{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:06:38Z","timestamp":1793239598409,"version":"4.5.0"},"reference-count":130,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Ministry of Research, Development and Innovation, developed with the support of UEFISCDI","doi-asserted-by":"publisher","award":["14 PFE-2022-2024"],"award-info":[{"award-number":["14 PFE-2022-2024"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>In recent years, more scientific data have pointed out the close connection between intestinal microbial community, nutritional habits, lifestyle, and the appearance of various affections located at certain anatomical systems. Gut dysbiosis enhances the formation and accumulation of specific metabolites with toxic potential that induce the appearance of kidney-associated illnesses. Intestinal microbes are involved in the degradation of food, drugs, or other ingested products that lead to the formation of various metabolites that end up in renal tissue. Over the last few years, the possibilities of modulating the gut microbiota for the biosynthesis of targeted compounds with bioactive properties for reducing the risk of chronic illness development were investigated. In this regard, the present narrative review provides an overview of the scientific literature across the last decade considering the relationship between bioactive compounds, pre-, pro-, and post-biotics, uremic toxicity, and kidney-associated affections, and the possibility of alleviating the accumulation and the negative effects of uremic toxins into the renal system.<\/jats:p>","DOI":"10.3390\/toxins15090548","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T10:24:30Z","timestamp":1693823070000},"page":"548","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5232-7978","authenticated-orcid":false,"given":"Laura","family":"Mitrea","sequence":"first","affiliation":[{"name":"Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"},{"name":"Life Science Institute, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-9632","authenticated-orcid":false,"given":"M\u0103d\u0103lina","family":"Medeleanu","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-3397","authenticated-orcid":false,"given":"Carmen-Rodica","family":"Pop","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4544-5754","authenticated-orcid":false,"given":"Ancu\u021ba-Mihaela","family":"Rotar","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5407-8071","authenticated-orcid":false,"given":"Dan-Cristian","family":"Vodnar","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"},{"name":"Life Science Institute, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.ajpath.2018.01.011","article-title":"Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor","volume":"188","author":"Alexeev","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Plamada, D., and Vodnar, D.C. (2022). Polyphenols\u2014Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics. Nutrients, 14.","DOI":"10.3390\/nu14010137"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1017\/S0007114519000680","article-title":"Gut Prevotella as a possible biomarker of diet and its eubiotic versus dysbiotic roles: A comprehensive literature review","volume":"122","author":"Precup","year":"2019","journal-title":"Br. J. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"C\u0103linoiu, L.F., and Vodnar, D.C. (2018). Whole Grains and Phenolic Acids: A Review on Bioactivity, Functionality, Health Benefits and Bioavailability. Nutrients, 10.","DOI":"10.3390\/nu10111615"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41581-019-0118-7","article-title":"Immunity, microbiota and kidney disease","volume":"15","author":"Knauf","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_7","unstructured":"Kopple, J.D., Massry, S.G., Kalantar-Zadeh, K., and Fouque, D. (2022). Nutritional Management of Renal Disease, Academic Press. [4th ed.]."},{"key":"ref_8","first-page":"2","article-title":"Wound Healing in Patients With Impaired Kidney Function","volume":"5","author":"Maroz","year":"2013","journal-title":"J. Am. Coll. Clin. Wound Spec."},{"key":"ref_9","unstructured":"Kimmel, P.L., and Rosenberg, M.E. (2020). Chronic Renal Disease, Academic Press. [2nd ed.]."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6651367","DOI":"10.1155\/2021\/6651367","article-title":"Uremic Toxins, Oxidative Stress, Atherosclerosis in Chronic Kidney Disease, and Kidney Transplantation","volume":"2021","author":"Wojtaszek","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_11","unstructured":"Alpern, R.J., Moe, O.W., and Caplan, M. (2013). Seldin and Giebisch\u2019s The Kidney, Academic Press. [5th ed.]