis in the United States, 1996\u20132010: Review of surveillance data from 2 systems","volume":"54","author":"Newton","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/aem.44.4.820-824.1982","article-title":"Effect of temperature and salinity on Vibrio (Beneckea) vulnificus occurrence in a Gulf Coast environment","volume":"44","author":"Kelly","year":"1982","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0168-1605(97)00100-1","article-title":"Development and evaluation of a predictive model for the effect of temperature and water activity on the growth rate of Vibrio parahaemolyticus","volume":"38","author":"Miles","year":"1997","journal-title":"Int. J. Food Microbiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02512384","article-title":"Vibrio parahaemolyticus andVibrio alginolyticus: Short generation-time marine bacteria","volume":"1","author":"Ulitzur","year":"1974","journal-title":"Microb. Ecol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fcimb.2013.00097","article-title":"Distribution and dynamics of epidemic and pandemic Vibrio parahaemolyticus virulence factors","volume":"3","author":"Ceccarelli","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1286-4579(00)00270-7","article-title":"Epidemiology and pathogenesis of Vibrio vulnificus","volume":"2","author":"Strom","year":"2000","journal-title":"Microbes Infect."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/infdis\/173.5.1176","article-title":"The epidemiology of Vibrio infections in Florida, 1981\u20131993","volume":"173","author":"Hlady","year":"1996","journal-title":"J. Infect Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"318","DOI":"10.7326\/0003-4819-109-4-318","article-title":"Syndromes of Vibrio vulnificus infections. Clinical and epidemiologic features in Florida cases, 1981\u20131987","volume":"109","author":"Klontz","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/iai.59.1.192-197.1991","article-title":"The extracellular cytolysin of Vibrio vulnificus: Inactivation and relationship to virulence in mice","volume":"59","author":"Wright","year":"1991","journal-title":"Infect. Immun."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/infdis\/155.2.236","article-title":"Mouse skin damage caused by cytolysin from Vibrio vulnificus and by V. vulnificus infection","volume":"155","author":"Gray","year":"1987","journal-title":"J. Infect. Dis."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1128\/iai.55.8.1936-1939.1987","article-title":"Activation of the plasma kallikrein-kinin system by Vibrio vulnificus protease","volume":"55","author":"Miyoshi","year":"1987","journal-title":"Infect. Immun."},{"key":"ref_169","first-page":"118","article-title":"Molecular Pathogenesis of Vibrio vulnificus","volume":"43","author":"Gulig","year":"2005","journal-title":"J. Microbiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1462-5822.2007.01088.x","article-title":"Vibrio vulnificus RTX toxin kills host cells only after contact of the bacteria with host cells","volume":"10","author":"Kim","year":"2008","journal-title":"Cell. Microbiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tim.2019.08.006","article-title":"Vibrio vulnificus","volume":"28","author":"Oliver","year":"2020","journal-title":"Trends Microbiol."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Lad, A., Su, R.C., Breidenbach, J.D., Stemmer, P.M., Carruthers, N.J., Sanchez, N.K., Khalaf, F.K., Zhang, S., Kleinhenz, A.L., and Dube, P. (2019). Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease. Toxins, 11.","DOI":"10.3390\/toxins11090486"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11356-022-21814-6","article-title":"Risk assessment of cyanobacteria toxic metabolites on freshwater ecosystems applying molecular methods","volume":"30","author":"Moreira","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e096","DOI":"10.1097\/EE9.0000000000000096","article-title":"Estimating the number of excess deaths attributable to heat in 297 United States counties","volume":"4","author":"Weinberger","year":"2020","journal-title":"Environ. Epidemiol."},{"key":"ref_175","unstructured":"IPCC-AR6 ASRCC (2023, February 27). AR6 Synthesis Report: Climate Change 2023. Available online: https:\/\/www.ipcc.ch\/2021\/08\/09\/ar6-wg1-20210809-pr\/."