{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:09:39Z","timestamp":1791227379853,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>It is crucial to define risk factors that contribute to host invasion by  Staphylococcus aureus. Here, we demonstrate that the chromosomally encoded EDIN-B isoform from S. aureus contributes to the onset of bacteremia during the course of pneumonia. Deletion of edinB in a European lineage community-acquired methicillin resistant S. aureus (CA-MRSA) strain (ST80-MRSA-IV) dramatically decreased the frequency and magnitude of bacteremia in mice suffering from pneumonia. This deletion had no effect on the bacterial burden in both blood circulation and lung tissues. Re-expression of wild-type EDIN-B, unlike the catalytically inactive mutant EDIN-R185E, restored the invasive characteristics of ST80-MRSA-IV.<\/jats:p>","DOI":"10.3390\/toxins7104131","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T12:44:06Z","timestamp":1444913046000},"page":"4131-4142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia"],"prefix":"10.3390","volume":"7","author":[{"given":"Johan","family":"Courjon","sequence":"first","affiliation":[{"name":"INSERM U1065, Equipe Labellis\u00e9e Ligue Contre le Cancer,  Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Universit\u00e9 de Nice Sophia-Antipolis,  Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Munro","sequence":"additional","affiliation":[{"name":"INSERM U1065, Equipe Labellis\u00e9e Ligue Contre le Cancer,  Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Universit\u00e9 de Nice Sophia-Antipolis,  Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Benito","sequence":"additional","affiliation":[{"name":"CIRI, International Center for Infectiology Research, Inserm U1111, Universit\u00e9 Lyon 1,  Ecole Normale Sup\u00e9rieure de Lyon, CNRS UMR5308, 7 Rue Guillaume Paradin, Lyon 69372, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orane","family":"Visvikis","sequence":"additional","affiliation":[{"name":"INSERM U1065, Equipe Labellis\u00e9e Ligue Contre le Cancer,  Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Universit\u00e9 de Nice Sophia-Antipolis,  Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Bouchiat","sequence":"additional","affiliation":[{"name":"CIRI, International Center for Infectiology Research, Inserm U1111, Universit\u00e9 Lyon 1,  Ecole Normale Sup\u00e9rieure de Lyon, CNRS UMR5308, 7 Rue Guillaume Paradin, Lyon 69372, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1375-1706","authenticated-orcid":false,"given":"Laurent","family":"Boyer","sequence":"additional","affiliation":[{"name":"INSERM U1065, Equipe Labellis\u00e9e Ligue Contre le Cancer,  Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Universit\u00e9 de Nice Sophia-Antipolis,  Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Doye","sequence":"additional","affiliation":[{"name":"INSERM U1065, Equipe Labellis\u00e9e Ligue Contre le Cancer,  Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Universit\u00e9 de Nice Sophia-Antipolis,  Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Lepidi","sequence":"additional","affiliation":[{"name":"CNRS UMR 7278, IRD198, INSERM U1095, Aix-Marseille Universit\u00e9, 27 Bd Jean Moulin,  Marseille 13385, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ghigo","sequence":"additional","affiliation":[{"name":"CNRS UMR 7278, IRD198, INSERM U1095, Aix-Marseille Universit\u00e9, 27 Bd Jean Moulin,  Marseille 13385, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Lavigne","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, CHU Car\u00e9meau, Place du Professeur Robert Debr\u00e9, N\u00eemes 30029, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Vandenesch","sequence":"additional","affiliation":[{"name":"CIRI, International Center for Infectiology Research, Inserm U1111, Universit\u00e9 Lyon 1,  Ecole Normale Sup\u00e9rieure de Lyon, CNRS UMR5308, 7 Rue Guillaume Paradin, Lyon 69372, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Lemichez","sequence":"additional","affiliation":[{"name":"INSERM U1065, Equipe Labellis\u00e9e Ligue Contre le Cancer,  Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Universit\u00e9 de Nice Sophia-Antipolis,  Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jcrc.2010.09.002","article-title":"Bacteremia in Staphylococcus aureus pneumonia: Outcomes and epidemiology","volume":"26","author":"Schreiber","year":"2011","journal-title":"J. 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