."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"103545","DOI":"10.1016\/j.micpath.2019.103545","article-title":"Escherichia coli K12: An evolving opportunistic commensal gut microbe distorts barrier integrity in human intestinal cells","volume":"133","author":"Bhat","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s12602-019-09608-8","article-title":"Potential Probiotic Lactobacillus rhamnosus (MTCC-5897) Inhibits Escherichia coli Impaired Intestinal Barrier Function by Modulating the Host Tight Junction Gene Response","volume":"12","author":"Bhat","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Simon, E., C\u0103linoiu, L.F., Mitrea, L., and Vodnar, D.C. (2021). Probiotics, Prebiotics, and Synbiotics: Implications and Beneficial Effects against Irritable Bowel Syndrome. Nutrients, 13.","DOI":"10.3390\/nu13062112"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Usuda, H., Okamoto, T., and Wada, K. (2021). Leaky Gut: Effect of Dietary Fiber and Fats on Microbiome and Intestinal Barrier. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147613"},{"key":"ref_16","unstructured":"NIDDK (2022, July 01). National Institute on Diabetes and Digestive and Kidney Diseases, Available online: https:\/\/www.niddk.nih.gov\/health-information\/health-statistics\/kidney-disease."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"El Chamieh, C., Liabeuf, S., and Massy, Z. (2022). Uremic Toxins and Cardiovascular Risk in Chronic Kidney Disease: What Have We Learned Recently beyond the Past Findings?. Toxins, 14.","DOI":"10.3390\/toxins14040280"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"686249","DOI":"10.3389\/fphys.2021.686249","article-title":"Uremic Toxins: An Alarming Danger Concerning the Cardiovascular System","volume":"12","author":"Falconi","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00281-014-0416-x","article-title":"Hemolytic uremic syndrome","volume":"36","author":"Mele","year":"2014","journal-title":"Semin. Immunopathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1016\/j.lpm.2011.11.013","article-title":"Management of hemolytic uremic syndrome","volume":"41","author":"Loirat","year":"2012","journal-title":"La Presse M\u00e9dicale"},{"key":"ref_21","unstructured":"EUTox (2022, July 06). European Uremic Toxins Work Group. Available online: https:\/\/www.uremic-toxins.org\/."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e2127014","DOI":"10.1001\/jamanetworkopen.2021.27014","article-title":"Trends in Chronic Kidney Disease Care in the US by Race and Ethnicity, 2012\u20132019","volume":"4","author":"Chu","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1093\/ckj\/sfac056","article-title":"Probiotics for kidney disease","volume":"15","author":"Favero","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"850425","DOI":"10.3389\/fnut.2022.850425","article-title":"Probiotics, Prebiotics, and Synbiotics Improve Uremic, Inflammatory, and Gastrointestinal Symptoms in End-Stage Renal Disease With Dialysis: A Network Meta-Analysis of Randomized Controlled Trials","volume":"9","author":"Yu","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lim, Y.J., Sidor, N.A., Tonial, N.C., Che, A., and Urquhart, B.L. (2021). Uremic Toxins in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Mechanisms and Therapeutic Targets. Toxins, 13.","DOI":"10.3390\/toxins13020142"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/ckj\/sfab262","article-title":"The relationship between uremic toxins and symptoms in older men and women with advanced chronic kidney disease","volume":"15","author":"Massy","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"03000605211053276","DOI":"10.1177\/03000605211053276","article-title":"Association between gut dysbiosis and chronic kidney disease: A narrative review of the literature","volume":"49","author":"Feng","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"575559","DOI":"10.3389\/fcimb.2020.575559","article-title":"Coronavirus Disease (COVID-19) Caused by (SARS-CoV-2) Infections: A Real Challenge for Human Gut Microbiota","volume":"10","author":"Vodnar","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"813204","DOI":"10.3389\/fmed.2022.813204","article-title":"Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders","volume":"9","author":"Mitrea","year":"2022","journal-title":"Front. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41522-022-00280-5","article-title":"The microbiota-gut-kidney axis mediates host osmoregulation in a small desert mammal","volume":"8","author":"Nouri","year":"2022","journal-title":"npj Biofilms Microbiomes"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1053\/j.ajkd.2019.05.031","article-title":"Timing of Recovery from Moderate to Severe AKI and the Risk for Future Loss of Kidney Function","volume":"75","author":"Siew","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1053\/j.ajkd.2014.10.015","article-title":"Predictors of Outpatient Kidney Function Recovery Among Patients Who Initiate Hemodialysis in the Hospital","volume":"65","author":"Hickson","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Florens, N., Calzada, C., Lyasko, E., Juillard, L., and Soulage, C.O. (2016). Modified Lipids and Lipoproteins in Chronic Kidney Disease: A New Class of Uremic Toxins. Toxins, 8.","DOI":"10.3390\/toxins8120376"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/aor.13383","article-title":"Increasing the removal of protein-bound uremic toxins by liposome-supported hemodialysis","volume":"43","author":"Shi","year":"2019","journal-title":"Artif. Organs"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","article-title":"Acute kidney injury","volume":"380","author":"Bellomo","year":"2012","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(19)32563-2","article-title":"Acute kidney injury","volume":"394","author":"Ronco","year":"2019","journal-title":"Lancet"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Shao, X., Tian, L., Xu, W., Zhang, Z., Wang, C., Qi, C., Ni, Z., and Mou, S. (2014). Diagnostic Value of Urinary Kidney Injury Molecule 1 for Acute Kidney Injury: A Meta-Analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0084131"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"122234","DOI":"10.1016\/j.jchromb.2020.122234","article-title":"Two rapid, accurate liquid chromatography tandem mass spectrometry methods for the quantification of seven uremic toxins: An application for describing their accumulation kinetic profile in a context of acute kidney injury","volume":"1152","author":"Bennis","year":"2020","journal-title":"J. Chromatogr. B"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Acosta-Ochoa, I., Bustamante-Munguira, J., Mendiluce-Herrero, A., Bustamante-Bustamante, J., and Coca-Rojo, A. (2019). Impact on Outcomes across KDIGO-2012 AKI Criteria According to Baseline Renal Function. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091323"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.31925\/farmacia.2021.6.20","article-title":"Evaluation Of Endotoxemia, Soluble Cd14 And Il-1\u03b2 In Dogs With Intestinal Dysbiosis That Were Treated With Probiotics: A Prospective Study","volume":"69","author":"Matei","year":"2021","journal-title":"Farmacia"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Vacca, M., Celano, G., Lenucci, M.S., Fontana, S., Forgia, F.M., Minervini, F., Scarano, A., Santino, A., Dalfino, G., and Gesualdo, L. (2021). In Vitro Selection of Probiotics, Prebiotics, and Antioxidants to Develop an Innovative Synbiotic (NatuREN G) and Testing Its Effect in Reducing Uremic Toxins in Fecal Batches from CKD Patients. Microorganisms, 9.","DOI":"10.3390\/microorganisms9061316"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1136\/gutjnl-2019-319766","article-title":"Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents","volume":"69","author":"Xifan","year":"2020","journal-title":"Gut"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.clnesp.2018.08.010","article-title":"Effect of Lactobacillus Rhamnosus on serum uremic toxins (phenol and P-Cresol) in hemodialysis patients: A double blind randomized clinical trial","volume":"28","author":"Eidi","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Popkov, V.A., Zharikova, A.A., Demchenko, E.A., Andrianova, N.V., Zorov, D.B., and Plotnikov, E.Y. (2022). Gut Microbiota as a Source of Uremic Toxins. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010483"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Margiotta, E., Caldiroli, L., Callegari, M.L., Miragoli, F., Zanoni, F., Armelloni, S., Rizzo, V., Messa, P., and Vettoretti, S. (2021). Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress. Toxins, 13.","DOI":"10.3390\/toxins13070472"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"114447","DOI":"10.1016\/j.biopha.2023.114447","article-title":"Gut microbiota dysbiosis in AKI to CKD transition","volume":"161","author":"Saranya","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chou, Y.-T., Kan, W.-C., and Shiao, C.