{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:36:22Z","timestamp":1769006182597,"version":"3.49.0"},"reference-count":20,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>This study investigated two outbreaks of spontaneous poisoning by Baccharis coridifolia (Asteraceae) in early-weaned beef calves in Tacuaremb\u00f3, Uruguay. A total of 34 affected calves showed signs of salivation, anorexia, apathy, marked dehydration, and diarrhea. Deaths occurred 36\u201372 h after consumption and mortality varied from 37.5% to 43.3% for outbreak 1 and outbreak 2, respectively. The main pathological findings include diffuse severe necrosis of the prestomachs and lymphoid tissues. Ultrastructurally, epithelial cells of the rumen showed swelling, lysis of the organelles, degradation of intercellular attachments, and degradation of the nuclear chromatin. Using LC-MS with diagnostic fragmentation filtering, 56 macrocyclic trichothecenes including glycosyl and malonyl conjugates were identified. The total concentration of macrocyclic trichothecenes, including conjugates, was estimated to be 1.2 \u00b1 0.1 mg\/g plant material. This is the first report of these malonyl\u2013glucose conjugates from Baccharis coridifolia.<\/jats:p>","DOI":"10.3390\/toxins15120681","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T04:12:56Z","timestamp":1701403976000},"page":"681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Poisoning by Baccharis coridifolia in Early-Weaned Beef Calves: Pathological Study and New Macrocyclic Trichothecene Identification"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-884X","authenticated-orcid":false,"given":"Mizael","family":"Machado","sequence":"first","affiliation":[{"name":"Plataforma de Investigaci\u00f3n en Salud Animal (PSA), Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA), Estaci\u00f3n Experimental Tacuaremb\u00f3, Tacuaremb\u00f3 45000, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Independent Researcher, Tacuaremb\u00f3 45000, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol","family":"Andres","sequence":"additional","affiliation":[{"name":"CENUR Noreste, Universidad de la Rep\u00fablica, Tacuaremb\u00f3 45000, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-1656","authenticated-orcid":false,"given":"Mark W.","family":"Sumarah","sequence":"additional","affiliation":[{"name":"London Research and Development Centre, Agriculture & Agri-Food Canada, London, ON N5V 4T3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin B.","family":"Renaud","sequence":"additional","affiliation":[{"name":"London Research and Development Centre, Agriculture & Agri-Food Canada, London, ON N5V 4T3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-9945","authenticated-orcid":false,"given":"An\u00edbal G.","family":"Armi\u00e9n","sequence":"additional","affiliation":[{"name":"California Animal Health & Food Safety Laboratory System (CAHFS), School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio S. L.","family":"Barros","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia (FMZV), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin","family":"Riet-Correa","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia Animal nos Tr\u00f3picos, Universidade Federal da Bahia (UFBA), Salvador 49170-110, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejo","family":"Menchaca","sequence":"additional","affiliation":[{"name":"Plataforma de Investigaci\u00f3n en Salud Animal (PSA), Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA), Estaci\u00f3n Experimental Tacuaremb\u00f3, Tacuaremb\u00f3 45000, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-3039","authenticated-orcid":false,"given":"Carlos O.","family":"Schild","sequence":"additional","affiliation":[{"name":"Plataforma de Investigaci\u00f3n en Salud Animal (PSA), Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA), Estaci\u00f3n Experimental Tacuaremb\u00f3, Tacuaremb\u00f3 45000, Uruguay"},{"name":"California Animal Health and Food Safety Laboratory System\u2013San Bernardino Branch, University of California, San Bernardino, CA 92408, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"ref_1","first-page":"79","article-title":"Intoxica\u00e7ao experimental em bovinos por mio-mio, Baccharis coridifolia","volume":"10","author":"Tokarnia","year":"1975","journal-title":"Pesqui. 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