{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:59:25Z","timestamp":1791575965016,"version":"4.3.4"},"reference-count":112,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","award":["2022\/09354-9"],"award-info":[{"award-number":["2022\/09354-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Angiogenesis, the formation of new blood vessels, plays a critical role in various physiological and pathological conditions. Snake venom disintegrins (SVDs) have been identified as significant regulators of this process. In this review, we explore the dual roles of SVD in angiogenesis, both as antiangiogenic agents by inhibiting integrin binding and interfering with vascular endothelial growth factors and as proangiogenic agents by enhancing integrin binding, stimulating cell migration and proliferation, and inducing neoangiogenesis. Studies in vitro and in animal models have demonstrated these effects and offer significant therapeutic opportunities. The potential applications of SVD in diseases related to angiogenesis, such as cancer, ocular diseases, tissue regeneration, wound healing, and cardiovascular diseases, are also discussed. Overall, SVDs are promising potential therapeutics, and further advances in this field could lead to innovative treatments for diseases related to angiogenesis.<\/jats:p>","DOI":"10.3390\/toxins16030127","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T06:07:53Z","timestamp":1709273273000},"page":"127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Role of Snake Venom Disintegrins in Angiogenesis"],"prefix":"10.3390","volume":"16","author":[{"given":"Patricia Bianca","family":"Clissa","sequence":"first","affiliation":[{"name":"Immunopathology Laboratory, Butantan Institute, S\u00e3o Paulo 05585-090, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisa Splendore","family":"Della-Casa","sequence":"additional","affiliation":[{"name":"Immunopathology Laboratory, Butantan Institute, S\u00e3o Paulo 05585-090, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7125-5380","authenticated-orcid":false,"given":"Bianca Cestari","family":"Zychar","sequence":"additional","affiliation":[{"name":"Physiopathology Laboratory, Butantan Institute, S\u00e3o Paulo 05585-090, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabri Saeed","family":"Sanabani","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of S\u00e3o Paulo, Sao Paulo 05508-220, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat. 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