-C. (2022). Acute Kidney Injury and Gut Dysbiosis: A Narrative Review Focus on Pathophysiology and Treatment. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073658"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Antonelli, G., Cappelli, L., Cinelli, P., Cuffaro, R., Manca, B., Nicchi, S., Tondi, S., Vezzani, G., Viviani, V., and Delany, I. (2021). Strategies to Tackle Antimicrobial Resistance: The Example of Escherichia coli and Pseudomonas aeruginosa. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094943"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"103796","DOI":"10.1016\/j.micpath.2019.103796","article-title":"Evaluation of hematogenous spread and ascending infection in the pathogenesis of acute pyelonephritis due to group B streptococcus in mice","volume":"138","author":"Sullivan","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_50","unstructured":"Lucian, B., Zsolt, P., Klara, H., Monica, B., and Trombaco, R.G. (2020). Advanced Nanostructures for Environmental Health, Elsevier."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Takayasu, M., Hirayama, K., Shimohata, H., Kobayashi, M., and Koyama, A. (2022). Staphylococcus aureus infection-related glomerulonephritis with dominant IgA deposition. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137482"},{"key":"ref_52","first-page":"1","article-title":"IgA-dominant infection-related glomerulonephritis with NAPlr-positive tubulointerstitial nephritis","volume":"2023","author":"Okunaga","year":"2023","journal-title":"CEN Case Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2333794X211022263","DOI":"10.1177\/2333794X211022263","article-title":"Salmonella Renal Abscess in an Immunocompetent Child: Case Report and Literature Review","volume":"8","author":"Poh","year":"2021","journal-title":"Glob. Pediatr. Health"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"J\u00e4rvisalo, M.J., Hellman, T., and Uusalo, P. (2021). Mortality and associated risk factors in patients with blood culture positive sepsis and acute kidney injury requiring continuous renal replacement therapy\u2014A retrospective study. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0249561"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Caggiano, G., Stasi, A., Franzin, R., Fiorentino, M., Cimmarusti, M.T., Deleonardis, A., Palieri, R., Pontrelli, P., and Gesualdo, L. (2023). Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives. Toxins, 15.","DOI":"10.3390\/toxins15020115"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/MOG.0000000000000789","article-title":"Role of gut-kidney axis in renal diseases and IgA nephropathy","volume":"37","author":"Monteiro","year":"2021","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3389\/fcimb.2022.904401","article-title":"Gut Microbiome Characteristics in IgA Nephropathy: Qualitative and Quantitative Analysis from Observational Studies","volume":"12","author":"Han","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.ekir.2020.08.009","article-title":"Why Target the Gut to Treat IgA Nephropathy?","volume":"5","author":"Barratt","year":"2020","journal-title":"Kidney Int. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Sato, Y., Tsukaguchi, H., Higasa, K., Kawata, N., Inui, K., Linh, T.N.T., Quynh, T.T.H., Yoshihiko, I., Koiwa, F., and Yoshimura, A. (2021). Positive renal familial history in IgA nephropathy is associated with worse renal outcomes: A single-center longitudinal study. BMC Nephrol., 22.","DOI":"10.1186\/s12882-021-02425-8"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"De Angelis, M., Montemurno, E., Piccolo, M., Vannini, L., Lauriero, G., Maranzano, V., Gozzi, G., Serrazanetti, D., Dalfino, G., and Gobbetti, M. (2014). Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN). PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099006"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40168-016-0195-9","article-title":"Intestinal microbiota in pediatric patients with end stage renal disease: A Midwest Pediatric Nephrology Consortium study","volume":"4","author":"Vehaskari","year":"2016","journal-title":"Microbiome"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"\u0218tef\u0103nescu, B.E., Nemes, S.A., Teleky, B.E., Calinoiu, L.F., Mitrea, L., Martau, G.A., Szabo, K., Mihai, M., Vodnar, D.C., and Cri\u0219an, G. (2022). Microencapsulation and Bioaccessibility of Phenolic Compounds of Vaccinium Leaf Extracts. Antioxidants, 11.","DOI":"10.3390\/antiox11040674"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1042\/CS20160191","article-title":"Disposition and clinical implications of protein-bound uremic toxins","volume":"131","author":"Jansen","year":"2017","journal-title":"Clin. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1053\/j.jrn.2020.11.008","article-title":"The Role of Dietary Fiber Supplementation in Regulating Uremic Toxins in Patients With Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials","volume":"31","author":"Yang","year":"2021","journal-title":"J. Ren. Nutr."},{"key":"ref_65","first-page":"2","article-title":"Hematological Aspects on Dogs with Apparent Dysbiosis after Bacillus Subtilis, Bacillus Licheniformis and Pediococcus Acidilactici Probiotic Administration- Pilot Study","volume":"77","author":"Matei","year":"2020","journal-title":"Bull. UASVM Vet. Med."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"\u015awi\u0105tek, \u0141., Jeske, J., Miedziaszczyk, M., and Idasiak-Piechocka, I. (2023). The impact of a vegetarian diet on chronic kidney disease (CKD) progression\u2014A systematic review. BMC Nephrol., 24.","DOI":"10.1186\/s12882-023-03233-y"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1590\/2175-8239-jbn-2021-0126","article-title":"Effect of vegetarian diets on renal function in patients with chronic kidney disease under non-dialysis treatment: A scoping review","volume":"44","author":"Valim","year":"2022","journal-title":"J. Bras. Nefrol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Rysz, J., Franczyk, B., \u0141awi\u0144ski, J., Olszewski, R., Cia\u0142kowska-Rysz, A., and Gluba-Brz\u00f3zka, A. (2021). The impact of CKD on uremic toxins and gut microbiota. Toxins, 13.","DOI":"10.3390\/toxins13040252"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1053\/j.jrn.2015.06.004","article-title":"Trimethylamine N-Oxide From Gut Microbiota in Chronic Kidney Disease Patients: Focus on Diet","volume":"25","author":"Moraes","year":"2015","journal-title":"J. Ren. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Lauriola, M., Farr\u00e9, R., Evenepoel, P., Overbeek, S.A., and Meijers, B. (2023). Food-Derived Uremic Toxins in Chronic Kidney Disease. Toxins, 15.","DOI":"10.3390\/toxins15020116"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"18","DOI":"10.26502\/jfsnr.2642-11000036","article-title":"Soluble Fiber and Omega-3 Fatty Acids Reduce Levels of Advanced Glycation End Products and Uremic Toxins in Senior Dogs by Modulating the Gut Microbiome","volume":"3","author":"Ephraim","year":"2020","journal-title":"J. Food Sci. Nutr. Res."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Nemes, S.A., C\u0103linoiu, L.F., Dulf, F.V., F\u0103rcas, A.C., and Vodnar, D.C. (2022). Integrated Technology for Cereal Bran Valorization: Perspectives for a Sustainable Industrial Approach. Antioxid., 11.","DOI":"10.3390\/antiox11112159"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13098-016-0159-z","article-title":"Interactions between kidney disease and diabetes: Dangerous liaisons","volume":"8","author":"Abensur","year":"2016","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1159\/000518456","article-title":"Dyslipidemia in Chronic Kidney Disease: Contemporary Concepts and Future Therapeutic Perspectives","volume":"52","author":"Theofilis","year":"2021","journal-title":"Am. J. Nephrol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Hobson, S., de Loor, H., Kublickiene, K., Beige, J., Evenepoel, P., Stenvinkel, P., and Ebert, T. (2022). Lipid Profile Is Negatively Associated with Uremic Toxins in Patients with Kidney Failure-A Tri-National Cohort. Toxins, 14.","DOI":"10.3390\/toxins14060412"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Ceja-Galicia, Z.A., Aranda-Rivera, A.K., Amador-Mart\u00ednez, I., Aparicio-Trejo, O.E., Tapia, E., Trujillo, J., Ram\u00edrez, V., and Pedraza-Chaverri, J. (2023). The Development of Dyslipidemia in Chronic Kidney Disease and Associated Cardiovascular Damage, and the Protective Effects of Curcuminoids. Foods, 12.","DOI":"10.3390\/foods12050921"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Nishi, H., Higashihara, T., and Inagi, R. (2019). Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction. Nutrients, 11.","DOI":"10.3390\/nu11071664"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9036450","DOI":"10.1155\/2017\/9036450","article-title":"Chronic Kidney Disease and Disproportionally Increased Cardiovascular Damage: Does Oxidative Stress Explain the Burden?","volume":"2017","author":"Duni","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Rapp, N., Evenepoel, P., Stenvinkel, P., and Schurgers, L. (2020). Uremic Toxins and Vascular Calcification\u2013Missing the Forest for All the Trees. Toxins, 12.","DOI":"10.3390\/toxins12100624"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2215\/CJN.05240418","article-title":"Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor","volume":"14","author":"Madero","year":"2019","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Rocchetti, M.T., Di Iorio, B.R., Vacca, M., Cosola, C., Marzocco, S., di Bari, I., Calabrese, F.M., Ciarcia, R., De Angelis, M., and Gesualdo, L. (2021). Ketoanalogs\u2019 Effects on Intestinal Microbiota Modulation and Uremic Toxins Serum Levels in Chronic Kidney Disease (Medika2 Study). J. Clin. Med., 10.","DOI":"10.3390\/jcm10040840"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Rocchetti, M.T., Cosola, C., di Bari, I., Magnani, S., Galleggiante, V., Scandiffio, L., Dalfino, G., Netti, G.S., Atti, M., and Corciulo, R. (2020). Efficacy of divinylbenzenic resin in removing indoxyl sulfate and p-cresol sulfate in hemodialysis patients: Results from an in vitro study and an in vivo pilot trial (xuanro4-Nature 3.2). Toxins, 12.","DOI":"10.3390\/toxins12030170"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.jrn.2016.07.005","article-title":"Protein-Bound Uremic Toxins from Gut Microbiota and Inflammatory Markers in Chronic Kidney Disease","volume":"26","author":"Borges","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Graboski, A.L., and Redinbo, M.R. (2020). Gut-Derived Protein-Bound Uremic Toxins. Toxins, 12.","DOI":"10.3390\/toxins12090590"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s40620-022-01560-1","article-title":"Gut microbiota disturbances and protein-energy wasting in chronic kidney disease: A narrative review","volume":"36","author":"Avesani","year":"2023","journal-title":"J. Nephrol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.clnu.2016.06.007","article-title":"Protein-energy wasting and nutritional supplementation in patients with end-stage renal disease on hemodialysis","volume":"36","author":"Sabatino","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Ebersolt, M., Santana Machado, T., Mallmann, C., Mc-Kay, N., Dou, L., Bouchouareb, D., Brunet, P., Burtey, S., and Sall\u00e9e, M. (2022). Protein\/Fiber Index Modulates Uremic Toxin Concentrations in Hemodialysis Patients. Toxins, 14.","DOI":"10.3390\/toxins14090589"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s40620-017-0406-x","article-title":"Uremic Toxicity and Bone in CKD","volume":"30","author":"Yamamoto","year":"2017","journal-title":"J. Nephrol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Kyriakidis, N.C., Cobo, G., Dai, L., Lindholm, B., and Stenvinkel, P. (2021). Role of Uremic Toxins in Early Vascular Ageing and Calcification. Toxins, 13.","DOI":"10.3390\/toxins13010026"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Chao, C.-T., and Lin, S.-H. (2020). Uremic Vascular Calcification: The Pathogenic Roles and Gastrointestinal Decontamination of Uremic Toxins. Toxins, 12.","DOI":"10.3390\/toxins12120812"},{"key":"ref_91","first-page":"10","article-title":"Phosphate binders in patients with chronic kidney disease","volume":"40","author":"Chan","year":"2017","journal-title":"Aust. Prescr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.nefroe.2018.08.001","article-title":"Pharmacological interactions of phosphate binders","volume":"38","author":"Arenas","year":"2018","journal-title":"Nefrolog\u00eda (Engl. Ed.)"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e13888","DOI":"10.1111\/apha.13888","article-title":"Uremic toxins in chronic kidney disease highlight a fundamental gap in understanding their detrimental effects on cardiac electrophysiology and arrhythmogenesis","volume":"236","author":"Cornelissen","year":"2022","journal-title":"Acta Physiol."},{"key":"ref_94","unstructured":"Chmielewski, M., Heimb\u00fcrger, O., Stenvinkel, P., and Lindholm, B. (2013). Nutritional Management of Renal Disease, Elsevier Inc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1111\/hdi.12701","article-title":"A need for a paradigm shift in focus: From Kt\/Vurea to appropriate removal of sodium (the ignored uremic toxin)","volume":"22","author":"Twardowski","year":"2018","journal-title":"Hemodial. Int."