{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T17:07:28Z","timestamp":1777223248741,"version":"3.51.4"},"reference-count":65,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONICYT + FONDEF\/CONCURSO IDeA I+D, FONDEF\/CONICYT","award":["2020 N\u00b0ID20I10056"],"award-info":[{"award-number":["2020 N\u00b0ID20I10056"]}]},{"DOI":"10.13039\/501100012655","name":"Universidad de Antofagasta","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012655","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002848","name":"National Commission for Scientific and Technological Research","doi-asserted-by":"crossref","award":["D-21151173"],"award-info":[{"award-number":["D-21151173"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Toxins"],"abstract":"<jats:p>Spiders of the Sicarius genera (Araneae: Sicariidae) are commonly known as six-eyed sand spiders. Of the species described in Latin America, the species S. thomisoides has previously been shown to possess venom with a toxic potential comparable to that observed in the venom of the spider L. laeta. Although identifying the phospholipase D activity in the venom of S. thomisoides, it is still unknown what other components are part of the venom. In this study, we described the identification of the main protein components of S. thomisoides venom, revealing that the phospholipase D family were the majority toxins, followed by Astacin-like metalloproteinases and serine proteases. Additionally, the presence of CRISP-type allergens and peptides from the U-PHTX-Pmx family was identified for the first time in venoms from Sicarius genera. Identifying the components of the Sicarius spider venom is an essential step to understanding its toxicological potential.<\/jats:p>","DOI":"10.3390\/toxins17100486","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:01:39Z","timestamp":1759154499000},"page":"486","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Proteome Analysis of the Six-Eyed Sand-Spider Sicarius thomisoides Venom"],"prefix":"10.3390","volume":"17","author":[{"given":"Tom\u00e1s","family":"Ar\u00e1n-Sekul","sequence":"first","affiliation":[{"name":"Molecular Parasitology Research Laboratory, Department of Medical Technology, Faculty of Health Sciences, University of Antofagasta, Antofagasta 1270300, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-5014","authenticated-orcid":false,"given":"Juan","family":"San Francisco","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Research Laboratory, Department of Medical Technology, Faculty of Health Sciences, University of Antofagasta, Antofagasta 1270300, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Rojas","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Research Laboratory, Department of Medical Technology, Faculty of Health Sciences, University of Antofagasta, Antofagasta 1270300, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-720X","authenticated-orcid":false,"given":"Kyung-Mee","family":"Moon","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Foster","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Research Laboratory, Department of Medical Technology, Faculty of Health Sciences, University of Antofagasta, Antofagasta 1270300, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"ref_1","unstructured":"WSC (2025, May 07). 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