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Microbial aflatoxin control has recently emerged as a promising, sustainable, and environmentally friendly strategy for reducing aflatoxin contamination. However, growing evidence suggests that reductions in AF levels within microbial treatment systems may arise not only from direct toxin degradation, but also from inhibition of fungal growth, adsorption or sequestration processes, and suppression of AF biosynthesis. In microbial co-culture systems involving viable toxigenic fungi, exogenous microorganisms and their metabolites can establish persistent ecological stress through nutrient competition, oxidative stress, and interspecies signaling. These stresses activate fungal cell wall integrity pathways, MAPK signaling cascades, and transcriptional regulatory networks, leading to membrane remodeling, alterations in lipid and energy metabolism, and redistribution of cellular resources. As a consequence, fungal physiology progressively shifts from a growth- and toxin-production-oriented state toward a survival- and defense-oriented state, resulting in impaired growth and reduced AF biosynthesis. This review proposes the internal disintegration framework, which conceptualizes AF suppression as a progressive loss of toxin-producing capacity caused by sustained microbial-induced physiological remodeling rather than solely by fungal growth inhibition or toxin degradation. It will provide new perspectives for developing precise, efficient, and eco-friendly dual-target control strategies.<\/jats:p>","DOI":"10.3390\/toxins18090374","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:55:56Z","timestamp":1788155756000},"page":"374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Internal Disintegration Effect in Microbial Aflatoxin Control Systems: From Detoxification to Suppression of Aflatoxin Biosynthesis in Toxigenic Fungi"],"prefix":"10.3390","volume":"18","author":[{"given":"Xue","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7520-943X","authenticated-orcid":false,"given":"Esa Abiso","family":"Godana","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-4713","authenticated-orcid":false,"given":"Hongyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiya","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cheng, K., Niu, J., Zheng, X., Qiao, Y., Zhang, J., Guo, R., Dong, G., Song, Z., Huang, J., and Wang, J. (2023). Aflatoxin-B1-Exposure-Induced Hepatic Injury Could Be Alleviated by Polydatin through Reducing Oxidative Stress, Inhibiting Inflammation and Improving Mitophagy. Toxics, 11.","DOI":"10.3390\/toxics11040309"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"137775","DOI":"10.1016\/j.foodchem.2023.137775","article-title":"Aflatoxins: Occurrence, Biosynthesis, Mechanism of Action and Effects, Conventional\/Emerging Detection Techniques","volume":"436","author":"Okechukwu","year":"2024","journal-title":"Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/s42003-024-06738-w","article-title":"Comparative Analysis of the Genomes and Aflatoxin Production Patterns of Three Species within the Aspergillus Section Flavi Reveals an Undescribed Chemotype and Habitat-Specific Genetic Traits","volume":"7","author":"Schamann","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"108262","DOI":"10.1016\/j.toxicon.2025.108262","article-title":"The Impact of Aflatoxin B1 on Animal Health: Metabolic Processes, Detection Methods, and Preventive Measures","volume":"255","author":"Wang","year":"2025","journal-title":"Toxicon"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ahmad, T., Wang, S., and Liu, Y. (2025). Aspergillus flavus and Aflatoxins (3rd Edition). Toxins, 17.","DOI":"10.3390\/toxins17070326"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez, J., Hern\u00e1ndez-Rodr\u00edguez, M., M\u00e9ndez-Albores, A., T\u00e9llez-Isa\u00edas, G., Mera Jim\u00e9nez, E., Nicol\u00e1s-V\u00e1zquez, M.I., and Miranda Ruvalcaba, R. (2023). Computational Studies of Aflatoxin B1 (AFB1): A Review. Toxins, 15.","DOI":"10.3390\/toxins15020135"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"K\u0119pka-Borkowska, K., Cha\u0142a\u015bkiewicz, K., Og\u0142uszka, M., Borkowski, M., Lepczy\u0144ski, A., Pareek, C.S., Starzy\u0144ski, R.R., Lichwiarska, E., Sultana, S., and Kalra, G. (2025). Current Approaches to Aflatoxin B1 Control in Food and Feed Safety: Detection, Inhibition, and Mitigation. