{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:17:55Z","timestamp":1790626675053,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260627"],"award-info":[{"award-number":["32260627"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022QB-078"],"award-info":[{"award-number":["2022QB-078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universities of Gansu Province Foundation for Young doctor","award":["32260627"],"award-info":[{"award-number":["32260627"]}]},{"name":"Universities of Gansu Province Foundation for Young doctor","award":["2022QB-078"],"award-info":[{"award-number":["2022QB-078"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The jujube is one of the most popular fruits in China because of its delicious taste and high nutritional value. It has a long history of usage as an important food or traditional medicine. However, the jujube is easily infected by fungi, which causes economic losses and threatens human health. When the jujube was infected by Aspergillus niger (H1), the changes in nutritional qualities were determined, such as the content of total acid, vitamin C, reducing sugar, etc. In addition, the ability of A. niger (H1) to produce ochratoxin A (OTA) in different inoculation times and culture media was evaluated, and the content of OTA in jujubes was also analyzed. After jujubes were infected by A. niger (H1), the total acid, and vitamin C contents increased, while the total phenol content decreased, and the reducing sugar content increased after an initial decrease. Although A. niger (H1) infection caused the jujubes to rot and affected its quality, OTA had not been detected. This research provides a theoretical foundation for maximizing edible safety and evaluating the losses caused by fungal disease in jujubes.<\/jats:p>","DOI":"10.3390\/toxins15070406","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T03:18:38Z","timestamp":1687317518000},"page":"406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Aspergillus niger Infection on the Quality of Jujube and Ochratoxin A Cumulative Effect"],"prefix":"10.3390","volume":"15","author":[{"given":"Xueyan","family":"Xin","sequence":"first","affiliation":[{"name":"College of Science, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Nan","sequence":"additional","affiliation":[{"name":"College of Science, Gansu Agricultural University, Lanzhou 730070, China"},{"name":"Basic Experiment Teaching Center, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bi","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Science, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Basic Experiment Teaching Center, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Science, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Science, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1038\/ncomms6315","article-title":"The complex jujube genome provides insights into fruit tree biology","volume":"5","author":"Liu","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.ijbiomac.2020.02.018","article-title":"Comparison of structural characterization and antioxidant activity of polysaccharides from jujube (Ziziphus jujuba Mill.) fruit","volume":"2020","author":"Ji","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_3","first-page":"1683","article-title":"Historical achievements and frontier advances in the production and research of Chinese jujube (Ziziphus jujuba Mill.) in China","volume":"42","author":"Liu","year":"2015","journal-title":"Acta Hortic. Sin."},{"key":"ref_4","first-page":"1369","article-title":"Fruit scientific research in new China in the past 70 years: Chinese jujube","volume":"36","author":"Liu","year":"2019","journal-title":"J. Fruit Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.17660\/ActaHortic.2009.840.80","article-title":"Sensory evaluation of different products of Ziziphus Jujuba Mill","volume":"2009","author":"Krska","year":"2009","journal-title":"Acta Hortic."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41438-020-00346-5","article-title":"The historical and current research progress on jujube\u2013a superfruit for the future","volume":"7","author":"Liu","year":"2020","journal-title":"Hortic. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/14786410701192827","article-title":"Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen","volume":"21","author":"Jiang","year":"2007","journal-title":"Ziziphus jujube. Nat. Prod. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1002\/jssc.201400499","article-title":"Multiresidue analysis of 16 pesticides in jujube using gas chromatography and mass spectrometry with multiwalled carbon nanotubes as a sorbent","volume":"37","author":"Zhao","year":"2014","journal-title":"J. Sep. Sci."