{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:22:01Z","timestamp":1793154121800,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003827","name":"Hungarian National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["FK138184"],"award-info":[{"award-number":["FK138184"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"Hungarian National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["TKP2021-EGA-17"],"award-info":[{"award-number":["TKP2021-EGA-17"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"Hungarian National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["HUN-REN-MATE"],"award-info":[{"award-number":["HUN-REN-MATE"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"Hungarian National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"Hungarian National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["RRF-2.3.1-21-2022-00015"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00015"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Culture and Innovation of Hungary","award":["FK138184"],"award-info":[{"award-number":["FK138184"]}],"id":[{"id":"https:\/\/ror.org\/03vhmm238","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Culture and Innovation of Hungary","award":["TKP2021-EGA-17"],"award-info":[{"award-number":["TKP2021-EGA-17"]}],"id":[{"id":"https:\/\/ror.org\/03vhmm238","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Culture and Innovation of Hungary","award":["HUN-REN-MATE"],"award-info":[{"award-number":["HUN-REN-MATE"]}],"id":[{"id":"https:\/\/ror.org\/03vhmm238","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Culture and Innovation of Hungary","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}],"id":[{"id":"https:\/\/ror.org\/03vhmm238","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Culture and Innovation of Hungary","award":["RRF-2.3.1-21-2022-00015"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00015"]}],"id":[{"id":"https:\/\/ror.org\/03vhmm238","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["FK138184"],"award-info":[{"award-number":["FK138184"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["TKP2021-EGA-17"],"award-info":[{"award-number":["TKP2021-EGA-17"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["HUN-REN-MATE"],"award-info":[{"award-number":["HUN-REN-MATE"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["RRF-2.3.1-21-2022-00015"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00015"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hungarian National Laboratory project","award":["FK138184"],"award-info":[{"award-number":["FK138184"]}]},{"name":"Hungarian National Laboratory project","award":["TKP2021-EGA-17"],"award-info":[{"award-number":["TKP2021-EGA-17"]}]},{"name":"Hungarian National Laboratory project","award":["HUN-REN-MATE"],"award-info":[{"award-number":["HUN-REN-MATE"]}]},{"name":"Hungarian National Laboratory project","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}]},{"name":"Hungarian National Laboratory project","award":["RRF-2.3.1-21-2022-00015"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00015"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","award":["FK138184"],"award-info":[{"award-number":["FK138184"]}],"id":[{"id":"https:\/\/ror.org\/02ks8qq67","id-type":"ROR","asserted-by":"crossref"}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","award":["TKP2021-EGA-17"],"award-info":[{"award-number":["TKP2021-EGA-17"]}],"id":[{"id":"https:\/\/ror.org\/02ks8qq67","id-type":"ROR","asserted-by":"crossref"}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","award":["HUN-REN-MATE"],"award-info":[{"award-number":["HUN-REN-MATE"]}],"id":[{"id":"https:\/\/ror.org\/02ks8qq67","id-type":"ROR","asserted-by":"crossref"}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}],"id":[{"id":"https:\/\/ror.org\/02ks8qq67","id-type":"ROR","asserted-by":"crossref"}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences","award":["RRF-2.3.1-21-2022-00015"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00015"]}],"id":[{"id":"https:\/\/ror.org\/02ks8qq67","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["FK138184"],"award-info":[{"award-number":["FK138184"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["TKP2021-EGA-17"],"award-info":[{"award-number":["TKP2021-EGA-17"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["HUN-REN-MATE"],"award-info":[{"award-number":["HUN-REN-MATE"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["RRF-2.3.1-21-2022-00007"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00007"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["RRF-2.3.1-21-2022-00015"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00015"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Mycotoxins