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"16688","DOI":"10.1038\/s41598-021-96191-0","article-title":"A unifying model to estimate the effect of heat stress in the human innate immunity during physical activities","volume":"11","author":"Presbitero","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4161\/cc.3.1.625","article-title":"Why do cells require heat shock proteins to survive heat stress?","volume":"3","author":"Riezman","year":"2004","journal-title":"Cell. Cycle"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s12088-021-00948-0","article-title":"Effects of Heat Stress on Gut Microbiome in Rats","volume":"61","author":"Qu","year":"2021","journal-title":"Indian J. Microbiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.3382\/ps\/pez026","article-title":"Impact of gut microbiota structure in heat-stressed broilers","volume":"98","author":"Shi","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/jam.14504","article-title":"Effects of acute heat stress on intestinal microbiota in grow-finishing pigs, and associations with feed intake and serum profile","volume":"128","author":"Xiong","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"G204","DOI":"10.1152\/ajpgi.00401.2005","article-title":"Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability","volume":"290","author":"Dokladny","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1111\/j.1440-1746.2006.04710.x","article-title":"Investigation into the signal transduction pathway via which heat stress impairs intestinal epithelial barrier function","volume":"22","author":"Yang","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI200421086","article-title":"Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis","volume":"114","author":"Karhausen","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"101731","DOI":"10.1016\/j.hal.2019.101731","article-title":"Climate Change and Harmful Algal Blooms: Insights and perspective","volume":"91","author":"Gobler","year":"2020","journal-title":"Harmful Algae"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5334\/aogh.2831","article-title":"Human Health and Ocean Pollution","volume":"86","author":"Landrigan","year":"2020","journal-title":"Ann. Glob. Health"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Cao, L., Massey, I.Y., Feng, H., and Yang, F. (2019). A Review of Cardiovascular Toxicity of Microcystins. Toxins, 11.","DOI":"10.3390\/toxins11090507"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/jat.2550150412","article-title":"Hemodynamic and calorimetric changes induced by microcystin-LR in the rat","volume":"15","author":"LeClaire","year":"1995","journal-title":"J. Appl. Toxicol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/00984100050136599","article-title":"Microcystin-LR decreases hepatic and renal perfusion, and causes circulatory shock, severe hypoglycemia, and terminal hyperkalemia in intravascularly dosed swine","volume":"61","author":"Beasley","year":"2000","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tox.2008.12.012","article-title":"The profound effects of microcystin on cardiac antioxidant enzymes, mitochondrial function and cardiac toxicity in rat","volume":"257","author":"Qiu","year":"2009","journal-title":"Toxicology"},{"key":"ref_190","first-page":"295","article-title":"The acute toxic effects of microcystin LR in SD rats","volume":"36","author":"Zhang","year":"2002","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.freeradbiomed.2014.09.031","article-title":"Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases","volume":"78","author":"Sozen","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.toxicon.2021.06.018","article-title":"Allium sativum mitigates oxidative damages induced by Microcystin-LR in heart and liver tissues of mice","volume":"200","author":"Taibi","year":"2021","journal-title":"Toxicon"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1021\/bi051593z","article-title":"Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation","volume":"45","author":"Hall","year":"2006","journal-title":"Biochemistry"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Kimura, T., Han, W., Pagel, P., Nairn, A.C., and Caplan, M.J. (2011). Protein phosphatase 2A interacts with the Na,K-ATPase and modulates its trafficking by inhibition of its association with arrestin. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0029269"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"942159","DOI":"10.1155\/2015\/942159","article-title":"Microcystins Induces Vascular Inflammation in Human Umbilical Vein Endothelial Cells via Activation of NF-kappaB","volume":"2015","author":"Shi","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.chemosphere.2016.10.037","article-title":"Epigallocatechin-3-gallate attenuates microcystin-LR induced oxidative stress and inflammation in human umbilical vein endothelial cells","volume":"168","author":"Shi","year":"2017","journal-title":"Chemosphere"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2018). 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes\u20142019. Diabetes Care, 42, S13\u2013S28.","DOI":"10.2337\/dc19-S002"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/MED.0b013e32833c5c48","article-title":"Obesity genes and insulin resistance","volume":"17","author":"Belkina","year":"2010","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/j.scitotenv.2008.12.039","article-title":"Transfer, distribution and bioaccumulation of microcystins in the aquatic food web in Lake Taihu, China, with potential risks to human health","volume":"407","author":"Zhang","year":"2009","journal-title":"Sci. Total Environ."