{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:50:46Z","timestamp":1778601046181,"version":"3.51.4"},"reference-count":64,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research Program","award":["2023YFD1301005"],"award-info":[{"award-number":["2023YFD1301005"]}]},{"name":"National Science Fund for Outstanding Young Scholars","award":["32222080"],"award-info":[{"award-number":["32222080"]}]},{"name":"Guangdong Province Natural Science Funds for Distinguished Young Scholar","award":["2022B1515020016"],"award-info":[{"award-number":["2022B1515020016"]}]},{"name":"Funds for International Cooperation and Exchange of the National Natural Science Foundation of China","award":["W2412010"],"award-info":[{"award-number":["W2412010"]}]},{"DOI":"10.13039\/501100012453","name":"China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS-42-15"],"award-info":[{"award-number":["CARS-42-15"]}],"id":[{"id":"10.13039\/501100012453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Applied Basic Research Foundation","award":["2022B1515130003"],"award-info":[{"award-number":["2022B1515130003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The objective of this study was to evaluate the protective effect of curcumin (Cur) on reproductive toxicity induced by fumonisin B1 (FB1) in laying ducks during the peak egg-laying period. A total of seventy-two 50-week-old Cherry Valley ducks were randomly assigned to four groups: control, FB1 (30 mg\/kg), Cur (200 mg\/kg), and Cur + FB1 (200 mg\/kg + 30 mg\/kg). The experiment lasted for 35 days. Our results showed that cur supplementation effectively restored the reductions in final body weight (p = 0.005) and oviduct length (p = 0.020) induced by FB1 exposure. Residual FB1 concentrations in serum, liver, and ovaries were markedly increased in the FB1-treated group, while Cur significantly decreased the FB1 residual in duck liver (p &lt; 0.05). Meanwhile, Cur supplementation markedly counteracted the FB1-induced reductions in serum total protein, albumin, triglycerides, and high-density lipoprotein induced by FB1 exposure. Cur supplementation effectively regulated FB1-induced oxidative stress, inflammation, and endocrine disruption. Specifically, Cur lowered FB1-induced malondialdehyde levels (p &lt; 0.010), attenuated interleukin-1\u03b2 increase (p = 0.083), and reversed the reduction in immunoglobulin G levels. FB increased the levels of hormones associated with duck reproduction, including estradiol, follicle-stimulating hormone, and luteinizing hormone; in contrast, curcumin supplementation decreased the levels of these hormones (p &lt; 0.010). Histopathological analysis revealed that Cur significantly alleviated the inflammation and necrosis in the liver, kidneys, ovaries, and oviducts induced by FB1. In conclusion, dietary Cur supplementation effectively alleviated FB1-induced reproductive toxicity in laying ducks by enhancing antioxidant capacity, improving lipid metabolism, and restoring hormonal homeostasis.<\/jats:p>","DOI":"10.3390\/toxins18010034","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:03:16Z","timestamp":1767974596000},"page":"34","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin Mitigates Fumonisin B1-Induced Ovarian Toxicity in Peak-Laying Ducks via Hormone Metabolic Protection and Enhanced Reproductive Resilience"],"prefix":"10.3390","volume":"18","author":[{"given":"Lihua","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyun","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Mujtaba","family":"Shah","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyi","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinze","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqing","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-3553","authenticated-orcid":false,"given":"Lukuyu A.","family":"Bernard","sequence":"additional","affiliation":[{"name":"International Livestock Research Institute, Nairobi 00100, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Kashif","family":"Saleemi","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Agriculture Faisalabad, Faisalabad 38040, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-7141","authenticated-orcid":false,"given":"Wence","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"},{"name":"Gurdon Institute and the Department of Genetics, University of Cambridge, Cambridge CB2 1QN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"ref_1","first-page":"022","article-title":"Mycotoxin toxicity and