are frequent food contaminants posing health risk to humans and animals. Since these interactions have been barely studied yet, we examined the potential complex formation of mycotoxins with human \u03b11-acid glycoprotein (AGP) and with bovine milk proteins (including casein (CSN), \u03b2-lactoglobulin (LG), and \u03b1-lactalbumin (LA)) based on fluorescence spectroscopic and ultracentrifugation techniques. Only weak interactions (logK = 2.7 to 3.5) of certain mycotoxins were observed with CSN, LG, and\/or LA. Ultracentrifugation experiments demonstrated that aflatoxin M1, zearalenone, and \u03b1-zearalenol form more stable complexes with CSN than with LG or LA. These mycotoxins bound to bovine serum albumin with more than a tenfold higher affinity compared to CSN; nevertheless, it has likely limited importance due to the relatively low levels of BSA in bovine milk. Zearalenone, zearalenols, and sterigmatocystin showed strong interactions with AGP (logK = 5.5 to 6.4), suggesting that AGP may play an important role in the plasma protein binding of these mycotoxins.<\/jats:p>","DOI":"10.3390\/toxins17040151","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T04:48:18Z","timestamp":1742791698000},"page":"151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interaction of Mycotoxins with \u03b11-Acid Glycoprotein (AGP) and Bovine Milk Proteins: Zearalenone, Zearalenols, and Sterigmatocystin Form Highly Stable Complexes with AGP"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-7459","authenticated-orcid":false,"given":"Mikl\u00f3s","family":"Po\u00f3r","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Medical School, University of P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 13, H-7624 P\u00e9cs, Hungary"},{"name":"Molecular Medicine Research Group, J\u00e1nos Szent\u00e1gothai Research Centre, University of P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 20, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"G\u00f6mb\u00f6s","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Nutrition, Department of Physiology and Animal Health, Agribiotechnology and Precision Breeding for Food Security National Laboratory, Hungarian University of Agriculture and Life Sciences, H-2103 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-0024","authenticated-orcid":false,"given":"Andr\u00e1s","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Nutrition, Department of Physiology and Animal Health, Agribiotechnology and Precision Breeding for Food Security National Laboratory, Hungarian University of Agriculture and Life Sciences, H-2103 G\u00f6d\u00f6ll\u0151, Hungary"},{"name":"HUN-REN-MATE Mycotoxins in the Food Chain Research Group, Hungarian University of Agriculture and Life Sciences, Guba S\u00e1ndor u. 40, H-7400 Kaposv\u00e1r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs Zolt\u00e1n","family":"Zsid\u00f3","sequence":"additional","affiliation":[{"name":"Pharmacoinformatics Unit, Department of Pharmacology and Pharmacotherapy, Medical School, University of P\u00e9cs, Szigeti \u00fat 12, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8013-971X","authenticated-orcid":false,"given":"Csaba","family":"Het\u00e9nyi","sequence":"additional","affiliation":[{"name":"Pharmacoinformatics Unit, Department of Pharmacology and Pharmacotherapy, Medical School, University of P\u00e9cs, Szigeti \u00fat 12, H-7624 P\u00e9cs, Hungary"},{"name":"National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Medical School, University of P\u00e9cs, Szigeti \u00fat 12, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Luk\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Medical School, University of P\u00e9cs, Szigeti \u00fat 12, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-4225","authenticated-orcid":false,"given":"S\u00e1ndor","family":"Kuns\u00e1gi-M\u00e1t\u00e9","sequence":"additional","affiliation":[{"name":"Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of P\u00e9cs, Honv\u00e9d u. 1, H-7624 P\u00e9cs, Hungary"},{"name":"Green Chemistry Research Group, J\u00e1nos Szent\u00e1gothai Research Centre, University of P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 20, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fct.2013.07.047","article-title":"Mycotoxins: Occurrence, toxicology, and exposure assessment","volume":"60","author":"Marin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.fct.2015.02.005","article-title":"In vivo toxicity studies of fusarium mycotoxins in the last decade: A review","volume":"78","author":"Font","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.foodcont.2015.01.020","article-title":"Presence of mycotoxins in animal milk: A review","volume":"53","author":"Lizarraga","year":"2015","journal-title":"Food Control"},{"key":"ref_4","first-page":"R544","article-title":"Mycotoxins in Bovine Milk and Dairy Products: A Review","volume":"81","author":"Castagnaro","year":"2016","journal-title":"J. Food Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Weidenb\u00f6rner, M. (2011). Mycotoxins and Their Metabolites in Humans and Animals, Springer.","DOI":"10.1007\/978-1-4419-7433-4"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"112661","DOI":"10.1016\/j.fct.2021.112661","article-title":"Multi-mycotoxin occurrence in feed, metabolism and carry-over to animal-derived food products: A review","volume":"158","author":"Tolosa","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jat.2550090204","article-title":"Toxicokinetics of ochratoxin A in several species and its plasma-binding properties","volume":"9","author":"Hagelberg","year":"1989","journal-title":"J. Appl. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jlumin.2013.08.059","article-title":"Quantitation of species differences in albumin-ligand interactions for bovine, human and rat serum albumins using fluorescence spectroscopy: A test case with some Sudlow\u2019s site I ligands","volume":"145","author":"Poor","year":"2014","journal-title":"J. Lumin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12550-018-0321-6","article-title":"Interactions of zearalenone and its reduced metabolites \u03b1-zearalenol and \u03b2-zearalenol with serum albumins: Species differences, binding sites, and thermodynamics","volume":"34","author":"Faisal","year":"2018","journal-title":"Mycotoxin Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Flisz\u00e1r-Ny\u00fal, E., Lemli, B., Kuns\u00e1gi-M\u00e1t\u00e9, S., Dellafiora, L., Dall\u2019Asta, C., Cruciani, G., Peth\u0151, G., and Po\u00f3r, M. (2019). Interaction of mycotoxin alternariol with serum albumin. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092352"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1517\/17425255.2013.790364","article-title":"Albumin and \u03b11-acid glycoprotein: Old acquaintances","volume":"9","author":"Filip","year":"2013","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11095-018-2551-x","article-title":"Pharmacokinetic and Pharmacodynamic Considerations for Drugs Binding to Alpha-1-Acid Glycoprotein","volume":"36","author":"Smith","year":"2019","journal-title":"Pharm. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/nutrit\/nuab099","article-title":"Bioactives in bovine milk: Chemistry, technology, and applications","volume":"79","author":"Lin","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Fox, P.F., Uniacke-Lowe, T., McSweeney, P.L.H., and O\u2019Mahony, J.A. (2015). Milk Proteins. Dairy Chemistry and Biochemistry, Springer.","DOI":"10.1007\/978-3-319-14892-2"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.idairyj.2015.02.011","article-title":"An optical biosensor-based immunoassay for the determination of bovine serum albumin in milk and milk products","volume":"47","author":"Indyk","year":"2015","journal-title":"Int. Dairy J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF01042721","article-title":"Association of aflatoxin M1 with casein","volume":"174","author":"Brackett","year":"1982","journal-title":"Z. Lebensm.-Unters. Und-Forsch."