{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:22:42Z","timestamp":1791901362469,"version":"4.3.4"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>(1) Background: Sequels of facial palsy lead to major psychosocial repercussions, disrupting patients\u2019 quality of life (QoL). Botulinum toxin (BoNT) injections can permit us to treat long-standing facial palsy, improving facial symmetry and functional signs including synkinesis and contractures. (2) Methods: The main aim of this study was to assess the evolution of the QoL for patients with long-standing facial palsy before, at 1 month, and at 4 months after BoNT injections by using three questionnaires (HFS-30, FaCE, and HAD). The other goals were to find clinical factors associated with the improvement in the QoL and to assess the HFS-30 questionnaire for patients with unilateral facial palsy (3) Results: Eighty-eight patients were included in this study. There was a statistically significant improvement in QoL at 1 month after injections, assessed using the three questionnaires. This improvement was sustained at 4 months after the injections, with a statistically significant difference for the HFS-30 and FaCE questionnaires. (4) Conclusions: This study showed that the BoNT injections lead to a significant increase in the QoL of patients with unilateral facial palsy. This improvement is sustained 4 months after the injections.<\/jats:p>","DOI":"10.3390\/toxins16030140","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:52:11Z","timestamp":1709869931000},"page":"140","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Botulinum Toxin Injections on Quality of Life of Patients with Long-Standing Peripheral Facial Palsy"],"prefix":"10.3390","volume":"16","author":[{"given":"J\u00e9r\u00e9my","family":"Amar","sequence":"first","affiliation":[{"name":"ENT Department, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Tankere","sequence":"additional","affiliation":[{"name":"ENT Department, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-1760","authenticated-orcid":false,"given":"Diane","family":"Picard","sequence":"additional","affiliation":[{"name":"ENT Department, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5928-1511","authenticated-orcid":false,"given":"Lauranne","family":"Alciato","sequence":"additional","affiliation":[{"name":"ENT Department, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5897-8296","authenticated-orcid":false,"given":"Fabienne","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"ENT Department, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Foirest","sequence":"additional","affiliation":[{"name":"ENT Department, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"ref_1","first-page":"1204","article-title":"Bell\u2019s palsy","volume":"2014","author":"Holland","year":"2014","journal-title":"BMJ Clin. 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