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Rysz, J., Franczyk, B., \u0141awi\u0144ski, J., and Gluba-Brz\u00f3zka, A. (2020). Oxidative Stress in ESRD Patients on Dialysis and the Risk of Cardiovascular Diseases. Antioxidants, 9.","DOI":"10.3390\/antiox9111079"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Hamza, E., Metzinger, L., and Metzinger-Le Meuth, V. (2020). Uremic Toxins Affect Erythropoiesis during the Course of Chronic Kidney Disease: A Review. Cells, 9.","DOI":"10.3390\/cells9092039"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s41983-020-00234-8","article-title":"Lentiform fork sign in a uremic patient with a high anion gap metabolic acidosis with seizures: A case report from North West of Ireland","volume":"56","author":"Mansoor","year":"2020","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_99","unstructured":"Coman, V., Teleky, B.-E., Mitrea, L., Mart\u0103u, G.A., Szabo, K., C\u0103linoiu, L.-F., and Vodnar, D.C. (2019). Advances in Food and Nutrition Research, Academic Press."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s11255-020-02760-z","article-title":"Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study","volume":"53","author":"Salarolli","year":"2021","journal-title":"Int. Urol. Nephrol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Santana-G\u00e1lvez, J., Cisneros-Zevallos, L., and Jacobo-Vel\u00e1zquez, D.A. (2017). Chlorogenic acid: Recent advances on its dual role as a food additive and a nutraceutical against metabolic syndrome. Molecules, 22.","DOI":"10.3390\/molecules22030358"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.jrn.2020.07.008","article-title":"Associations among plant-based diet quality, uremic toxins, and gut microbiota profile in adults undergoing hemodialysis therapy","volume":"31","author":"Stanford","year":"2021","journal-title":"J. Ren. Nutr."},{"key":"ref_103","unstructured":"Patel, V.B. (2020). Molecular Nutrition, Academic Press."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1053\/j.ajkd.2015.09.005","article-title":"Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones","volume":"67","author":"Ferraro","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2147\/TCRM.S274122","article-title":"Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review","volume":"16","year":"2020","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"642296","DOI":"10.3389\/fmed.2021.642296","article-title":"Anemia in Chronic Kidney Disease: From Pathophysiology and Current Treatments, to Future Agents","volume":"8","author":"Broseta","year":"2021","journal-title":"Front. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"E390","DOI":"10.1503\/cmaj.180465","article-title":"Use of vitamin D drops leading to kidney failure in a 54-year-old man","volume":"191","author":"Auguste","year":"2019","journal-title":"Can. Med. Assoc. J."},{"key":"ref_108","unstructured":"Kopple, J.D., Massry, S.G., Kalantar-Zadeh, K., and Fouque, D. (2022). Nutritional Management of Renal Disease, Academic Press. [4th ed.]."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Hall, J.A., Jackson, M.I., Farace, G., Yerramilli, M., and Jewell, D.E. (2019). Influence of Dietary Ingredients on Lean Body Percent, Uremic Toxin Concentrations, and Kidney Function in Senior-Adult Cats. Metabolites, 9.","DOI":"10.3390\/metabo9100238"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1093\/ckj\/sfac154","article-title":"Decreasing microbiota-derived uremic toxins to improve CKD outcomes","volume":"15","author":"Beker","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Headley, S.A., Chapman, D.J., Germain, M.J., Evans, E.E., Hutchinson, J., Madsen, K.L., Ikizler, T.A., Miele, E.M., Kirton, K., and O\u2019Neill, E. (2020). The effects of 16-weeks of prebiotic supplementation and aerobic exercise training on inflammatory markers, oxidative stress, uremic toxins, and the microbiota in pre-dialysis kidney patients: A randomized controlled trial-protocol paper. BMC Nephrol., 21.","DOI":"10.1186\/s12882-020-02177-x"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e020863","DOI":"10.1136\/bmjopen-2017-020863","article-title":"Probiotics, prebiotics and synbiotics for chronic kidney disease: Protocol for a systematic review and meta-analysis","volume":"8","author":"Pei","year":"2018","journal-title":"BMJ Open"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Lai, S., Mazzaferro, S., Muscaritoli, M., Mastroluca, D., Testorio, M., Perrotta, A., Esposito, Y., Carta, M., Campagna, L., and Di Grado, M. (2020). Prebiotic Therapy with Inulin Associated with Low Protein Diet in Chronic Kidney Disease Patients: Evaluation of Nutritional, Cardiovascular and Psychocognitive Parameters. Toxins, 12.","DOI":"10.3390\/toxins12060381"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1093\/ndt\/gfy171","article-title":"Effect of prebiotic (fructooligosaccharide) on uremic toxins of chronic kidney disease patients: A randomized controlled