{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:40:21Z","timestamp":1792798821600,"version":"4.5.0"},"reference-count":171,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T00:00:00Z","timestamp":1366675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>There is a need to develop food-compatible conditions to alter the structures of fungal, bacterial, and plant toxins, thus transforming toxins to nontoxic molecules. The term \u2018chemical genetics\u2019 has been used to describe this approach. This overview attempts to survey and consolidate the widely scattered literature on the inhibition by natural compounds and plant extracts of the biological (toxicological) activity of the following food-related toxins: aflatoxin B1, fumonisins, and ochratoxin A produced by fungi; cholera toxin produced by Vibrio cholerae bacteria; Shiga toxins produced by E. coli bacteria; staphylococcal enterotoxins produced by Staphylococcus aureus bacteria; ricin produced by seeds of the castor plant Ricinus communis; and the glycoalkaloid \u03b1-chaconine synthesized in potato tubers and leaves. The reduction of biological activity has been achieved by one or more of the following approaches: inhibition of the release of the toxin into the environment, especially food; an alteration of the structural integrity of the toxin molecules; changes in the optimum microenvironment, especially pH, for toxin activity; and protection against adverse effects of the toxins in cells, animals, and humans (chemoprevention). The results show that food-compatible and safe compounds with  anti-toxin properties can be used to reduce the toxic potential of these toxins. Practical applications and research needs are suggested that may further facilitate reducing the  toxic burden of the diet. Researchers are challenged to (a) apply the available methods without adversely affecting the nutritional quality, safety, and sensory attributes of animal feed and human food and (b) educate food producers and processors and the public about available approaches to mitigating the undesirable effects of natural toxins that may  present in the diet.<\/jats:p>","DOI":"10.3390\/toxins5040743","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T06:22:31Z","timestamp":1366698151000},"page":"743-775","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Review of the Inhibition of Biological Activities of Food-Related Selected Toxins by Natural Compounds"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-7517","authenticated-orcid":false,"given":"Mendel","family":"Friedman","sequence":"first","affiliation":[{"name":"Produce Safety and Microbiology Research Unit, Agricultural Research Service, USDA, Albany,  CA 94710,  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuven","family":"Rasooly","sequence":"additional","affiliation":[{"name":"Foodborne Contaminants Research Unit, Agricultural Research Service, USDA, Albany,    CA 94710,  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,4,23]]},"reference":[{"key":"ref_1","unstructured":"Fratamico, P.M., Bhunia, A.K., and Smith, J.L. (2005). Foodborne Pathogens-Microbiology and Molecular Biology, Caister Academic Press."},{"key":"ref_2","unstructured":"Friedman, M. (1973). The Chemistry and Biochemistry of the Sulfhydryl Group in Amino Acids, Peptides, and Proteins, Pergamon Press."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0015-6264(82)80223-X","article-title":"Inactivation of aflatoxin B1 mutagenicity by thiols","volume":"20","author":"Friedman","year":"1982","journal-title":"Food Chem. Toxicol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4684-4790-3_2","article-title":"Sulfhydryl Groups and Food Safety","volume":"177","author":"Friedman","year":"1984","journal-title":"Nutritional and Toxicological Aspects of Food Safety (Advances in Experimental Medicine and Biology)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"122S","DOI":"10.1016\/0002-9343(91)90295-9","article-title":"Antioxidant activity and other mechanisms of thiols involved in chemoprevention of mutation and cancer","volume":"91","author":"Izzotti","year":"1991","journal-title":"Am. J. Med."},{"key":"ref_6","first-page":"19","article-title":"Role of Glutathione and N-Acetylcysteine as Inhibitors of Mutagenesis and Carcinogenesis","volume":"3","author":"Friedman","year":"1989","journal-title":"Absorption and Utilization of Amino Acids"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0165-1218(89)90115-8","article-title":"Modifying role of dietary factors on the mutagenicity of aflatoxin B1: In vitro effect of sulphur-containing amino acids","volume":"222","author":"Shetty","year":"1989","journal-title":"Mutat. Res. Genet. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0027-5107(97)00289-3","article-title":"Activation and detoxication of aflatoxin B1","volume":"402","author":"Guengerich","year":"1998","journal-title":"Mutat. Res. Fund. Mol. Mech. Mutagen."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3390\/toxins2040738","article-title":"Antigenotoxic studies of different substances to reduce the DNA damage induced by aflatoxin B1 and ochratoxin A","volume":"2","year":"2010","journal-title":"Toxins"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s13530-012-0119-4","article-title":"Preventive strategies aimed at reducing the health risks of Aflatoxin B1","volume":"4","author":"Tenorio","year":"2012","journal-title":"Toxicol. Environ. Health Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1590\/S1415-47572005000200025","article-title":"Cashew (Anacardium occidentale) apple juice lowers mutagenicity of aflatoxin B1 in S. typhimurium TA102","volume":"28","author":"Cavalcante","year":"2005","journal-title":"Genet. Mol. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1021\/jf00057a020","article-title":"Inactivation of a tetrachloroimide mutagen from simulated processing water","volume":"43","author":"Stevens","year":"1995","journal-title":"J. Agric. Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1021\/jf0730486","article-title":"Review of methods for the reduction of dietary content and toxicity of acrylamide","volume":"56","author":"Friedman","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1021\/jf1023998","article-title":"l-Cysteine, N-acetyl-l-cysteine, and glutathione protect Xenopus laevis embryos against acrylamide-induced malformations and mortality in the Frog Embryo Teratogenesis Assay","volume":"58","author":"Rayburn","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Stadler, R.H., and Lineback, D.R. (2009). Process-Induced Food Toxicants: Occurrence, Formation, Mitigation, and Health Risks, John Wiley & Sons, Inc.","DOI":"10.1002\/9780470430101"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1021\/tx010156s","article-title":"Reaction of aflatoxin B1 oxidation products with lysine","volume":"15","author":"Guengerich","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1158\/1055-9965.EPI-07-2780","article-title":"Human aflatoxin albumin adducts quantitatively compared by ELISA, HPLC with fluorescence detection, and HPLC with isotope dilution mass spectrometry","volume":"17","author":"McCoy","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tox.2012.10.020","article-title":"Physiologically based toxicokinetics of serum aflatoxin B1-lysine adduct in F344 rats","volume":"303","author":"Qian","year":"2013","journal-title":"Toxicology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jat.982","article-title":"Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2)","volume":"24","author":"Renzulli","year":"2004","journal-title":"J. Appl. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1079\/BJN20051425","article-title":"Cyanidin-3-O-\u03b2-glucopyranoside, a natural fee-radical scavenger against aflatoxin B1-and ochratoxin A- induced cell damage in a human hepatoma cell line (Hep G2) and a human colonic adenocarcinoma cell line (CaCo-2)","volume":"94","author":"Guerra","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jat.1186","article-title":"Carnosic acid from rosemary extracts: A potential chemoprotective agent against aflatoxin B1. An in vitro study","volume":"27","author":"Costa","year":"2007","journal-title":"J. Appl. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jat.1372","article-title":"In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage","volume":"29","author":"Costa","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1007\/s11274-008-9776-5","article-title":"Utilization of diets amended with yeast and amino acids for the control of aflatoxicosis","volume":"24","author":"Baptista","year":"2008","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/carcin\/bgg194","article-title":"Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity","volume":"25","author":"Miyata","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1207\/s15327914nc5502_9","article-title":"Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content","volume":"55","author":"Singh","year":"2006","journal-title":"Nutr. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2972S","DOI":"10.1093\/jn\/135.12.2972S","article-title":"Synergy among phytochemicals within crucifers: Does it translate into chemoprotection?","volume":"135","author":"Wallig","year":"2005","journal-title":"J. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/BF02214006","article-title":"An overview of aflatoxicosis of poultry: Its characteristics, prevention and reduction","volume":"10","author":"Dalvi","year":"1986","journal-title":"Vet. Res. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.rvsc.2010.04.011","article-title":"Aflatoxin B1 in poultry: Toxicology, metabolism and prevention","volume":"89","author":"Rawal","year":"2010","journal-title":"Res. Vet. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.fct.2004.09.009","article-title":"Safety and efficacy evaluation of aqueous citric acid to degrade B-aflatoxins in maize","volume":"43","year":"2005","journal-title":"Food Chem. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1472-765X.2008.02376.x","article-title":"Effect of lactic and citric acid on the stability of B-aflatoxins in extrusion-cooked sorghum","volume":"47","year":"2008","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.lwt.2011.02.012","article-title":"Reduction of aflatoxins in peanut meal by extrusion cooking in the presence of nucleophiles","volume":"44","author":"Saalia","year":"2011","journal-title":"Lebensm.-Wiss. u.-Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"M180","DOI":"10.1111\/j.1750-3841.2007.00394.x","article-title":"Natural maize phenolic acids for control of aflatoxigenic fungi on maize","volume":"72","author":"Nesci","year":"2007","journal-title":"J. Food Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.fm.2006.10.003","article-title":"Can phenolic compounds be used for the protection of corn from fungal invasion and mycotoxin contamination during storage?","volume":"24","author":"Samapundo","year":"2007","journal-title":"Food Microbiol."},{"key":"ref_34","first-page":"M381","article-title":"Volatile trans-2-hexenal, a soybean aldehyde, inhibits Aspergillus flavus growth and aflatoxin production in corn","volume":"76","author":"Bhatnagar","year":"2011","journal-title":"J. Food Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Mohamadi Sani, A., Gholampour Azizi, E., Ataye Salehi, E., and Rahimi, K. (2012). Reduction of aflatoxin in rice by different cooking methods. Toxicol. Ind. Health, Published online Sept. 27.","DOI":"10.1177\/0748233712462466"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Sun, Z., Chen, T., Thorgeirsson, S.S., Zhan, Q., Chen, J., Park, J.H., Lu, P., Hsia, C.C., Wang, N., and Xu, L. (2013). Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China. Carcinogenesis, published online Jan. 14.","DOI":"10.1093\/carcin\/bgt007"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/19440040903573032","article-title":"Strategies to reduce mycotoxin levels in maize during storage: A review","volume":"27","author":"Chulze","year":"2010","journal-title":"Food Addit. Contam."