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136534"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s44187-025-00680-4","article-title":"Comprehensive Review of Aflatoxin Contamination, Its Occurrence, Effects, Management, and Future Perspectives","volume":"5","author":"Syraji","year":"2025","journal-title":"Discov. Food"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1007\/s12161-018-1235-9","article-title":"Using of Tyramine Signal Amplification to Improve the Sensitivity of ELISA for Aflatoxin B1 in Edible Oil Samples","volume":"11","author":"Zhang","year":"2018","journal-title":"Food Anal. Methods"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Deng, J., Zhao, M., and Jiang, H. (2025). Research Progress in the Detection of Mycotoxins in Cereals and Their Products by Vibrational Spectroscopy. Foods, 14.","DOI":"10.3390\/foods14152688"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"103474","DOI":"10.1016\/j.jcs.2022.103474","article-title":"Characteristic Wavelengths Optimization Improved the Predictive Performance of Near-Infrared Spectroscopy Models for Determination of Aflatoxin B1 in Maize","volume":"105","author":"Deng","year":"2022","journal-title":"J. Cereal Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"128652","DOI":"10.1016\/j.foodchem.2020.128652","article-title":"SERS Based Sensor for Mycotoxins Detection: Challenges and Improvements","volume":"344","author":"Hassan","year":"2021","journal-title":"Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"109028","DOI":"10.1016\/j.foodcont.2022.109028","article-title":"Ultrasensitive Immuno-PCR for Detecting Aflatoxin B1 Based on Magnetic Separation and Barcode DNA","volume":"138","author":"Li","year":"2022","journal-title":"Food Control"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"113657","DOI":"10.1016\/j.lwt.2022.113657","article-title":"Determination of Aflatoxin B1 Value in Corn Based on Fourier Transform Near-Infrared Spectroscopy: Comparison of Optimization Effect of Characteristic Wavelengths","volume":"164","author":"Liu","year":"2022","journal-title":"LWT"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1111\/1541-4337.12686","article-title":"Recent Progress in Mycotoxins Detection Based on Surface-enhanced Raman Spectroscopy","volume":"20","author":"Zhai","year":"2021","journal-title":"Compr. Rev. Food Sci. Food Safe"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"133883","DOI":"10.1016\/j.foodchem.2022.133883","article-title":"Rapid and Stable Detection of Three Main Mycotoxins in Rice Using SERS Optimized AgNPs@K30 Coupled Multivariate Calibration","volume":"398","author":"He","year":"2023","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7224","DOI":"10.1007\/s11694-024-02732-2","article-title":"Establishment, Application and Comparison of Three Immunoaffinity Pretreatment Techniques for Mycotoxins Systematically","volume":"18","author":"Tian","year":"2024","journal-title":"J. Food Meas. Charact."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101303","DOI":"10.1016\/j.crfs.2026.101303","article-title":"Tri-Mode Fluorescence\/Colorimetric\/Strip Aptasensor with CRISPR\/Cas12a-Driven Cascade Strategy for Mycotoxin","volume":"12","author":"Yang","year":"2026","journal-title":"Curr. Res. Food Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"140040","DOI":"10.1016\/j.foodchem.2024.140040","article-title":"Quantitative SERS Sensor for Mycotoxins with Extraction and Identification Function","volume":"456","author":"Zhang","year":"2024","journal-title":"Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"133277","DOI":"10.1016\/j.foodchem.2022.133277","article-title":"Dispersive