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This systematic review aims to evaluate scientific evidence on therapies used to target local effects caused by envenomation. The PubMed, MEDLINE, and LILACS databases were used to perform a literature search on the topic. The review was based on studies that cited procedures performed on local injuries following envenomation with the aim of being an adjuvant therapeutic strategy. The literature regarding local treatments used following envenomation reports the use of several alternative methods and\/or therapies. The venomous animals found in the search were snakes (82.05%), insects (2.56%), spiders (2.56%), scorpions (2.56%), and others (jellyfish, centipede, sea urchin\u201410.26%). In regard to the treatments, the use of tourniquets, corticosteroids, antihistamines, and cryotherapy is questionable, as well as the use of plants and oils. Low-intensity lasers stand out as a possible therapeutic tool for these injuries. Local complications can progress to serious conditions and may result in physical disabilities and sequelae. This study compiled information on adjuvant therapeutic measures and underscores the importance of more robust scientific evidence for recommendations that act on local effects together with the antivenom.<\/jats:p>","DOI":"10.3390\/toxins15050313","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T09:54:53Z","timestamp":1682675693000},"page":"313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prospecting Local Treatments Used in Conjunction with Antivenom Administration Following Envenomation Caused by Animals: A Systematic Review"],"prefix":"10.3390","volume":"15","author":[{"given":"\u00c9rica S.","family":"Carvalho","sequence":"first","affiliation":[{"name":"School of Health Sciences, Amazonas State University, Manaus 69050030, Amazonas, Brazil"},{"name":"Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus 69040000, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2036-1191","authenticated-orcid":false,"given":"Isadora","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040903, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds P.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Amazonas State University, Manaus 69050030, Amazonas, Brazil"},{"name":"Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus 69040000, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Vilhena","family":"da Silva Neto","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Amazonas State University, Manaus 69050030, Amazonas, Brazil"},{"name":"Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus 69040000, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda A. S.","family":"Leal","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Amazonas State University, Manaus 69050030, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Q.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Amazonas State University, Manaus 69050030, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno F. V.","family":"Juli\u00e3o","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Amazonas State University, Manaus 69050030, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R. 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S.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Teaching and Research, Alfredo da Matta Foundation, Manaus 69065130, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan Hui","family":"Wen","sequence":"additional","affiliation":[{"name":"Butantan Institute, S\u00e3o Paulo 05501000, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-7068","authenticated-orcid":false,"given":"Manuela B.","family":"Pucca","sequence":"additional","affiliation":[{"name":"Medical School, Federal University of Roraima, Boa Vista 69310000, Roraima, Brazil"},{"name":"Health Sciences Postgraduate Program, Federal University of Roraima, Boa Vista 69310000, Roraima, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-1940","authenticated-orcid":false,"given":"Wuelton M.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Amazonas State University, Manaus 69050030, Amazonas, Brazil"},{"name":"Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus 69040000, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A. 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Enferm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1590\/1413-81232020255.16572018","article-title":"Epidemiology of the injury with venomous animals in the state of Rio Grande do Norte, Northeast of Brazil","volume":"25","author":"Tavares","year":"2020","journal-title":"Ci\u00eanc. Sa\u00fade Coletiva"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.wem.2020.03.001","article-title":"Bothrops atrox Snakebite: How a Bad Decision May Lead to a Chronic Disability: A Case Report","volume":"31","author":"Sachett","year":"2020","journal-title":"Wilderness Environ. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Barreto, G.N.L.S., de Oliveira, S.S., dos Anjos, I.V., Chalkidis, H.D.M., Mour\u00e3o, R.H.V., Moura-Da-Silva, A.M., Sano-Martins, I.S., and Gon\u00e7alves, L.R.D.C. (2017). Experimental Bothrops atrox envenomation: Efficacy of antivenom therapy and the combination of Bothrops antivenom with dexamethasone. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005458"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.wem.2012.10.001","article-title":"Scorpion Stings Presenting to an Emergency Department in Singapore with Special Reference to Isometrus maculatus","volume":"24","author":"Tan","year":"2013","journal-title":"Wilderness Environ. Med."},{"key":"ref_7","unstructured":"Minist\u00e9rio da Sa\u00fade do Brasil (2001). Manual de Diagn\u00f3stico e Tratamento de Acidentes por Animais Pe\u00e7onhentos, Funda\u00e7\u00e3o Nacional de Sa\u00fade."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0196-0644(88)80360-3","article-title":"Wound care of spider and snake envenomations","volume":"17","author":"Wasserman","year":"1988","journal-title":"Ann. Emerg. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1007\/s00284-017-1313-z","article-title":"Assessment of Cultivable Oral Bacterial Flora from Important Venomous Snakes of India and Their Antibiotic Susceptibilities","volume":"74","author":"Shaikh","year":"2017","journal-title":"Curr. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"R\u00e9si\u00e8re, D., Olive, C., Kallel, H., Cabi\u00e9, A., N\u00e9vi\u00e8re, R., M\u00e9garbane, B., Guti\u00e9rrez, J., and Mehdaoui, H. (2018). Oral Microbiota of the Snake Bothrops lanceolatus in Martinique. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15102122"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e0244-2021","DOI":"10.1590\/0037-8682-0244-2021","article-title":"Secondary infection profile after snakebite treated at a tertiary referral center in the Brazilian Amazon","volume":"55","author":"Mendes","year":"2022","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.19178\/Sci.Amazon.v4i1.73-84","article-title":"Acidentes of\u00eddicos na Regi\u00e3o Norte do Brasil e o uso de esp\u00e9cies vegetais como tratamento alternativo e complementar \u00e0 soroterapia","volume":"4","year":"2015","journal-title":"Sci. Amazon"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5748256","DOI":"10.1155\/2017\/5748256","article-title":"Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence","volume":"2017","author":"Zucolotto","year":"2017","journal-title":"Evid.-Based Complement. Alternat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3831\/KPI.2017.20.020","article-title":"A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants","volume":"20","author":"Shrivastava","year":"2017","journal-title":"J. Pharmacopunct."},{"key":"ref_15","first-page":"97","article-title":"Efic\u00e1cia da esp\u00e9cie vegetal Peltodon radicans (Labiatae, Lameaceae) na neutraliza\u00e7\u00e3o da atividade edematog\u00eanica e inefic\u00e1cia do extrato vegetal Espec\u00edfico Pessoa na neutraliza\u00e7\u00e3o das principais atividades do veneno de Bothrops atrox","volume":"1","author":"Borges","year":"1996","journal-title":"Rev. Univ. Amaz."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1590\/S1678-91992010000300014","article-title":"Low-level laser therapy decreases local effects induced by myotoxins isolated from Bothrops jararacussu snake venom","volume":"16","author":"Barbosa","year":"2010","journal-title":"J. Venom. Anim. Toxins Trop. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/lsm.10237","article-title":"Effects of the Ga-As laser irradiation on myonecrosis caused by Bothrops moojeni snake venom","volume":"33","author":"Dourado","year":"2003","journal-title":"Lasers Surg. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S0196-0644(05)80649-3","article-title":"Effects of constriction bands on rattlesnake venom absorption: A pharmacokinetic study","volume":"21","author":"Burgess","year":"1992","journal-title":"Ann. Emerg. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(79)90580-4","article-title":"Rationalisation of first-aid measures for elapid snakebite","volume":"313","author":"Sutherland","year":"1979","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0196-0644(88)80118-5","article-title":"Electric shock does not save snakebitten rats","volume":"17","author":"Howe","year":"1988","journal-title":"Ann. Emerg. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/php.12189","article-title":"Analgesic Effect of Light-Emitting Diode (LED) Therapy at Wavelengths of 635 and 945 nm on Bothrops moojeni Venom-Induced Hyperalgesia","volume":"90","author":"Zamuner","year":"2014","journal-title":"Photochem. Photobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.toxicon.2008.02.007","article-title":"Effect of low-level laser therapy in the inflammatory response induced by Bothrops jararacussu snake venom","volume":"51","author":"Barbosa","year":"2008","journal-title":"Toxicon"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1039\/c3pp50036e","article-title":"Effects of a low-level semiconductor gallium arsenide laser on local pathological alterations induced by Bothrops moojeni snake venom","volume":"12","author":"Bittencourt","year":"2013","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10103-011-0914-1","article-title":"Effects of photobiostimulation on edema and hemorrhage induced by Bothrops moojeni venom","volume":"27","author":"Barbosa","year":"2012","journal-title":"Lasers Med. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/2446-4740.04515","article-title":"Low-intensity laser therapy improves tetanic contractions in mouse anterior tibialis muscle injected with Bothrops jararaca snake venom","volume":"32","author":"Giaretta","year":"2016","journal-title":"Res. Biomed. Eng."},{"key":"ref_26","first-page":"97","article-title":"Low-level laser therapy reduces edema, leukocyte influx and hyperalgesia induced by Bothrops jararacussu snake venom","volume":"52","author":"Souza","year":"2011","journal-title":"Clin. Exp. Med. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1751-1097.2008.00397.x","article-title":"The Ability of Low Level Laser Therapy to Prevent Muscle Tissue Damage Induced by Snake Venom","volume":"85","author":"Baranauskas","year":"2009","journal-title":"Photochem. Photobiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Nadur-Andrade, N., Dale, C.S., Oliveira, V.R.D.S., Toniolo, E.F., Feliciano, R.D.S., da Silva, J.A., and Zamuner, S.R. (2016). Analgesic Effect of Photobiomodulation on Bothrops Moojeni Venom-Induced Hyperalgesia: A Mechanism Dependent on Neuronal Inhibition, Cytokines and Kinin Receptors Modulation. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004998"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1089\/pho.2008.2296","article-title":"Effect of Low-Level Laser Therapy in the Myonecrosis Induced by Bothrops jararacussu Snake Venom","volume":"27","author":"Barbosa","year":"2009","journal-title":"Photomed. Laser Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s10103-017-2252-4","article-title":"Effects of photobiomodulation therapy on Bothrops moojeni snake-envenomed gastrocnemius of mice using enzymatic biomarkers","volume":"32","author":"Dourado","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Vieira, W.F., Kenzo-Kagawa, B., Cogo, J.C., Baranauskas, V., and da Cruz-H\u00f6fling, M.A. (2016). Low-Level Laser Therapy (904 nm) Counteracts Motor Deficit of Mice Hind Limb following Skeletal Muscle Injury Caused by Snakebite-Mimicking Intramuscular Venom Injection. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158980"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1751-1097.2010.00878.x","article-title":"Low-level Laser Therapy Promotes Vascular Endothelial Growth Factor Receptor-1 Expression in Endothelial and Nonendothelial Cells of Mice Gastrocnemius Exposed to Snake Venom","volume":"87","author":"Dourado","year":"2011","journal-title":"Photochem. Photobiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1039\/c4pp00111g","article-title":"Photobiostimulation reduces edema formation induced in mice by Lys-49 phospholipases A2 isolated from Bothrops moojeni venom","volume":"13","author":"Dale","year":"2014","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_34","first-page":"423","article-title":"The effects of low-level laser on muscle damage caused by Bothrops neuwiedi venom","volume":"14","author":"Dourado","year":"2008","journal-title":"J. Venom. Anim. Toxins Trop. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jtcme.2017.10.001","article-title":"Rosemary leaves extract: Anti-snake action against Egyptian Cerastes cerastes venom","volume":"8","author":"Salama","year":"2018","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e6101742","DOI":"10.1155\/2016\/6101742","article-title":"Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom","volume":"2016","author":"Gomes","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Tribuiani, N., da Silva, A.M., Ferraz, M.C., Silva, M.G., Bentes, A.P.G., Graziano, T.S., dos Santos, M.G., Cogo, J.C., Varanda, E.A., and Groppo, F.C. (2014). Vellozia flavicans Mart. ex Schult. hydroalcoholic extract inhibits the neuromuscular blockade induced by Bothrops jararacussu venom. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-48"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4103\/ijp.IJP_708_16","article-title":"Antitoxin activity of aqueous extract of Cyclea peltata root against Naja naja venom","volume":"49","author":"Sivaraman","year":"2017","journal-title":"Indian J. Pharmacol."},{"key":"ref_39","first-page":"e820761","article-title":"Abarema cochliacarpos Extract Decreases the Inflammatory Process and Skeletal Muscle Injury Induced by Bothrops leucurus Venom","volume":"2014","author":"Santos","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_40","first-page":"4495","article-title":"Small Incisions Combined with Negative-Pressure Wound Therapy for Treatment of Protobothrops mucrosquamatus Bite Envenomation: A New Treatment Strategy","volume":"25","author":"Zeng","year":"2019","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_41","first-page":"e408068","article-title":"Inhibitory Effect of Plant Manilkara subsericea against Biological Activities of Lachesis muta Snake Venom","volume":"2014","author":"Fernandes","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0196-0644(95)70296-2","article-title":"Therapy of Brown Spider Envenomation: A Controlled Trial of Hyperbaric Oxygen, Dapsone, and Cyproheptadine","volume":"25","author":"Phillips","year":"1995","journal-title":"Ann. Emerg. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.jaci.2009.03.017","article-title":"Venom immunotherapy reduces large local reactions to insect stings","volume":"123","author":"Golden","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.trstmh.2003.12.009","article-title":"Failure of chloramphenicol prophylaxis to reduce the frequency of abscess formation as a complication of envenoming by Bothrops snakes in Brazil: A double-blind randomized controlled trial","volume":"98","author":"Jorge","year":"2004","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0035-9203(87)90150-7","article-title":"The efficacy of tourniquets as a first-aid measure for Russell\u2019s viper bites in Burma","volume":"81","author":"Warrell","year":"1987","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.toxicon.2006.11.002","article-title":"Study of the efficacy of the black stone on envenomation by snake bite in the murine model","volume":"49","author":"Chippaux","year":"2007","journal-title":"Toxicon"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0041-0101(97)00132-3","article-title":"Tourniquet ineffectiveness to reduce the severity of envenoming after Crotalus durissus snake bite in Belo Horizonte, Minas Gerais, Brazil","volume":"36","author":"Amaral","year":"1998","journal-title":"Toxicon"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4103\/0971-6580.172287","article-title":"A Multidisciplinary Approach with Hyperbaric Oxygen Therapy Improve Outcome in Snake Bite Injuries","volume":"22","author":"Korambayil","year":"2015","journal-title":"Toxicol. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1177\/0960327114551394","article-title":"A randomized trial comparing intravenous paracetamol, topical lidocaine, and ice application for treatment of pain associated with scorpion stings","volume":"34","author":"Aksel","year":"2015","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"625","DOI":"10.5694\/j.1326-5377.1989.tb139632.x","article-title":"Cold packs: Effective topical analgesia in the treatment of painful stings by Physalia and other jellyfish","volume":"151","author":"Exton","year":"1989","journal-title":"Med. J. Aust."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1053\/ajem.2002.35710","article-title":"A randomized paired comparison trial of cutaneous treatments for acute jellyfish (Carybdea alata) stings","volume":"20","author":"Nomura","year":"2002","journal-title":"Am. J. Emerg. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1080\/15563650802084821","article-title":"Comparisons of ice packs, hot water immersion, and analgesia injection for the treatment of centipede envenomations in Taiwan","volume":"47","author":"Chaou","year":"2009","journal-title":"Clin. Toxicol."},{"key":"ref_53","first-page":"127","article-title":"Clinical, epidemiological and treatment aspects of five cases of sea urchin envenomation in Adicora, Paraguan\u00e1 peninsula, Falc\u00f3n state, Venezuela","volume":"50","author":"Cazorla","year":"2010","journal-title":"Bol. Malariol. Salud Ambient."},{"key":"ref_54","first-page":"82","article-title":"GRADE System: Classification of Quality of Evidence and Strength of Recommendation","volume":"92","year":"2014","journal-title":"Cir. Esp."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.toxicon.2018.07.006","article-title":"Photobiomodulation therapy on Bothrops snake venom-induced local pathological effects: A systematic review","volume":"152","author":"Silva","year":"2018","journal-title":"Toxicon"},{"key":"ref_56","first-page":"17","article-title":"Snake Envenomation Incidence, Clinical Presentation and Management","volume":"4","author":"Nelson","year":"1989","journal-title":"Med. Toxicol. Advers. Drug Exp."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"29867","DOI":"10.1016\/S0021-9258(18)43961-0","article-title":"Neutralizing interaction between heparins and myotoxin II, a lysine 49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling","volume":"269","author":"Lomonte","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10103-006-0423-9","article-title":"An in-vivo experimental evaluation of He\u2013Ne laser photostimulation in healing Achilles tendons","volume":"22","author":"Elwakil","year":"2007","journal-title":"Lasers Med. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Feitosa, E.L., Sampaio, V.S., Salinas, J.L., Queiroz, A.M., da Silva, I.M., Gomes, A.A., Sachett, J., Siqueira, A.M., Ferreira, L.C.L., and dos Santos, M.C. (2015). Older Age and Time to Medical Assistance Are Associated with Severity and Mortality of Snakebites in the Brazilian Amazon: A Case-Control Study. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132237"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5603\/IMH.2019.0004","article-title":"Toxic jellyfish in Thailand","volume":"70","author":"Premmaneesakul","year":"2019","journal-title":"Int. Marit. Health"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/ACI.0000000000000289","article-title":"Large local reactions to insect envenomation","volume":"16","author":"Carlson","year":"2016","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.toxicon.2018.08.007","article-title":"Venomous caterpillars: From inoculation apparatus to venom composition and envenomation","volume":"153","author":"Tambourgi","year":"2018","journal-title":"Toxicon"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.ctsap.2006.10.002","article-title":"Hymenoptera Stings","volume":"21","author":"Fitzgerald","year":"2006","journal-title":"Clin. Tech. Small Anim. Pract."