},{"key":"ref_38","first-page":"851","article-title":"Aflatoxin-induced biochemical changes in liver of mice and its mitigation by black tea extract","volume":"69","author":"Jha","year":"2012","journal-title":"Acta Poloniae Pharm."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Rasooly, R., Hernlem, B., and Friedman, M. (2013). Low levels of aflatoxin B1, ricin, and milk enhance recombinant protein production in mammalian cells. PLoS One, submitted for publication.","DOI":"10.1371\/journal.pone.0071682"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1016\/j.fct.2012.06.053","article-title":"Fumonisin B1 and the kidney: Modes of action for renal tumor formation by fumonisin B1 in rodents","volume":"50","author":"Dekant","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.fct.2011.11.029","article-title":"Fumonisin B1 and risk of hepatocellular carcinoma in two Chinese cohorts","volume":"50","author":"Persson","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2478\/10004-1254-63-2012-2239","article-title":"Fumonisin B1: A neurotoxic mycotoxin","volume":"63","author":"Domijan","year":"2012","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijfoodmicro.2007.07.034","article-title":"Post-harvest control strategies: Minimizing mycotoxins in the food chain","volume":"119","author":"Magan","year":"2007","journal-title":"Int. J. Food Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1002\/mnfr.200900483","article-title":"Fumonisin exposure through maize in complementary foods is inversely associated with linear growth of infants in Tanzania","volume":"54","author":"Kimanya","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1740-8709.2011.00337.x","article-title":"Strategies to reduce exposure of fumonisins from complementary foods in rural Tanzania","volume":"8","author":"Kimanya","year":"2012","journal-title":"Matern. Child Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Sumalan, R.-M., Alexa, E., and Poiana, M.-A. (2013). Assessment of inhibitory potential of essential oils on natural mycoflora and Fusarium mycotoxins production in wheat. Chem. Cent. J., 7.","DOI":"10.1186\/1752-153X-7-32"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.toxicon.2012.12.010","article-title":"Study of the chemical reduction of the fumonisins toxicity using allyl, benzyl and phenyl isothiocyanate in model solution and in food products","volume":"63","author":"Azaiez","year":"2013","journal-title":"Toxicon"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Brown, K.A., Mays, T., Romoser, A., Marroquin-Cardona, A., Mitchell, N.J., Elmore, S.E., and Phillips, T.D. (2012). Modified hydra bioassay to evaluate the toxicity of multiple mycotoxins and predict the detoxification efficacy of a clay-based sorbent. J. Appl. Toxicol.","DOI":"10.1002\/jat.2824"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1021\/jf202042z","article-title":"Efficacy of a mycotoxin binder against dietary fumonisin, deoxynivalenol, and zearalenone in rats","volume":"59","author":"Qiang","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_50","first-page":"S312","article-title":"Extrusion cooking with glucose supplementation of fumonisin-contaminated corn grits protects against nephrotoxicity and disrupted sphingolipid metabolism in rats","volume":"55","author":"Voss","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Voss, K.A., Riley, R.T., Moore, N.D., and Burns, T.D. (2012). Alkaline cooking (nixtamalisation) and the reduction in the in vivo toxicity of fumonisin-contaminated corn in a rat feeding bioassay. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess.","DOI":"10.1080\/19440049.2012.712064"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.toxicon.2010.03.006","article-title":"Aquilegia vulgaris L. extract counteracts oxidative stress and cytotoxicity of fumonisin in rats","volume":"56","author":"Hassan","year":"2010","journal-title":"Toxicon"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.fct.2009.12.006","article-title":"Red ginseng extract protects against aflatoxin B1 and fumonisins-induced hepatic pre-cancerous lesions in rats","volume":"48","author":"Hassan","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.fct.2008.11.004","article-title":"Chemoprotective properties of rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) herbal and green and black (Camellia sinensis) teas against cancer promotion induced by fumonisin B1 in rat liver","volume":"47","author":"Marnewick","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.4315\/0362-028X-65.10.1545","article-title":"Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica","volume":"65","author":"Friedman","year":"2002","journal-title":"J. Food Prot."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4315\/0362-028X.JFP-11-307","article-title":"Kinetics of thermal destruction of Salmonella in ground chicken containing trans-cinnamaldehyde and carvacrol","volume":"75","author":"Juneja","year":"2012","journal-title":"J. Food Prot."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.fm.2012.12.001","article-title":"Antimicrobial activity of oregano oil against antibiotic-resistant Salmonella enterica on organic leafy greens at varying exposure times and storage temperatures","volume":"34","author":"Gerber","year":"2013","journal-title":"Food Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1021\/jf00088a040","article-title":"Composition of jimson weed (Datura stramonium) seeds","volume":"37","author":"Friedman","year":"1989","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0378-4274(90)90181-K","article-title":"The effects of low levels of dietary toxic weed seeds (jimson weed, Datura stramonium and sicklepod, Cassia obtusifolia) on the relative size of rat liver and levels and function of cytochrome P-450","volume":"54","author":"Crawford","year":"1990","journal-title":"Toxicol. Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0278-6915(89)90045-8","article-title":"Toxicological evaluation of jimson weed (Datura stramonium) seed","volume":"27","author":"Dugan","year":"1989","journal-title":"Food Chem. Toxicol."},{"key":"ref_61","first-page":"2","article-title":"Ochratoxin A in food and feed: Occurrence, legislation and mode of action","volume":"37","year":"1998","journal-title":"Z. Ernaehrungswiss."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1365-2672.2005.02695.x","article-title":"Water, temperature and gas composition interactions affect growth and ochratoxin A production by isolates of Penicillium verrucosum on wheat grain","volume":"99","author":"Aldred","year":"2005","journal-title":"J. Appl. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.ijfoodmicro.2006.02.006","article-title":"Occurrence of ochratoxin A in wine and ochratoxigenic mycoflora in grapes and dried vine fruits in South America","volume":"111","author":"Chulze","year":"2006","journal-title":"Int. J. Food Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ijfoodmicro.2006.09.027","article-title":"Occurrence of ochratoxigenic fungi and ochratoxin A in grapes from a Tunisian vineyard","volume":"114","author":"Lasram","year":"2007","journal-title":"Int. J. Food Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/j.fct.2008.02.026","article-title":"Fungal contamination and Aflatoxin B1 and Ochratoxin A in Lebanese wine-grapes and musts","volume":"46","author":"Rizk","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tox.2004.08.004","article-title":"Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells","volume":"206","author":"Kamp","year":"2005","journal-title":"Toxicology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2008.06.008","article-title":"Individual and combined effects of ochratoxin A and citrinin on viability and DNA fragmentation in cultured Vero cells and on chromosome aberrations in mice bone marrow cells","volume":"251","author":"Bouslimi","year":"2008","journal-title":"Toxicology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10565-009-9131-0","article-title":"Characterization of ochratoxin A-induced apoptosis in primary rat hepatocytes","volume":"26","author":"Chopra","year":"2010","journal-title":"Cell Biol. Toxicol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/mnfr.200600137","article-title":"Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans","volume":"51","author":"Manderville","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_70","first-page":"133","article-title":"Ochratoxin A induces craniofacial malformation in mice acting on Dlx5 gene expression","volume":"2","author":"Napoletano","year":"2010","journal-title":"Front. Biosci. Elite Ed."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.4315\/0362-028X-73.8.1493","article-title":"Food-grade antioxidants and antimicrobials to control growth and ochratoxin a production by Aspergillus section Nigri on peanut kernels","volume":"73","author":"Barberis","year":"2010","journal-title":"J. Food Prot."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/j.1365-2672.2007.03700.x","article-title":"Isolation of Bacillus spp. from Thai fermented soybean (Thua-nao): Screening for aflatoxin B1 and ochratoxin A detoxification","volume":"104","author":"Petchkongkaew","year":"2008","journal-title":"J. Appl. Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/toxins4020068","article-title":"Biocontrol of Penicillium nordicum growth and ochratoxin A production by native yeasts of dry cured ham","volume":"4","author":"Virgili","year":"2012","journal-title":"Toxins"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijfoodmicro.2011.09.010","article-title":"Inhibition of A. carbonarius growth and reduction of ochratoxin A by bacteria and yeast composites of technological importance in culture media and beverages","volume":"152","author":"Kapetanakou","year":"2012","journal-title":"Int. J. Food Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.febslet.2012.11.007","article-title":"The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals","volume":"587","author":"Pirazzini","year":"2013","journal-title":"FEBS Lett."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1021\/ja910761y","article-title":"Botulinum neurotoxin a protease: Discovery of natural product exosite inhibitors","volume":"132","author":"Salzameda","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Chalk, C., Benstead, T.J., and Keezer, M. (2011). Medical treatment for botulism. Cochrane Database Syst. Rev., 3.","DOI":"10.1002\/14651858.CD008123.pub2"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Hill, S.E., Iqbal, R., Cadiz, C.L., and Le, J. (2013). Foodborne botulism treated with heptavalent botulism antitoxin. Ann. Pharmacother., 47.","DOI":"10.1345\/aph.1R646"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/cid\/cis901","article-title":"National outbreak of type a foodborne botulism associated with a widely distributed commercially canned hot dog chili sauce","volume":"56","author":"Juliao","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.4315\/0362-028X.JFP-11-128","article-title":"Three outbreaks of foodborne botulism caused by unsafe home canning of vegetables-ohio and Washington, 2008 and 2009","volume":"74","author":"Date","year":"2011","journal-title":"J. Food Prot."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1745-4565.2000.tb00292.x","article-title":"Effect of ethanol vapor on growth and toxin production by Clostridium botulinum in a high moisture bakery product","volume":"20","author":"Daifas","year":"2000","journal-title":"J. Food Saf."},{"key":"ref_82","first-page":"507","article-title":"Challenge studies with Clostridium botulinum in high moisture bakery products packaged under modified atmospheres","volume":"51","author":"Daifas","year":"1999","journal-title":"Food Aust."