Micro Solid Phase Extraction Based Ionic Liquid Functionalized ZnO Nanoflowers Couple with Chromatographic Methods for Rapid Determination of Aflatoxins in Wheat and Peanut Samples","volume":"391","author":"Zhu","year":"2022","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"131443","DOI":"10.1016\/j.foodchem.2021.131443","article-title":"Label-Free Ratiometric Homogeneous Electrochemical Aptasensor Based on Hybridization Chain Reaction for Facile and Rapid Detection of Aflatoxin B1 in Cereal Crops","volume":"373","author":"Zhu","year":"2022","journal-title":"Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"115047","DOI":"10.1016\/j.lwt.2023.115047","article-title":"Simultaneous Analysis of Mildew Degree and Aflatoxin B1 of Wheat by a Multi-Task Deep Learning Strategy Based on Microwave Detection Technology","volume":"184","author":"Deng","year":"2023","journal-title":"LWT"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"108135","DOI":"10.1016\/j.jfca.2025.108135","article-title":"Beyond the Surface: SERS-Enabled Lateral Flow Assay for Detecting Food Contaminants","volume":"148","author":"Bruce","year":"2025","journal-title":"J. Food Compos. Anal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"108518","DOI":"10.1016\/j.jfca.2025.108518","article-title":"Innovative Applications of Au\u2013Ag Bimetallic Nanoparticles in Food Safety: Detection of Bacterial Pathogens and Mycotoxins through Advanced Biosensing Technologies","volume":"148","author":"Gao","year":"2025","journal-title":"J. Food Compos. Anal."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"147677","DOI":"10.1016\/j.foodchem.2025.147677","article-title":"Portable SERS-Based Lateral Flow Strip for Simultaneous Rapid Detection of Three Typical Corn Mycotoxins","volume":"502","author":"Yin","year":"2026","journal-title":"Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/10408390500436185","article-title":"Strategies to Prevent Mycotoxin Contamination of Food and Animal Feed: A Review","volume":"46","author":"Kabak","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wu, S., Huang, W., Wang, F., Zou, X., Li, X., Liu, C.-M., Zhang, W., and Yan, S. (2023). Integrated Metabolomics and Lipidomics Analyses Suggest the Temperature-Dependent Lipid Desaturation Promotes Aflatoxin Biosynthesis in Aspergillus flavus. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1137643"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105238","DOI":"10.1016\/j.biocontrol.2023.105238","article-title":"Biological Control of Major Pathogenic Bacteria of Potato by Bacillus amyloliquefaciens Strains SS-12.6 and SS-38.4","volume":"182","year":"2023","journal-title":"Biol. Control"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10526-023-10187-5","article-title":"Inhibitory Effect of Volatile Organic Compounds from Bacillus flexus TR-1 against Aspergillus flavus and Aflatoxins in Grains during Storage","volume":"68","author":"Gong","year":"2023","journal-title":"BioControl"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/09540105.2022.2045908","article-title":"Aflatoxin B1 Variations in Animal Feeds along the Supply Chain in Tanzania and Its Possible Reduction by Heat Treatment","volume":"33","author":"Mwakosya","year":"2022","journal-title":"Food Agric. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Liu, S., Yang, D., Huang, J., Huang, H., Sun, J., Yang, Z., and Zhou, C. (2025). Advances in Atmospheric Cold Plasma Technology for Plant-Based Food Safety, Functionality, and Quality Implications. Foods, 14.","DOI":"10.3390\/foods14172999"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"111572","DOI":"10.1016\/j.foodcont.2025.111572","article-title":"Exploring Diverse Physical Technologies for Microbial Inactivation and Toxin Degradation in Rice: A Comprehensive Review","volume":"179","author":"Wu","year":"2026","journal-title":"Food