its alleviation strategy on female mammalian reproduction and fertility","volume":"1","author":"Lu","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0278-6915(99)00034-4","article-title":"Fumonisin B1, a mycotoxin contaminant of cereal grains, and inducer of apoptosis via the tumour necrosis factor pathway and caspase activation","volume":"37","author":"Jones","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"ref_3","first-page":"259","article-title":"An overview of rodent toxicities: Liver and kidney effects of fumonisins and Fusarium moniliforme","volume":"109","author":"Voss","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ma, J., Huang, R., Zhang, H., Liu, D., Dong, X., Xiong, Y., Xiong, X., Lan, D., Fu, W., and He, H. (2024). The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25168764"},{"key":"ref_5","first-page":"e07534","article-title":"Assessment of information as regards the toxicity of fumonisins for pigs, poultry and horses","volume":"20","author":"Schrenk","year":"2022","journal-title":"EFSA J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Yu, S., Jia, B., Lin, H., Zhang, S., Yu, D., Liu, N., and Wu, A. (2022). Effects of Fumonisin B and Hydrolyzed Fumonisin B on Growth and Intestinal Microbiota in Broilers. Toxins, 14.","DOI":"10.3390\/toxins14030163"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"104517","DOI":"10.1016\/j.micpath.2020.104517","article-title":"Laying hens fed mycotoxin-contaminated feed produced by Fusarium fungi (T-2 toxin and fumonisin B1) and Saccharomyces cerevisiae lysate: Impacts on poultry health, productive efficiency, and egg quality","volume":"149","author":"Dazuk","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.theriogenology.2021.01.011","article-title":"Fumonisin B1 exposure adversely affects porcine oocyte maturation in vitro by inducing mitochondrial dysfunction and oxidative stress","volume":"164","author":"Li","year":"2021","journal-title":"Theriogenology"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lumsangkul, C., Chiang, H.I., Lo, N.W., Fan, Y.K., and Ju, J.C. (2019). Developmental Toxicity of Mycotoxin Fumonisin B1 in Animal Embryogenesis: An Overview. Toxins, 11.","DOI":"10.3390\/toxins11020114"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/ps\/83.12.1953","article-title":"Effects of prolonged administration of aflatoxin B1 and fumonisin B1 in laying Japanese quail","volume":"83","author":"Ogido","year":"2004","journal-title":"Poult. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.anireprosci.2007.11.006","article-title":"Testicular and epididymal sperm reserves and sperm production of pubertal boars fed dietary fumonisin B(1)","volume":"105","author":"Gbore","year":"2008","journal-title":"Anim. Reprod. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"113748","DOI":"10.1016\/j.fct.2023.113748","article-title":"Quercetin alleviates gliotoxin-induced duckling tissue injury by inhibiting oxidative stress, inflammation and increasing heterophil extracellular traps release","volume":"176","author":"Jin","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Xia, S., Yan, C., Gu, J., Yuan, Y., Zou, H., Liu, Z., and Bian, J. (2024). Resveratrol Alleviates Zearalenone-Induced Intestinal Dysfunction in Mice through the NF-\u03baB\/Nrf2\/HO-1 Signalling Pathway. Foods, 13.","DOI":"10.3390\/foods13081217"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"154306","DOI":"10.1016\/j.phymed.2022.154306","article-title":"Role of curcumin in the treatment of acute kidney injury: Research challenges and opportunities","volume":"104","author":"Cai","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chen, J., Xiong, D., and Long, M. (2025). Curcumin Attenuates Fumonisin B1-Induced PK-15 Cell Apoptosis by Upregulating miR-1249 Expression to Inhibit the IRE1\/MKK7\/JNK\/CASPASE3 Signaling Pathway. Antioxidants, 14.","DOI":"10.3390\/antiox14020168"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"113317","DOI":"10.1016\/j.envpol.2019.113317","article-title":"Aflatoxin B(1) promotes autophagy associated with oxidative stress-related PI3K\/AKT\/mTOR signaling pathway in mice testis","volume":"255","author":"Huang","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12550-025-00586-1","article-title":"Protective effect of curcumin against endoplasmic reticulum stress and lipid metabolism disorders in AFB1-intoxicated duck liver","volume":"41","author":"Su","year":"2025","journal-title":"Mycotoxin Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s12550-023-00504-3","article-title":"Curcumin