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.toxlet.2018.05.019","article-title":"Microcystis bloom containing microcystin-LR induces type 2 diabetes mellitus","volume":"294","author":"Zhang","year":"2018","journal-title":"Toxicol. Lett."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1021\/es5059132","article-title":"Effects of chronic exposure to microcystin-LR on hepatocyte mitochondrial DNA replication in mice","volume":"49","author":"Li","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/tox.22856","article-title":"Microcystin-LR exposure disrupts the insulin signaling pathway in C2C12 mice muscle cell line","volume":"35","author":"Ma","year":"2020","journal-title":"Environ. Toxicol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4254\/wjh.v9.i16.715","article-title":"Non-alcoholic fatty liver disease: An expanded review","volume":"9","author":"Benedict","year":"2017","journal-title":"World J. Hepatol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"595371","DOI":"10.3389\/fmed.2021.595371","article-title":"Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review","volume":"8","author":"Marciano","year":"2021","journal-title":"Front. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0002-9378(87)80372-1","article-title":"Human embryo viability related to freezing and thawing procedures","volume":"157","author":"Testart","year":"1987","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1055\/s-0042-1755316","article-title":"Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD","volume":"42","author":"Han","year":"2022","journal-title":"Semin. Liver Dis."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2131\/jts.32.453","article-title":"Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis","volume":"32","author":"Nagata","year":"2007","journal-title":"J. Toxicol. Sci."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/toxsci\/kft104","article-title":"Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice","volume":"134","author":"Seth","year":"2013","journal-title":"Toxicol. Sci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"10780","DOI":"10.1021\/acs.est.6b01604","article-title":"Automatic High Frequency Monitoring for Improved Lake and Reservoir Management","volume":"50","author":"Marce","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"101828","DOI":"10.1016\/j.hal.2020.101828","article-title":"CyanoTRACKER: A cloud-based integrated multi-platform architecture for global observation of cyanobacterial harmful algal blooms","volume":"96","author":"Mishra","year":"2020","journal-title":"Harmful Algae"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.scitotenv.2019.01.044","article-title":"Highly time-resolved analysis of seasonal water dynamics and algal kinetics based on in-situ multi-sensor-system monitoring data in Lake Taihu, China","volume":"660","author":"Yang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"13529","DOI":"10.1038\/s41598-022-17299-5","article-title":"Chlorophyll soft-sensor based on machine learning models for algal bloom predictions","volume":"12","author":"Mozo","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Wei, X., Wang, S., Zhan, Y., Kai, T., and Ding, P. (2022). Sensitive Identification of Microcystin-LR via a Reagent-Free and Reusable Electrochemical Biosensor Using a Methylene Blue-Labeled Aptamer. Biosensors, 12.","DOI":"10.3390\/bios12080556"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"114669","DOI":"10.1016\/j.jenvman.2022.114669","article-title":"Removal of microcystin (MC-LR) in constructed wetlands integrated with microbial fuel cells: Efficiency, bioelectricity generation and microbial response","volume":"309","author":"Cheng","year":"2022","journal-title":"J. Environ. Manag."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.toxicon.2005.03.013","article-title":"Removal of the cyanobacterial toxin microcystin-LR by human probiotics","volume":"46","author":"Meriluoto","year":"2005","journal-title":"Toxicon"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.toxicon.2008.04.169","article-title":"Specific strains of probiotic bacteria are efficient in removal of several different cyanobacterial toxins from solution","volume":"52","author":"Nybom","year":"2008","journal-title":"Toxicon"}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/15\/4\/289\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:17:24Z","timestamp":1760123844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/15\/4\/289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":216,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["toxins15040289"],"URL":"https:\/\/doi.org\/10.3390\/toxins15040289","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]}}}