Control"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"145584","DOI":"10.1016\/j.foodchem.2025.145584","article-title":"Microbial and Enzymatic Strategies for Aflatoxin Control: Integrating Intelligent Detection and Computational Design","volume":"492","author":"Ouyang","year":"2025","journal-title":"Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.foodcont.2016.12.036","article-title":"Isolation and Characterization of a Bacillus subtilis Strain with Aflatoxin B 1 Biodegradation Capability","volume":"75","author":"Xia","year":"2017","journal-title":"Food Control"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e13397","DOI":"10.1111\/1541-4337.13397","article-title":"Revisiting the Current and Emerging Concepts of Postharvest Fresh Fruit and Vegetable Pathology for Next-generation Antifungal Technologies","volume":"23","author":"Yang","year":"2024","journal-title":"Compr. Rev. Food Sci. Food Safe"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"104955","DOI":"10.1016\/j.fm.2025.104955","article-title":"Microbial-Mycotoxin Interactions in Food: A Review of Ecotoxicological Implications and Omics Approaches for Understanding Detoxification Mechanisms","volume":"135","author":"Okoye","year":"2026","journal-title":"Food Microbiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"137696","DOI":"10.1016\/j.foodchem.2023.137696","article-title":"Biodegradation of Patulin in Fresh Pear Juice by an Aldo-Keto Reductase from Meyerozyma Guilliermondii","volume":"436","author":"Zhang","year":"2024","journal-title":"Food Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"138421","DOI":"10.1016\/j.foodchem.2024.138421","article-title":"Degradation Kinetics of Sugars (Glucose and Xylose), Amino Acids (Proline and Aspartic Acid) and Their Binary Mixtures in Subcritical Water: Effect of Maillard Reaction","volume":"442","author":"Illera","year":"2024","journal-title":"Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12550-023-00515-0","article-title":"Metabolites and Degradation Pathways of Microbial Detoxification of Aflatoxins: A Review","volume":"40","author":"Arimboor","year":"2024","journal-title":"Mycotoxin Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00203-025-04683-8","article-title":"Microbial and Enzymatic Biodegradation of Aflatoxins and Ochratoxins: Mechanisms, Applications, and Emerging Innovations","volume":"208","author":"Aasa","year":"2026","journal-title":"Arch. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Niu, A., Tan, L., Tan, S., Wang, G., and Qiu, W. (2023). The Temporal Dynamics of Sensitivity, Aflatoxin Production, and Oxidative Stress of Aspergillus flavus in Response to Cinnamaldehyde Vapor. Foods, 12.","DOI":"10.3390\/foods12234311"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2527381","DOI":"10.1080\/21501203.2025.2527381","article-title":"Functionally Redundant Rho GTPases Cdc42 and RacA Regulate Aflatoxin Synthesis and Pathogenicity in Aspergillus flavus by Controlling Morphogenesis, Oxidative Balance and Energy Metabolism","volume":"17","author":"Xu","year":"2025","journal-title":"Mycology"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Alves Martins, B.A., Filho, O.D.M., Lopes, A.C.B., De Faria, R.J., Silva, C., Lemos, G.D.O., Silveira, D.B., and De Sousa, J.B. (2023). Nutritional Status in Perianal Crohn\u2019s Disease: Are We Underestimating the Impact?. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1271825"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Loi, M., De Leonardis, S., Ciasca, B., Paciolla, C., Mul\u00e8, G., and Haidukowski, M. (2023). Aflatoxin B1 Degradation by Ery4 Laccase: From In Vitro to Contaminated Corn. Toxins, 15.","DOI":"10.3390\/toxins15050310"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"15841","DOI":"10.1021\/acs.jafc.4c04055","article-title":"Biodegradation Characteristics and Mechanism of Aflatoxin B1 by Bacillus amyloliquefaciens from Enzymatic and Multiomics Perspectives","volume":"72","author":"Shi","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"20762","DOI":"10.1021\/acs.jafc.3c05725","article-title":"Mining