alleviates AFB1-induced nephrotoxicity in ducks: Regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis","volume":"39","author":"Liu","year":"2023","journal-title":"Mycotoxin Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Niu, Y., He, J., Zhao, Y., Shen, M., Zhang, L., Zhong, X., Wang, C., and Wang, T. (2019). Effect of Curcumin on Growth Performance, Inflammation, Insulin level, and Lipid Metabolism in Weaned Piglets with IUGR. Animals, 9.","DOI":"10.3390\/ani9121098"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.jaci.2022.12.808","article-title":"ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice","volume":"151","author":"Yoshida","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3389\/fmicb.2017.02317","article-title":"Lactobacillus plantarum MYS6 Ameliorates Fumonisin B1-Induced Hepatorenal Damage in Broilers","volume":"8","author":"Deepthi","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3382\/ps\/pex382","article-title":"Effects of fumonisin B1 and mycotoxin binders on growth performance, tibia characteristics, gut physiology, and stress indicators in broiler chickens raised in different stocking densities","volume":"97","author":"Lee","year":"2018","journal-title":"Poult. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1080\/00071660400012766","article-title":"Effect of dietary fumonisin B1 on laying Japanese quail","volume":"45","author":"Butkeraitis","year":"2004","journal-title":"Br. Poult. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lumsangkul, C., Tso, K.H., Fan, Y.K., Chiang, H.I., and Ju, J.C. (2021). Mycotoxin Fumonisin B1 Interferes Sphingolipid Metabolisms and Neural Tube Closure during Early Embryogenesis in Brown Tsaiya Ducks. Toxins, 13.","DOI":"10.3390\/toxins13110743"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3389\/fnins.2017.00558","article-title":"Curcumin Activates AMPK Pathway and Regulates Lipid Metabolism in Rats Following Prolonged Clozapine Exposure","volume":"11","author":"Liu","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wu, X., Du, X., Pian, H., and Yu, D. (2024). Effect of Curcumin on Hepatic mRNA and lncRNA Co-Expression in Heat-Stressed Laying Hens. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105393"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Aoyanagi, M., Budi\u00f1o, F.E.L., Raj, J., Vasiljevi\u0107, M., Ali, S., Ramalho, L.N.Z., Ramalho, F.S., Corassin, C.H., Ghantous, G.F., and Oliveira, C.A.F. (2023). Efficacy of Two Commercially Available Adsorbents to Reduce the Combined Toxic Effects of Dietary Aflatoxins, Fumonisins, and Zearalenone and Their Residues in the Tissues of Weaned Pigs. Toxins, 15.","DOI":"10.3390\/toxins15110629"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3382\/ps.2012-02510","article-title":"In vitro and in vivo efficacy of a hydrated sodium calcium aluminosilicate to bind and reduce aflatoxin residues in tissues of broiler chicks fed aflatoxin B1","volume":"92","author":"Neeff","year":"2013","journal-title":"Poult. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Laurain, J., Tardieu, D., Matard-Mann, M., Rodriguez, M.A., and Guerre, P. (2021). Fumonisin B1 Accumulates in Chicken Tissues over Time and This Accumulation Was Reduced by Feeding Algo-Clay. Toxins, 13.","DOI":"10.3390\/toxins13100701"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Peillod, C., Laborde, M., Travel, A., Mika, A., Bailly, J.D., Cleva, D., Boissieu, C., Le Guennec, J., Albaric, O., and Labrut, S. (2021). Toxic Effects of Fumonisins, Deoxynivalenol and Zearalenone Alone and in Combination in Ducks Fed the Maximum EUTolerated Level. Toxins, 13.","DOI":"10.3390\/toxins13020152"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Chen, Y., Qu, G., Quan, H., Wang, Y., Wang, C., Haque, M.A., and He, C. (2022). A Novel Cost-Effective Nanobody against Fumonisin B1 Contaminations: Efficacy Test in Dairy Milk and Chickens. Toxins, 14.","DOI":"10.3390\/toxins14120821"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ashry, A., Taha, N.M., Lebda, M.A., Abdo, W., El-Diasty, E.M., Fadl, S.E., and Morsi Elkamshishi, M. (2022). Ameliorative effect of nanocurcumin and Saccharomyces cell wall alone and in combination against aflatoxicosis in broilers. BMC Vet. Res., 18.","DOI":"10.1186\/s12917-022-03256-x"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1039\/c1np00051a","article-title":"Multitargeting by curcumin as revealed by molecular interaction