{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:47:46Z","timestamp":1787856466241,"version":"build-2784847793"},"reference-count":121,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Food contamination with mycotoxin-producing fungi increases the risk of many diseases, including neurological diseases closely related to the neurotoxicity of these toxins. Based on the latest literature data, we presented the association of common Fusarium mycotoxins with neurological diseases. Articles from 2001 to 2024 were analyzed. The mechanisms underlying the neurotoxicity of the described mycotoxins were presented. They are mainly related to the increase in oxidative stress in neuronal cells, which leads to higher levels of pro-inflammatory cytokines as IL-1\u03b2, IL-6 and TNF-\u03b1, enzymatic activity as GST, GPx, CAT and SOD and neurotransmitter dysfunction (5-HT, serotonin, dopamine and GABA). At the end of the article, based on the literature data, we attempted to present ways to mitigate mycotoxin neurotoxicity using mainly natural substances of plant origin. The data in this review focus on the Fusarium mycotoxins most frequently found in food and will be useful as comparative information for future studies. It is important to conduct further studies to mitigate the neurotoxic effects of Fusarium mycotoxins in order to reduce the development of diseases of the nervous system.<\/jats:p>","DOI":"10.3390\/toxins17010024","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T08:08:52Z","timestamp":1736150932000},"page":"24","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-1347","authenticated-orcid":false,"given":"Aleksandra","family":"Ku\u0107-Szymanek","sequence":"first","affiliation":[{"name":"Faculty of Medical and Health Sciences, University in Siedlce, Stanis\u0142awa Konarskiego St. 2, 08-110 Siedlce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3588-5764","authenticated-orcid":false,"given":"Daria","family":"Kubik-Machura","sequence":"additional","affiliation":[{"name":"Provincial Specialist Hospital No. 5 St. Barbara in Sosnowiec, Trauma Center, Plac Medyk\u00f3w St. 1, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia","family":"Ko\u015bcielecka","sequence":"additional","affiliation":[{"name":"Municipal Hospital in Zabrze, Zamkowa St. 4, 41-803 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"M\u0119cik-Kronenberg","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology, Faculty of Medical Sciences in Zabrze, 3 Maja St. 13, 41-800 Zabrze, Poland"},{"name":"Collegium Medicum im. Dr. W\u0142adys\u0142aw Biega\u0144ski, Jan D\u0142ugosz University, Wahington St. 4\/8, 42-200 Czestochowa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-7333","authenticated-orcid":false,"given":"Lidia","family":"Radko","sequence":"additional","affiliation":[{"name":"Department of Preclinical Sciences and Infectious Diseases, Faculty of Veterinary Medicine and Animal Sciences, Poznan University of Life Sciences, Wolynska St. 35, 60-637 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9967334","DOI":"10.1155\/2021\/9967334","article-title":"Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells","volume":"2021","author":"Pei","year":"2021","journal-title":"Oxidative Med. Cell. 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