{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:47:25Z","timestamp":1790970445665,"version":"4.1.0"},"reference-count":67,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Research of Santa Catarina (FAPESC)","award":["307987\/2021-3"],"award-info":[{"award-number":["307987\/2021-3"]}]},{"name":"Foundation for Research of Santa Catarina (FAPESC)","award":["2081094"],"award-info":[{"award-number":["2081094"]}]},{"name":"National Council for Scientific and Technological Development (CNPq)","award":["307987\/2021-3"],"award-info":[{"award-number":["307987\/2021-3"]}]},{"name":"National Council for Scientific and Technological Development (CNPq)","award":["2081094"],"award-info":[{"award-number":["2081094"]}]},{"name":"Foundation for Support of University Research and Extension (FAPEU)","award":["307987\/2021-3"],"award-info":[{"award-number":["307987\/2021-3"]}]},{"name":"Foundation for Support of University Research and Extension (FAPEU)","award":["2081094"],"award-info":[{"award-number":["2081094"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>This overview aimed at assessing botulinum toxin type A (BoNT-A)\u2019s effectiveness in managing bruxism compared to a placebo, the absence of treatment, or other interventions in adults. Only systematic reviews (SRs), with or without a meta-analysis, were included. A comprehensive literature search was conducted on 16 June 2024, encompassing seven databases and grey literature sources. Experts and reference lists of the included SRs were also consulted. Study selection was conducted in two phases by two independent authors. Methodological quality was evaluated using AMSTAR-2. Overlap was assessed using the corrected covered area. The 14 included SRs addressed several outcomes. In most studies, BoNT-A showed effectiveness in reducing pain (n = 10), the frequency of bruxism events (n = 7), and the maximum bite force (n = 5). None of the SRs effectively evaluated BoNT-A\u2019s impact on functional movements. All of the included SRs scored \u201ccritically low\u201d and \u201clow\u201d confidence rates in AMSTAR-2. Only one SR attempted to assess the certainty of the evidence, although unsuccessfully. The overlap across included SRs was rated as \u201chigh\u201d, with a corrected covered area of 10.11%. The current systematic reviews on BoNT-A for bruxism lack methodological quality, limiting the reliability of their findings. Despite evidence indicating a potential reduction in pain, bruxism events, and the maximum bite force, methodological limitations prevent definitive conclusions from being drawn. High-quality research with standardized methodologies is essential to establish BoNT-A\u2019s efficacy and support evidence-based clinical practice.<\/jats:p>","DOI":"10.3390\/toxins17050249","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T08:32:29Z","timestamp":1747384349000},"page":"249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Botulinum Toxin for Bruxism: An Overview"],"prefix":"10.3390","volume":"17","author":[{"given":"Manuella Salm","family":"Coelho","sequence":"first","affiliation":[{"name":"Brazilian Centre for Evidence-Based Research (COBE), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florian\u00f3polis 88040-535, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Meller Dias de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Brazilian Centre for Evidence-Based Research (COBE), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florian\u00f3polis 88040-535, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Polmann","sequence":"additional","affiliation":[{"name":"Brazilian Centre for Evidence-Based Research (COBE), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florian\u00f3polis 88040-535, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1762-7059","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Pauletto","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Universidad de las Americas (UDLA), Quito 170513, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine Miron","family":"Stefani","sequence":"additional","affiliation":[{"name":"Department of Dentistry, University of Bras\u00edlia, Bras\u00edlia 70910-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Catarine De Luca","family":"Maciel","sequence":"additional","affiliation":[{"name":"Centre for Cell Biology & Cutaneous Research, Blizard Institute, Queen Mary University of London, London E1 2AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziela De Luca","family":"Canto","sequence":"additional","affiliation":[{"name":"Brazilian Centre for Evidence-Based Research (COBE), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florian\u00f3polis 88040-535, Brazil"},{"name":"Emergency Medicine and Evidence-Based Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 040023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/joor.12011","article-title":"Bruxism Defined and Graded: An International Consensus","volume":"40","author":"Lobbezoo","year":"2013","journal-title":"J. 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