{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:04:36Z","timestamp":1791414276051,"version":"4.3.3"},"reference-count":23,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010457","name":"CHU de Bordeaux","doi-asserted-by":"publisher","award":["CHUBX 2013\/11"],"award-info":[{"award-number":["CHUBX 2013\/11"]}],"id":[{"id":"10.13039\/501100010457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins in the saliva. A total of 88 patients were included in the study, with chronic kidney disease stage 2 to 5 (without kidney replacement). We analysed the total concentrations of eight uremic toxins (trimethylamine N-oxide -TMAO-, Indoxyl Sulfate, P-cresyl-sulfate, Indole 3-acetic acid, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid -CMPF-, Kynurenine, Hippuric acid and Phenylacetylglutamine) and three precursors of uremic toxins (Tyrosine, Phenylalanine and Tryptophan) in the saliva using LC-MS\/MS. We observed, for the first time, the association between various dental scores: DMFT, FST, CPITN, and OHIS, and saliva uremic toxins and precursors: TMAO, indoxyl sulfate, or hippuric acid. Further prospective interventional studies are required to confirm our results.<\/jats:p>","DOI":"10.3390\/toxins15110666","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T01:54:12Z","timestamp":1700445252000},"page":"666","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between Dental Scores and Saliva Uremic Toxins"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5569-5562","authenticated-orcid":false,"given":"Claire","family":"Rigothier","sequence":"first","affiliation":[{"name":"Service de N\u00e9phrologie-Transplantation-Dialyse-Aph\u00e9r\u00e8ses, H\u00f4pital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France"},{"name":"INSERM, Bio-Ing\u00e9nierie Tissulaire (BioTis), UMR 1026, Universit\u00e9 de Bordeaux, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3419-3467","authenticated-orcid":false,"given":"Sylvain","family":"Catros","sequence":"additional","affiliation":[{"name":"INSERM, Bio-Ing\u00e9nierie Tissulaire (BioTis), UMR 1026, Universit\u00e9 de Bordeaux, 33076 Bordeaux, France"},{"name":"D\u00e9partement de Chirurgie Orale, CHU de Bordeaux, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"B\u00e9nard","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit (USMR), CHU de Bordeaux, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6087-2375","authenticated-orcid":false,"given":"Johan","family":"Samot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chirurgie Orale, CHU de Bordeaux, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-8897","authenticated-orcid":false,"given":"Olivier","family":"Quintin","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit (USMR), CHU de Bordeaux, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-573X","authenticated-orcid":false,"given":"Christian","family":"Combe","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie-Transplantation-Dialyse-Aph\u00e9r\u00e8ses, H\u00f4pital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France"},{"name":"INSERM, Bio-Ing\u00e9nierie Tissulaire (BioTis), UMR 1026, Universit\u00e9 de Bordeaux, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-5342","authenticated-orcid":false,"given":"Islam","family":"Larabi","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie-Toxicologie, H\u00f4pital Raymond Poincar\u00e9, AP-HP, 92380 Garchesy, France"},{"name":"MasSpecLab, Plateforme de Spectrom\u00e9trie de Masse, Inserm U-1173, Universit\u00e9 Paris Saclay (Versailles Saint Quentin-en-Yvelines), 78035 Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Massy","sequence":"additional","affiliation":[{"name":"Centre for Research in Epidemiology and Population Health, Inserm UMRS 1018, Clinical Epidemiology Team, Universit\u00e9 Paris Saclay (Versailles Saint Quentin-en-Yvelines), 78035 Villejuif, France"},{"name":"Department of Nephrology, CHU Ambroise Par\u00e9, APHP, Boulogne Billancourt, 92100 Paris Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5344-9475","authenticated-orcid":false,"given":"Jean-Claude","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie-Toxicologie, H\u00f4pital Raymond Poincar\u00e9, AP-HP, 92380 Garchesy, France"},{"name":"MasSpecLab, Plateforme de Spectrom\u00e9trie de Masse, Inserm U-1173, Universit\u00e9 Paris Saclay (Versailles Saint Quentin-en-Yvelines), 78035 Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/ndt\/gfv413","article-title":"Patterns of oral disease in adults with chronic kidney disease treated with hemodialysis","volume":"31","author":"Palmer","year":"2016","journal-title":"Nephrol. 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