{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:32:26Z","timestamp":1760549546518,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Enterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there remains no broadly protective ETEC vaccine. The discovery of new virulence proteins and an improved appreciation of the complexity of the molecular events required for effective toxin delivery may provide additional avenues to pursue in development of an effective vaccine to prevent severe diarrhea caused by these important pathogens.<\/jats:p>","DOI":"10.3390\/toxins6061799","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T11:50:51Z","timestamp":1402401051000},"page":"1799-1812","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli"],"prefix":"10.3390","volume":"6","author":[{"given":"James","family":"Fleckenstein","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Washington University School of Medicine, 660 South Euclid Avenue; Saint Louis, MO 63110, USA"},{"name":"Molecular Microbiology and Microbiobial Pathogenesis Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue; Saint Louis, MO 63110, USA"},{"name":"Veterans Affairs Medical Center, Saint Louis, MO 63106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaullah","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Molecular Microbiology and Microbiobial Pathogenesis Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue; Saint Louis, MO 63110, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): A prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1128\/IAI.00459-07","article-title":"Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh","volume":"75","author":"Qadri","year":"2007","journal-title":"Infect. 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