{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:49:01Z","timestamp":1790830141990,"version":"4.1.0"},"reference-count":67,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NOAA Monitoring and Event Response for Harmful Algal Blooms (MERHAB) program","award":["NA19NOS 4780184"],"award-info":[{"award-number":["NA19NOS 4780184"]}]},{"DOI":"10.13039\/100014522","name":"NOAA National Ocean Service through the Central and Northern California Ocean Observing System","doi-asserted-by":"publisher","award":["NA21NOS0120090"],"award-info":[{"award-number":["NA21NOS0120090"]}],"id":[{"id":"10.13039\/100014522","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Domoic acid (DA), produced by Pseudo-nitzschia diatoms, is the one of the major toxin threats from harmful algal blooms (HABs) on the west coast of the United States. DA events vary in magnitude, timing, and duration, and elucidating drivers for individual events is a persistent challenge. Monterey Bay experiences near-annual DA events and hosts long-term HAB monitoring at the Santa Cruz Municipal Wharf (SCW). Here we characterize two toxin events, occurring in May 2023 and March 2024. The events were similar in magnitude and duration, but an exploration of physical, biological, and chemical dynamics revealed distinct environmental drivers. These differences resulted in a significant deviation in cellular DA (cDA) within the same species of Pseudo-nitzschia. In addition, opportunistic solid-phase adsorption toxin tracking (SPATT) was used for environmental metabolomics. The novel application of SPATT revealed 159 metabolites that were strongly correlated with DA in both events and produced a spectral match to a new marine natural product using Global Natural Products Social Molecular Networking (GNPS). This work takes a multivariable approach to understanding toxin drivers and lends proof of concept for the integration of environmental metabolomics in HAB monitoring.<\/jats:p>","DOI":"10.3390\/toxins17100511","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:39:34Z","timestamp":1760701174000},"page":"511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["One Bloom Is Not Like the Other\u2014Distinct Environmental Drivers Result in Domoic Acid Events in Monterey Bay, California"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-8811","authenticated-orcid":false,"given":"Aubrey","family":"Trapp","sequence":"first","affiliation":[{"name":"Department of Ocean Sciences, University of California, 1156 High Street, Santa Cruz, CA 95064, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Baker","sequence":"additional","affiliation":[{"name":"Waters Corporation, 5720 Stoneridge Dr., Pleasonton, CA 94588, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1600-9504","authenticated-orcid":false,"given":"Kendra","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Ocean Sciences, University of California, 1156 High Street, Santa Cruz, CA 95064, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-1205","authenticated-orcid":false,"given":"Raphael M.","family":"Kudela","sequence":"additional","affiliation":[{"name":"Department of Ocean Sciences, University of California, 1156 High Street, Santa Cruz, CA 95064, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tsikoti, C., and Genitsaris, S. 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