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00006205-199206000-00013","article-title":"Prevention and Primary Care Treatment of Stings from Imported Fire Ants","volume":"17","author":"Hibel","year":"1992","journal-title":"Nurse Pract."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s00508-017-1217-8","article-title":"Yellow sac spider (Cheiracanthium punctorium) bites in Slovenia: Case series and review","volume":"129","author":"Varl","year":"2017","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1177\/014556130408300712","article-title":"Brown Recluse Spider Bites to the Head: Three Cases and a Review","volume":"83","author":"Leach","year":"2004","journal-title":"Ear Nose Throat J."},{"key":"ref_67","unstructured":"da Sa\u00fade, M., and de Vigil\u00e2ncia em Sa\u00fade, S. (2021). Guia de Vigil\u00e2ncia em Sa\u00fade, Departamento de Articula\u00e7\u00e3o Estrat\u00e9gica de Vigil\u00e2ncia em Sa\u00fade. [5th ed.]."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF03259994","article-title":"Acute Arthropod Envenomation: Incidence, Clinical Features and Management","volume":"4","author":"Binder","year":"1989","journal-title":"Med. Toxicol. Advers. Drug Exp."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.toxicon.2009.04.015","article-title":"Local envenoming by the Western hognose snake (Heterodon nasicus): A case report and review of medically significant Heterodon bites","volume":"54","author":"Weinstein","year":"2009","journal-title":"Toxicon"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Sachett, J.A.G., da Silva, I.M., Alves, E.C., Oliveira, S.S., Sampaio, V.S., do Vale, F.F., Romero, G.A.S., dos Santos, M.C., Marques, H.O., and Colombini, M. (2017). Poor efficacy of preemptive amoxicillin clavulanate for preventing secondary infection from Bothrops snakebites in the Brazilian Amazon: A randomized controlled clinical trial. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005745"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.2174\/138161207782023784","article-title":"Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations","volume":"13","author":"Gutierrez","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Maciel Salazar, G.K., Saturnino Cristino, J., Vilhena Silva-Neto, A., Seabra Farias, A., Alc\u00e2ntara, J.A., Azevedo Machado, V., Murta, F., Souza Sampaio, V., Val, F., and Sachett, A. (2021). Snakebites in \u201cInvisible Populations\u201d: A cross-sectional survey in riverine populations in the remote western Brazilian Amazon. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009758"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2684108","DOI":"10.1155\/2019\/2684108","article-title":"Wound Healing and the Use of Medicinal Plants","volume":"2019","author":"Shedoeva","year":"2019","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1089\/pho.2005.23.78","article-title":"Laser (and LED) Therapy Is Phototherapy","volume":"23","author":"Smith","year":"2005","journal-title":"Photomed. Laser Surg."},{"key":"ref_75","first-page":"1071","article-title":"The Effects of Low Level Laser Therapy on the Expression of Collagen Type I Gene and Proliferation of Human Gingival Fibroblasts (Hgf3-Pi 53): In vitro Study","volume":"16","author":"Frozanfar","year":"2013","journal-title":"Iran J. Basic Med. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Silva, L.M.G., da Silva, C.A.A., da Silva, A., Vieira, R.P., Mesquita-Ferrari, R.A., Cogo, J.C., and Zamuner, S.R. (2016). Photobiomodulation Protects and Promotes Differentiation of C2C12 Myoblast Cells Exposed to Snake Venom. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152890"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s10103-019-02884-4","article-title":"Photobiomodulation reduces cell death and cytokine production in C2C12 cells exposed to Bothrops venoms","volume":"35","author":"Gouveia","year":"2020","journal-title":"Lasers Med. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1590\/bjpt-rbf.2014.0046","article-title":"Effect of low-level laser therapy on the modulation of the mitochondrial activity of macrophages","volume":"18","author":"Souza","year":"2014","journal-title":"Braz. J. Phys. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3844\/ajptsp.2012.141.148","article-title":"Influence of a low-level semiconductor gallium arsenate laser in experimental envenomation induced by Bothrops atrox snake venom","volume":"7","author":"Bittencourt","year":"2012","journal-title":"Am. J. Pharmacol. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s42600-021-00184-x","article-title":"The use of ozone therapy and photobiomodulation therapy to treat local effects of Bothrops jararacussu snake venom","volume":"37","author":"David","year":"2021","journal-title":"Res. Biomed. Eng."}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/15\/5\/313\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:25:55Z","timestamp":1760124355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/15\/5\/313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":80,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["toxins15050313"],"URL":"https:\/\/doi.org\/10.3390\/toxins15050313","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,28]]}}}