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In this study, we investigated the effects of the specialized pro-resolving lipid mediator (SPM) maresin 2 (MaR2) in a murine model of BjV-evoked pain and inflammation. Mice received a single intraperitoneal (i.p.) injection of MaR2 30 min before the intraplantar BjV injection. MaR2 treatment significantly attenuated mechanical (electronic aesthesiometer) and thermal (hot plate) hyperalgesia in a dose-dependent manner. Additionally, MaR2 restored the balance for the hind-paw static weight distribution. When BjV (0.01, 0.1, and 1 \u03bcg) stimulus was administered intraperitoneally, pre-treatment with MaR2 (0.3, 1, or 3 ng) ameliorated mechanical and thermal hyperalgesia in a dose-dependent manner. Moreover, MaR2 (3 ng) effectively reduced the levels of myeloperoxidase activity and cytokines (TNF-\u03b1, IL-1\u03b2, and IL-6) and superoxide anion (O2\u2022\u2212) production induced by intraplantar injection of BjV while enhancing total antioxidant levels (ABTS scavenging). For the peritonitis model induced by BjV, MaR2 pretreatment decreased leukocyte recruitment, hemorrhage, nitric oxide (NO), and O2\u2022\u2212 generation and gp91phox and inducible nitric oxide synthase (iNOS) mRNA expression. In conclusion, this study presents the first evidence that MaR2 effectively mitigated BjV-induced pain, hemorrhage, and inflammation.<\/jats:p>","DOI":"10.3390\/toxins17080367","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T08:13:31Z","timestamp":1753431211000},"page":"367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maresin 2, a Specialized Pro-Resolution Lipid Mediator, Reduces Pain and Inflammation Induced by Bothrops\u00a0jararaca Venom in Mice"],"prefix":"10.3390","volume":"17","author":[{"given":"Kassyo L. S.","family":"Dantas","sequence":"first","affiliation":[{"name":"Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz H. S.","family":"Bianchini","sequence":"additional","affiliation":[{"name":"Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7414-7919","authenticated-orcid":false,"given":"Matheus D. V.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4099-3492","authenticated-orcid":false,"given":"Maiara","family":"Piva","sequence":"additional","affiliation":[{"name":"Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0897-091X","authenticated-orcid":false,"given":"Joice M.","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Federal University of Paran\u00e1, Curitiba 81531-980, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3448-5646","authenticated-orcid":false,"given":"Janaina M.","family":"Zanoveli","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Federal University of Paran\u00e1, Curitiba 81531-980, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0068-9974","authenticated-orcid":false,"given":"Fernanda C.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0842-9130","authenticated-orcid":false,"given":"Fabiana T. M. C.","family":"Vicentini","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-903, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-0773","authenticated-orcid":false,"given":"Camila R.","family":"Ferraz","sequence":"additional","affiliation":[{"name":"Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia B.","family":"Clissa","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-1668","authenticated-orcid":false,"given":"Rubia","family":"Casagrande","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Center of Health Sciences, Londrina State University, Londrina 86039-440, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-9283","authenticated-orcid":false,"given":"Waldiceu A.","family":"Verri","sequence":"additional","affiliation":[{"name":"Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"ref_1","unstructured":"da Sa\u00fade, M. (2022). Boletim Epidemiol\u00f3gico Vol. 53-No 36."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1590\/S0037-86821997000600006","article-title":"Bites by snakes in the genus Bothrops: A series of 3139 cases","volume":"30","author":"Ribeiro","year":"1997","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.ijbiomac.2021.02.178","article-title":"Jararhagin, a Snake Venom Metalloproteinase, Induces Mechanical Hyperalgesia in Mice with the Neuroinflammatory Contribution of Spinal Cord Microglia and Astrocytes","volume":"179","author":"Ferraz","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.toxicon.2015.06.024","article-title":"Jararhagin-Induced Mechanical Hyperalgesia Depends on TNF-\u03b1, IL-1\u03b2 and NF\u03baB in Mice","volume":"103","author":"Ferraz","year":"2015","journal-title":"Toxicon"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/S0041-0101(01)00131-3","article-title":"The Effect of Jararhagin, a Metalloproteinase from Bothrops Jararaca Venom, on pro-Inflammatory Cytokines Released by Murine Peritoneal Adherent Cells","volume":"39","author":"Clissa","year":"2001","journal-title":"Toxicon"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/0041-0101(95)00085-Z","article-title":"Phospholipase A2 Myotoxins from Bothrops Snake Venoms","volume":"33","author":"Lomonte","year":"1995","journal-title":"Toxicon"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0163-7258(94)90049-3","article-title":"Hemorrhagic