{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:59:02Z","timestamp":1791575942500,"version":"4.3.4"},"reference-count":92,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Active compounds from natural sources, particularly snake venoms, are crucial for pharmaceutical development despite challenges in drug discovery. Snake venoms, historically used for medicinal purposes, contain bioactive peptides and enzymes that show therapeutic potential for conditions such as arthritis, asthma, cancer, chronic pain, infections and cardiovascular diseases. The objective of this study was to examine pharmacological and biomedical innovations by identifying the key research trends, the most studied snake species, and their therapeutic applications. A systematic review of patents related to snake venoms was conducted using the European Patent Office database, Espacenet, covering 2014 to mid-2024. The search employed the keyword \u201cvenom,\u201d applying IPC classification A61K38\/00, resulting in 31 patents after screening. A PubMed survey on \u201csnake venom derivatives innovations\u201d was conducted to compare the scientific literature volume with the identified patents. This review highlights the therapeutic potential of snake venom-derived products for coagulation disorders, cancer, inflammation, and pain management. Despite challenges in pharmacokinetics and venom variability, advancements in biotechnology offer promise for personalized therapies. The future of snake venom-based treatments appears promising for addressing complex medical conditions.<\/jats:p>","DOI":"10.3390\/toxins17030136","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:29:18Z","timestamp":1741926558000},"page":"136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Innovations in Snake Venom-Derived Therapeutics: A Systematic Review of Global Patents and Their Pharmacological Applications"],"prefix":"10.3390","volume":"17","author":[{"given":"Diana Carolina","family":"Zona Rubio","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n Cuidado Cardiorrespiratorio, Universidad Manuela Beltr\u00e1n, Bogot\u00e1 110231, Colombia"},{"name":"Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-3771","authenticated-orcid":false,"given":"Diana Marcela","family":"Arag\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabel","family":"Almeida Alves","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Departamento do Medicamento, Universidade Federal da Bahia, Salvador 40110-909, Bahia, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farm\u00e1cia, Universidade Estadual da Bahia, Salvador 40110-909, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. 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