{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:24:56Z","timestamp":1780943096836,"version":"3.54.1"},"reference-count":78,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Innovation and Technology","award":["GINOP-2.3.2-15-2016-00046"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00046"]}]},{"name":"Ministry of Innovation and Technology","award":["EFOP-3.6.3-VEKOP-16-2017-00005"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00005"]}]},{"name":"Ministry of Innovation and Technology","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}]},{"name":"Ministry of Human Resources","award":["GINOP-2.3.2-15-2016-00046"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00046"]}]},{"name":"Ministry of Human Resources","award":["EFOP-3.6.3-VEKOP-16-2017-00005"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00005"]}]},{"name":"Ministry of Human Resources","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}]},{"name":"ELKH office for Supported Research Groups","award":["GINOP-2.3.2-15-2016-00046"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00046"]}]},{"name":"ELKH office for Supported Research Groups","award":["EFOP-3.6.3-VEKOP-16-2017-00005"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00005"]}]},{"name":"ELKH office for Supported Research Groups","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}]},{"name":"Hungarian National Laboratory Project","award":["GINOP-2.3.2-15-2016-00046"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00046"]}]},{"name":"Hungarian National Laboratory Project","award":["EFOP-3.6.3-VEKOP-16-2017-00005"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00005"]}]},{"name":"Hungarian National Laboratory Project","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>This study investigated effects of dietary fumonisins (FBs) on gut and faecal microbiota of weaned pigs. In total, 18 7-week-old male pigs were fed either 0, 15 or 30 mg FBs (FB1 + FB2 + FB3)\/kg diet for 21 days. The microbiota was analysed with amplicon sequencing of the 16S rRNA gene V3-V4 regions (Illumina MiSeq). Results showed no treatment effect (p &gt; 0.05) on growth performance, serum reduced glutathione, glutathione peroxidase and malondialdehyde. FBs increased serum aspartate transaminase, gamma glutamyl-transferase and alkaline phosphatase activities. A 30 mg\/kg FBs treatment shifted microbial population in the duodenum and ileum to lower levels (compared to control (p &lt; 0.05)) of the families Campylobacteraceae and Clostridiaceae, respectively, as well as the genera Alloprevotella, Campylobacter and Lachnospiraceae Incertae Sedis (duodenum), Turicibacter (jejunum), and Clostridium sensu stricto 1 (ileum). Faecal microbiota had higher levels of the Erysipelotrichaceae and Ruminococcaceae families and Solobacterium, Faecalibacterium, Anaerofilum, Ruminococcus, Subdoligranulum, Pseudobutyrivibrio, Coprococcus and Roseburia genera in the 30 mg\/kg FBs compared to control and\/or to the 15 mg\/kg FBs diets. Lactobacillus was more abundant in the duodenum compared to faeces in all treatment groups (p &lt; 0.01). Overall, the 30 mg\/kg FBs diet altered the pig gut microbiota without suppressing animal growth performance.<\/jats:p>","DOI":"10.3390\/toxins15050328","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T04:29:01Z","timestamp":1683779341000},"page":"328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Gut-Faecal Microbial and Health-Marker Response to Dietary Fumonisins in Weaned Pigs"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-8915","authenticated-orcid":false,"given":"Yarsmin Yunus","family":"Zeebone","sequence":"first","affiliation":[{"name":"Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"},{"name":"ELKH-MATE Mycotoxins in the Food Chain Research Group, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitta","family":"B\u00f3ta","sequence":"additional","affiliation":[{"name":"ELKH-MATE Mycotoxins in the Food Chain Research Group, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0729-3769","authenticated-orcid":false,"given":"Veronika","family":"Halas","sequence":"additional","affiliation":[{"name":"Department of Farm Animal Nutrition, Institute of Animal Physiology and Nutrition, Kaposv\u00e1r Campus, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Libisch","sequence":"additional","affiliation":[{"name":"Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Gy\u00f6rgyi. Str., H-2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-6605","authenticated-orcid":false,"given":"Ferenc","family":"Olasz","sequence":"additional","affiliation":[{"name":"Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Gy\u00f6rgyi. Str., H-2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Papp","sequence":"additional","affiliation":[{"name":"Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Gy\u00f6rgyi. Str., H-2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Kereszt\u00e9ny","sequence":"additional","affiliation":[{"name":"Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Gy\u00f6rgyi. Str., H-2100 G\u00f6d\u00f6ll\u0151, Hungary"},{"name":"Doctoral School of Biology, Hungarian University of Agriculture and Life Sciences, H-2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8366-9036","authenticated-orcid":false,"given":"Annam\u00e1ria","family":"Ger\u0151cs","sequence":"additional","affiliation":[{"name":"Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Gy\u00f6rgyi. Str., H-2100 G\u00f6d\u00f6ll\u0151, Hungary"},{"name":"Doctoral School of Biology, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University, H-1117 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-0161","authenticated-orcid":false,"given":"Omeralfaroug","family":"Ali","sequence":"additional","affiliation":[{"name":"Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"},{"name":"ELKH-MATE Mycotoxins in the Food Chain Research Group, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"},{"name":"ELKH-MATE Mycotoxins in the Food Chain Research Group, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-0024","authenticated-orcid":false,"given":"Andr\u00e1s","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"},{"name":"ELKH-MATE Mycotoxins in the Food Chain Research Group, Hungarian University of Agriculture and Life Sciences, Guba S. Str., H-7400 Kaposv\u00e1r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"ref_1","first-page":"103","article-title":"Fumonisins","volume":"Volume 47","author":"Bolger","year":"2001","journal-title":"Safety Evaluation of Certain Mycotoxins in Food"},{"key":"ref_2","first-page":"325","article-title":"Fumonisins (Addendum)","volume":"65","author":"Bulder","year":"2012","journal-title":"Saf. Eval. Certain Food Addit. 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