Metalloproteinases from Snake Venoms","volume":"62","author":"Bjarnason","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0041-0101(99)00227-5","article-title":"Increments in Serum Cytokine and Nitric Oxide Levels in Mice Injected with Bothrops Asper and Bothrops jararaca Snake Venoms","volume":"38","author":"Petricevich","year":"2000","journal-title":"Toxicon"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.2174\/1568026619666190809100319","article-title":"Bothrops Alternatus Snake Venom Induces Cytokine Expression and Oxidative Stress on Renal Function","volume":"19","author":"Jorge","year":"2019","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of Apoptosis Signalling Pathways by Reactive Oxygen Species","volume":"1863","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1590\/S0100-879X2002001000016","article-title":"Evaluation of Antivenoms in the Neutralization of Hyperalgesia and Edema Induced by Bothrops jararaca and Bothrops Asper Snake Venoms","volume":"35","author":"Picolo","year":"2002","journal-title":"Brazilian J. Med. Biol. Res. Rev. Bras. Pesqui. Medicas e Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0041-0101(00)00082-9","article-title":"Neutralizing Potency of Horse Antibothropic Brazilian Antivenom against Bothrops Snake Venoms from the Amazonian Rain Forest","volume":"38","author":"Muniz","year":"2000","journal-title":"Toxicon"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Dias da Silva, W., De Andrade, S.A., Megale, \u00c2.A.A., De Souza, D.A., Sant\u2019Anna, O.A., Magnoli, F.C., Guidolin, F.R., Godoi, K.S., Saladini, L.Y., and Spencer, P.J. (2022). Antibodies as Snakebite Antivenoms: Past and Future. Toxins, 14.","DOI":"10.3390\/toxins14090606"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Kondo, F.V., Cabrera, W.H.K., Ribeiro, O.G., De Franco, M., Jensen, J.R., Picolo, G., Sant\u2019Anna, M.B., Spadafora-Ferreira, M., Borrego, A., and Iba\u00f1ez, O.M. (2021). Pain and Cellular Migration Induced by Bothrops jararaca Venom in Mice Selected for an Acute Inflammatory Response: Involvement of Mast Cells. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.779473"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/sj.bjp.0707630","article-title":"Different Mechanisms Underlie the Analgesic Actions of Paracetamol and Dipyrone in a Rat Model of Inflammatory Pain","volume":"153","author":"Rezende","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7394","DOI":"10.4103\/jfmpc.jfmpc_1371_22","article-title":"Role of steroid on management of limb swelling and local pain in haematotoxic snake bite","volume":"11","author":"Ghosh","year":"2022","journal-title":"J. Family Med. Prim. Care."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/aas.14237","article-title":"Glucocorticoids Added to Paracetamol and NSAIDs for Post-Operative Pain: A Systematic Review with Meta-Analysis and Trial Sequential Analysis","volume":"67","author":"Stormholt","year":"2023","journal-title":"Acta Anaesthesiol. Scand"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"874","DOI":"10.4269\/ajtmh.23-0278","article-title":"Snakebite-Associated Infections: A Systematic Review and Meta-Analysis","volume":"110","author":"Siddiq","year":"2024","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/00002508-198906002-00005","article-title":"The Management of Pain in Orthopaedics","volume":"5","author":"Fetrow","year":"1989","journal-title":"Clin. J. Pain"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.immuni.2014.02.009","article-title":"Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation","volume":"40","author":"Buckley","year":"2014","journal-title":"Immunity"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.coph.2013.05.012","article-title":"Resolution Phase Lipid Mediators of Inflammation: Agonists of Resolution","volume":"13","author":"Serhan","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zaninelli, T.H., Fattori, V., and Verri, W.A.J. (2021). Harnessing Inflammation Resolution in Arthritis: Current Understanding of Specialized Pro-Resolving Lipid Mediators\u2019 Contribution to Arthritis Physiopathology and Future Perspectives. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.729134"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"104549","DOI":"10.1016\/j.phrs.2019.104549","article-title":"Specialized Pro-Resolving Lipid Mediators: A New Class of Non-Immunosuppressive and Non-Opioid Analgesic Drugs","volume":"151","author":"Fattori","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Rasquel-Oliveira, F.S., Silva, M.D.V.D., Martelossi-Cebinelli, G., Fattori, V., Casagrande, R., and Verri, W.A.J. (2023). Specialized Pro-Resolving Lipid Mediators: Endogenous Roles and Pharmacological Activities in Infections. Molecules, 28.","DOI":"10.3390\/molecules28135032"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev-pharmtox-051921-084047","article-title":"Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch","volume":"63","author":"Ji","year":"2023","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1111\/bph.14647","article-title":"The Specialised Pro-Resolving Lipid Mediator Maresin 1 Reduces Inflammatory Pain with a Long-Lasting Analgesic Effect","volume":"176","author":"Fattori","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Deng, B., Wang, C.