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-P\u00e9rez, C., Tello-Sol\u00eds, S.R., G\u00f3mez-Castro, C.Z., Alatorre-Santamar\u00eda, S., G\u00f3mez-Ruiz, L., Rodr\u00edguez-Serrano, G., Cruz-Borbolla, J., Garc\u00eda-Garibay, M., and Cruz-Guerrero, A. (2020). Spectroscopic studies and molecular modelling of the aflatoxin M1-bovine \u03b1-lactalbumin complex formation. J. Photochem. Photobiol. B Biol., 209.","DOI":"10.1016\/j.jphotobiol.2020.111957"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12133","DOI":"10.1080\/07391102.2023.2268178","article-title":"Evaluation of the pH effect on complex formation between bovine \u03b2-lactoglobulin and aflatoxin M1: A molecular dynamic simulation and molecular docking study","volume":"42","author":"Carlos","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.fct.2008.02.028","article-title":"Fate of aflatoxin M1 in Iranian white cheese processing","volume":"46","author":"Kamkar","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.foodcont.2016.09.005","article-title":"Distribution, stability, and protein interactions of Aflatoxin M1 in fresh cheese","volume":"73","author":"Molina","year":"2017","journal-title":"Food Control"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Flisz\u00e1r-Ny\u00fal, E., Faisal, Z., Skaper, R., Lemli, B., Bayartsetseg, B., Het\u00e9nyi, C., G\u00f6mb\u00f6s, P., Szab\u00f3, A., and Po\u00f3r, M. (2022). Interaction of the Emerging Mycotoxins Beauvericin, Cyclopiazonic Acid, and Sterigmatocystin with Human Serum Albumin. Biomolecules, 12.","DOI":"10.3390\/biom12081106"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.2042-7158.1998.tb06183.x","article-title":"Extensive binding of the bioflavonoid quercetin to human plasma proteins","volume":"50","author":"Boulton","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jphotobiol.2017.03.016","article-title":"Interaction of mycotoxin zearalenone with human serum albumin","volume":"170","author":"Poor","year":"2017","journal-title":"J. Photochem. Photobiol. B-Biol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Poor, M., Zand, A., Szente, L., Lemli, B., and Kunsagi-Mate, S. (2017). Interaction of alpha- and beta-zearalenols with beta-cyclodextrins. Molecules, 22.","DOI":"10.3390\/molecules22111910"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"125204","DOI":"10.1016\/j.foodchem.2019.125204","article-title":"BSA-based sample clean-up columns for ochratoxin A determination in wine: Method development and validation","volume":"300","author":"Leal","year":"2019","journal-title":"Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"114180","DOI":"10.1016\/j.molliq.2020.114180","article-title":"Extraction of mycotoxin alternariol from red wine and from tomato juice with beta-cyclodextrin bead polymer","volume":"319","author":"Szente","year":"2020","journal-title":"J. Mol. Liq."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Poor, M., Balint, M., Hetenyi, C., Goder, B., Kunsagi-Mate, S., Koszegi, T., and Lemli, B. (2017). Investigation of Non-Covalent Interactions of Aflatoxins (B1, B2, G1, G2, and M1) with Serum Albumin. Toxins, 9.","DOI":"10.3390\/toxins9110339"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"18054","DOI":"10.1021\/acsomega.1c01799","article-title":"Aflatoxin B1Induced Structural and Conformational Changes in Bovine Serum Albumin: A Multispectroscopic and Circular Dichroism-Based Study","volume":"6","author":"Qureshi","year":"2021","journal-title":"ACS Omega"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lakowicz, J.R. (2006). Principles of Fluorescence Spectroscopy, Springer. [3rd ed.].","DOI":"10.1007\/978-0-387-46312-4"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3168\/jds.2018-14993","article-title":"Ability of milk pH to predict subclinical mastitis and intramammary infection in quarters from lactating dairy cattle","volume":"102","author":"Kandeel","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Landin, E.J.B., Williams, C., Ryan, S.A., Bochel, A., Akter, N., Redfield, C., Sessions, R.B., Dedi, N., Taylor, R.J., and Crump, M.P. (2021). The structural basis for high affinity binding of \u03b11-acid glycoprotein to the potent antitumor compound UCN-01. J. Biol. Chem., 297.","DOI":"10.1016\/j.jbc.2021.101392"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"Software news and updates AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zsid\u00f3, B.Z., B\u00f6rzsei, R., Pint\u00e9r, E., and Het\u00e9nyi, C. (2021). Prerequisite binding modes determine the dynamics of action of covalent agonists of ion channel trpa1. Pharmaceuticals, 14.","DOI":"10.3390\/ph14100988"}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/17\/4\/151\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:58:12Z","timestamp":1760029092000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/17\/4\/151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["toxins17040151"],"URL":"https:\/\/doi.org\/10.3390\/toxins17040151","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]}}}