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4315\/0362-028X-62.4.349","article-title":"Growth and toxin production by Clostridium botulinum in English-style crumpets packaged under modified atmospheres","volume":"62","author":"Daifas","year":"1999","journal-title":"J. Food Prot."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.fm.2010.04.004","article-title":"Quantitative risk assessment for hazards that arise from non-proteolytic Clostridium botulinum in minimally processed chilled dairy-based foods","volume":"28","author":"Malakar","year":"2011","journal-title":"Food Microbiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.4315\/0362-028X.JFP-11-358","article-title":"Botulism challenge studies of a modified atmosphere package for fresh mussels: Inoculated pack studies","volume":"75","author":"Newell","year":"2012","journal-title":"J. Food Prot."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ijfoodmicro.2012.02.009","article-title":"Prevalence of Clostridium botulinum and thermophilic heat-resistant spores in raw carrots and green beans used in French canning industry","volume":"155","author":"Sevenier","year":"2012","journal-title":"Int. J. Food Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ijfoodmicro.2004.01.017","article-title":"Effects of mastic resin and its essential oil on the growth of proteolytic Clostridium botulinum","volume":"94","author":"Daifas","year":"2004","journal-title":"Int. J. Food Microbiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.4315\/0362-028X.JFP-12-056","article-title":"Inhibition of toxigenesis of group II (nonproteolytic) Clostridium botulinum type B in meat products by using a reduced level of nitrite","volume":"75","author":"Puolanne","year":"2012","journal-title":"J. Food Prot."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"M427","DOI":"10.1111\/j.1750-3841.2011.02260.x","article-title":"Inhibition of Escherichia coli O157:H7 and Clostridium sporogenes in spinach packaged in modified atmospheres after treatment combined with chlorine and lactic acid bacteria","volume":"76","author":"Brown","year":"2011","journal-title":"J. Food Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3136\/nskkk.49.808","article-title":"Black tea extract reduces the oral toxicity of botulinum neurotoxin applied to food","volume":"49","author":"Sawamura","year":"2002","journal-title":"Nippon Shokuhin Kagaku Kogaku Kaishi"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2131\/jts.27.441","article-title":"A mechanism of the thearubigin fraction of black tea (Camellia sinensis) extract protecting against the effect of tetanus toxin","volume":"27","author":"Satoh","year":"2002","journal-title":"J. Toxicol. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/sj.bjp.0703883","article-title":"Black tea extract, thearubigin fraction, counteract the effects of botulinum neurotoxins in mice","volume":"132","author":"Satoh","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"ref_93","first-page":"116P","article-title":"Isolation and determination of an antidote for botulinum neurotoxin from black tea extract","volume":"120","author":"Sawamura","year":"2002","journal-title":"Folia Pharmacol. Jpn."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/09637480500398801","article-title":"Ethyl acetate extract from black tea prevents neuromuscular blockade by botulinum neurotoxin type A in vitro","volume":"56","author":"Satoh","year":"2005","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1742-7843.2004.pto950503.x","article-title":"Inhibition of the protease activity of the light chain of type A botulinum neurotoxin by aqueous extract from stinging nettle (Urtica dioica) leaf","volume":"95","author":"Gul","year":"2004","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1021\/ml100074s","article-title":"Identification of a natural product antagonist against the botulinum neurotoxin light chain protease","volume":"1","author":"Eubanks","year":"2010","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/mnfr.200600173","article-title":"Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas","volume":"51","author":"Friedman","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"C550","DOI":"10.1111\/j.1365-2621.2005.tb08304.x","article-title":"Distribution of catechins, theaflavins, caffeine, and theobromine in 77 teas consumed in the United States","volume":"70","author":"Friedman","year":"2005","journal-title":"J. Food Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"C328","DOI":"10.1111\/j.1750-3841.2006.00090.x","article-title":"HPLC analysis of catechins, theaflavins, and alkaloids in commercial teas and green tea dietary supplements: Comparison of water and 80% ethanol\/water extracts","volume":"71","author":"Friedman","year":"2006","journal-title":"J. Food Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.4315\/0362-028X-70.6.1429","article-title":"Control of Clostridium perfringens spores by green tea leaf extracts during cooling of cooked ground beef, chicken, and pork","volume":"70","author":"Juneja","year":"2007","journal-title":"J. Food Prot."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4315\/0362-028X-70.1.218","article-title":"Carvacrol, cinnamaldehyde, oregano oil, and thymol inhibit Clostridium perfringens spore germination and outgrowth in ground turkey during chilling","volume":"70","author":"Juneja","year":"2007","journal-title":"J. Food Prot."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10408410590912952","article-title":"Clostridium botulinum: A bug with beauty and weapon","volume":"31","author":"Shukla","year":"2005","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1128\/AAC.00482-11","article-title":"A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na+-driven flagellar motor and virulence gene expression in Vibrio cholerae","volume":"55","author":"Rasmussen","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2672.1991.tb04435.x","article-title":"The protective activity of tea against infection by Vibrio cholerae O1","volume":"70","author":"Toda","year":"1991","journal-title":"J. Appl. Bacteriol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1348-0421.1992.tb02103.x","article-title":"The protective activity of tea catechins against experimental infection by Vibrio cholerae O1","volume":"36","author":"Toda","year":"1992","journal-title":"Microbiol. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"23303","DOI":"10.1074\/jbc.M502093200","article-title":"Differential activities of plant polyphenols on the binding and internalization of cholera toxin in vero cells","volume":"280","author":"Morinaga","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_107","first-page":"175","article-title":"Catechin - Multifunctional biodefense agent","volume":"57","author":"Toda","year":"1997","journal-title":"J. Showa Med. Assoc."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1128\/iai.53.3.700-701.1986","article-title":"Inhibition of cholera toxin production by thiols in Vibrio cholerae","volume":"53","author":"Shimamura","year":"1986","journal-title":"Infect. Immun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/jf0009246","article-title":"Nutritional and health benefits of soy proteins","volume":"49","author":"Friedman","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1023\/A:1012558530359","article-title":"Application of the S-pyridylethylation reaction to the elucidation of the structures and functions of proteins","volume":"20","author":"Friedman","year":"2001","journal-title":"J. Protein Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1089\/fpd.2009.0387","article-title":"Inhibition of binding of the AB5-type enterotoxins LT-I and cholera toxin to ganglioside GM1 by galactose-rich dietary components","volume":"7","author":"Becker","year":"2010","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1016\/j.carres.2009.06.038","article-title":"Carbohydrate-based anti-adhesive inhibition of Vibrio cholerae toxin binding to GM1-OS immobilized into artificial planar lipid membranes","volume":"344","author":"Sinclair","year":"2009","journal-title":"Carbohydr. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1574-6968.2010.01931.x","article-title":"Capsaicin, a potential inhibitor of cholera toxin production in Vibrio cholerae","volume":"306","author":"Chatterjee","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"9172","DOI":"10.1021\/jf050469j","article-title":"Analysis of eight capsaicinoids in peppers and pepper-containing foods by high-performance liquid chromatography and liquid chromatography-mass spectrometry","volume":"53","author":"Kozukue","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1021\/jf061157z","article-title":"Analysis of the contents of pungent compounds in fresh Korean red peppers and in pepper-containing foods","volume":"54","author":"Choi","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_116","first-page":"232","article-title":"Inhibition of virulence potential of Vibrio cholerae by natural compounds","volume":"133","author":"Yamasaki","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jep.2012.07.039","article-title":"Anti-diarrheal activity of (-)-epicatechin from Chiranthodendron pentadactylon Larreat: Experimental and computational studies","volume":"143","author":"Barbosa","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/mnfr.201200515","article-title":"Antitumor effects of dietary black and brown rice brans in tumor-bearing mice: Relationship to composition","volume":"57","author":"Choi","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_119","first-page":"S117","article-title":"Antimicrobial activity of rice bran extracts for diarrheal disease","volume":"94","author":"Kondo","year":"2011","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Holmgren, J., Bourgeois, L., Carlin, N., Clements, J., Gustafsson, B., Lundgren, A., Nygren, E., Tobias, J., Walker, R., and Svennerholm, A.M. (2013). Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA\/I, CS3, CS5 and CS6 combined with a hybrid LT\/CT B subunit antigen, administered alone and together with dmLT adjuvant. Vaccine.","DOI":"10.1016\/j.vaccine.2013.03.027"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ijfoodmicro.2009.10.005","article-title":"Shiga toxin Stx2 is heat-stable and not inactivated by pasteurization","volume":"136","author":"Rasooly","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"9281","DOI":"10.1021\/jf101744z","article-title":"Ingested Shiga toxin 2 (Stx2) causes histopathological changes in kidney, spleen and thymus tissues and mortality in mice","volume":"58","author":"Rasooly","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"211","DOI":"10.11150\/kansenshogakuzasshi1970.72.211","article-title":"[Bactericidal and anti-toxin activities of catechin on enterohemorrhagic Escherichia coli]","volume":"72","author":"Okubo","year":"1998","journal-title":"Kansenshogaku Zasshi"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0304-4165(99)00102-6","article-title":"Epigallocatechin gallate and gallocatechin gallate in green tea catechins inhibit extracellular release of Vero toxin from enterohemorrhagic Escherichia coli O157:H7","volume":"1472","author":"Amano","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Takemasa, N., Ohnishi, S., Tsuji, M., Shikata, T., and Yokoigawa, K. (2009). Screening and analysis of spices with ability to suppress verocytotoxin production by Escherichia coli O157. J. Food Sci., 74.","DOI":"10.1111\/j.1750-3841.2009.01326.x"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"959","DOI":"10.4315\/0362-028x.jfp-11-332","article-title":"Effect of preservatives on Shiga toxigenic phages and Shiga toxin of Escherichia coli O157:H7","volume":"75","author":"Subils","year":"2012","journal-title":"J. Food Prot."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1021\/bc100095w","article-title":"Glycan encapsulated gold nanoparticles selectively inhibit Shiga toxins 1 and 2","volume":"21","author":"Kulkarni","year":"2010","journal-title":"Bioconjug. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Branson, T.R., and Turnbull, W.B. (2012). Bacterial toxin inhibitors based on multivalent scaffolds. Chem. Soc. Rev.","DOI":"10.1002\/chin.201334214"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1128\/AEM.02230-08","article-title":"Novel cell-based method to detect Shiga toxin 2 from Escherichia coli O157:H7 and inhibitors of toxin activity","volume":"75","author":"Massey","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"M296","DOI":"10.1111\/j.1750-3841.2010.01615.x","article-title":"Inhibition of Shiga toxin 2 (Stx2) in apple juices and its resistance to pasteurization","volume":"75","author":"Rasooly","year":"2010","journal-title":"J. Food Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"M270","DOI":"10.1111\/1750-3841.12021","article-title":"Bactericidal activities of health-promoting, food-derived powders against the foodborne pathogens Escherichia coli, Listeria monocytogenes, Salmonella enterica, and Staphylococcus aureus","volume":"78","author":"Friedman","year":"2013","journal-title":"J. Food Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1439-0396.2011.01229.x","article-title":"In vitro inhibition of ETEC K88 adhesion by pea hulls and of LT enterotoxin binding by faba bean hulls","volume":"96","author":"Becker","year":"2012","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1017\/S0022029912000659","article-title":"Lactobacillus plantarum isolated from kefir protects Vero cells from cytotoxicity by type-II Shiga toxin from Escherichia coli O157:H7","volume":"80","author":"Kakisu","year":"2013","journal-title":"J. Dairy Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1097\/MCG.0b013e31826852b7","article-title":"Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains","volume":"46","author":"Mogna","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"M372","DOI":"10.1111\/j.1750-3841.2009.01282.x","article-title":"Effects of allspice, cinnamon, and clove bud essential oils in edible apple films on physical properties and antimicrobial activities","volume":"74","author":"Du","year":"2009","journal-title":"J. Food Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"M390","DOI":"10.1111\/j.1750-3841.2009.01289.x","article-title":"Antibacterial effects of allspice, garlic, and oregano essential oils in tomato films determined by overlay and vapor-phase methods","volume":"74","author":"Du","year":"2009","journal-title":"J. Food Sci."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Esparza-Gordillo, J., and Dekio, I. (2012). Atopic Dermatitis-Disease Etiology and Clinical Management, InTech-Open Access Publishers.","DOI":"10.5772\/1448"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00403-003-0411-x","article-title":"Inhibitory effect of catechin against the superantigen staphylococcal enterotoxin B (SEB)","volume":"295","author":"Hisano","year":"2003","journal-title":"Arch. Dermatol. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1472-765X.2002.01166.x","article-title":"Helichrysum italicum extract interferes with the production of enterotoxins by Staphylococcus aureus","volume":"35","author":"Nostro","year":"2002","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1605(98)00038-5","article-title":"Effect of intestinal Lactobacillus starter cultures on the behaviour of Staphylococcus aureus in fermented sausage","volume":"41","author":"Sameshima","year":"1998","journal-title":"Int. J. Food Microbiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijfoodmicro.2013.01.006","article-title":"The effect of undissociated lactic acid on Staphylococcus aureus growth and enterotoxin A production","volume":"162","author":"Lindblad","year":"2013","journal-title":"Int. J. Food Microbiol."},{"key":"ref_142","first-page":"46","article-title":"Influence of the food products, enriched with pectin, on properties of potentially patogenic representatives of the microflora of the large intenstine","volume":"75","author":"Fluer","year":"2006","journal-title":"Voprosy pitaniia"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3358\/shokueishi.49.116","article-title":"Examination of Staphylococcus aureus survival and growth during cheese-making process","volume":"49","author":"Aoyama","year":"2008","journal-title":"J. Food Hyg. Soc. Jpn."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1089\/fpd.2009.0279","article-title":"Effect of Eleutherine americana merr. Extract on enzymatic activity and enterotoxin production of Staphylococcus aureus in broth and cooked pork","volume":"6","author":"Ifesan","year":"2009","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e7499","DOI":"10.1371\/journal.pone.0007499","article-title":"Glycerol monolaurate and dodecylglycerol effects on Staphylococcus aureus and toxic shock syndrome toxin-1 in vitro and in vivo","volume":"4","author":"Lin","year":"2009","journal-title":"PLoS One"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1021\/jf904021b","article-title":"Inhibition of biological activity of staphylococcal enterotoxin A (SEA) by apple juice and apple polyphenols","volume":"58","author":"Rasooly","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"M558","DOI":"10.1111\/j.1750-3841.2011.02365.x","article-title":"The olive compound hydroxytyrosol inactivates Staphylococcus aureus bacteria and Staphylococcal enterotoxin A (SEA)","volume":"76","author":"Friedman","year":"2011","journal-title":"J. Food Sci."