-W., Arnardottir, H.H., Li, Y., Cheng, C.-Y.C., Dalli, J., and Serhan, C.N. (2014). Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and pro-Resolving Mediator from Human Macrophages. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102362"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e2218162120","DOI":"10.1073\/pnas.2218162120","article-title":"Maresin-2 Promotes Mucosal Repair and Has Therapeutic Potential When Encapsulated in Thermostable Nanoparticles","volume":"120","author":"Miranda","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.toxrep.2022.06.010","article-title":"Evaluation of the Effects of Loxosceles Intermedia\u2019s Venom in Zebrafish","volume":"9","author":"Tozzi","year":"2022","journal-title":"Toxicol. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109189","DOI":"10.1016\/j.neuropharm.2022.109189","article-title":"Maresin 2 Is an Analgesic Specialized Pro-Resolution Lipid Mediator in Mice by Inhibiting Neutrophil and Monocyte Recruitment, Nociceptor Neuron TRPV1 and TRPA1 Activation, and CGRP Release","volume":"216","author":"Fattori","year":"2022","journal-title":"Neuropharmacology"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lopes, R.V., Baggio, D.F., Ferraz, C.R., Bertozzi, M.M., Saraiva-Santos, T., Verri Junior, W.A., and Chichorro, J.G. (2023). Maresin-2 Inhibits Inflammatory and Neuropathic Trigeminal Pain and Reduces Neuronal Activation in the Trigeminal Ganglion. Curr. Res. Neurobiol., 4.","DOI":"10.1016\/j.crneur.2023.100093"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in Inflammation: Emergence of the pro-Resolving Superfamily of Mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"102673","DOI":"10.1016\/j.dnarep.2019.102673","article-title":"Inflammation-Induced DNA Damage, Mutations and Cancer","volume":"83","author":"Kay","year":"2019","journal-title":"DNA Repair"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/paa.1999.111.5.383","article-title":"Myeloperoxidase","volume":"111","author":"Klebanoff","year":"1999","journal-title":"Proc. Assoc. Am. Physicians"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-Resolving Lipid Mediators Are Leads for Resolution Physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0041-008X(03)00337-5","article-title":"Pulmonary Hemorrhage Induced by Jararhagin, a Metalloproteinase from Bothrops Jararaca Snake Venom","volume":"193","author":"Escalante","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.biochi.2007.11.009","article-title":"Collagen Binding Is a Key Factor for the Hemorrhagic Activity of Snake Venom Metalloproteinases","volume":"90","author":"Ramos","year":"2008","journal-title":"Biochimie"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0041-0101(96)00017-7","article-title":"Insights into the Mechanism of Haemorrhage Caused by Snake Venom Metalloproteinases","volume":"34","author":"Kamiguti","year":"1996","journal-title":"Toxicon"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.toxicon.2020.09.006","article-title":"Polymorphonuclear neutrophil leukocytes in snakebite envenoming","volume":"187","author":"Zuliani","year":"2020","journal-title":"Toxicon"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.molimm.2022.03.118","article-title":"Maresin-2 Alleviates Allergic Airway Inflammation in Mice by Inhibiting the Activation of NLRP3 Inflammasome, Th2 Type Immune Response and Oxidative Stress","volume":"146","author":"Yu","year":"2022","journal-title":"Mol. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.toxicon.2021.06.009","article-title":"Synergistic Effect of Serine Protease Inhibitors and a Bothropic Antivenom in Reducing Local Hemorrhage and Coagulopathy Caused by Bothrops jararaca Venom","volume":"199","author":"Silva","year":"2021","journal-title":"Toxicon"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Fattori, V., Hohmann, M.S., Rossaneis, A.C., Pinho-Ribeiro, F.A., and Verri, W.A. (2016). Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses. Molecules, 21.","DOI":"10.3390\/molecules21070844"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.1073\/pnas.0603286103","article-title":"IL-15 Mediates Immune Inflammatory Hypernociception by Triggering a Sequential Release of IFN-Gamma, Endothelin, and Prostaglandin","volume":"103","author":"Verri","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s10753-018-0739-1","article-title":"Acute Inflammation and Metabolism","volume":"41","author":"Varela","year":"2018","journal-title":"Inflammation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.0959-9673.2005.00419.x","article-title":"Effects of Neutrophil Depletion in the Local Pathological Alterations and Muscle Regeneration in Mice Injected with Bothrops jararaca Snake Venom","volume":"86","author":"Teixeira","year":"2005","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40409-018-0170-y","article-title":"Cytotoxic and Inflammatory Potential of a Phospholipase A2 from Bothrops jararaca Snake Venom","volume":"24","author":"Cedro","year":"2018","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s00011-004-1288-7","article-title":"V Chronic Blockade of Nitric Oxide Biosynthesis in Rats: Effect on Leukocyte Endothelial Interaction and on Leukocyte Recruitment","volume":"53","author":"Farsky","year":"2004","journal-title":"Inflamm. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0041-0101(96)00135-3","article-title":"Leukocyte Response Induced by Bothrops jararaca Crude Venom: In Vivo and in Vitro Studies","volume":"35","author":"Farsky","year":"1997","journal-title":"Toxicon"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil Recruitment and Function in Health and Inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sikora, J.P., Karawani, J., and Sobczak, J. (2023). Neutrophils and the Systemic Inflammatory Response Syndrome (SIRS). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713469"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/01.RES.0000326772.76822.7a","article-title":"Myeloperoxidase delays neutrophil apoptosis through CD11b\/CD18 integrins and prolongs inflammation","volume":"103","author":"Pan","year":"2008","journal-title":"Circ. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1073\/pnas.0405193102","article-title":"Myeloperoxidase Mediates Neutrophil Activation by Association with CD11b\/CD18 Integrins","volume":"102","author":"Lau","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/bj3270275","article-title":"Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid","volume":"327","author":"Carr","year":"1997","journal-title":"Biochem. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1046\/j.1365-2141.2003.04602.x","article-title":"Neutrophil Myeloperoxidase Activity and the Influence of Two Single-Nucleotide Promoter Polymorphisms","volume":"123","author":"Rutgers","year":"2003","journal-title":"Br. J. Haematol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1016\/j.cell.2022.10.007","article-title":"Macrophages in Health and Disease","volume":"185","author":"Park","year":"2022","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0002-9440(10)64036-9","article-title":"Macrophage Myeloperoxidase Regulation by Granulocyte Macrophage Colony-Stimulating Factor in Human Atherosclerosis and Implications in Acute Coronary Syndromes","volume":"158","author":"Sugiyama","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","article-title":"Myeloperoxidase: Its Role for Host Defense, Inflammation, and Neutrophil Function","volume":"640","author":"Aratani","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.toxicon.2009.07.025","article-title":"Contribution of Metalloproteases, Serine Proteases and Phospholipases A2 to the Inflammatory Reaction Induced by Bothrops Jararaca Crude Venom in Mice","volume":"55","author":"Zychar","year":"2010","journal-title":"Toxicon"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"107350","DOI":"10.1016\/j.toxicon.2023.107350","article-title":"Hemoperitoneum after a Bothrops Snakebite: Case Report","volume":"237","author":"Santoro","year":"2024","journal-title":"Toxicon"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric Oxide Synthases: Regulation and Function","volume":"33","author":"Sessa","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0041-0101(01)00123-4","article-title":"Bothrops Asper and Bothrops jararaca Snake Venoms Trigger Microbicidal Functions of Peritoneal Leukocytes in Vivo","volume":"39","author":"Zamuner","year":"2001","journal-title":"Toxicon"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1096\/fj.11-201442","article-title":"Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain","volume":"26","author":"Serhan","year":"2012","journal-title":"FASEB J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"102870","DOI":"10.1016\/j.ceca.2024.102870","article-title":"TRPV1: Receptor Structure, Activation, Modulation and Role in Neuro-Immune Interactions and Pain","volume":"119","author":"Maximiano","year":"2024","journal-title":"Cell Calcium"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"174185","DOI":"10.1016\/j.ejphar.2021.174185","article-title":"TRP Channels in Cancer Pain","volume":"904","author":"Almeida","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_65","first-page":"6481812","article-title":"Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation","volume":"2019","author":"Fattori","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/0962935021000051548","article-title":"Cell Adhesion Molecules Involved in the Leukocyte Recruitment Induced by Venom of the Snake Bothrops Jararaca","volume":"11","author":"Zamuner","year":"2002","journal-title":"Mediat. Inflamm."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"da Silva Fernandes Ribas, A., de Godoi, K.S., Sant\u2019Anna, S.S., da Rocha, M.M.T., and da Silva, W.D. (2025). Release of Cytokines in the Peritoneal Fluid of C57BL\/6 Mice After Bothrops Jararaca and Bothrops Atrox Venom Injection. Toxins, 17.","DOI":"10.3390\/toxins17040164"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1021\/acs.jnatprod.9b00887","article-title":"Diosmin Treats Lipopolysaccharide-Induced Inflammatory Pain and Peritonitis by Blocking NF-\u039aB Activation in Mice","volume":"83","author":"Fattori","year":"2020","journal-title":"J. Nat. 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