},{"key":"ref_9","first-page":"e190015","article-title":"Genetic improvement of Chinese jujube for disease resistances: Status, knowledge gaps and research needs","volume":"1","author":"Song","year":"2019","journal-title":"Crop Breed. Genet. Genom."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1080\/13693780600921037","article-title":"Aspergillus niger genomics: Past, present and into the future","volume":"44","author":"Baker","year":"2006","journal-title":"Med. Mycol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s42770-020-00390-2","article-title":"Molecular analysis of Aspergillus section Nigri isolated from onion samples reveals the prevalence of A. welwitschia","volume":"52","author":"Massi","year":"2020","journal-title":"Braz. J. Microbiol."},{"key":"ref_12","unstructured":"Chen, Y. (2020). Nitric Oxide Fumigation on Disease Inhibition and Mycotoxin Removal in Dried Fruit During Storage. [Ph.D. Thesis, Xinjiang University]."},{"key":"ref_13","first-page":"87","article-title":"Investigation on main fungal diseases of maoye jujube in Yunnan Province","volume":"32","author":"Zhang","year":"2006","journal-title":"Plant Prot."},{"key":"ref_14","first-page":"5","article-title":"Study on bioloy of Yuancui jujube after harvest infected by Aspergillus niger TL-10 and its control","volume":"35","author":"Guo","year":"2015","journal-title":"China Plant Prot."},{"key":"ref_15","first-page":"297","article-title":"Nitric oxide fumigation inhibiting Apgliluss niger disease and maintaining storage quality of dried ash jujube","volume":"35","author":"Chen","year":"2019","journal-title":"Trans. Chin. Soc. Agric. Eng."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"107230","DOI":"10.1016\/j.foodcont.2020.107230","article-title":"Ochratoxin-Characteristics, influences and challenges of global research","volume":"114","author":"Klingelhofer","year":"2020","journal-title":"Food Control"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Nan, M.N., Xue, H.L., and Bi, Y. (2022). Contamination, Detection and Control of Mycotoxins in Fruits and Vegetables. Toxins, 14.","DOI":"10.3390\/toxins14050309"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1021\/jf011015z","article-title":"Fungal flora and ochratoxin A production in grapes and musts from France","volume":"50","author":"Sage","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_19","first-page":"5","article-title":"Ochratoxin A in dried figs, raisings, apricots, dates on Iranian retail market","volume":"2013","author":"Rahimi","year":"2013","journal-title":"Health"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1080\/02652030500260447","article-title":"Incidence of toxigenic fungi and ochratoxin A in dried fruits sold in Brazil","volume":"22","author":"Iamanaka","year":"2005","journal-title":"Food Addit. Contam."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.foodcont.2014.11.033","article-title":"Survey of mycotoxins in dates and dried fruits from Tunisian and Spanish markets","volume":"51","author":"Azaiez","year":"2015","journal-title":"Food Control"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1080\/19440049.2014.976844","article-title":"Ochratoxin A in Chinese dried jujube: Method development and survey","volume":"32","author":"Zhang","year":"2015","journal-title":"Food. Addit. Contam. Part A"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"110708","DOI":"10.1016\/j.scienta.2021.110708","article-title":"Inhibition effect of Aspergillus niger and quality preservation of apple by in-package sterilization medium flow of circulating","volume":"293","author":"Zheng","year":"2022","journal-title":"Sci. Hortic."},{"key":"ref_24","first-page":"5","article-title":"Study on the Wound Pahogenciy of Aspergills niger and lts Antonistic Bacteria Sreening of Postharvest Red Globe Grapes at Room Tmperature","volume":"41","author":"Li","year":"2020","journal-title":"Food Res. Dev."},{"key":"ref_25","first-page":"173","article-title":"Influence of arbuscular mycorrhizal fungi on soil structure and aggregate stability of a vertisol","volume":"218","author":"Birgitte","year":"2000","journal-title":"Plant. Soil."},{"key":"ref_26","first-page":"89","article-title":"Effect of Gaseous H2S Fumigation on Aspergillusnige Inhibition and Posthar-vest Quality of Table Grape","volume":"34","author":"Zhang","year":"2018","journal-title":"Mod. Food Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00217-007-0620-1","article-title":"Characterization of water soluble polysaccharides from organs of Chinese Jujube (Ziziphus jujuba Mill. cv. Dongzao)","volume":"226","author":"Zhao","year":"2008","journal-title":"Eur. Food Res. Technol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s11738-014-1559-z","article-title":"The role of sugar signaling in plant defense responses against fungal pathogens","volume":"36","author":"Morkunas","year":"2014","journal-title":"Acta Physiol. Plant."