Lactonase Gene from Aflatoxin B1 -Degrading Strain Bacillus megaterium and Degrading Properties of the Recombinant Enzyme","volume":"71","author":"Cheng","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"109679","DOI":"10.1016\/j.foodcont.2023.109679","article-title":"Efficient Aflatoxin B1 Degradation by a Novel Isolate, Pseudomonas aeruginosa M-4","volume":"149","author":"Xu","year":"2023","journal-title":"Food Control"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.1021\/acs.jafc.3c09094","article-title":"Targeted Detoxification of Aflatoxin B1 in Edible Oil by an Enzyme\u2013Metal Nanoreactor","volume":"72","author":"Fu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"14641","DOI":"10.1021\/acs.jafc.5c02392","article-title":"Engineering of Bacillus Laccase frL103 for Highly Efficient Degradation of Aflatoxin B1","volume":"73","author":"Bian","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"lxae112","DOI":"10.1093\/jambio\/lxae112","article-title":"Antifungal Mechanisms Investigation of Lactic Acid Bacteria against Aspergillus flavus: Through Combining Microbial Metabolomics and Co-Culture System","volume":"135","author":"Yun","year":"2024","journal-title":"J. Appl. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"107749","DOI":"10.1016\/j.toxicon.2024.107749","article-title":"Antifungal Mechanisms of Binary Combinations of Volatile Organic Compounds Produced by Lactic Acid Bacteria Strains against Aspergillus flavus","volume":"243","author":"Zhang","year":"2024","journal-title":"Toxicon"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Xu, L., Yang, M., Fu, H., Sun, S., Qiao, H., Zhang, W., Gong, Y., Jiang, S., Xiong, Y., and Jin, S. (2018). Molecular Cloning and Expression of MnGST-1 and MnGST-2 from Oriental River Prawn, Macrobrachium Nipponense, in Response to Hypoxia and Reoxygenation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103102"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Peng, S., Hu, L., Ge, W., Deng, J., Yao, L., Li, H., Xu, D., and Mo, H. (2024). ChIP-Seq Analysis of AtfA Interactions in Aspergillus flavus Reveals Its Involvement in Aflatoxin Metabolism and Virulence Under Oxidative Stress. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252212213"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ren, Y., Jin, J., Zheng, M., Yang, Q., and Xing, F. (2020). Ethanol Inhibits Aflatoxin B1 Biosynthesis in Aspergillus flavus by Up-Regulating Oxidative Stress-Related Genes. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02946"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Wang, X., Zha, W., Liang, L., Fasoyin, O.E., Wu, L., and Wang, S. (2020). The bZIP Transcription Factor AflRsmA Regulates Aflatoxin B1 Biosynthesis, Oxidative Stress Response and Sclerotium Formation in Aspergillus flavus. Toxins, 12.","DOI":"10.3390\/toxins12040271"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1038\/s41598-021-82488-7","article-title":"Transcriptomic Responses of Aspergillus flavus to Temperature and Oxidative Stresses during Aflatoxin Production","volume":"11","author":"Tian","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"RP94743","DOI":"10.7554\/eLife.94743.5","article-title":"SntB Triggers the Antioxidant Pathways to Regulate Development and Aflatoxin Biosynthesis in Aspergillus flavus","volume":"13","author":"Wu","year":"2024","journal-title":"eLife"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/mbo3.63","article-title":"Evidence That a Transcription Factor Regulatory Network Coordinates Oxidative Stress Response and Secondary Metabolism in Aspergilli","volume":"2","author":"Hong","year":"2013","journal-title":"MicrobiologyOpen"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Zhao, Q., Pei, H., Zhou, X., Zhao, K., Yu, M., Han, G., Fan, J., and Tao, F. (2022). Systematic Characterization of bZIP Transcription Factors Required for Development and Aflatoxin Generation by