{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:57:50Z","timestamp":1792177070047,"version":"4.4.0"},"reference-count":38,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2011,8,10]],"date-time":"2011-08-10T00:00:00Z","timestamp":1312934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>The Malayan pit viper, Calloselasma rhodostoma, produces a potent venom toxin, rhodocytin (aggretin) which causes platelet aggregation. Rhodocytin is a ligand for the receptor CLEC-2 on the surface of platelets. The interaction of these two molecules initiates a signaling pathway which results in platelet activation and aggregation. We have previously solved the crystal structures of CLEC-2 and of rhodocytin, and have proposed models by which tetrameric rhodocytin may interact with either two monomers of CLEC-2, or with one or two copies of dimeric CLEC-2. In the current study we use a range of approaches to analyze the molecular interfaces and dynamics involved in the models of the interaction of rhodocytin with either one or two copies of dimeric CLEC-2, and their implications for clustering of CLEC-2 on the platelet surface.<\/jats:p>","DOI":"10.3390\/toxins3080991","type":"journal-article","created":{"date-parts":[[2011,8,10]],"date-time":"2011-08-10T11:13:48Z","timestamp":1312974828000},"page":"991-1003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular Analysis of the Interaction of the Snake Venom Rhodocytin with the Platelet Receptor CLEC-2"],"prefix":"10.3390","volume":"3","author":[{"given":"Aleksandra A.","family":"Watson","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Cambridge\/ 80 Tennis Court Road, Cambridge, CB2 1GA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"O\u2019Callaghan","sequence":"additional","affiliation":[{"name":"Henry Wellcome Building for Molecular Physiology, University of Oxford\/ Roosevelt Drive, Oxford, OX3 7BN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,8,10]]},"reference":[{"key":"ref_1","unstructured":"Pirkle, H., and Markland, F.S. 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