},{"key":"ref_148","first-page":"399","article-title":"Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin 1 (TSST-1), leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice","volume":"12","author":"Nakagawa","year":"2005","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"14349","DOI":"10.1021\/bi701202w","article-title":"\u03b1 and \u03b2 chains of hemoglobin inhibit production of Staphylococcus aureus exotoxins","volume":"46","author":"Schlievert","year":"2007","journal-title":"Biochemistry"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/fpd.2009.0440","article-title":"Screening of phenolic antioxidants for their inhibitory activity against foodborne Staphylococcus aureus strains","volume":"7","year":"2010","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e13253","DOI":"10.1371\/journal.pone.0013253","article-title":"Inhibition of toxic shock by human monoclonal antibodies against staphylococcal enterotoxin B","volume":"5","author":"Larkin","year":"2010","journal-title":"PLoS One"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2012.08.013","article-title":"Inhibition of emetic and superantigenic activities of staphylococcal enterotoxin A by synthetic peptides","volume":"38","author":"Maina","year":"2012","journal-title":"Peptides"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2165\/00139709-200322010-00006","article-title":"Ricin. Mechanism of cytotoxicity","volume":"22","author":"Lord","year":"2003","journal-title":"Toxicol. Rev."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3390\/toxins3101233","article-title":"Structure-based design of ricin inhibitors","volume":"3","author":"Jasheway","year":"2011","journal-title":"Toxins"},{"key":"ref_155","first-page":"41","article-title":"Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction","volume":"357","author":"Mantis","year":"2012","journal-title":"Ricin and Shiga Toxins"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0014-5793(04)00286-8","article-title":"Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins","volume":"563","author":"Barbieri","year":"2004","journal-title":"FEBS Lett."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1021\/bi011580v","article-title":"The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol","volume":"41","author":"Deeks","year":"2002","journal-title":"Biochemistry"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"27924","DOI":"10.1074\/jbc.M112.362988","article-title":"Milk inhibits the biological activity of ricin","volume":"287","author":"Rasooly","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4315\/0362-028x.jfp-11-448","article-title":"Sensitive bioassay for detection of biologically active ricin in food","volume":"75","author":"Rasooly","year":"2012","journal-title":"J. Food Prot."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.toxicon.2010.05.009","article-title":"Identification of new classes of ricin toxin inhibitors by virtual screening","volume":"56","author":"Bai","year":"2010","journal-title":"Toxicon"},{"key":"ref_161","first-page":"418","article-title":"Interstitial chemotherapy with ricin-loaded thermosensitive hydrogel in pancreatic cancer xenograft","volume":"8","author":"Chen","year":"2009","journal-title":"Hepatobiliary Pancreatic Dis. Int."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1590\/S0100-879X2012007500132","article-title":"Simultaneous allergen inactivation and detoxification of castor bean cake by treatment with calcium compounds","volume":"45","author":"Fernandes","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"T65","DOI":"10.1111\/j.1750-3841.2010.01570.x","article-title":"Thermal stability of ricin in orange and apple juices","volume":"75","author":"Jackson","year":"2010","journal-title":"J. Food Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jenvman.2012.10.023","article-title":"Potential of castor bean (Ricinus communis L.) for phytoremediation of mine tailings and oil production","volume":"114","year":"2013","journal-title":"J. Environ. Manage."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"8655","DOI":"10.1021\/jf061471t","article-title":"Potato glycoalkaloids and metabolites: Roles in the plant and in the diet","volume":"54","author":"Friedman","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0278-6915(91)90046-A","article-title":"Developmental toxicology of potato alkaloids in the frog embryo teratogenesis assay-Xenopus (FETAX)","volume":"29","author":"Friedman","year":"1991","journal-title":"Food Chem. Toxicol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0278-6915(95)00080-1","article-title":"Protective effects of glucose-6-phosphate and NADP against \u03b1-chaconine-induced developmental toxicity in Xenopus embryos","volume":"33","author":"Rayburn","year":"1995","journal-title":"Food Chem. Toxicol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1021\/jf9702205","article-title":"Folic acid protects against potato glycoalkaloid \u03b1-chaconine-induced disruption of frog embryo cell membranes and developmental toxicity","volume":"45","author":"Friedman","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0278-6915(00)00090-9","article-title":"The folic acid analogue methotrexate protects frog embryo cell membranes against damage by the potato glycoalkaloid \u03b1-chaconine","volume":"38","author":"McWilliams","year":"2000","journal-title":"Food Chem. Toxicol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1095\/biolreprod.110.088351","article-title":"Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy","volume":"84","author":"Williams","year":"2011","journal-title":"Biol. Reprod."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"M377","DOI":"10.1111\/j.1750-3841.2012.02751.x","article-title":"Inactivation of Listeria monocytogenes on ham and bologna using pectin-based apple, carrot, and hibiscus edible films containing carvacrol and cinnamaldehyde","volume":"77","author":"Ravishankar","year":"2012","journal-title":"J. Food Sci."}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/5\/4\/743\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:46:18Z","timestamp":1760219178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/5\/4\/743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,23]]},"references-count":171,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4]]}},"alternative-id":["toxins5040743"],"URL":"https:\/\/doi.org\/10.3390\/toxins5040743","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,23]]}}}