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wang, S.S., Han, Y.H., Chen, J.L., Zhang, D.C., Shi, X.X., Ye, Y.X., Chen, D.L., and Li, M. (2018). Insights into Bacterial Cellulose Biosynthesis from Different Carbon Sources and the Associated Biochemical Transformation Pathways in Komagataeibacter sp W1. Polymers, 10.","DOI":"10.3390\/polym10090963"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"25627","DOI":"10.1016\/j.foodchem.2019.125627","article-title":"Effects of chitosan treatment on the storability and quality properties of longan fruit during storage","volume":"306","author":"Lin","year":"2020","journal-title":"Food Chem."},{"key":"ref_31","first-page":"77","article-title":"Effects of symbiotic fungi on fruit quality and soil characteristics of Lane Late navel orange","volume":"41","author":"Lei","year":"2022","journal-title":"J. Huazhong Agric. Univ."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wei, S., Hu, C.J., Nie, P., Zhai, H.C., Zhang, S.B., Li, N., Lv, Y.Y., and Hu, Y.S. (2022). Insights into the Underlying Mechanism of Ochratoxin A Production in Aspergillus niger CBS 513.88 Using Different Carbon Sources. Toxins, 14.","DOI":"10.3390\/toxins14080551"},{"key":"ref_33","first-page":"303","article-title":"Effects of Black Spot Disease on Nutritional Composition of Red Jujubes Grown in Xinjiang","volume":"41","author":"Fan","year":"2020","journal-title":"Food Sci."},{"key":"ref_34","first-page":"177","article-title":"Change of Disease Related Sub-stances Content in Branches During the Process of Valsa ceratosperma","volume":"31","author":"Liu","year":"2015","journal-title":"Chin. Agric. Sci. Bull."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"(2009). The Physiological and Molecular [w] Responses of Arabidopsis thaliana to the Stress of Oxalic Acid. Agric. Sci. China, 8, 828\u2013834.","DOI":"10.1016\/S1671-2927(08)60284-9"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hua, S.H., Hsu, H.C., and Han, P. (2019). Development of Detection System with Low Predictive Errors for Determining Vitamin C Content of Indian Jujube. Appl. Sci., 9.","DOI":"10.3390\/app9245317"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1034\/j.1399-3054.2001.1110210.x","article-title":"Ascorbic acid metabolism during white spruce somatic embryo maturation and germination","volume":"111","author":"Claudio","year":"2001","journal-title":"Physiol. Plant."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0031-9422(02)00367-9","article-title":"Gene expression of ascorbic acid-related enzymes in tobacco","volume":"61","author":"Tabata","year":"2002","journal-title":"Phytochemistry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s002530051628","article-title":"Perspectives in the biological function and the technological application of polygalacturonases","volume":"53","author":"Lang","year":"2000","journal-title":"Appl. Microbiol. Biot."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"935991","DOI":"10.3389\/fnut.2022.935991","article-title":"Vitamin C Intake and Ischemic Stroke","volume":"9","author":"Tang","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_41","unstructured":"Xu, W.Y. (2020). Effect of Umbelliferone Tteatment on Fruit Quality and Disease Resistance of \u201cXuXiang\u201d Kiwifrutt. [Master\u2019s Thesis, Zhejiang Gongshang University]."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/s41598-018-19363-5","article-title":"Melatonin increases chilling tolerance in postharvest peach fruit by alleviating oxidative damage","volume":"8","author":"Cao","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s13197-017-3013-x","article-title":"Kinetic modeling of non-enzymatic browning and changes of physio-chemical parameters of peach juice during storage","volume":"55","author":"Liu","year":"2018","journal-title":"J. Food. Sci. Technol."},{"key":"ref_44","first-page":"53","article-title":"Effects of solid fermentation of Aspergillus, yeast and lactic acid bacteria on antioxidant activity of polyphenols and flavonoids in Figure","volume":"36","author":"Liao","year":"2023","journal-title":"Southwest China J. Agric. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1007\/s11947-011-0582-y","article-title":"Polyphenolic antioxidant mobilization in apple pomace by different methods of solid-state fermentation and evaluation of its antioxidant activity","volume":"5","author":"Ajila","year":"2012","journal-title":"Food Bioprocess. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.scienta.2018.09.039","article-title":"Effect of carnauba wax-based coating containing glycerol monolaurate on the quality maintenance and shelf-life of Indian jujube (Zizyphus mauritiana Lamk.) fruit during storage","volume":"244","author":"Chen","year":"2019","journal-title":"Sci. Hortic."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.foodchem.2012.10.087","article-title":"Structure and antioxidant activity of \u03b2-lactoglobulin-glycoconjugates obtained by high-intensity-ultrasound-induced Maillard reaction in aqueous model systems under neutral conditions","volume":"138","author":"Prodic","year":"2013","journal-title":"Food Chem."},{"key":"ref_48","unstructured":"Tian, Y. (2020). Effect of Aspergillus niger on Southern-Route Tea Quality during Fermentation. [Bachelor\u2019s Thesis, Sichuan Agricultural University]."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.foodchem.2011.01.078","article-title":"Enzymatic treatment to improve the quality of black tea extracts","volume":"127","author":"Chandini","year":"2011","journal-title":"Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1007\/s10529-008-9819-x","article-title":"Antifungal mechanism of antibacterial peptide, ABP-CM4, from Bombyx mori against Aspergillus niger","volume":"30","author":"Zhang","year":"2008","journal-title":"Biotechnol. Lett."},{"key":"ref_51","first-page":"433","article-title":"An ochratoxigenic strain of Aspergillus niger and its ochratoxin A production conditions","volume":"36","author":"Zhang","year":"2017","journal-title":"Mycosystema"},{"key":"ref_52","first-page":"4","article-title":"Study on the isolation of Aspergilus carbonarius and ochratoxin A production from wine grape","volume":"144","author":"He","year":"2009","journal-title":"Sino-Overseas Grapevine Wine"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.fm.2005.09.007","article-title":"Ochratoxin A-producing fungi from grapes intended for liqueur wine production","volume":"23","author":"Bragulat","year":"2006","journal-title":"Food Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.1021\/jf025747i","article-title":"Biodegradation of ochratoxin A by fungi isolated from grapes","volume":"50","author":"Abrunhosa","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1605(00)00230-0","article-title":"Degradation of ochratoxin A by Aspergillus species","volume":"59","author":"Varga","year":"2000","journal-title":"Int. J. Food Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1574-6968.2005.00073.x","article-title":"Biodegradation of ochratoxin A by Aspergillus section Nigri species isolated from French grapes: A potential means of ochratoxin A decontamination in grape juices and musts","volume":"255","author":"Bejaoui","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"M137","DOI":"10.1111\/1750-3841.12724","article-title":"Combination of UV-C Treatment and Metschnikowia pulcherrimas for Controlling Alternaria Rot in Postharvest Winter Jujube Fruit","volume":"80","author":"Guo","year":"2015","journal-title":"J. Food Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Nan, M.N., Bi, Y., Xue, H.L., Xue, S.L., Long, H.T., Pu, L.M., and Fu, G.R. (2019). Rapid determination of ochratoxin A in grape and its commodities based on a label-free impedimetric aptasensor constructed by layer-by-layer self-assembly. Toxins, 11.","DOI":"10.3390\/toxins11020071"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s13197-022-05358-8","article-title":"Investigation on the effect of thermal sterilization versus non-thermal sterilization on the quality parameters of jujube juice fermented by Lactobacillus plantarum","volume":"59","author":"Zhang","year":"2022","journal-title":"J. Food Sci. Technol."},{"key":"ref_60","first-page":"840","article-title":"Study on the antioxidants and total phenol content of optimally selected jujube cultivars","volume":"2009","author":"Liu","year":"2009","journal-title":"Acta Hortic."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"fyac008","DOI":"10.1093\/fqsafe\/fyac008","article-title":"Arginine induces the resistance of postharvest jujube fruit against Alternaria rot","volume":"6","author":"Chang","year":"2022","journal-title":"Food Qual. Saf."}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/15\/7\/406\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:57:44Z","timestamp":1760126264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/15\/7\/406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":61,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["toxins15070406"],"URL":"https:\/\/doi.org\/10.3390\/toxins15070406","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]}}}