High-Throughput Gene Knockout in Aspergillus flavus. J. Fungi, 8.","DOI":"10.3390\/jof8040356"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e00791-21","DOI":"10.1128\/spectrum.00791-21","article-title":"New Insights of Transcriptional Regulator AflR in Aspergillus flavus Physiology","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"108079","DOI":"10.1016\/j.fbio.2025.108079","article-title":"Novel Zn2Cys6 Transcription Factor AfEcm22 Positively Regulates Aflatoxin Biosynthesis in Aspergillus flavus","volume":"75","author":"Wei","year":"2026","journal-title":"Food Biosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/toxins3010082","article-title":"Loss of msnA, a Putative Stress Regulatory Gene, in Aspergillus parasiticus and Aspergillus flavus Increased Production of Conidia, Aflatoxins and Kojic Acid","volume":"3","author":"Chang","year":"2011","journal-title":"Toxins"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.fgb.2018.04.008","article-title":"Carbon Catabolite Repression Gene creA Regulates Morphology, Aflatoxin Biosynthesis and Virulence in Aspergillus flavus","volume":"115","author":"Fasoyin","year":"2018","journal-title":"Fungal Genet. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Ma, X., Jiang, Y., Ma, L., Luo, S., Du, H., Li, X., and Xing, F. (2022). Corepressors SsnF and RcoA Regulate Development and Aflatoxin B1 Biosynthesis in Aspergillus flavus NRRL 3357. Toxins, 14.","DOI":"10.3390\/toxins14030174"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"132677","DOI":"10.1016\/j.jhazmat.2023.132677","article-title":"Comprehensive Analysis of Aflatoxin B1 Biosynthesis in Aspergillus flavus via Transcriptome-Wide m6A Methylome Response to Cycloleucine","volume":"461","author":"Liang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Hanano, A., Alkara, M., Almousally, I., Shaban, M., Rahman, F., Hassan, M., and Murphy, D.J. (2018). The Peroxygenase Activity of the Aspergillus flavus Caleosin, AfPXG, Modulates the Biosynthesis of Aflatoxins and Their Trafficking and Extracellular Secretion via Lipid Droplets. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.00158"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"145655","DOI":"10.1016\/j.foodchem.2025.145655","article-title":"Pulsed Light Inhibits Aflatoxins Production of Aspergillus flavus, Degrades Aflatoxin B1 and Its Potential Mechanisms","volume":"492","author":"Zhou","year":"2025","journal-title":"Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Yao, Q., Xu, H., Zhuang, J., Cui, D., Ma, R., and Jiao, Z. (2023). Inhibition of Fungal Growth and Aflatoxin B1 Synthesis in Aspergillus flavus by Plasma-Activated Water. Foods, 12.","DOI":"10.3390\/foods12132490"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"RP89478","DOI":"10.7554\/eLife.89478.5","article-title":"The Target of Rapamycin Signaling Pathway Regulates Vegetative Development, Aflatoxin Biosynthesis, and Pathogenicity in Aspergillus flavus","volume":"12","author":"Li","year":"2024","journal-title":"eLife"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"10065","DOI":"10.1021\/acs.jafc.4c01229","article-title":"Fus3 Interacts with Gal83, Revealing the MAPK Crosstalk to Snf1\/AMPK to Regulate Secondary Metabolic Substrates in Aspergillus flavus","volume":"72","author":"Ma","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Casares, D., Escrib\u00e1, P.V., and Rossell\u00f3, C.A. (2019). Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092167"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrm.2017.138","article-title":"Understanding the Diversity of Membrane Lipid Composition","volume":"19","author":"Harayama","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"101245","DOI":"10.1016\/j.funeco.2023.101245","article-title":"Truffles in the Sky: The Impact of Stochastic and Deterministic Drivers on Rhizopogon Communities of the Madrean Sky Island Archipelago","volume":"63","author":"Carson","year":"2023","journal-title":"Fungal Ecol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"153983","DOI":"10.1016\/j.tox.2024.153983","article-title":"Aflatoxin B1-Induced Hepatotoxicity through Mitochondrial Dysfunction, Oxidative Stress, and Inflammation as Central Pathological Mechanisms: A Review of Experimental Evidence","volume":"509","author":"Moloi","year":"2024","journal-title":"Toxicology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e2504044","DOI":"10.4014\/jmb.2504.04044","article-title":"A Review of Research Progress on the Microbial or Enzymatic Degradation and Mechanism of Aflatoxin B1","volume":"35","author":"Zhang","year":"2025","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Sch\u00f6ppner, P., Lutz, A.P., Lutterbach, B.J., Br\u00fcckner, S., Essen, L.-O., and M\u00f6sch, H.-U. (2022). Structure of the Yeast Cell Wall Integrity Sensor Wsc1 Reveals an Essential Role of Surface-Exposed Aromatic Clusters. J. Fungi, 8.","DOI":"10.3390\/jof8040379"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Yoshimi, A., Miyazawa, K., Kawauchi, M., and Abe, K. (2022). Cell Wall Integrity and Its Industrial Applications in Filamentous Fungi. J. Fungi, 8.","DOI":"10.3390\/jof8050435"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2503434","DOI":"10.1080\/21505594.2025.2503434","article-title":"Stress Responsive Glycosylphosphatidylinositol-Anchored Protein SsGSP1 Contributes to Sclerotinia Sclerotiorum Virulence","volume":"16","author":"Liao","year":"2025","journal-title":"Virulence"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Mochizuki, T., Tanigawa, T., Shindo, S., Suematsu, M., Oguchi, Y., Mioka, T., Kato, Y., Fujiyama, M., Hatano, E., and Yamaguchi, M. (2022). The CWI Pathway Is Activated through High Hydrostatic Pressure, Enhancing Glycerol Efflux via the Aquaglyceroporin Fps1 in Saccharomyces Cerevisiae 2022. bioRxiv.","DOI":"10.1101\/2022.11.15.516693"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Li, L., Li, Y., Lu, K., Chen, R., and Jiang, J. (2022). Bacillus subtilis KLBMPGC81 Suppresses Appressorium-Mediated Plant Infection by Altering the Cell Wall Integrity Signaling Pathway and Multiple Cell Biological Processes in Magnaporthe Oryzae. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.983757"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Ianutsevich, E.A., Danilova, O.A., Saharova, S.A., and Tereshina, V.M. (2025). Membrane Lipids and Osmolytes Rearrangements Under Cell Wall Stress in Aspergillus niger. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262210888"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Liu, T., Wang, Y., Chen, G., Fang, X., Zhou, G., and Wang, J. (2023). ChsA, a Class II Chitin Synthase, Contributes to Asexual Conidiation, Mycelial Morphology, Cell Wall Integrity, and the Production of Enzymes and Organic Acids in Aspergillus niger. J. Fungi, 9.","DOI":"10.3390\/jof9080801"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e00287\u201324","DOI":"10.1128\/msphere.00287-24","article-title":"Disruption to de Novo Uridine Biosynthesis Alters \u03b2-1,3-Glucan Masking in Candida Albicans","volume":"9","author":"Mangrum","year":"2024","journal-title":"mSphere"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Mitosch, K., Bey\u00df, M., Phapale, P., Drotleff, B., N\u00f6h, K., Alexandrov, T., Patil, K.R., and Typas, A. (2023). A Pathogen-Specific Isotope Tracing Approach Reveals Metabolic Activities and Fluxes of Intracellular Salmonella. PLoS Biol., 21.","DOI":"10.1371\/journal.pbio.3002198"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Yasin, R., Usman, S., Qin, Q., Gong, X., Wang, B., Wang, L., Jin, C., and Fang, W. (2025). Key Sugar Transporters Drive Development and Pathogenicity in Aspergillus flavus. Front. Cell. Infect. Microbiol., 15.","DOI":"10.3389\/fcimb.2025.1661799"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e00057-24","DOI":"10.1128\/msphere.00057-24","article-title":"The EH Domain-Containing Protein, EdeA, Is Involved in Endocytosis, Cell Wall Integrity, and Pathogenicity in Aspergillus fumigatus","volume":"9","author":"Dai","year":"2024","journal-title":"mSphere"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Guruceaga, X., Perez-Cuesta, U., Martin-Vicente, A., Pelegri-Martinez, E., Thorn, H.I., Cendon-Sanchez, S., Xie, J., Nywening, A.V., Ramirez-Garcia, A., and Fortwendel, J.R. (2024). The Aspergillus fumigatus maiA Gene Contributes to Cell Wall Homeostasis and Fungal Virulence. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1327299"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e01885-23","DOI":"10.1128\/aem.01885-23","article-title":"Histone Acetyltransferase Sas3 Contributes to Fungal Development, Cell Wall Integrity, and Virulence in Aspergillus fumigatus","volume":"90","author":"Wang","year":"2024","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e01138-24","DOI":"10.1128\/aem.01138-24","article-title":"Nitrate Assimilation Compensates for Cell Wall Biosynthesis in the Absence of Aspergillus fumigatus Phosphoglucose Isomerase","volume":"90","author":"Gong","year":"2024","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e00642-18","DOI":"10.1128\/mBio.00642-18","article-title":"Biological Roles Played by Sphingolipids in Dimorphic and Filamentous Fungi","volume":"9","author":"Fernandes","year":"2018","journal-title":"mBio"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.4014\/jmb.2402.02007","article-title":"Morphological Engineering of Filamentous Fungi: Research Progress and Perspectives","volume":"34","author":"Lu","year":"2024","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"111302","DOI":"10.1016\/j.ijfoodmicro.2025.111302","article-title":"The Putative Rho Guanine Nucleotide Exchange Factor GerA in Aspergillus flavus Regulates Growth, Development, and Aflatoxin Synthesis","volume":"441","author":"Xu","year":"2025","journal-title":"Int. J. Food Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tifs.2016.03.012","article-title":"Control of Ochratoxin A-Producing Fungi in Grape Berry by Microbial Antagonists: A Review","volume":"51","author":"Zhang","year":"2016","journal-title":"Trends Food Sci. Technol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/aab.12452","article-title":"The Mechanisms Involved in Ochratoxin A Elimination by Yarrowia Lipolytica Y-2","volume":"173","author":"Zhang","year":"2018","journal-title":"Ann. Appl. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"108259","DOI":"10.1016\/j.foodcont.2021.108259","article-title":"Isolation and Characterization of Bacillus amyloliquefaciens MQ01, a Bifunctional Biocontrol Bacterium with Antagonistic Activity against Fusarium graminearum and Biodegradation Capacity of Zearalenone","volume":"130","author":"Xu","year":"2021","journal-title":"Food Control"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Zhai, C., Yu, Y., Han, J., Hu, J., He, D., Zhang, H., Shi, J., Mohamed, S.R., Dawood, D.H., and Wang, G. (2022). Isolation, Characterization, and Application of Clostridium Sporogenes F39 to Degrade Zearalenone under Anaerobic Conditions. Foods, 11.","DOI":"10.3390\/foods11091194"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jprot.2016.04.017","article-title":"Biodegradation of Zearalenone by Saccharomyces Cerevisiae: Possible Involvement of ZEN Responsive Proteins of the Yeast","volume":"143","author":"Zhang","year":"2016","journal-title":"J. Proteom."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Zhang, H., Zhang, H., Qin, X., Wang, X., Wang, Y., Bin, Y., Xie, X., Zheng, F., and Luo, H. (2021). Biodegradation of Deoxynivalenol by Nocardioides Sp. ZHH-013: 3-Keto-Deoxynivalenol and 3-Epi-Deoxynivalenol as Intermediate Products. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.658421"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Zheng, X., Zhang, X., Zhao, L., Apaliya, M., Yang, Q., Sun, W., Zhang, X., and Zhang, H. (2017). Screening of Deoxynivalenol Producing Strains and Elucidation of Possible Toxigenic Molecular Mechanism. 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