studies","volume":"28","author":"Gupta","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Yim-im, W., Sawatdichaikul, O., Semsri, S., Horata, N., Mokmak, W., Tongsima, S., Suksamrarn, A., and Choowongkomon, K. (2014). Computational analyses of curcuminoid analogs against kinase domain of HER2. BMC Bioinform., 15.","DOI":"10.1186\/1471-2105-15-261"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cgh.2023.05.023","article-title":"Curcumin-QingDai Combination for Patients With Active Ulcerative Colitis: A Randomized, Double-Blinded, Placebo-Controlled Trial","volume":"22","author":"Salomon","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"138929","DOI":"10.1016\/j.foodchem.2024.138929","article-title":"Glucuronidation dynamics of curcumin and tetrahydrocurcumin for differential structures and chemical reactivities in human liver microsome and uridine diphosphate glucuronosyltransferase 2B7","volume":"448","author":"Guo","year":"2024","journal-title":"Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Alhelaisi, A., Alrezaki, A., Nahdi, S., Aldahmash, W., Alwasel, S., and Harrath, A.H. (2023). Early-Life Exposure to the Mycotoxin Fumonisin B1 and Developmental Programming of the Ovary of the Offspring: The Possible Role of Autophagy in Fertility Recovery. Toxics, 11.","DOI":"10.20944\/preprints202309.1557.v1"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jep.2004.04.022","article-title":"Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rat s and ovarian histology","volume":"94","author":"Bhutani","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cbi.2005.07.009","article-title":"Serum sphinganine and the sphinganine to sphingosine ratio as a biomarker of dietary fumonisins during chronic exposure in ducks","volume":"160","author":"Tran","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1093\/ps\/86.9.1887","article-title":"Chronic toxicity of fumonisins in turkeys","volume":"86","author":"Tardieu","year":"2007","journal-title":"Poult. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1194\/jlr.M088443","article-title":"Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages","volume":"60","author":"Vaidya","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"103233","DOI":"10.1016\/j.psj.2023.103233","article-title":"Curcumin improves the egg quality, antioxidant activity, and intestinal microbiota of quails during the late laying period","volume":"103","author":"Liu","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"105540","DOI":"10.1016\/j.psj.2025.105540","article-title":"Research note: Dietary curcumin cocrystals enhance egg quality and lipid metabolism in laying hens","volume":"104","author":"Kong","year":"2025","journal-title":"Poult. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11010-011-0978-z","article-title":"Curcumin promotes cholesterol efflux from adipocytes related to PPARgamma-LXRalpha-ABCA1 passway","volume":"358","author":"Dong","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"155468","DOI":"10.1016\/j.phymed.2024.155468","article-title":"The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK\/mTOR mediated autophagy","volume":"128","author":"Duan","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Kulcs\u00e1r, S., Turb\u00f3k, J., K\u00f6v\u00e9r, G., Balogh, K., Z\u00e1ndoki, E., G\u00f6mb\u00f6s, P., Ali, O., Szab\u00f3, A., and M\u00e9zes, M. (2024). The Effect of Combined Exposure of Fusarium Mycotoxins on Lipid Peroxidation, Antioxidant Defense, Fatty Acid Profile, and Histopathology in Laying Hens\u2019 Liver. Toxins, 16.","DOI":"10.3390\/toxins16040179"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chen, Z., Zhang, F., Jiang, L., Chen, Z., and Sun, H. (2021). Toxic Effects of Mycotoxin Fumonisin B1 at Six Different Doses on Female BALB\/c Mice. Toxins, 14.","DOI":"10.3390\/toxins14010021"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1111\/1750-3841.17213","article-title":"Fumonisin B1 induces endoplasmic reticulum damage and inflammation by activating the NXR response and disrupting the normal CYP450 system, leading to liver damage in juvenile quail","volume":"89","author":"Zhu","year":"2024","journal-title":"J. Food Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"113593","DOI":"10.1016\/j.fct.2022.113593","article-title":"Curcumin attenuates AFB1-induced duck liver injury by inhibiting oxidative stress and lysosomal damage","volume":"172","author":"Qiao","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.theriogenology.2021.02.003","article-title":"Ovarian