{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:53:42Z","timestamp":1792043622969,"version":"4.4.0"},"reference-count":74,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Society for the Promotion of Science (JSPS) and KAKENHI","award":["JP24592946"],"award-info":[{"award-number":["JP24592946"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) and KAKENHI","award":["JP22111201"],"award-info":[{"award-number":["JP22111201"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) and KAKENHI","award":["JP22K10091"],"award-info":[{"award-number":["JP22K10091"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Oromandibular dystonia (OMD) is a focal dystonia characterized by contractions of the masticatory, lingual, and other muscles of the stomatognathic system. We conducted a systematic review and meta-analysis to elucidate the impact and safety of botulinum toxin in OMD. The eligibility criteria were full-length original articles that provided data evaluating the efficacy and adverse effects of onabotulinumtoxinA injections in patients with OMD. PubMed and Embase were searched for articles published before 31 May 2023. We analyzed cases that showed a favorable response (&gt;0% improvement), moderate or greater response (&gt;50% improvement), and adverse effects. A fixed-model meta-analysis of 26 studies involving 1103 patients revealed that an overall favorable effect of onabotulinumtoxinA injection was observed in 96.2% (95% confidence interval [CI], 95\u201397.5%, p &lt; 0.00001) of patients, with significant heterogeneity (p &lt; 0.00001, I2 = 85%). A moderate response (&gt;50% improvement) was observed in 88.9% of patients (95% CI, 87\u201390.8%, p &lt; 0.00001) with significant heterogeneity (p &lt; 0.00001, I2 = 85%). Adverse effects were detected in 17.8% of patients, and the most common event was dysphagia (10.1%). Our systematic review found that onabotulinumtoxinA injection was effective, with a low rate of side effects. Further randomized controlled trials are required to clarify the evidence-based efficacy and adverse effects.<\/jats:p>","DOI":"10.3390\/toxins16120546","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T12:09:28Z","timestamp":1734350968000},"page":"546","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment with OnabotulinumtoxinA for Oromandibular Dystonia: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2985-4347","authenticated-orcid":false,"given":"Kazuya","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, National Hospital Organization, Kyoto Medical Center, Kyoto 612-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-1080","authenticated-orcid":false,"given":"Ryuji","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokushima University, Tokushima 770-8503, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/mds.25475","article-title":"Phenomenology and classification of dystonia: A consensus up date","volume":"28","author":"Albanese","year":"2013","journal-title":"Mov. 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