{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:44:40Z","timestamp":1784234680599,"version":"3.55.0"},"reference-count":76,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Echis ocellatus envenomings are a public health problem in West Africa, leading to bleeding and hypocoagulability. The aim of this study was to assess the hemostasis disorders associated with E. ocellatus envenoming. Envenomed patients with an abnormal whole blood clotting test (WBCT) were prospectively included at Tangui\u00e9ta, Benin. A WBCT with a sequential reading (i.e., at 20, 30, and 60 min), viscoelastic analysis (VA) using the Quantra analyzer, and blood count were performed on admission. VA and the WBCT were also assessed at 4, 8, 12, 24, 48, and 72 h after antivenom administration. Nineteen patients were included. On admission, the main results were an absence of a clot on VA and a slight decrease in platelets. Clot time gradually decreased over time while clot stiffness, fibrinogen, and platelet contributions to stiffness increased. Sequential reading improved the sensitivity of the WBCT. At H48, all patients with recurrence bleeding after antivenom administration had an abnormal WBCT while patients with a normal WBCT never had bleeding during their follow-up. VA allows the identification of various hemostasis disorders. Hypofibrinogenemia was the main disorder that persisted for several days after treatment. A WBCT with a sequential reading is an effective alternative for monitoring hypocoagulability in the absence of a laboratory.<\/jats:p>","DOI":"10.3390\/toxins17010003","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T10:58:32Z","timestamp":1735037912000},"page":"3","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Viscoelastic Study of Hemostasis Disorders Associated with Echis ocellatus Envenoming in North Benin Using a Quantra Analyzer"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8961-7132","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Larr\u00e9ch\u00e9","sequence":"first","affiliation":[{"name":"Department of Medical Biology, B\u00e9gin National Military Teaching Hospital, F-94160 Saint-Mand\u00e9, France"},{"name":"Inserm UMRS-1144, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Benes","family":"Chacha","sequence":"additional","affiliation":[{"name":"Benin Clinical Research Institute, Abomey-Calavi, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9","family":"Sodjinou","sequence":"additional","affiliation":[{"name":"Benin Clinical Research Institute, Abomey-Calavi, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seidou Alassane","family":"Ouorou","sequence":"additional","affiliation":[{"name":"Emergency Department, Saint-Jean de Dieu Hospital, Tangui\u00e9ta, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ganhouingnon","sequence":"additional","affiliation":[{"name":"Medical Biology Laboratory, Saint-Jean de Dieu Hospital, Tangui\u00e9ta, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith Aloukoutou","family":"Layo","sequence":"additional","affiliation":[{"name":"Benin Clinical Research Institute, Abomey-Calavi, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-2764","authenticated-orcid":false,"given":"Bruno","family":"M\u00e9garbane","sequence":"additional","affiliation":[{"name":"Inserm UMRS-1144, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"},{"name":"Department of Medical and Toxicological Critical Care, Assistance Publique\u2013H\u00f4pitaux de Paris, Lariboisi\u00e8re Hospital, Federation of toxicology, F-75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille","family":"Massougbodji","sequence":"additional","affiliation":[{"name":"Benin Clinical Research Institute, Abomey-Calavi, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1976-8568","authenticated-orcid":false,"given":"Jean-Philippe","family":"Chippaux","sequence":"additional","affiliation":[{"name":"French National Research Institute for Development, Mother and Child in Tropical Environment: Pathogens, Health System and Epidemiological Transition, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.toxicon.2010.12.022","article-title":"Estimate of the Burden of Snakebites in Sub-Saharan Africa: A Meta-Analytic Approach","volume":"57","author":"Chippaux","year":"2011","journal-title":"Toxicon"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2018.12.002","article-title":"Snakebite Burden in Sub-Saharan Africa: Estimates from 41 Countries","volume":"159","author":"Halilu","year":"2019","journal-title":"Toxicon"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Habib, A.G., Kuznik, A., Hamza, M., Abdullahi, M.I., Chedi, B.A., Chippaux, J.-P., and Warrell, D.A. 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