trial","volume":"34","author":"Ramos","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Jerez-Morales, A., Merino, J.S., D\u00edaz-Castillo, S.T., Smith, C.T., Fuentealba, J., Bernasconi, H., Echeverr\u00eda, G., and Garc\u00eda-Cancino, A. (2021). The Administration of the Synbiotic Lactobacillus bulgaricus 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model. Toxins, 13.","DOI":"10.3390\/toxins13030192"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.3390\/toxins5112042","article-title":"From the Gastrointestinal Tract (GIT) to the Kidneys: Live Bacterial Cultures (Probiotics) Mediating Reductions of Uremic Toxin Levels via Free Radical Signaling","volume":"5","author":"Vitetta","year":"2013","journal-title":"Toxins"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2215\/CJN.13631215","article-title":"Effect of Synbiotic Therapy on Gut-Derived Uremic Toxins and the Intestinal Microbiome in Patients with CKD","volume":"11","author":"Vaziri","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e00446-22","DOI":"10.1128\/msphere.00446-22","article-title":"Probiotic Bifidobacteria Mitigate the Deleterious Effects of para-Cresol in a Drosophila melanogaster Toxicity Model","volume":"7","author":"Stuivenberg","year":"2022","journal-title":"mSphere"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.jrn.2021.08.005","article-title":"Biotic Supplements in Patients With Chronic Kidney Disease: Meta-Analysis of Randomized Controlled Trials","volume":"32","author":"Liu","year":"2022","journal-title":"J. Ren. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","article-title":"The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics","volume":"18","author":"Salminen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.foodres.2018.08.024","article-title":"Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial","volume":"116","author":"Lopes","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"756730","DOI":"10.3389\/fnut.2021.756730","article-title":"Short-Chain Fatty Acids Alleviate Hepatocyte Apoptosis Induced by Gut-Derived Protein-Bound Uremic Toxins","volume":"8","author":"Deng","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jff.2014.01.018","article-title":"Selection of uremic toxin-reducing probiotics in vitro and in vivo","volume":"7","author":"Fang","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_124","first-page":"1130","article-title":"Lactobacillus salivarius BP121 prevents cisplatin-induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p-cresol sulfate via alleviating dysbiosis","volume":"45","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Inatomi, T., and Honma, M. (2023). Ameliorating effect of probiotics in a rat model of chronic kidney disease. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0281745"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12967-022-03585-3","article-title":"Probiotics ameliorate IgA nephropathy by improving gut dysbiosis and blunting NLRP3 signaling","volume":"20","author":"Tan","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2215\/CJN.05240515","article-title":"Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY): A Randomized Trial","volume":"11","author":"Rossi","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Poesen, R., Evenepoel, P., de Loor, H., Delcour, J.A., Courtin, C.M., Kuypers, D., Augustijns, P., Verbeke, K., and Meijers, B. (2016). The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153893"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1053\/j.jrn.2014.09.002","article-title":"Fiber supplementation lowers plasma p-cresol in chronic kidney disease patients","volume":"25","author":"Salmean","year":"2015","journal-title":"J. Ren. Nutr."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Marzocco, S., Fazeli, G., Di Micco, L., Autore, G., Adesso, S., Dal Piaz, F., Heidland, A., and Di Iorio, B. (2018). Supplementation of Short-Chain Fatty Acid, Sodium Propionate, in Patients on Maintenance Hemodialysis: Beneficial Effects on Inflammatory Parameters and Gut-Derived Uremic Toxins, A Pilot Study (PLAN Study). J. Clin. Med., 7.","DOI":"10.3390\/jcm7100315"}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/15\/9\/548\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:46:05Z","timestamp":1760129165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/15\/9\/548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":130,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["toxins15090548"],"URL":"https:\/\/doi.org\/10.3390\/toxins15090548","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,4]]}}}