toxicity by fusariotoxins in pigs: Does it imply in oxidative stress?","volume":"165","author":"Gerez","year":"2021","journal-title":"Theriogenology"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zhao, J., Pan, H., Liu, Y., He, Y., Shi, H., and Ge, C. (2023). Interacting Networks of the Hypothalamic-Pituitary-Ovarian Axis Regulate Layer Hens Performance. Genes, 14.","DOI":"10.3390\/genes14010141"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Yang, Z., Zhang, J., Yuan, Q., Wang, X., Zeng, W., Mi, Y., and Zhang, C. (2024). Flavonoid Fisetin Alleviates Ovarian Aging of Laying Chickens by Enhancing Antioxidant Capacity and Glucose Metabolic Homeostasis. Antioxidants, 13.","DOI":"10.3390\/antiox13121432"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"102319","DOI":"10.1016\/j.psj.2022.102319","article-title":"The adiponectin receptor agonist, AdipoRon, promotes reproductive hormone secretion and gonadal development via the hypothalamic-pituitary-gonadal axis in chickens","volume":"102","author":"Li","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.anireprosci.2014.02.013","article-title":"Corticosterone in ovo modifies aggressive behaviors and reproductive performances through alterations of the hypothalamic-pituitary-gonadal axis in the chicken","volume":"146","author":"Ahmed","year":"2014","journal-title":"Anim. Reprod. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Li, C., Gao, J., Guo, S., He, B., and Ma, W. (2023). Effects of Curcumin on the Egg Quality and Hepatic Lipid Metabolism of Laying Hens. Animals, 14.","DOI":"10.3390\/ani14010138"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Jin, S., Yang, H., Jiao, Y., Pang, Q., Wang, Y., Wang, M., Shan, A., and Feng, X. (2021). Dietary Curcumin Alleviated Acute Ileum Damage of Ducks (Anas platyrhynchos) Induced by AFB1 through Regulating Nrf2-ARE and NF-\u03baB Signaling Pathways. Foods, 10.","DOI":"10.3390\/foods10061370"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.theriogenology.2022.10.038","article-title":"Dietary curcumin supplementation relieves hydrogen peroxide-induced testicular injury by antioxidant and anti-apoptotic effects in roosters","volume":"197","author":"Wu","year":"2023","journal-title":"Theriogenology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"48075","DOI":"10.1021\/acsami.5c11952","article-title":"Synergistic Amino and Hydroxyl Groups That Enhance SOD-Like Activity in Curcumin Carbon Dots for Improved Colitis Treatment","volume":"17","author":"Du","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.3382\/ps\/pex280","article-title":"Enzymatic hydrolysis of fumonisins in the gastrointestinal tract of broiler chickens","volume":"96","author":"Grenier","year":"2017","journal-title":"Poult. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"102677","DOI":"10.1016\/j.psj.2023.102677","article-title":"Short-term exposure to fumonisins and deoxynivalenol, on broiler growth performance and cecal Salmonella load during experimental Salmonella Enteritidis infection","volume":"102","author":"Liu","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"113319","DOI":"10.1016\/j.ecoenv.2022.113319","article-title":"Protective role of curcumin on aflatoxin B1-induced TLR4\/RIPK pathway mediated-necroptosis and inflammation in chicken liver","volume":"233","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"136687","DOI":"10.1016\/j.ijbiomac.2024.136687","article-title":"Curcumin-loaded polysaccharide microparticles alleviated DSS-induced ulcerative colitis by improving intestinal microecology and regulating MAPK\/NF-\u03baB\/Nrf2\/NLRP3 pathways","volume":"281","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.str.2024.06.002","article-title":"Mechanism of ceramide synthase inhibition by fumonisin B(1)","volume":"32","author":"Zhang","year":"2024","journal-title":"Structure"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"115719","DOI":"10.1016\/j.jep.2022.115719","article-title":"Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway","volume":"300","author":"Chen","year":"2023","journal-title":"J. Ethnopharmacol."}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/18\/1\/34\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:06:43Z","timestamp":1767974803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/18\/1\/34"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["toxins18010034"],"URL":"https:\/\/doi.org\/10.3390\/toxins18010034","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]}}}