{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:17:33Z","timestamp":1787735853277,"version":"build-2784847793"},"reference-count":106,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>To date, there are no studies concerning the ear aging phases, nor adequate anti-aging protocols. The aims of this study are: (1) to propose an aesthetic classification of auricular aging; (2) to evaluate the aesthetic implications, efficacy, and safety levels of botulinum toxin application to the auricles as anti-aging treatment. A retrospective study was conducted in a single center on 40 patients\u2019 charts to define an aesthetic ear aging classification, focusing on the muscles involved in the aging process; then an analysis on the results of the treatment of 50 healthy women (50\u201365 years), with the botulinum toxin type A for ear rejuvenation was conducted; the technique, visual aesthetic results, incidence of side effects, and efficiency of the treatment were presented. All procedures were performed in 2024, and subjects were monitored for the duration of the effects. Auricle aging process may be classified into 4 degrees. The treatment of 50 women with aging ears degree 1\u20132 permits correction of both ear protrusion and shape. In 1.5% of the auricles, mild swelling and transient bruising at the injection site were observed immediately after the treatment and resolved within 2\u20133 days. Patient satisfaction was high, and two external reviewers confirmed the treatment\u2019s aesthetic efficiency. Aesthetic classification of auricle aging can be a useful tool in anti-aging decision-making. Ear treatment with botulinum toxin type A seems complementary to face treatment. The results are encouraging, but the number of subjects treated is limited. Further studies are required to outline age-related guidelines.<\/jats:p>","DOI":"10.3390\/toxins18090366","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:11:15Z","timestamp":1787731875000},"page":"366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-Surgical Ear Rejuvenation Through Selective Neuromodulation with Onabotulinum and Abobotulinum Toxin-A"],"prefix":"10.3390","volume":"18","author":[{"given":"Paola Rosalba","family":"Russo","sequence":"first","affiliation":[{"name":"Estemed Clinic, 41122 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sbarbati","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2618-1903","authenticated-orcid":false,"given":"Emanuele","family":"Bartoletti","sequence":"additional","affiliation":[{"name":"Department of Aesthetic Medicine, Gemelli Isola Tiberina Hospital, 00186 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Cavalieri","sequence":"additional","affiliation":[{"name":"Plastic Reconstructive and Aesthetic Surgery Unit, Italian Society of Aesthetic Medicine, 00195 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cavallini","sequence":"additional","affiliation":[{"name":"Clinical and Educational Center Agor\u00e0, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-397X","authenticated-orcid":false,"given":"Valentina","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Modena University Hospital, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7336-154X","authenticated-orcid":false,"given":"Giovanni","family":"Salti","sequence":"additional","affiliation":[{"name":"Medlight Institute, 50144 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-3306","authenticated-orcid":false,"given":"Sheila","family":"Veronese","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejrad.2007.10.019","article-title":"Congenital Malformations of the External and Middle Ear","volume":"69","author":"Omenzetter","year":"2009","journal-title":"Eur. 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