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Malaria is an important global public health problem due to its high rates of morbidity and mortality. At present, drug therapies and vector control with insecticides are respectively the most commonly used methods for the treatment and control of malaria. However, several studies have shown the resistance of Plasmodium to drugs that are recommended for the treatment of malaria. In view of this, it is necessary to carry out studies to discover new antimalarial molecules as lead compounds for the development of new medicines. In this sense, in the last few decades, animal venoms have attracted attention as a potential source for new antimalarial molecules. Therefore, the aim of this review was to summarize animal venom toxins with antimalarial activity found in the literature. From this research, 50 isolated substances, 4 venom fractions and 7 venom extracts from animals such as anurans, spiders, scorpions, snakes, and bees were identified. These toxins act as inhibitors at different key points in the biological cycle of Plasmodium and may be important in the context of the resistance of Plasmodium to currently available antimalarial drugs.<\/jats:p>","DOI":"10.3390\/toxins15060375","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T02:18:29Z","timestamp":1685931509000},"page":"375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Toxins from Animal Venoms as a Potential Source of Antimalarials: A Comprehensive Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-8728","authenticated-orcid":false,"given":"Zeca M.","family":"Salimo","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil"},{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil"},{"name":"Grupo de Pesquisa em Metabol\u00f4mica e Espectrometria de Massas, Universidade do Estado do Amazonas, Manaus 69065-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9804-4188","authenticated-orcid":false,"given":"Andr\u00e9 L.","family":"Barros","sequence":"additional","affiliation":[{"name":"Setor de Medicina Veterin\u00e1ria, Universidade Nilton Lins, Manaus 69058-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asenate A. 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